PE20090357A1 - Compuestos heterociclicos con actividad sobre los receptores muscarinicos m3 - Google Patents

Compuestos heterociclicos con actividad sobre los receptores muscarinicos m3

Info

Publication number
PE20090357A1
PE20090357A1 PE2008000323A PE2008000323A PE20090357A1 PE 20090357 A1 PE20090357 A1 PE 20090357A1 PE 2008000323 A PE2008000323 A PE 2008000323A PE 2008000323 A PE2008000323 A PE 2008000323A PE 20090357 A1 PE20090357 A1 PE 20090357A1
Authority
PE
Peru
Prior art keywords
alkylene
alkyl
oxazol
octane
hydroxy
Prior art date
Application number
PE2008000323A
Other languages
English (en)
Inventor
Barbara Giuseppina Avitabile
Harry Finch
Jamie David Knight
Alan John Nadin
Nicholas Charles Ray
Original Assignee
Argenta Discovery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0702994A external-priority patent/GB0702994D0/en
Priority claimed from GB0722678A external-priority patent/GB0722678D0/en
Application filed by Argenta Discovery Ltd filed Critical Argenta Discovery Ltd
Publication of PE20090357A1 publication Critical patent/PE20090357A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

REFERIDA A UN COMPUESTO DE FORMULA (I), DONDE R2 ES H, -(Z)p-R7, -Z-Y-R7 O -Y-R7; p ES 0 O 1; R4 Y R5 ES ALQUILO C1-C6, ARILO, CICLOALQUILO, ENTRE OTROS; R6 ES OH, ALQUILO C1-C6, ALCOXI C1-C6, NITRILO, ENTRE OTROS; UNO DE W, V Y A ES N O NR11; OTRO DE W, V Y A SON N, O, S O CR8; Y OTRO DE W, V Y A ES N O CR8; X ES ALQUILENO C1-C4, ALQUENILENO C2-C4 O ALQUINILENO C2-C4; R7 ES ALQUILO C1-C6, ALQUENILO C2-C6, ARILO, ENTRE OTROS; t, u Y v SON 1, 2 O 3, Z ES ALQUILENO C1-C4, ALQUENILENO C2-C4, ALQUINILENO C2-C4; Y ESO, -OC(O)-, N(H)C(O) O S(O)n; n ES UN ENTERO DE 0 A 2; R8 Y R11 SON H O ALQUILO C1-C6; D- ES UN CONTRAION. SON COMPUESTOS PREFERIDOS: 1-[2-(HIDROXI-DIFENIL-METIL)-OXAZOL-5-ILMETIL]-3-FENOXI-1-AZONIABICICLO[2,2,2]OCTANO, (R)-1-[2-((R)-CICLOHEXIL-HIDROXI-FENIL-METIL)-OXAZOL-5-ILMETIL]-3-FENOXI-1-AZONIA-BICICLO[2,2,2]OCTANO, (R)-3-BENCILOXI-1-[2-((R)-CICLOHEXIL-HIDROXI-FENIL-METIL)-OXAZOL-5-ILMETIL]-1-AZONIA-BICICLO[2,2,2]-OCTANO, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS ACTUAN SOBRE LOS RECEPTORES MUSCARINICOS M3 Y SON UTILES EN EL TRATAMIENTO DE LA ENFERMEDAD PULMONAR OBSTRUCTIVA, ASMA, BRONQUITIS CRONICA, ENTRE OTRAS
PE2008000323A 2007-02-15 2008-02-14 Compuestos heterociclicos con actividad sobre los receptores muscarinicos m3 PE20090357A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0702994A GB0702994D0 (en) 2007-02-15 2007-02-15 Compound and thier use
GB0722678A GB0722678D0 (en) 2007-11-19 2007-11-19 Compounds and their use II

Publications (1)

Publication Number Publication Date
PE20090357A1 true PE20090357A1 (es) 2009-04-01

Family

ID=39323641

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000323A PE20090357A1 (es) 2007-02-15 2008-02-14 Compuestos heterociclicos con actividad sobre los receptores muscarinicos m3

Country Status (21)

