ES2393498T3 - Moduladores macrocíclicos del receptor de ghrelina - Google Patents

Moduladores macrocíclicos del receptor de ghrelina Download PDF

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Publication number
ES2393498T3
ES2393498T3 ES05785185T ES05785185T ES2393498T3 ES 2393498 T3 ES2393498 T3 ES 2393498T3 ES 05785185 T ES05785185 T ES 05785185T ES 05785185 T ES05785185 T ES 05785185T ES 2393498 T3 ES2393498 T3 ES 2393498T3
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ES
Spain
Prior art keywords
boc
modulator
bts
phe
use according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES05785185T
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English (en)
Spanish (es)
Inventor
Hamid Hoveyda
Mark Peterson
Graeme Fraser
Mahesh Ramaseshan
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Tranzyme Pharma Inc
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Tranzyme Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/872,142 external-priority patent/US7521420B2/en
Application filed by Tranzyme Pharma Inc filed Critical Tranzyme Pharma Inc
Application granted granted Critical
Publication of ES2393498T3 publication Critical patent/ES2393498T3/es
Active legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
ES05785185T 2004-06-18 2005-06-13 Moduladores macrocíclicos del receptor de ghrelina Active ES2393498T3 (es)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US10/872,142 US7521420B2 (en) 2003-06-18 2004-06-18 Macrocyclic antagonists of the motilin receptor
US872142 2004-06-18
US62164204P 2004-10-26 2004-10-26
US621642P 2004-10-26
US62200504P 2004-10-27 2004-10-27
US622005P 2004-10-27
US64227105P 2005-01-07 2005-01-07
US642271P 2005-01-07
US149731 2005-06-10
US11/149,731 US7476653B2 (en) 2003-06-18 2005-06-10 Macrocyclic modulators of the ghrelin receptor
PCT/US2005/020857 WO2006009674A1 (en) 2004-06-18 2005-06-13 Macrocyclic modulators of the ghrelin receptor

Publications (1)

Publication Number Publication Date
ES2393498T3 true ES2393498T3 (es) 2012-12-21

Family

ID=35427667

Family Applications (1)

Application Number Title Priority Date Filing Date
ES05785185T Active ES2393498T3 (es) 2004-06-18 2005-06-13 Moduladores macrocíclicos del receptor de ghrelina

Country Status (7)

Country Link
US (2) US7476653B2 (US20090221689A1-20090903-C00008.png)
EP (3) EP2457893B1 (US20090221689A1-20090903-C00008.png)
JP (1) JP5363726B2 (US20090221689A1-20090903-C00008.png)
CN (1) CN101111512B (US20090221689A1-20090903-C00008.png)
CA (1) CA2579726C (US20090221689A1-20090903-C00008.png)
ES (1) ES2393498T3 (US20090221689A1-20090903-C00008.png)
WO (1) WO2006009674A1 (US20090221689A1-20090903-C00008.png)

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