DE60324461D1 - Therapeutische quinazolin-derivate - Google Patents
Therapeutische quinazolin-derivateInfo
- Publication number
- DE60324461D1 DE60324461D1 DE60324461T DE60324461T DE60324461D1 DE 60324461 D1 DE60324461 D1 DE 60324461D1 DE 60324461 T DE60324461 T DE 60324461T DE 60324461 T DE60324461 T DE 60324461T DE 60324461 D1 DE60324461 D1 DE 60324461D1
- Authority
- DE
- Germany
- Prior art keywords
- quinazoline derivatives
- therapeutic
- therapy
- processes
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical class N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
- C07F9/65128—Six-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02293240 | 2002-12-24 | ||
PCT/GB2003/005640 WO2004058782A1 (en) | 2002-12-24 | 2003-12-22 | Therapeutic quinazoline derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60324461D1 true DE60324461D1 (de) | 2008-12-11 |
Family
ID=32668917
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60324461T Expired - Fee Related DE60324461D1 (de) | 2002-12-24 | 2003-12-22 | Therapeutische quinazolin-derivate |
Country Status (8)
Country | Link |
---|---|
US (1) | US20060058325A1 (de) |
EP (1) | EP1575966B1 (de) |
JP (1) | JP2006512387A (de) |
AT (1) | ATE412657T1 (de) |
AU (1) | AU2003294142A1 (de) |
DE (1) | DE60324461D1 (de) |
ES (1) | ES2314271T3 (de) |
WO (1) | WO2004058782A1 (de) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003290322A1 (en) * | 2002-12-24 | 2004-07-22 | Astrazeneca Ab | Quinazoline compounds |
CA2522079A1 (en) | 2003-04-16 | 2004-11-04 | Astrazeneca Ab | Quinazoline derivatives for treatment of cancer |
EP2543376A1 (de) | 2004-04-08 | 2013-01-09 | Targegen, Inc. | Benzotriazin Kinasehemmer |
JP5275628B2 (ja) | 2004-08-25 | 2013-08-28 | ターゲジェン インコーポレーティッド | 複素環式化合物および使用方法 |
AU2005293336B2 (en) | 2004-10-12 | 2009-05-28 | Astrazeneca Ab | Quinazoline derivatives |
ATE479687T1 (de) | 2004-10-15 | 2010-09-15 | Takeda Pharmaceutical | Kinaseinhibitoren |
US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
CA2628283C (en) | 2005-11-01 | 2017-06-27 | Targegen, Inc. | Bi-aryl meta-pyrimidine inhibitors of kinases |
US8604042B2 (en) | 2005-11-01 | 2013-12-10 | Targegen, Inc. | Bi-aryl meta-pyrimidine inhibitors of kinases |
US8133900B2 (en) | 2005-11-01 | 2012-03-13 | Targegen, Inc. | Use of bi-aryl meta-pyrimidine inhibitors of kinases |
NZ568946A (en) | 2005-12-29 | 2010-07-30 | Lexicon Pharmaceuticals Inc | Multicyclic amino acid derivatives and methods of their use |
US8101621B2 (en) | 2006-04-27 | 2012-01-24 | Msd K.K. | Aminopyridine derivatives having aurora a selective inhibitory action |
GEP20135728B (en) | 2006-10-09 | 2013-01-25 | Takeda Pharmaceuticals Co | Kinase inhibitors |
MX2011004018A (es) * | 2008-10-14 | 2011-06-24 | Ning Xi | Compuestos y metodos de uso. |
CA2816957A1 (en) | 2010-11-07 | 2012-05-10 | Targegen, Inc. | Compositions and methods for treating myelofibrosis |
CN103304489B (zh) * | 2012-03-16 | 2015-03-11 | 中国农业科学院兰州畜牧与兽药研究所 | 嘧啶苯甲酰胺类化合物及其制备和应用 |
WO2014127214A1 (en) | 2013-02-15 | 2014-08-21 | Kala Pharmaceuticals, Inc. | Therapeutic compounds and uses thereof |
EP2958895B1 (de) | 2013-02-20 | 2020-08-19 | Kala Pharmaceuticals, Inc. | Therapeutische verbindungen und verwendungen davon |
US9688688B2 (en) | 2013-02-20 | 2017-06-27 | Kala Pharmaceuticals, Inc. | Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof |
US9890173B2 (en) | 2013-11-01 | 2018-02-13 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
CN106061261B (zh) | 2013-11-01 | 2018-04-24 | 卡拉制药公司 | 治疗化合物的结晶形式及其用途 |
WO2018048747A1 (en) | 2016-09-08 | 2018-03-15 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
EP3509423A4 (de) | 2016-09-08 | 2020-05-13 | Kala Pharmaceuticals, Inc. | Kristalline formen von therapeutischen verbindungen und verwendungen davon |
MX2019002629A (es) | 2016-09-08 | 2019-10-07 | Kala Pharmaceuticals Inc | Formas cristalinas de compuestos terapéuticos y usos de los mismos. |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6258820B1 (en) * | 1999-03-19 | 2001-07-10 | Parker Hughes Institute | Synthesis and anti-tumor activity of 6,7-dialkoxy-4-phenylamino-quinazolines |
GB9922171D0 (en) * | 1999-09-21 | 1999-11-17 | Zeneca Ltd | Chemical compounds |
CA2384282A1 (en) * | 1999-09-21 | 2001-03-29 | Astrazeneca Ab | Quinazoline compounds and pharmaceutical compositions containing them |
US20030064119A1 (en) * | 2001-06-21 | 2003-04-03 | Emerson Ralph W. | Methods and compositions for applying essential oils and naturally occurring compounds to plants to activate endogenous plant pathogen defense pathways |
-
2003
- 2003-12-22 WO PCT/GB2003/005640 patent/WO2004058782A1/en active Application Filing
- 2003-12-22 AU AU2003294142A patent/AU2003294142A1/en not_active Abandoned
- 2003-12-22 AT AT03789562T patent/ATE412657T1/de not_active IP Right Cessation
- 2003-12-22 ES ES03789562T patent/ES2314271T3/es not_active Expired - Lifetime
- 2003-12-22 JP JP2004563355A patent/JP2006512387A/ja active Pending
- 2003-12-22 US US10/539,483 patent/US20060058325A1/en not_active Abandoned
- 2003-12-22 DE DE60324461T patent/DE60324461D1/de not_active Expired - Fee Related
- 2003-12-22 EP EP03789562A patent/EP1575966B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ES2314271T3 (es) | 2009-03-16 |
EP1575966B1 (de) | 2008-10-29 |
AU2003294142A1 (en) | 2004-07-22 |
ATE412657T1 (de) | 2008-11-15 |
EP1575966A1 (de) | 2005-09-21 |
WO2004058782A1 (en) | 2004-07-15 |
JP2006512387A (ja) | 2006-04-13 |
US20060058325A1 (en) | 2006-03-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |