ES2109936T3 - Derivados de piperacina. - Google Patents
Derivados de piperacina.Info
- Publication number
- ES2109936T3 ES2109936T3 ES91309509T ES91309509T ES2109936T3 ES 2109936 T3 ES2109936 T3 ES 2109936T3 ES 91309509 T ES91309509 T ES 91309509T ES 91309509 T ES91309509 T ES 91309509T ES 2109936 T3 ES2109936 T3 ES 2109936T3
- Authority
- ES
- Spain
- Prior art keywords
- lower alkyl
- aryl
- hydrogen
- alkyl
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Abstract
DERIVADOS DE PIPERACINA DE FORMULA Y LAS FARMACEUTICAMENTE ACEPTABLES SALES DE ADICION ACIDA, DONDE A ES UNA CADENA DE ALQUILENO DE 1 O 2 ATOMOS DE CARBONO OPCIONALMENTE SUSTITUIDOS POR UNO O MAS GRUPOS ALQUILO INFERIORES, M ES 0, 1 O 2, R ES HIDROGENO O ALQUILO INFERIOR, R ELEVADO 1 ES ARILO O UN RADICAL HETEROARILO MONOUN ALQUILO INFERIOR, R ELEVADO 3 ES UN RADICAL HETEROARILO, R ELEVADO 4 ES HIDROGENO, ALQUILO INFERIOR O ARILO, Y R ELEVADO 5 ES HIDROGENO, ALQUILO INFERIOR, CICLOALQUILO, CICLOALQUIL(INFERIOR)ALQUILO, ARILO, O ARIL(INFERIOR)ALQUILO O R ELEVADO 4 Y R ELEVADO 5 JUNTO CON EL ATOMO DE NITROGENO AL CUAL ESTAN AMBOS UNIDOS REPRESENTANDO UN ANILLO HETEROCICLICO SATURADO, LOS CUALES PUEDEN CONTENER UN HETERO ATOMO MAS ALEJADO SIENDO AGENTES DE ENLACE 5-HT1AXIOLITICOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB909022821A GB9022821D0 (en) | 1990-10-19 | 1990-10-19 | Piperazine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2109936T3 true ES2109936T3 (es) | 1998-02-01 |
Family
ID=10684054
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91309509T Expired - Lifetime ES2109936T3 (es) | 1990-10-19 | 1991-10-16 | Derivados de piperacina. |
Country Status (16)
Country | Link |
---|---|
US (1) | US5169845A (es) |
EP (1) | EP0481742B1 (es) |
JP (1) | JP3012048B2 (es) |
KR (1) | KR100193927B1 (es) |
AT (1) | ATE160562T1 (es) |
AU (1) | AU642043B2 (es) |
CA (1) | CA2053705C (es) |
DE (1) | DE69128272T2 (es) |
DK (1) | DK0481742T3 (es) |
ES (1) | ES2109936T3 (es) |
GB (2) | GB9022821D0 (es) |
GR (1) | GR3025590T3 (es) |
HU (2) | HU217610B (es) |
IE (1) | IE64632B1 (es) |
NZ (1) | NZ240272A (es) |
PT (1) | PT99250B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9022790D0 (en) * | 1990-10-19 | 1990-12-05 | Wyeth John & Brother Ltd | Piperazine derivatives |
GB9300195D0 (en) * | 1993-01-06 | 1993-03-03 | Wyeth John & Brother Ltd | Piperazine derivatives |
GB9314758D0 (en) * | 1993-07-16 | 1993-08-25 | Wyeth John & Brother Ltd | Heterocyclic derivatives |
US5418236A (en) * | 1993-12-23 | 1995-05-23 | Ortho Pharmaceutical Corporation | Anxiolytic aroyl piperidinyl and piperazinylacyl pyrroles |
US5609849A (en) * | 1994-03-11 | 1997-03-11 | The Trustees Of The University Of Pennsylvania | Serotonin (5-HT1A) receptor ligands and imaging agents |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4968684A (en) * | 1987-04-01 | 1990-11-06 | Janssen Pharmaceutica N.V. | Method of improving sleep |
