ES2334875B1 - Metodo para preparar escitalopram. - Google Patents

Metodo para preparar escitalopram. Download PDF

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Publication number
ES2334875B1
ES2334875B1 ES200802582A ES200802582A ES2334875B1 ES 2334875 B1 ES2334875 B1 ES 2334875B1 ES 200802582 A ES200802582 A ES 200802582A ES 200802582 A ES200802582 A ES 200802582A ES 2334875 B1 ES2334875 B1 ES 2334875B1
Authority
ES
Spain
Prior art keywords
acid
benzonitrile
dimethylamino
fluorophenyl
hydroxybutyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES200802582A
Other languages
English (en)
Spanish (es)
Other versions
ES2334875A1 (es
Inventor
Carla De Faveri
Florian Anton Martin Huber
Robert James Dancer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39735675&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2334875(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Publication of ES2334875A1 publication Critical patent/ES2334875A1/es
Application granted granted Critical
Publication of ES2334875B1 publication Critical patent/ES2334875B1/es
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/32—Separation; Purification; Stabilisation; Use of additives
    • C07C253/34—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/53—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES200802582A 2007-09-11 2008-09-10 Metodo para preparar escitalopram. Expired - Fee Related ES2334875B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200701314 2007-09-11
DKPA200701314 2007-09-11

Publications (2)

Publication Number Publication Date
ES2334875A1 ES2334875A1 (es) 2010-03-16
ES2334875B1 true ES2334875B1 (es) 2010-10-27

Family

ID=39735675

Family Applications (2)

Application Number Title Priority Date Filing Date
ES08801398T Active ES2368294T3 (es) 2007-09-11 2008-09-10 Método para la fabricación de escitalopram.
ES200802582A Expired - Fee Related ES2334875B1 (es) 2007-09-11 2008-09-10 Metodo para preparar escitalopram.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES08801398T Active ES2368294T3 (es) 2007-09-11 2008-09-10 Método para la fabricación de escitalopram.

Country Status (52)

Country Link
EP (2) EP2061753B1 (fi)
JP (1) JP4966933B2 (fi)
KR (1) KR101054224B1 (fi)
CN (1) CN101386583A (fi)
AR (2) AR068174A1 (fi)
AT (2) ATE518829T1 (fi)
AU (1) AU2008212055C1 (fi)
BE (1) BE1017548A6 (fi)
BG (1) BG110206A (fi)
BR (1) BRPI0804121B1 (fi)
CA (1) CA2638499C (fi)
CH (1) CH697885B1 (fi)
CL (1) CL2008002686A1 (fi)
CO (1) CO6140012A1 (fi)
CY (2) CY2600B1 (fi)
CZ (1) CZ2008537A3 (fi)
DE (1) DE102008046530A1 (fi)
DK (2) DK2061753T3 (fi)
EA (1) EA012787B1 (fi)
EE (1) EE00864U1 (fi)
ES (2) ES2368294T3 (fi)
FI (1) FI121570B (fi)
FR (1) FR2920766A1 (fi)
GB (1) GB2448848B (fi)
GR (1) GR1006595B (fi)
HR (2) HRP20080425A2 (fi)
HU (1) HUP0800549A2 (fi)
IE (1) IES20080708A2 (fi)
IL (1) IL193845A (fi)
IS (1) IS8758A (fi)
LT (1) LT5577B (fi)
LU (1) LU91479B1 (fi)
LV (1) LV13813B (fi)
ME (1) ME00176B (fi)
MX (1) MX2008011451A (fi)
MY (1) MY144210A (fi)
NL (1) NL2001953C2 (fi)
NO (1) NO20083756L (fi)
NZ (1) NZ570884A (fi)
PL (2) PL386026A1 (fi)
PT (2) PT104169A (fi)
RO (1) RO125301A2 (fi)
RS (2) RS20080401A (fi)
SE (1) SE533041C2 (fi)
SG (1) SG151195A1 (fi)
SI (2) SI22567A2 (fi)
SK (1) SK500302008A3 (fi)
TR (2) TR200806903A2 (fi)
TW (1) TWI391383B (fi)
UA (2) UA41919U (fi)
WO (1) WO2009033488A1 (fi)
ZA (1) ZA200807753B (fi)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7939680B2 (en) 2005-07-27 2011-05-10 Aurobindo Pharma Ltd. Process for the preparation of Escitalopram
CN102796065A (zh) * 2011-05-27 2012-11-28 江苏豪森医药集团连云港宏创医药有限公司 一种制备光学纯度高的艾司西酞普兰的方法
CN104119240A (zh) * 2013-04-23 2014-10-29 中国人民解放军军事医学科学院毒物药物研究所 (S)-(-)-α-甲胺基苯丙酮的制备方法
CN103497145B (zh) * 2013-10-10 2016-01-27 南昌大学 一种光学纯多奈哌齐的制备工艺
CN104119248A (zh) * 2014-08-08 2014-10-29 广东东阳光药业有限公司 S-西酞普兰的制备方法
ES2881105T3 (es) * 2014-11-14 2021-11-26 Zhejiang Huahai Pharm Co Ltd Método para la resolución del producto intermedio de citalopram 5-cianodiol

