EE05473B1 - Levodopa/karbidopa/entakapooni farmatseutiline preparaat, selle valmistamise meetod ja kasutamine - Google Patents

Levodopa/karbidopa/entakapooni farmatseutiline preparaat, selle valmistamise meetod ja kasutamine

Info

Publication number
EE05473B1
EE05473B1 EEP200100716A EEP200100716A EE05473B1 EE 05473 B1 EE05473 B1 EE 05473B1 EE P200100716 A EEP200100716 A EE P200100716A EE P200100716 A EEP200100716 A EE P200100716A EE 05473 B1 EE05473 B1 EE 05473B1
Authority
EE
Estonia
Prior art keywords
preparation
entacapone
carbidopa
levodopa
pharmaceutical preparation
Prior art date
Application number
EEP200100716A
Other languages
English (en)
Estonian (et)
Inventor
Kallioinen Sari
Kervinen Lasse
Laaksonen Marja
Lintulaakso Jarmo
Niskanen Mervi
Partanen Marja
Ritala Marja
Vahervuo Kari
Virkki Matti
Original Assignee
Orion Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8554988&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EE05473(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Orion Corporation filed Critical Orion Corporation
Publication of EE200100716A publication Critical patent/EE200100716A/xx
Publication of EE05473B1 publication Critical patent/EE05473B1/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/275Nitriles; Isonitriles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
EEP200100716A 1999-06-30 2000-06-29 Levodopa/karbidopa/entakapooni farmatseutiline preparaat, selle valmistamise meetod ja kasutamine EE05473B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI991485A FI109453B (fi) 1999-06-30 1999-06-30 Farmaseuttinen koostumus
PCT/FI2000/000593 WO2001001984A1 (en) 1999-06-30 2000-06-29 Levodopa / carbidopa / entacapone pharmaceutical preparation

Publications (2)

Publication Number Publication Date
EE200100716A EE200100716A (et) 2003-02-17
EE05473B1 true EE05473B1 (et) 2011-10-17

Family

ID=8554988

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200100716A EE05473B1 (et) 1999-06-30 2000-06-29 Levodopa/karbidopa/entakapooni farmatseutiline preparaat, selle valmistamise meetod ja kasutamine

Country Status (42)

