EP1462447A3 - Method for the preparation of pure citalopram - Google Patents

Method for the preparation of pure citalopram Download PDF

Info

Publication number
EP1462447A3
EP1462447A3 EP04004482A EP04004482A EP1462447A3 EP 1462447 A3 EP1462447 A3 EP 1462447A3 EP 04004482 A EP04004482 A EP 04004482A EP 04004482 A EP04004482 A EP 04004482A EP 1462447 A3 EP1462447 A3 EP 1462447A3
Authority
EP
European Patent Office
Prior art keywords
citalopram
crude
group
preparation
amide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP04004482A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1462447A2 (en
Inventor
Marco Villa
Federico Sbrogio
Robert Dancer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Publication of EP1462447A2 publication Critical patent/EP1462447A2/en
Publication of EP1462447A3 publication Critical patent/EP1462447A3/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
EP04004482A 2000-12-22 2001-03-07 Method for the preparation of pure citalopram Withdrawn EP1462447A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK200001929 2000-12-22
DKPA200001929 2000-12-22
EP01913726A EP1181713B1 (en) 2000-12-22 2001-03-07 Method for the preparation of pure citalopram

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
EP01913726A Division EP1181713B1 (en) 2000-12-22 2001-03-07 Method for the preparation of pure citalopram

Publications (2)

Publication Number Publication Date
EP1462447A2 EP1462447A2 (en) 2004-09-29
EP1462447A3 true EP1462447A3 (en) 2004-11-17

Family

ID=8159922

Family Applications (2)

Application Number Title Priority Date Filing Date
EP04004482A Withdrawn EP1462447A3 (en) 2000-12-22 2001-03-07 Method for the preparation of pure citalopram
EP01913726A Expired - Lifetime EP1181713B1 (en) 2000-12-22 2001-03-07 Method for the preparation of pure citalopram

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP01913726A Expired - Lifetime EP1181713B1 (en) 2000-12-22 2001-03-07 Method for the preparation of pure citalopram

Country Status (43)

Country Link
US (1) US6455710B1 (ja)
EP (2) EP1462447A3 (ja)
JP (1) JP3798982B2 (ja)
KR (1) KR100439329B1 (ja)
CN (1) CN1282648C (ja)
AR (1) AR030056A1 (ja)
AT (2) ATE277920T1 (ja)
AU (2) AU3920101A (ja)
BE (2) BE1013212A6 (ja)
BG (1) BG65131B1 (ja)
BR (1) BR0106272A (ja)
CA (1) CA2360303C (ja)
CH (1) CH691535A5 (ja)
CZ (1) CZ292200B6 (ja)
DE (2) DE60105926T2 (ja)
DK (1) DK1181713T3 (ja)
EA (1) EA003581B1 (ja)
ES (2) ES2228824T3 (ja)
FI (2) FI108639B (ja)
FR (1) FR2812877B1 (ja)
GB (1) GB2357763B (ja)
GR (1) GR1003874B (ja)
HK (1) HK1048812B (ja)
HR (1) HRP20020004A2 (ja)
HU (2) HU0101029D0 (ja)
IE (1) IES20010254A2 (ja)
IL (1) IL147226A (ja)
IS (1) IS2060B (ja)
IT (1) ITMI20010602A1 (ja)
MX (1) MXPA01013151A (ja)
NL (2) NL1017525C1 (ja)
NO (1) NO20011271A (ja)
NZ (1) NZ516298A (ja)
PL (1) PL205724B1 (ja)
PT (1) PT1181713E (ja)
SE (1) SE517623C2 (ja)
SG (1) SG167655A1 (ja)
SI (1) SI1181713T1 (ja)
SK (2) SK284428B6 (ja)
TR (1) TR200201166T1 (ja)
UA (1) UA71634C2 (ja)
WO (1) WO2001045483A2 (ja)
ZA (1) ZA200110179B (ja)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
PL198024B1 (pl) 1999-04-14 2008-05-30 Lundbeck & Co As H Sposób wytwarzania citalopramu, związki pośrednie i ich zastosowanie do wytwarzania citalopramu
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
CH692421A5 (de) 1999-10-25 2002-06-14 Lundbeck & Co As H Verfahren zur Herstellung von Citalopram.
PL355532A1 (en) 1999-12-28 2004-05-04 H.Lundbeck A/S Method for the preparation of citalopram
CZ20022627A3 (cs) 1999-12-30 2002-10-16 H. Lundbeck A/S Způsob výroby citalopramu
SK286879B6 (sk) 2000-01-14 2009-07-06 H. Lundbeck A/S Spôsob prípravy 5-kyanoftalidu
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
JP2003527387A (ja) 2000-03-13 2003-09-16 ハー・ルンドベック・アクチエゼルスカベット シタロプラムの製造方法
JP2003527385A (ja) 2000-03-13 2003-09-16 ハー・ルンドベック・アクチエゼルスカベット ５−置換された１−（４−フルオロフェニル）−１，３−ジヒドロイソベンゾフランの段階的アルキル化法
PT1265882E (pt) 2000-03-14 2004-06-30 Lundbeck & Co As H Metodo para preparacao de citalopram; composto e citalopram
TR200202168T2 (tr) * 2000-03-16 2002-12-23 H. Lundbeck A/S 5-Siyano-1-(4-Florofenil)-1,3-Dihidroizobenzofuranların preparasyon metodu
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
FI20011622A (fi) 2000-08-18 2002-02-19 Lundbeck & Co As H Menetelmä sitalopraamin valmistamiseksi
KR100430746B1 (ko) 2000-12-28 2004-05-10 하. 룬트벡 아크티에 셀스카브 순수한 시탈로프람의 제조방법
GB0105627D0 (en) * 2001-03-07 2001-04-25 Cipla Ltd Preparation of phthalanes
CA2439856A1 (en) * 2001-03-09 2002-09-19 Swargam Sathyanarayana Process for the preparation of citalopram
US6967259B2 (en) * 2001-09-24 2005-11-22 Pharmachem Technologies Limited Process for the preparation of Citalopram intermediate
BR0213949A (pt) * 2001-11-08 2004-08-31 Sepracor Inc Métodos para o tratamento de depressão e outros distúrbios do snc utilizando metabólitos desmetila e didesmetila de citalopram enanciomericamente enriquecidos
WO2003057132A2 (en) * 2002-01-07 2003-07-17 Sun Pharmaceutical Industries Limited Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
GB0204607D0 (en) * 2002-02-27 2002-04-10 Matrix Lab Ltd Process
CN1330628C (zh) * 2002-11-15 2007-08-08 阿克佐诺贝尔股份有限公司 脂肪腈的提纯/脱色处理
US20050154052A1 (en) * 2003-03-24 2005-07-14 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
US7019153B2 (en) * 2003-06-10 2006-03-28 Sun Pharmaceutical Industries Limited Process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran acetamido-3-substituted-3-cephem-4-carboxylic acid
AU2003278409A1 (en) * 2003-10-28 2005-05-19 Krishnaji Upadhye Bhargav Improved process for the manufacture of citalopram hydrobromide
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
TWI358407B (en) * 2005-06-22 2012-02-21 Lundbeck & Co As H Crystalline base of escitalopram and orodispersibl
CN114763343A (zh) * 2021-01-14 2022-07-19 浙江华海药业股份有限公司 一种西酞普兰或s-西酞普兰的纯化方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE536169C (de) * 1926-08-21 1931-10-20 British Dyestuffs Corp Ltd Verfahren zur Gewinnung von tertiaeren aromatischen Aminen aus ihren Gemischen mit sekundaeren und primaeren aromatischen Aminen
US1992111A (en) * 1931-06-20 1935-02-19 Du Pont Separation of secondary and tertiary amines
DE1032261B (de) * 1955-03-08 1958-06-19 Leda Chemicals Ltd Verfahren zur Abtrennung sekundaerer Amine aus einer primaeres und sekundaeres Amin enthaltenden Mischung
EP0413259A2 (de) * 1989-08-12 1991-02-20 Hoechst Aktiengesellschaft Verfahren zur Verminderung von primärem und sekundärem Amin in einem tertiären Amin
DE20007303U1 (de) * 2000-03-13 2000-07-27 H. Lundbeck A/S, Kopenhagen/Koebenhavn Kristalline Base von Citalopram