Country Link
US (1) US20100056565A1 (es)
EP (1) EP2121688A1 (es)
JP (1) JP2010519193A (es)
KR (1) KR20090110353A (es)
CN (1) CN101657452A (es)
AR (1) AR065344A1 (es)
AU (1) AU2008215924B2 (es)
BR (1) BRPI0807913A2 (es)
CA (1) CA2676581A1 (es)
CL (1) CL2008000474A1 (es)
CO (1) CO6190612A2 (es)
EC (1) ECSP099573A (es)
IL (1) IL199971A0 (es)
MX (1) MX2009008323A (es)
NZ (1) NZ578489A (es)
PE (1) PE20090357A1 (es)
RU (1) RU2009133258A (es)
SA (1) SA08290066B1 (es)
TW (1) TW200843759A (es)
UY (1) UY30916A1 (es)
WO (1) WO2008099186A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200825084A (en) 2006-11-14 2008-06-16 Astrazeneca Ab New compounds 521
WO2009098453A1 (en) * 2008-02-06 2009-08-13 Astrazeneca Ab Azonia bicycloalkanes as m3 muscarinic acetylcholin receptor antagonists
EA017627B1 (ru) 2008-05-13 2013-01-30 Астразенека Аб Хинуклидиновые производные в качестве антагонистов мускаринового м3 рецептора
JP2011530588A (ja) * 2008-08-12 2011-12-22 アストラゼネカ・アクチエボラーグ ２−ヒドロキシ−エタンスルホン酸塩
GB0814728D0 (en) * 2008-08-12 2008-09-17 Argenta Discovery Ltd New combination
WO2010018352A1 (en) * 2008-08-12 2010-02-18 Argenta Discovery Limited Heterocyclic compounds used in the treatment of diseases where enhanced m3 receptor activation is implicated
GB0814729D0 (en) * 2008-08-12 2008-09-17 Argenta Discovery Ltd New combination
TW201036957A (en) 2009-02-20 2010-10-16 Astrazeneca Ab Novel salt 628
CN104418851A (zh) * 2013-09-02 2015-03-18 上海龙翔生物医药开发有限公司 奎宁环衍生物的制备方法及纯化方法
TR201908031T4 (tr) * 2014-08-26 2019-06-21 Astellas Pharma Inc İdrar kesesi hastalıklarının tedavisine yönelik muskarinik m3 ligandları olarak 2-aminotiyazol türevleri veya bunların tuzu.

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8334494D0 (en) * 1983-12-24 1984-02-01 Tanabe Seiyaku Co Carbostyril derivatives
NZ225999A (en) * 1987-09-10 1992-04-28 Merck Sharp & Dohme Azacyclic- or azabicyclic-substituted thiadiazole derivatives and pharmaceutical compositions
IL88846A0 (en) * 1988-01-08 1989-07-31 Merck Sharp & Dohme Lipophilic oxadiazoles,their preparation and pharmaceutical compositions containing them
GB9603755D0 (en) * 1996-02-22 1996-04-24 Pfizer Ltd Therapeutic agents
DE19856475A1 (de) * 1998-11-27 2000-05-31 Schering Ag Nichtsteroidale Entzündungshemmer
US20020052312A1 (en) * 2000-05-30 2002-05-02 Reiss Theodore F. Combination therapy of chronic obstructive pulmonary disease using muscarinic receptor antagonists
EE05404B1 (et) * 2000-12-28 2011-04-15 Almirall Prodesfarma Ag Kinuklidiini derivaat, selle saamine ja kasutamine ravimi valmistamiseks, mis on ette n„htud respiratoorsete, kuseelundite v?i mao-soolte haiguste ravimiseks, ning seda sisaldav ravimkompositsioon
MXPA05003344A (es) * 2002-09-30 2005-11-23 Neurosearch As Derivados novedosos de 1,4-diazabicicloalcano, su preparacion y uso.
DK1551835T3 (da) * 2002-09-30 2007-06-04 Neurosearch As Hidtil ukendte 1,4-diazabicycloalkanderivater, deres fremstilling og anvendelse
US7056916B2 (en) * 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
ES2239546B1 (es) * 2004-03-15 2006-12-01 Almirall Prodesfarma, S.A. Nuevos esteres de quinuclidina cuaternizados.
GB0516313D0 (en) * 2005-08-08 2005-09-14 Argenta Discovery Ltd Azole derivatives and their uses

Also Published As

Publication number Publication date
BRPI0807913A2 (pt) 2014-06-17
CL2008000474A1 (es) 2008-08-22
WO2008099186A1 (en) 2008-08-21
CO6190612A2 (es) 2010-08-19
US20100056565A1 (en) 2010-03-04
CN101657452A (zh) 2010-02-24
ECSP099573A (es) 2009-12-28
WO2008099186A8 (en) 2008-11-13
NZ578489A (en) 2011-05-27
IL199971A0 (en) 2010-04-15
MX2009008323A (es) 2009-08-13
RU2009133258A (ru) 2011-03-20
AU2008215924A1 (en) 2008-08-21
UY30916A1 (es) 2008-09-30
EP2121688A1 (en) 2009-11-25
JP2010519193A (ja) 2010-06-03
KR20090110353A (ko) 2009-10-21
TW200843759A (en) 2008-11-16
SA08290066B1 (ar) 2011-05-14
AR065344A1 (es) 2009-06-03
CA2676581A1 (en) 2008-08-21
AU2008215924B2 (en) 2011-04-21

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