Country Link
US (2) US6500867B1 (ko)
EP (1) EP1189608B1 (ko)
JP (2) JP4204783B2 (ko)
KR (1) KR100905428B1 (ko)
CN (1) CN1168440C (ko)
AR (1) AR033796A1 (ko)
AT (1) ATE245417T1 (ko)
AU (1) AU765932B2 (ko)
BG (1) BG65364B1 (ko)
BR (2) BR0011867A (ko)
CA (1) CA2378469C (ko)
CO (1) CO5180579A1 (ko)
CZ (2) CZ303010B6 (ko)
DE (1) DE60004052T2 (ko)
DK (1) DK1189608T3 (ko)
EA (1) EA004503B1 (ko)
EE (1) EE05473B1 (ko)
ES (1) ES2203495T3 (ko)
FI (1) FI109453B (ko)
FR (1) FR2797587A1 (ko)
GE (1) GEP20043314B (ko)
HK (1) HK1047040B (ko)
HR (1) HRP20020088B1 (ko)
HU (1) HU230395B1 (ko)
IL (1) IL146807A (ko)
IT (1) ITMI20001450A1 (ko)
ME (1) ME00520B (ko)
MX (1) MXPA01013167A (ko)
MY (1) MY127685A (ko)
NO (2) NO330260B1 (ko)
NZ (1) NZ515780A (ko)
PE (1) PE20010399A1 (ko)
PL (1) PL197818B1 (ko)
PT (1) PT1189608E (ko)
RS (1) RS50368B (ko)
SI (1) SI1189608T1 (ko)
SK (1) SK286451B6 (ko)
TR (1) TR200103763T2 (ko)
TW (1) TWI241187B (ko)
UA (1) UA75047C2 (ko)
WO (1) WO2001001984A1 (ko)
ZA (1) ZA200109868B (ko)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI109453B (fi) 1999-06-30 2002-08-15 Orion Yhtymae Oyj Farmaseuttinen koostumus
US7094427B2 (en) * 2002-05-29 2006-08-22 Impax Laboratories, Inc. Combination immediate release controlled release levodopa/carbidopa dosage forms
US20040166159A1 (en) * 2002-05-29 2004-08-26 Chien-Hsuan Han Pharmaceutical dosage forms having immediate and controlled release properties that contain an aromatic amino acid decarboxylase inhibitor and levodopa
US20030224045A1 (en) * 2002-05-29 2003-12-04 Chien-Hsuan Han Combination immediate release sustained release levodopa/carbidopa dosage forms
US20060013875A1 (en) * 2002-05-29 2006-01-19 Impax Laboratories, Inc. Combination immediate release controlled release levodopa/carbidopa dosage forms
US20050147670A1 (en) * 2002-05-29 2005-07-07 Impax Laboratories Inc. Oral disintegrating dosage forms
US20040006072A1 (en) * 2002-06-25 2004-01-08 Franz Robert M. Sustained-release alprazolam composition
AU2003282603A1 (en) * 2002-10-11 2004-05-04 Depomed Development Ltd Gastro-retentive levodopa delivery form
AR044007A1 (es) 2003-04-11 2005-08-24 Newron Pharmaceuticals Inc Metodos para el tratamiento de la enfermedad de parkinson
EP1588704A1 (en) * 2004-04-22 2005-10-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders
SE0401842D0 (sv) * 2004-07-12 2004-07-12 Dizlin Medical Design Ab Infusion and injection solution of levodopa
US20060241183A1 (en) * 2004-09-28 2006-10-26 Farouk Karoum Compositions and methods of using D-DOPA to treat Parkinson's disease
US20060173074A1 (en) 2004-11-10 2006-08-03 Juha Ellmen Treatment of restless legs syndrome
AU2012216377C1 (en) * 2005-06-08 2013-10-10 Orion Corporation Oral dosage form
EP2050447B1 (en) * 2005-06-08 2017-10-11 Orion Corporation An entacapone-containing oral dosage form
US20070148238A1 (en) * 2005-06-23 2007-06-28 Spherics, Inc. Dosage forms for movement disorder treatment
MY148644A (en) 2005-07-18 2013-05-15 Orion Corp New pharmaceutical compounds
NZ565460A (en) 2005-07-26 2011-06-30 Bial Portela & Ca Sa Nitrocatechol derivatives as COMT inhibitors
US8877802B2 (en) * 2005-07-28 2014-11-04 Duke Univerity Antiparkinsonian action of phenylisopropylamines
WO2007034024A2 (en) * 2005-09-21 2007-03-29 Orion Corporation Treatment of symptoms of parkinson' s disease
US20070178149A1 (en) * 2005-11-07 2007-08-02 Moshe Flashner-Barak Levodopa compositions
WO2007069274A2 (en) * 2005-11-09 2007-06-21 Torrent Pharmaceuticals Limited Pharmaceutical composition comprising a compound having a catechol moiety and an alkalising agent
GB2429645A (en) * 2006-03-10 2007-03-07 Sekhsaria Chemicals Ltd Solid pharmaceutical composition comprising a COMT inhibitor, a starch and a wetting agent
CN100384411C (zh) * 2006-03-17 2008-04-30 北京科信必成医药科技发展有限公司 卡左双多巴口腔崩解片
WO2007113371A1 (en) * 2006-03-31 2007-10-11 Iprbox Oy Pharmaceutical composition and preparation method thereof
EP1845097A1 (en) 2006-04-10 2007-10-17 Portela & Ca., S.A. Oxadiazole derivatives as COMT inhibitors
EP1870097A1 (en) * 2006-06-15 2007-12-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of cognitive disorders
US8106056B2 (en) * 2006-06-16 2012-01-31 Solvay Pharmaceuticals B.V. Combination preparations comprising bifeprunox and a dopamine agonist
US20080131492A1 (en) * 2006-06-23 2008-06-05 Spherics, Inc. Dosage forms for movement disorder treatment
WO2008053297A2 (en) 2006-10-30 2008-05-08 Wockhardt Research Centre Pharmaceutical compositions comprising entacapone, levodopa, and carbidopa
AU2007338631A1 (en) * 2006-12-22 2008-07-03 Combinatorx, Incorporated Pharmaceutical compositions for treatment of parkinson's disease and related disorders
US20100104634A1 (en) * 2006-12-27 2010-04-29 Mahesh Rameshwar Kalantri Pharmaceutical compositions of entacapone
EP1946756A1 (en) * 2007-01-17 2008-07-23 Revotar Biopharmaceuticals AG Use of entacapone in cosmetic, dermatological and pharmaceutical compositions
US8524746B2 (en) 2007-01-31 2013-09-03 Bial-Portela & Ca., S.A. Dosage regimen for COMT inhibitors
US20110171275A1 (en) * 2007-08-20 2011-07-14 Team Academy Of Pharmaceutical Science Gastroretentive drug delivery system, preparation method and use thereof
JP5651478B2 (ja) * 2008-02-06 2015-01-14 ウォックハート リサーチ センター 糖アルコールと共微粒子化されたエンタカポンの医薬組成物
RU2485947C2 (ru) 2008-02-06 2013-06-27 Вокхардт Рисерч Сентер Фармацевтические композиции энтакапона, леводопы и карбидопы с улучшенной биодоступностью
AR070907A1 (es) 2008-03-17 2010-05-12 Bial Portela & Ca Sa Formas cristalinas de derivado de nitrocatecol
AU2009283814B2 (en) * 2008-08-22 2014-05-01 Wockhardt Research Centre Single unit oral dose pharmaceutical composition comprising levodopa, carbidopa and entacapone or salts thereof
US9289392B2 (en) * 2008-08-22 2016-03-22 Wockhardt Ltd. Extended release pharmaceutical composition of entacapone or salts thereof
TR200806646A2 (tr) * 2008-09-03 2009-06-22 Dr. F. Fri̇k İlaç San. Ve Ti̇c. A.Ş. Entakapon, levodopa ve karbidoba içeren farmasötik kombinasyonlar
EP2233131A1 (en) 2009-03-23 2010-09-29 Laboratorios Lesvi, S.L. Pharmaceutical composition containing levodopa, entacapone and carbidopa
ES2730678T3 (es) 2009-04-01 2019-11-12 Bial Portela & Ca Sa Formulaciones farmacéuticas que comprenden derivados de nitrocatecol y métodos para fabricarlas
MX364974B (es) * 2009-05-19 2019-05-16 Neuroderm Ltd Composiciones para la administracion continua de inhibidores de dopa descarboxilasa.
US9750702B2 (en) 2009-12-25 2017-09-05 Innopharmax, Inc. Pharmaceutical composition for treating parkinson's disease and preparation method thereof
AU2011222856B2 (en) 2010-03-04 2015-10-15 Orion Corporation Use of levodopa, carbidopa and entacapone for treating Parkinson's disease
DE102010023828A1 (de) 2010-06-15 2011-12-15 IIP - Institut für industrielle Pharmazie, Forschungs- und Entwicklungsgesellschaft mbH Pharmazeutisches Präparat, welches Entacapon, Levodopa und Carbidopa enthält
ES2776734T3 (es) 2010-11-15 2020-07-31 Neuroderm Ltd Administración continua de L-dopa, inhibidores de dopa descarboxilasa, inhibidores de catecol-o-metil transferasa y composiciones para ello
US20140045900A1 (en) 2011-02-11 2014-02-13 Bial-Portela & Ca, S.A. Administration regime for nitrocatechols
EP2508174A1 (en) 2011-04-06 2012-10-10 Ljiljana Sovic Brkicic Pharmaceutical composition
WO2012147099A1 (en) 2011-04-25 2012-11-01 Suven Nishtaa Pharma Pvt. Ltd. Pharmaceutical compositions of levodopa, carbidopa and entacapone
CN103476406B (zh) * 2011-04-26 2017-05-24 因华生技制药股份有限公司 安它可朋组合物
HUE047856T2 (hu) 2011-12-13 2020-05-28 Bial Portela & Ca Sa Kémiai vegyület, amely köztitermékként használható katechol-O-metil-transzferáz inhibitor elõállításához
TR201204839A2 (tr) 2012-04-25 2012-12-21 Ali̇ Rai̇f İlaç Sanayi̇ A.Ş. Uzatılmış salım sağlayan levodopa karbıdopa entakapon içeren tablet formülasyonu.
CN104349768B (zh) 2012-06-05 2017-11-07 纽罗德姆有限公司 包含阿朴吗啡和有机酸的组合物及其用途
CA2904838C (en) * 2013-03-13 2021-03-16 Neuroderm Ltd. Method for treatment of parkinson's disease
EP2799065A1 (en) * 2013-04-30 2014-11-05 Deva Holding Anonim Sirketi Levodopa carbidopa entacapone pharmaceutical formulations
EP3054929B1 (en) 2013-10-07 2020-08-05 Impax Laboratories, LLC Muco-adhesive, controlled release formulations of levodopa and/or esters of levodopa and uses thereof
US10987313B2 (en) 2013-10-07 2021-04-27 Impax Laboratories, Llc Muco-adhesive, controlled release formulations of levodopa and/or esters of levodopa and uses thereof
MX2016011837A (es) 2014-03-13 2017-04-27 Neuroderm Ltd Composiciones de inhibidores de la dopa decarboxilasa.
US10258585B2 (en) 2014-03-13 2019-04-16 Neuroderm, Ltd. DOPA decarboxylase inhibitor compositions
HUE052857T2 (hu) 2014-09-04 2021-05-28 Lobsor Pharmaceuticals Ab Levodopat, egy dopamin dekarboxiláz inhibitort és egy COMT inhibitort tartalmazó gyógyászati készítmények, és azok adagolási módszerei
WO2016083863A1 (en) 2014-11-28 2016-06-02 Bial - Portela & Ca, S.A. Medicaments for slowing parkinson's disease
EP3236957A1 (en) 2014-12-23 2017-11-01 Pharmathen S.A. Levodopa/carbidopa/entacapone pharmaceutical preparation and method for preparing the same
US10555922B2 (en) 2015-09-04 2020-02-11 Lobsor Pharmaceuticals Aktiebolag Method of treating a dopamine related disorder in a subject by administering levodopa, in combination with a dopamine decarboxylase inhibitor and a catechol-o-methyltransferase inhibitor
KR102443161B1 (ko) * 2016-07-11 2022-09-14 콘테라 파르마 에이/에스 아침 운동 불능을 치료하기 위한 박동성 약물 전달 시스템
EA036784B1 (ru) 2016-08-18 2020-12-21 Илько Илач Санайи Ве Тиджарет Аноним Ширкети Таблетированный состав с улучшенным профилем растворения для лечения болезни паркинсона
WO2019145773A1 (en) 2017-12-15 2019-08-01 Nos Life Sciences Corporation Liposomal-encapsulated formulations
JP7485874B2 (ja) 2018-03-23 2024-05-17 イントランス・メディカル・システムズ・インコーポレイテッド 神経変性障害の治療のための医薬組成物の連続的投与
US11331293B1 (en) 2020-11-17 2022-05-17 Neuroderm, Ltd. Method for treatment of Parkinson's disease
US11844754B2 (en) 2020-11-17 2023-12-19 Neuroderm, Ltd. Methods for treatment of Parkinson's disease
US11213502B1 (en) 2020-11-17 2022-01-04 Neuroderm, Ltd. Method for treatment of parkinson's disease
US11986449B2 (en) 2020-12-22 2024-05-21 Amneal Pharmaceuticals Llc Levodopa dosing regimen