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143703A (ja) 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
US4302399A (en) * 1978-09-28 1981-11-24 Dynapol Acetylation of crude reaction products containing polymeric colorants
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
US4943591A (en) 1984-10-17 1990-07-24 Glaxo Group Limited Dichloroaniline derivatives
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DK213290D0 (da) * 1990-09-06 1990-09-06 Lundbeck & Co As H Treatment of cerebrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
EP0993524B1 (en) * 1997-06-30 2002-11-20 Beloit Technologies, Inc. Method and apparatus for the high speed application of coating to a traveling paper web
EA001728B1 (ru) * 1997-07-08 2001-08-27 Х.Лундбекк А/С Способ получения циталопрама
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
SK283907B6 (sk) * 1997-11-11 2004-04-06 H. Lundbeck A/S Spôsob výroby citalopramu a medziprodukty
AU746665B2 (en) * 1998-10-20 2002-05-02 H. Lundbeck A/S Method for the preparation of citalopram
BR9916955A (pt) 1998-12-23 2001-09-11 Lundbeck & Co As H Método para preparação de 5-cianoftalida
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
PL198024B1 (pl) 1999-04-14 2008-05-30 Lundbeck & Co As H Sposób wytwarzania citalopramu, związki pośrednie i ich zastosowanie do wytwarzania citalopramu
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991486A1 (it) * 1999-07-06 2001-01-06 Vis Farmaceutici S P A Processo per la sintesi di citalopram
CH692421A5 (de) 1999-10-25 2002-06-14 Lundbeck & Co As H Verfahren zur Herstellung von Citalopram.
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
NL1017415C1 (nl) 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
FI20011622A (fi) 2000-08-18 2002-02-19 Lundbeck & Co As H Menetelmä sitalopraamin valmistamiseksi
KR100430746B1 (ko) 2000-12-28 2004-05-10 하. 룬트벡 아크티에 셀스카브 순수한 시탈로프람의 제조방법

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE536169C (de) * 1926-08-21 1931-10-20 British Dyestuffs Corp Ltd Verfahren zur Gewinnung von tertiaeren aromatischen Aminen aus ihren Gemischen mit sekundaeren und primaeren aromatischen Aminen
US1992111A (en) * 1931-06-20 1935-02-19 Du Pont Separation of secondary and tertiary amines
DE1032261B (de) * 1955-03-08 1958-06-19 Leda Chemicals Ltd Verfahren zur Abtrennung sekundaerer Amine aus einer primaeres und sekundaeres Amin enthaltenden Mischung
EP0413259A2 (de) * 1989-08-12 1991-02-20 Hoechst Aktiengesellschaft Verfahren zur Verminderung von primärem und sekundärem Amin in einem tertiären Amin
DE20007303U1 (de) * 2000-03-13 2000-07-27 H. Lundbeck A/S, Kopenhagen/Koebenhavn Kristalline Base von Citalopram
NL1016435C1 (nl) * 2000-03-13 2000-11-06 Lundbeck & Co As H Kristallijne base van Citalopram.

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
E. MÜLLER (EDITOR): "Methoden der Organischen Chemie (Houben-Weyl)", 1953, GEORG THIEME VERLAG, STUTTGART, DE (4TH EDITION), XP002296211 *
E. MÜLLER (EDITOR): "Methoden der Organischen Chemie Houben-Weyl)", 1953, GEORG THIEME VERLAG, STUTTGART, DE (4TH EDITION), XP002296212 *

Also Published As

Publication number Publication date
CA2360303C (en) 2003-08-12
HUP0102817A2 (hu) 2001-12-28
CZ2001890A3 (cs) 2002-08-14
HU0102817D0 (en) 2001-09-28
DE60105926T2 (de) 2005-11-24
EP1462447A2 (en) 2004-09-29
GR1003874B (el) 2002-04-24
EA003581B1 (ru) 2003-06-26
NL1018360C1 (nl) 2001-10-04
DE60105926D1 (de) 2004-11-04
SK284428B6 (sk) 2005-04-01
AU3920101A (en) 2001-07-03
ITMI20010602A0 (it) 2001-03-22
BE1013212A6 (fr) 2001-10-02
IS2060B (is) 2005-11-15
CA2360303A1 (en) 2001-06-28
WO2001045483A2 (en) 2001-06-28
MXPA01013151A (es) 2002-08-12
KR100439329B1 (ko) 2004-07-07
IL147226A (en) 2006-04-10
EP1181713A2 (en) 2002-02-27
WO2001045483A3 (en) 2001-12-27
NZ516298A (en) 2002-12-20
US6455710B1 (en) 2002-09-24
DE10112829C1 (de) 2002-07-25
NO20011271D0 (no) 2001-03-13
BR0106272A (pt) 2004-06-15
BG106203A (en) 2002-08-30
JP3798982B2 (ja) 2006-07-19
AU2001100405A4 (en) 2001-11-01
UA71634C2 (uk) 2004-12-15
FR2812877A1 (fr) 2002-02-15
GB2357763A (en) 2001-07-04
TR200201166T1 (tr) 2002-10-21
FI20010500A0 (fi) 2001-03-13
HRP20020004A2 (en) 2003-04-30
ES2170732A1 (es) 2002-08-01
SE517623C2 (sv) 2002-06-25
EP1181713B1 (en) 2004-09-29
SE0103045L (sv) 2002-06-23
BG65131B1 (bg) 2007-03-30
JP2003517484A (ja) 2003-05-27
SK286283B6 (sk) 2008-06-06
KR20020065345A (ko) 2002-08-13
PL205724B1 (pl) 2010-05-31
NO312462B1 (no) 2002-05-13
DK1181713T3 (da) 2005-01-31
FI20011577A0 (fi) 2001-07-26
ES2170732B2 (es) 2003-09-16
ITMI20010602A1 (it) 2002-09-22
AR030056A1 (es) 2003-08-13
HK1048812A1 (en) 2003-04-17
HU0101029D0 (en) 2001-05-28
NO20011271A (no) 2002-05-13
HUP0102817A3 (en) 2003-07-28
GB2357763B (en) 2002-01-16
SI1181713T1 (en) 2005-02-28
NL1017525C1 (nl) 2001-04-26
US20020120005A1 (en) 2002-08-29
GB0105983D0 (en) 2001-05-02
ATE277920T1 (de) 2004-10-15
SE0103045D0 (sv) 2001-09-14
HK1048812B (zh) 2007-06-01
EA200200018A1 (ru) 2002-04-25
AT4367U1 (de) 2001-06-25
PL353398A1 (en) 2003-11-17
ZA200110179B (en) 2002-12-11
CH691535A5 (de) 2001-08-15
ES2228824T3 (es) 2005-04-16
FI108639B (fi) 2002-02-28
CN1282648C (zh) 2006-11-01
SG167655A1 (en) 2011-01-28
CN1366525A (zh) 2002-08-28
SK18482001A3 (sk) 2002-05-09
PT1181713E (pt) 2005-02-28
IES20010254A2 (en) 2002-03-06
FR2812877B1 (fr) 2003-04-04
IL147226A0 (en) 2002-08-14
AU2001100405B4 (en) 2002-03-21
BE1013213A6 (fr) 2001-10-02
IS5883A (is) 2001-06-20
CZ292200B6 (cs) 2003-08-13

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