MX2010007502A - Compuestos de tienopiridazina, sus preparaciones, composiciones farmaceuticas y sus usos. - Google Patents

Compuestos de tienopiridazina, sus preparaciones, composiciones farmaceuticas y sus usos.

Info

Publication number
MX2010007502A
MX2010007502A MX2010007502A MX2010007502A MX2010007502A MX 2010007502 A MX2010007502 A MX 2010007502A MX 2010007502 A MX2010007502 A MX 2010007502A MX 2010007502 A MX2010007502 A MX 2010007502A MX 2010007502 A MX2010007502 A MX 2010007502A
Authority
MX
Mexico
Prior art keywords
compounds
pharmaceutical compositions
preparations
thienopyridazine
thienopyridazine compounds
Prior art date
Application number
MX2010007502A
Other languages
English (en)
Inventor
Zhanggui Wu
Original Assignee
Zhejiang Med Xinchang Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zhejiang Med Xinchang Pharm filed Critical Zhejiang Med Xinchang Pharm
Publication of MX2010007502A publication Critical patent/MX2010007502A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se relaciona a compuestos de la Fórmula (I), sus sales o hidratos farmacéuticamente aceptables, en donde R1 y R2 son independientemente H ó alquilo C1-4, R3 es un anillo saturado o insaturado de 5- ó 6- miembros conteniendo N, S ú O ó sus isómeros ópticos, R4 es un halofenilo monosustituido o bisustituido en cualquier posición. La presente invención proporciona los métodos de preparación de estos compuestos, las composiciones farmacéuticas conteniendo estos compuestos y los usos de éstos compuestos, particularmente en el tratamiento del cáncer. (ver fórmula (I)).
MX2010007502A 2008-01-08 2009-01-07 Compuestos de tienopiridazina, sus preparaciones, composiciones farmaceuticas y sus usos. MX2010007502A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN200810000936 2008-01-08
CN2009100003371A CN101481380B (zh) 2008-01-08 2009-01-06 噻吩并哒嗪类化合物及其制备方法、药物组合物及其用途
PCT/CN2009/000021 WO2009092278A1 (zh) 2008-01-08 2009-01-07 噻吩并哒嗪类化合物及其制备方法、药物组合物及其用途

Publications (1)

Publication Number Publication Date
MX2010007502A true MX2010007502A (es) 2010-10-15

Family

ID=40878690

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010007502A MX2010007502A (es) 2008-01-08 2009-01-07 Compuestos de tienopiridazina, sus preparaciones, composiciones farmaceuticas y sus usos.

Country Status (11)

Country Link
US (3) US8318740B2 (es)
EP (1) EP2241569B1 (es)
JP (1) JP5456694B2 (es)
KR (1) KR101512530B1 (es)
CN (1) CN101481380B (es)
AU (1) AU2009207968B2 (es)
BR (1) BRPI0907228B1 (es)
CA (1) CA2711629C (es)
MX (1) MX2010007502A (es)
RU (1) RU2494103C2 (es)
WO (1) WO2009092278A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2477496B1 (en) * 2009-09-18 2014-04-16 Zhanggui Wu Novel compounds and therapeutic use thereof for protein kinase inhibition
AU2014262547A1 (en) 2013-05-10 2015-11-26 Gilead Apollo, Llc ACC inhibitors and uses thereof
CN105358154A (zh) 2013-05-10 2016-02-24 尼普斯阿波罗有限公司 Acc抑制剂和其用途
KR20160007598A (ko) 2013-05-10 2016-01-20 님버스 아폴로, 인코포레이티드 Acc 억제제 및 이의 용도
WO2014182950A1 (en) * 2013-05-10 2014-11-13 Nimbus Apollo, Inc. Acc inhibitors and uses thereof
DK3013337T3 (en) 2013-06-26 2019-02-25 Abbvie Inc PRIMARY CARBOXAMIDES AS BTK INHIBITORS
CN103288614B (zh) * 2013-06-27 2014-09-17 中国科学院昆明植物研究所 具有抗肿瘤活性的间苯三酚类化合物及其药物组合物
EP3024457A4 (en) 2013-07-26 2017-06-28 Update Pharma Inc. Compositions to improve the therapeutic benefit of bisantrene
CN103694217A (zh) * 2013-12-20 2014-04-02 华东师范大学 一种2,4-二取代噻吩衍生物及其制备方法和应用
CN115038439A (zh) * 2020-01-07 2022-09-09 上海华禹生物科技有限公司 使用chk抑制剂的癌症联合疗法
CN115605484A (zh) * 2020-04-17 2023-01-13 浙江医药股份有限公司新昌制药厂（Cn） 一种噻吩并哒嗪类化合物的晶型及其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GT200000158A (es) * 1999-09-28 2002-03-16 Piridinas y piridacinas sustituidas con actividad de inhibicion de angiogenesis.
EP1660474B1 (en) * 2003-08-15 2008-10-29 AstraZeneca AB Substituted thiophenes and uses thereof
EP1732920B1 (en) * 2004-01-05 2011-03-09 AstraZeneca AB Thiophene derivatives as chk 1 inhibitors
EP1745051A1 (en) * 2004-05-04 2007-01-24 F.Hoffmann-La Roche Ag Thienopyridazines as ikk inhibitors
MX2007012448A (es) * 2005-04-06 2007-10-19 Astrazeneca Ab Heterociclos sustituidos y su uso como inhibidores de chk1, pdk1 y pak.
AU2007240568A1 (en) * 2006-04-21 2007-11-01 Amgen Inc. Thieno-[2,3-d]pyrimidine and thieno-pyridazine compounds and methods of use
WO2008134480A1 (en) * 2007-04-25 2008-11-06 Bristol-Myers Squibb Company Non-basic melanin concentrating hormone receptor-1 antagonists
WO2009003911A1 (en) * 2007-06-29 2009-01-08 4Sc Ag Thiophene-imidazopyridines

Also Published As

Publication number Publication date
AU2009207968A1 (en) 2009-07-30
CA2711629C (en) 2017-10-24
EP2241569B1 (en) 2012-05-23
US9249154B2 (en) 2016-02-02
JP5456694B2 (ja) 2014-04-02
CN101481380A (zh) 2009-07-15
CA2711629A1 (en) 2009-07-30
JP2011508750A (ja) 2011-03-17
EP2241569A4 (en) 2011-01-12
KR20100117069A (ko) 2010-11-02
CN101481380B (zh) 2012-10-17
BRPI0907228A2 (pt) 2015-07-14
WO2009092278A8 (zh) 2010-07-22
US20090275585A1 (en) 2009-11-05
BRPI0907228B1 (pt) 2021-08-03
US20130143887A1 (en) 2013-06-06
KR101512530B1 (ko) 2015-04-15
US8962626B2 (en) 2015-02-24
US20110009415A1 (en) 2011-01-13
EP2241569A1 (en) 2010-10-20
WO2009092278A1 (zh) 2009-07-30
US8318740B2 (en) 2012-11-27
AU2009207968B2 (en) 2014-04-24
RU2494103C2 (ru) 2013-09-27
RU2010128221A (ru) 2012-02-20

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