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4190672A (en) 1978-09-01 1980-02-26 Stanley Fahn Method and compositions of treating Parkinsonisms with levodopa and 3',4'-dihydroxy-2-methylisopropiophenone
GB8521350D0 (en) * 1985-08-28 1985-10-02 Euro Celtique Sa Analgesic composition
US5236952A (en) 1986-03-11 1993-08-17 Hoffmann-La Roche Inc. Catechol derivatives
NZ220599A (en) * 1986-06-16 1990-10-26 Merck & Co Inc Controlled release oral dosage formulation of carbidopa and levodopa
US5283352A (en) 1986-11-28 1994-02-01 Orion-Yhtyma Oy Pharmacologically active compounds, methods for the preparation thereof and compositions containing the same
DE4101873C2 (de) * 1991-01-23 1993-12-09 Isis Pharma Gmbh Peroral applizierbare Arzneiform zur Behandlung zentraler Dopaminmangelzustände
US5888534A (en) 1995-06-13 1999-03-30 Pentech Pharmaceuticals, Inc. Controlled release of drugs delivered by sublingual or buccal administration
GB2321190B (en) * 1997-01-16 2000-09-20 Britannia Pharmaceuticals Ltd Pharmaceutical composition
US6599530B2 (en) 1998-09-14 2003-07-29 Orion Corporation Oral compacted composition comprising catechol derivatives
FI109453B (fi) 1999-06-30 2002-08-15 Orion Yhtymae Oyj Farmaseuttinen koostumus