US4882432A (en) * | 1989-01-09 | 1989-11-21 | American Home Products Corporation | Polycyclic-carbamic acid piperazinoalkyl esters and amides |
GB2227018B (en) * | 1989-01-13 | 1992-05-20 | Wyeth John & Brother Ltd | Piperazinylalkylcarboxylic acid adamantylamides |
GB8909209D0 (en) * | 1989-04-22 | 1989-06-07 | Wyeth John & Brother Ltd | Piperazine derivatives |
GB9021535D0 (en) * | 1990-10-03 | 1990-11-14 | Wyeth John & Brother Ltd | Piperazine derivatives |
AU644488B2 (en) * | 1990-10-19 | 1993-12-09 | John Wyeth & Brother Limited | Piperazine derivatives |
-
1990
- 1990-10-19 GB GB909022821A patent/GB9022821D0/en active Pending
-
1991
- 1991-09-30 US US07/768,146 patent/US5169845A/en not_active Expired - Lifetime
- 1991-10-16 AT AT91309509T patent/ATE160562T1/de not_active IP Right Cessation
- 1991-10-16 DE DE69128272T patent/DE69128272T2/de not_active Expired - Fee Related
- 1991-10-16 GB GB9121944A patent/GB2254324B/en not_active Expired - Fee Related
- 1991-10-16 ES ES91309509T patent/ES2109936T3/es not_active Expired - Lifetime
- 1991-10-16 DK DK91309509.7T patent/DK0481742T3/da active
- 1991-10-16 EP EP91309509A patent/EP0481742B1/en not_active Expired - Lifetime
- 1991-10-17 NZ NZ240272A patent/NZ240272A/xx unknown
- 1991-10-17 AU AU85919/91A patent/AU642043B2/en not_active Ceased
- 1991-10-17 JP JP3269289A patent/JP3012048B2/ja not_active Expired - Fee Related
- 1991-10-17 PT PT99250A patent/PT99250B/pt active IP Right Grant
- 1991-10-18 KR KR1019910018374A patent/KR100193927B1/ko not_active IP Right Cessation
- 1991-10-18 HU HU293/91A patent/HU217610B/hu not_active IP Right Cessation
- 1991-10-18 IE IE366891A patent/IE64632B1/en not_active IP Right Cessation
- 1991-10-18 CA CA002053705A patent/CA2053705C/en not_active Expired - Fee Related
-
1995
- 1995-06-27 HU HU95P/P00448P patent/HU211588A9/hu unknown
-
1997
- 1997-12-03 GR GR970403242T patent/GR3025590T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
GB2254324A (en) | 1992-10-07 |
KR100193927B1 (ko) | 1999-06-15 |
IE913668A1 (en) | 1992-04-22 |
DE69128272T2 (de) | 1998-03-19 |
IE64632B1 (en) | 1995-08-23 |
HU217610B (hu) | 2000-03-28 |
EP0481742A1 (en) | 1992-04-22 |
GB9022821D0 (en) | 1990-12-05 |
HU913293D0 (en) | 1992-01-28 |
EP0481742B1 (en) | 1997-11-26 |
GR3025590T3 (en) | 1998-03-31 |
GB9121944D0 (en) | 1991-11-27 |
DK0481742T3 (da) | 1997-12-29 |
JPH04288073A (ja) | 1992-10-13 |
CA2053705A1 (en) | 1992-04-20 |
NZ240272A (en) | 1992-10-28 |
DE69128272D1 (de) | 1998-01-08 |
GB2254324B (en) | 1994-06-22 |
ATE160562T1 (de) | 1997-12-15 |
PT99250B (pt) | 1999-04-30 |
PT99250A (pt) | 1992-08-31 |
HUT60261A (en) | 1992-08-28 |
KR920008020A (ko) | 1992-05-27 |
AU8591991A (en) | 1992-04-30 |
CA2053705C (en) | 2002-02-12 |
HU211588A9 (en) | 1995-12-28 |
US5169845A (en) | 1992-12-08 |
AU642043B2 (en) | 1993-10-07 |
JP3012048B2 (ja) | 2000-02-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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