EP3062618A4 - Kristalline formen therapeutischer verbindungen und verwendungen davon - Google Patents
Kristalline formen therapeutischer verbindungen und verwendungen davon Download PDFInfo
- Publication number
- EP3062618A4 EP3062618A4 EP14857737.2A EP14857737A EP3062618A4 EP 3062618 A4 EP3062618 A4 EP 3062618A4 EP 14857737 A EP14857737 A EP 14857737A EP 3062618 A4 EP3062618 A4 EP 3062618A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- crystalline forms
- therapeutic compounds
- therapeutic
- compounds
- crystalline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Ophthalmology & Optometry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dispersion Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Urology & Nephrology (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361898741P | 2013-11-01 | 2013-11-01 | |
US201462039192P | 2014-08-19 | 2014-08-19 | |
US201462039177P | 2014-08-19 | 2014-08-19 | |
PCT/US2014/063444 WO2015066482A1 (en) | 2013-11-01 | 2014-10-31 | Crystalline forms of therapeutic compounds and uses thereof |
Publications (3)
Publication Number | Publication Date |
---|---|
EP3062618A1 EP3062618A1 (de) | 2016-09-07 |
EP3062618A4 true EP3062618A4 (de) | 2017-07-12 |
EP3062618B1 EP3062618B1 (de) | 2020-02-05 |
Family
ID=53005200
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP14857737.2A Active EP3062618B1 (de) | 2013-11-01 | 2014-10-31 | Kristalline formen therapeutischer verbindungen und verwendungen davon |
Country Status (10)
Country | Link |
---|---|
US (6) | US9458169B2 (de) |
EP (1) | EP3062618B1 (de) |
JP (2) | JP6426194B2 (de) |
KR (1) | KR20160099084A (de) |
CN (2) | CN106061261B (de) |
AU (1) | AU2014342042B2 (de) |
CA (1) | CA2928658A1 (de) |
MX (1) | MX355330B (de) |
NZ (1) | NZ719185A (de) |
WO (1) | WO2015066482A1 (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11596599B2 (en) * | 2012-05-03 | 2023-03-07 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
US10864219B2 (en) * | 2012-05-03 | 2020-12-15 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
US9827191B2 (en) * | 2012-05-03 | 2017-11-28 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
KR20160099084A (ko) | 2013-11-01 | 2016-08-19 | 칼라 파마슈티컬스, 인크. | 치료 화합물의 결정질 형태 및 그의 용도 |
CA3036336A1 (en) | 2016-09-08 | 2018-03-15 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
CA3036340A1 (en) * | 2016-09-08 | 2018-03-15 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
EP3509421A4 (de) * | 2016-09-08 | 2020-05-20 | Kala Pharmaceuticals, Inc. | Kristalline formen therapeutischer verbindungen und verwendungen davon |
BR112020007787A2 (pt) * | 2017-10-20 | 2020-10-06 | Kala Pharmaceuticals, Inc. | inibidores ret9 e vegfr2 |
JP2021506795A (ja) * | 2017-12-15 | 2021-02-22 | ボード オブ リージェンツ, ザ ユニバーシティ オブ テキサス システムBoard Of Regents, The University Of Texas System | エキソソーム関連遺伝子編集を用いてがんを処置するための方法および組成物 |
JP2023504162A (ja) * | 2019-12-02 | 2023-02-01 | アカデミア シニカ | PDIA4阻害剤及びβ細胞発症機序を阻害し、糖尿病を治療するためのこのPDIA4阻害剤の使用 |
US20230057383A1 (en) * | 2020-03-21 | 2023-02-23 | Mihan JAFARI JAVID | Composition and methods for prevention and treatment of vascular disorders, neurodegenerative disease and neuropathic disorders |
KR102491010B1 (ko) * | 2021-09-07 | 2023-01-20 | 경희대학교 산학협력단 | 현탁액에서의 물리적 분쇄를 이용한 안정상 결정 제조방법 |
Citations (6)
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---|---|---|---|---|
US20050085465A1 (en) * | 2002-02-01 | 2005-04-21 | Hennequin Laurent F.A. | Quinazoline compounds |
WO2006035203A1 (en) * | 2004-09-27 | 2006-04-06 | Astrazeneca Ab | Cancer combination therapy comprising azd2171 and imatinib |
US20090076044A1 (en) * | 2007-09-10 | 2009-03-19 | Changgeng Qian | Vegfr inhibitors containing a zinc binding moiety |
DE102008012435A1 (de) * | 2008-02-29 | 2009-09-03 | Schebo Biotech Ag | Neue Pharmazeutika, Verfahren zu ihrer Herstellung und ihre Verwendung in der Therapie |
US20100093727A1 (en) * | 2008-10-14 | 2010-04-15 | Ning Xi | Compounds and methods of use |
WO2014130612A1 (en) * | 2013-02-20 | 2014-08-28 | Kala Pharmaceuticals, Inc. | Therapeutic compounds and uses thereof |
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US20150125535A1 (en) | 2015-05-07 |
CA2928658A1 (en) | 2015-05-07 |
US10618906B2 (en) | 2020-04-14 |
EP3062618A1 (de) | 2016-09-07 |
CN106061261B (zh) | 2018-04-24 |
US10975090B2 (en) | 2021-04-13 |
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AU2014342042B2 (en) | 2017-08-17 |
US20210355133A1 (en) | 2021-11-18 |
MX355330B (es) | 2018-04-16 |
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MX2016005668A (es) | 2016-10-28 |
NZ719185A (en) | 2017-11-24 |
EP3062618B1 (de) | 2020-02-05 |
US20190077810A1 (en) | 2019-03-14 |
JP2019038825A (ja) | 2019-03-14 |
US9458169B2 (en) | 2016-10-04 |
US20160115176A1 (en) | 2016-04-28 |
US20180009824A1 (en) | 2018-01-11 |
KR20160099084A (ko) | 2016-08-19 |
AU2014342042A1 (en) | 2016-05-12 |
JP6426194B2 (ja) | 2018-11-21 |
US10160765B2 (en) | 2018-12-25 |
US20200216459A1 (en) | 2020-07-09 |
US9790232B2 (en) | 2017-10-17 |
CN106061261A (zh) | 2016-10-26 |
WO2015066482A1 (en) | 2015-05-07 |
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