Also Published As

Publication number Publication date
CZ20014636A3 (cs) 2002-05-15
EA004503B1 (ru) 2004-04-29
JP4204783B2 (ja) 2009-01-07
DE60004052T2 (de) 2004-04-15
US6797732B2 (en) 2004-09-28
NO20016203D0 (no) 2001-12-18
CA2378469C (en) 2009-10-06
BG65364B1 (bg) 2008-04-30
AU765932B2 (en) 2003-10-02
FI991485A0 (fi) 1999-06-30
ITMI20001450A1 (it) 2001-12-28
US6500867B1 (en) 2002-12-31
NO330260B1 (no) 2011-03-14
SK286451B6 (sk) 2008-10-07
NZ515780A (en) 2004-06-25
EP1189608A1 (en) 2002-03-27
SK19232001A3 (sk) 2002-06-04
PL352775A1 (en) 2003-09-08
KR100905428B1 (ko) 2009-06-30
YU92501A (sh) 2004-09-03
WO2001001984A1 (en) 2001-01-11
FR2797587A1 (fr) 2001-02-23
DE60004052D1 (de) 2003-08-28
PL197818B1 (pl) 2008-04-30
HUP0202273A3 (en) 2002-11-28
EA200200106A1 (ru) 2002-06-27
IL146807A (en) 2006-10-05
SI1189608T1 (en) 2004-04-30
HK1047040B (zh) 2005-04-29
TR200103763T2 (tr) 2002-04-22
GEP20043314B (en) 2004-02-10
BRPI0011867B1 (pt) 2019-01-08
AU5830600A (en) 2001-01-22
AR033796A1 (es) 2004-01-07
CZ304416B6 (cs) 2014-04-23
JP4885896B2 (ja) 2012-02-29
US20030017201A1 (en) 2003-01-23
BR0011867A (pt) 2002-03-05
CA2378469A1 (en) 2001-01-11
ZA200109868B (en) 2003-05-28
ES2203495T3 (es) 2004-04-16
ATE245417T1 (de) 2003-08-15
MY127685A (en) 2006-12-29
NO20110090L (no) 2002-02-25
HRP20020088A2 (en) 2005-10-31
CZ303010B6 (cs) 2012-02-29
CO5180579A1 (es) 2002-07-30
NO20016203L (no) 2002-02-25
ME00520B (me) 2011-10-10
BRPI0011867B8 (pt) 2021-05-25
HU230395B1 (hu) 2016-04-28
DK1189608T3 (da) 2003-11-10
ITMI20001450A0 (it) 2000-06-28
HUP0202273A2 (en) 2002-10-28
HRP20020088B1 (en) 2007-05-31
MXPA01013167A (es) 2002-07-02
FI991485A (fi) 2000-12-31
FI109453B (fi) 2002-08-15
KR20020010155A (ko) 2002-02-02
UA75047C2 (en) 2006-03-15
JP2008156373A (ja) 2008-07-10
BG106251A (en) 2002-08-30
JP2003503454A (ja) 2003-01-28
PT1189608E (pt) 2003-12-31
CN1358090A (zh) 2002-07-10
HK1047040A1 (en) 2003-02-07
PE20010399A1 (es) 2001-04-10
EE200100716A (et) 2003-02-17
CN1168440C (zh) 2004-09-29
TWI241187B (en) 2005-10-11
RS50368B (sr) 2009-11-10
EP1189608B1 (en) 2003-07-23

