ES2123858T3 - Derivados de amidas ciclicas. - Google Patents

Derivados de amidas ciclicas.

Info

Publication number
ES2123858T3
ES2123858T3 ES95108191T ES95108191T ES2123858T3 ES 2123858 T3 ES2123858 T3 ES 2123858T3 ES 95108191 T ES95108191 T ES 95108191T ES 95108191 T ES95108191 T ES 95108191T ES 2123858 T3 ES2123858 T3 ES 2123858T3
Authority
ES
Spain
Prior art keywords
aryl
cyclic amide
integer
amide compound
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95108191T
Other languages
English (en)
Inventor
Hachiro Sugimoto
Masahiro Yonaga
Norio Karibe
Youichi Iimura
Satoshi Nagato
Atsushi Sasaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Application granted granted Critical
Publication of ES2123858T3 publication Critical patent/ES2123858T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)

Abstract

EL DERIVADO DE LA CICLOAMIDA SE DEFINE POR LA FORMULA (I) O UNA SAL DE LA MISMA: R1-(CH2)N-Z EN DONDE R1 ES UN GRUPO DERIVADO DE UN COMPUESTO DE CICLOAMIDA, SUSTITUIDO O NO SUSTITUIDO, N ES CERO O UN ENTERO DE 1 A 10 Y Z ES : R2 ES UN ARILO, UN ARILO SUSTITUIDO, UN CICLOALQUILO O UN GRUPO HETEROCICLICO, M ES UN ENTERO DE 1 A 6, R3 ES UN HIDROGENO O UN ALQUILO BAJO, R4 ES UN ARILO O ARILO SUSTITUIDO, UN CICLOALQUILO O UN GRUPO HETEROCICLICO, P ES UN ENTERO DE 1 A 6 DEL QUE SE OBTIENE UN COMPUESTO DE CICLOAMIDA QUE ES QUINAZOLINA-ON O QUINAZOLINMA-DION, R2 Y R4 NO SON ARILOS NI TAMPOCO ARILOS USTITUIDOS. EL COMPUESTO DE CICLOAMIDA ES FARMACOLOGICAMENTE EFICAZ PARA PREVENIR Y TRATAR ENFERMEDADES DEBIDAS A INSUFICIENCIAS DE LAS FUNCIONES CENTRALES.
ES95108191T 1990-06-15 1991-06-13 Derivados de amidas ciclicas. Expired - Lifetime ES2123858T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15713490 1990-06-15

Publications (1)

Publication Number Publication Date
ES2123858T3 true ES2123858T3 (es) 1999-01-16

Family

ID=15642948

Family Applications (2)

Application Number Title Priority Date Filing Date
ES95108191T Expired - Lifetime ES2123858T3 (es) 1990-06-15 1991-06-13 Derivados de amidas ciclicas.
ES91109708T Expired - Lifetime ES2113355T3 (es) 1990-06-15 1991-06-13 Derivados de amidas ciclicas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES91109708T Expired - Lifetime ES2113355T3 (es) 1990-06-15 1991-06-13 Derivados de amidas ciclicas.

Country Status (17)

Country Link
US (6) US5292735A (es)
EP (3) EP0468187B1 (es)
JP (2) JP2807577B2 (es)
KR (1) KR940004391B1 (es)
CN (1) CN1045206C (es)
AT (3) ATE209198T1 (es)
AU (2) AU653938B2 (es)
CA (2) CA2044515C (es)
DE (3) DE69130120T2 (es)
DK (2) DK0677516T3 (es)
ES (2) ES2123858T3 (es)
FI (1) FI114797B (es)
HU (2) HU216188B (es)
NO (1) NO180540B1 (es)
NZ (2) NZ238534A (es)
PT (1) PT97993B (es)
ZA (1) ZA914423B (es)

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EP0742216A2 (en) 1996-11-13
EP0468187A3 (en) 1992-04-15
CA2044515A1 (en) 1991-12-16
EP0468187A2 (en) 1992-01-29
ATE164156T1 (de) 1998-04-15
EP0742216A3 (en) 1997-05-28
HU911986D0 (en) 1991-12-30
DE69130120T2 (de) 1999-02-18
PT97993B (pt) 1998-11-30
DE69129090T2 (de) 1998-08-06
NO912252A (no) 1991-12-16
NO180540C (no) 1997-05-07
KR920000754A (ko) 1992-01-29
EP0677516A1 (en) 1995-10-18
DE69132827D1 (de) 2002-01-03
DK0468187T3 (da) 1999-01-11
AU7813691A (en) 1991-12-19
US5620976A (en) 1997-04-15
HU216188B (hu) 1999-05-28
AU653938B2 (en) 1994-10-20
CA2175502C (en) 2001-07-10
CN1045206C (zh) 1999-09-22
US5919778A (en) 1999-07-06
NZ272015A (en) 1999-07-29
US5504088A (en) 1996-04-02
ATE170517T1 (de) 1998-09-15
CA2044515C (en) 1997-05-20
JPH04235161A (ja) 1992-08-24
AU680704B2 (en) 1997-08-07
ATE209198T1 (de) 2001-12-15
DE69130120D1 (de) 1998-10-08
DE69129090D1 (de) 1998-04-23
CN1057262A (zh) 1991-12-25
EP0468187B1 (en) 1998-03-18
FI114797B (fi) 2004-12-31
CA2175502A1 (en) 1991-12-16
EP0677516B1 (en) 1998-09-02
NZ238534A (en) 1995-07-26
NO180540B (no) 1997-01-27
JPH0899974A (ja) 1996-04-16
ZA914423B (en) 1992-03-25
US5521182A (en) 1996-05-28
ES2113355T3 (es) 1998-05-01
PT97993A (pt) 1992-03-31
DK0677516T3 (da) 1999-06-07
HUT61742A (en) 1993-03-01
NO180540B1 (no) 1997-05-26
FI912851A0 (fi) 1991-06-13
HU211895A9 (en) 1995-12-28
JP2807577B2 (ja) 1998-10-08
NO912252D0 (no) 1991-06-12
JP3224187B2 (ja) 2001-10-29
EP0742216B1 (en) 2001-11-21
AU1024695A (en) 1995-03-30
US5654308A (en) 1997-08-05
FI912851A (fi) 1991-12-16
DE69132827T2 (de) 2002-06-27
KR940004391B1 (en) 1994-05-25
US5292735A (en) 1994-03-08

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