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
AR034612A1 (es) 2001-06-25 2004-03-03 Lundbeck & Co As H Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram
AR034759A1 (es) * 2001-07-13 2004-03-17 Lundbeck & Co As H Metodo para la preparacion de escitalopram
IS7239A (is) * 2001-12-14 2004-04-29 H. Lundbeck A/S Aðferð til framleiðslu á essítalóprami
JP4505335B2 (ja) 2002-12-23 2010-07-21 ハー・ルンドベック・アクチエゼルスカベット ラセミ体シタロプラムジオール（ｒａｃｅｍｉｃｃｉｔａｌｏｐｒａｍｄｉｏｌ）および／またはＳ−もしくはＲ−シタロプラムジオールの製造方法、およびラセミ体シタロプラム、Ｒ−シタロプラムおよび／またはＳ−シタロプラムを製造するために、上記ジオールを使用する方法。
WO2004065375A1 (en) * 2003-01-17 2004-08-05 Natco Pharma Limited Processes for the preparation of escitalopram and its precursor
EP1706394B1 (en) * 2003-11-12 2014-12-17 Dr. Reddy's Laboratories, Inc. Preparation of escitalopram
EP1877394A1 (en) * 2005-04-04 2008-01-16 Jubilant Organosys Limited Process for the preparation of escitalopram or its acid addition salts
US7939680B2 (en) * 2005-07-27 2011-05-10 Aurobindo Pharma Ltd. Process for the preparation of Escitalopram

Also Published As

Publication number Publication date
RO125301A2 (ro) 2010-03-30
DK2061753T3 (da) 2011-09-26
EE00864U1 (et) 2009-10-15
SK500302008A3 (sk) 2009-04-06
FI121570B (fi) 2011-01-14
UA43461U (uk) 2009-08-25
RS20080401A (en) 2010-03-02
TWI391383B (zh) 2013-04-01
WO2009033488A1 (en) 2009-03-19
BRPI0804121B1 (pt) 2022-04-12
HUP0800549A2 (en) 2009-03-02
CA2638499C (en) 2010-09-28
PL2061753T3 (pl) 2011-12-30
EA012787B1 (ru) 2009-12-30
GR1006595B (el) 2009-11-16
GB2448848A (en) 2008-10-29
AT10984U1 (de) 2010-02-15
LT2008068A (en) 2009-03-25
AR068174A1 (es) 2009-11-11
ES2334875A1 (es) 2010-03-16
MEP10108A (en) 2010-10-10
IS8758A (is) 2009-03-12
SG151195A1 (en) 2009-04-30
PT2061753E (pt) 2011-09-14
EP2061753B1 (en) 2011-08-03
ZA200807753B (en) 2009-04-29
LU91479B1 (fr) 2010-03-11
CY1111924T1 (el) 2015-11-04
CN101386583A (zh) 2009-03-18
ATE518829T1 (de) 2011-08-15
PT104169A (pt) 2009-02-02
BRPI0804121A8 (pt) 2021-04-13
GB0815773D0 (en) 2008-10-08
MY144210A (en) 2011-08-15
SI22567A2 (sl) 2008-12-31
KR20090027185A (ko) 2009-03-16
DK200801265A (en) 2009-03-12
AU2008212055A1 (en) 2009-03-26
FR2920766A1 (fr) 2009-03-13
GB2448848B (en) 2011-01-26
EP2397461A1 (en) 2011-12-21
BRPI0804121A2 (pt) 2009-09-29
TW200906814A (en) 2009-02-16
HRP20080425A2 (hr) 2010-04-30
IL193845A (en) 2011-03-31
RS51909B (en) 2012-02-29
UA41919U (uk) 2009-06-10
NL2001953A1 (nl) 2008-12-22
LT5577B (lt) 2009-06-25
FI20085807A0 (fi) 2008-08-29
GR20080100581A (el) 2009-04-30
ES2368294T3 (es) 2011-11-16
EA200801797A2 (ru) 2008-12-30
EA200801797A3 (ru) 2009-02-27
DK177075B1 (da) 2011-06-14
PL386026A1 (pl) 2009-02-16
JP4966933B2 (ja) 2012-07-04
FI20085807A (fi) 2009-03-12
CO6140012A1 (es) 2010-03-19
NZ570884A (en) 2010-03-26
CA2638499A1 (en) 2008-11-21
SE0801929L (sv) 2009-03-12
ME00176B (me) 2011-02-10
NO20083756L (no) 2009-03-12
EP2061753A1 (en) 2009-05-27
TR200806903A2 (tr) 2009-03-23
TR200907629A2 (tr) 2009-11-23
CZ2008537A3 (cs) 2009-03-18
AU2008212055B2 (en) 2010-08-12
AR108885A2 (es) 2018-10-03
DE102008046530A1 (de) 2009-03-19
SI2061753T1 (sl) 2011-10-28
BE1017548A6 (fr) 2008-11-04
CY2600B1 (en) 2010-03-03
HU0800549D0 (en) 2008-10-28
LV13813B (en) 2008-11-20
BG110206A (en) 2009-03-31
SE533041C2 (sv) 2010-06-15
CL2008002686A1 (es) 2009-01-02
NL2001953C2 (en) 2009-05-07
IES20080708A2 (en) 2009-03-18
JP2009149600A (ja) 2009-07-09
MX2008011451A (es) 2009-03-10
AU2008212055C1 (en) 2011-06-02
CH697885B1 (de) 2009-03-13
KR101054224B1 (ko) 2011-08-08
HRP20110636T1 (hr) 2011-10-31

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