Similar Documents

Publication Publication Date Title
EE05473B1 (et) Levodopa/karbidopa/entakapooni farmatseutiline preparaat, selle valmistamise meetod ja kasutamine
EE04417B1 (et) Peroraalne farmatseutiline pulseeriva vabanemisega annusvorm, selle valmistamise meetod ja kasutamine
EE03676B1 (et) Mullpakend, selle valmistamise meetod ja mullpakendi kasutamine
NO980628D0 (no) Gjenstand med mikroorganismeavvisende belegg, dens fremstilling og anvendelse
EE04452B1 (et) Farmatseutiliselt aktiivne morfolinool ja selle kasutamine
IL175314A0 (en) Administration of levodopa and carbidopa
EE200300581A (et) Karboksamiid-asendatud fenüüluurea derivaadid ja nende kasutamine, ravim ja selle valmistamismeetod
EE200300529A (et) Antraniilhappe amiidid, nende kasutamine ja farmatseutiline preparaat
NO975513D0 (no) 3-hydroksypyridin-2-karboksylsyreamidester, fremstilling og anvendelse som legemiddel
EE04721B1 (et) Fenüülksantiini derivaadid, nende valmistamismeetodid ja kasutamine
IS2076B (is) Asýl-píperasínil-pýrimídínafleiður, framleiðsla og notkun þeirra sem lyfja
IS6181A (is) Ein- og tvíataðgengnar 3-própýl-gamma-amínósmjörsýrur
EE200400028A (et) Ravimpreparaat, selle valmistamise meetod ja selle kasutamine meditsiinis
EE200100314A (et) Meetod farmatseutilise kompositsiooni valmistamiseks, farmatseutiline kompositsioon ja selle kasutamine
EE200000099A (et) Antimükootiline kompositsioon, selle kasutamine ja valmistamismeetod ning antimükootiline toode
EE04902B1 (et) Mikrograanul, selle valmistamismeetod ja farmatseutiline preparaat
EE04770B1 (et) Tritsüklilised delta3-piperidiinid, nende valmistamismeetod, kasutamine, farmatseutiline kompositsioon ja selle valmistamismeetod
EE9800075A (et) Kombineeritud ravimpreparaat, selle kasutamine ja meetod selle valmistamiseks
NO326826B1 (no) Alfa-aminosyreamider, fremstilling og terapeutisk anvendelse derav
EE03798B1 (et) Söödalisandi valmistamise meetod, söödalisand ja selle kasutamine
EE200200096A (et) IREN-valk, selle valmistamine ja kasutamine
EE9600180A (et) Anti-HIV kompositsioon, meetod selle valmistamiseks ja selle kasutamine
EE03922B1 (et) 3-N,N-ditsüklobutüülamino-8-fluoro-3,4-dihüdro-2H-1-bensopüraan-5-karboksamiidi, selle R-enantiomeeri ja S-enantiomeeri valmistamise meetod
ATE252553T1 (de) ((aminoiminomethyl)amino) alkanecarboxamide und deren therapeutische verwendungen
FI20011892A0 (fi) Menetelmä entakaponia, levodopaa ja karbidopaa sisältävän farmaseuttisen koostumuksen valmistamiseksi

Legal Events

Date Code Title Description
GB1A Change in the ownership or in the address of the owner
HC1A Change of owner name