EE03964B1 - (S)-3-(aminometüül)-5-metüülheksaanhappe valmistamise meetodid - Google Patents

(S)-3-(aminometüül)-5-metüülheksaanhappe valmistamise meetodid

Info

Publication number
EE03964B1
EE03964B1 EE9700311A EE9700311A EE03964B1 EE 03964 B1 EE03964 B1 EE 03964B1 EE 9700311 A EE9700311 A EE 9700311A EE 9700311 A EE9700311 A EE 9700311A EE 03964 B1 EE03964 B1 EE 03964B1
Authority
EE
Estonia
Prior art keywords
acid
methylhexanoic acid
carbamoylmethyl
aminomethyl
reacting
Prior art date
Application number
EE9700311A
Other languages
English (en)
Estonian (et)
Other versions
EE9700311A (et
Inventor
Keith Huckabee Brian
Martin Sobieray Denis
Original Assignee
Warner-Lambert Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company
Publication of EE9700311A publication Critical patent/EE9700311A/xx
Publication of EE03964B1 publication Critical patent/EE03964B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C233/05—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EE9700311A 1995-06-02 1996-04-26 (S)-3-(aminometüül)-5-metüülheksaanhappe valmistamise meetodid EE03964B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/458,950 US5616793A (en) 1995-06-02 1995-06-02 Methods of making (S)-3-(aminomethyl)-5-methylhexanoic acid
PCT/US1996/005831 WO1996038405A1 (en) 1995-06-02 1996-04-26 Methods of making (s)-3-(aminomethyl)-5-methylhexanoic acid

Publications (2)

Publication Number Publication Date
EE9700311A EE9700311A (et) 1998-06-15
EE03964B1 true EE03964B1 (et) 2003-02-17

Family

ID=23822760

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9700311A EE03964B1 (et) 1995-06-02 1996-04-26 (S)-3-(aminometüül)-5-metüülheksaanhappe valmistamise meetodid

Country Status (16)

Country Link
US (2) US5616793A (de)
EP (1) EP0828704B1 (de)
JP (1) JP3965440B2 (de)
AT (1) ATE214361T1 (de)
AU (1) AU699982B2 (de)
CZ (1) CZ297631B6 (de)
DE (1) DE69619809T2 (de)
DK (1) DK0828704T3 (de)
EE (1) EE03964B1 (de)
ES (1) ES2173279T3 (de)
HU (1) HUP9802090A3 (de)
NZ (1) NZ307030A (de)
PL (1) PL185034B1 (de)
PT (1) PT828704E (de)
SK (1) SK283663B6 (de)
WO (1) WO1996038405A1 (de)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1094757C (zh) 1996-07-24 2002-11-27 沃尼尔·朗伯公司 用于治疗疼痛的异丁基γ－氨基丁酸及其衍生物
DE60102356T2 (de) * 2000-01-27 2005-02-17 Warner-Lambert Co. Asymmetrische synthese von pregabalin
EP1543831A1 (de) * 2003-12-18 2005-06-22 Pfizer GmbH Arzneimittelwerk Gödecke Zusammensetzung enthaltend Pregabalin
DE602005002253T2 (de) * 2004-03-12 2008-05-29 Warner-Lambert Company Llc C1-symmetrische bisphosphinliganden und deren verwendung bei der asymmetrischen synthese von pregabalin
CA2571040C (en) * 2004-06-21 2009-09-15 Warner-Lambert Company Llc Preparation of pregabalin and related compounds
CN101160281A (zh) * 2005-04-06 2008-04-09 特瓦制药工业有限公司 结晶形态的普瑞巴林
US7488846B2 (en) * 2005-04-11 2009-02-10 Teva Pharmaceuical Industries Ltd. Pregabalin free of lactam and a process for preparation thereof
US20070066846A1 (en) * 2005-04-11 2007-03-22 Asher Maymon Process for making (S)-Pregabalin
CA2604624A1 (en) * 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Optical resolution of 3-carbamoylmethyl-5-methyl hexanoic acid
CA2604600A1 (en) * 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Pregabalin free of isobutylglutaric acid and a process for preparation thereof
WO2006121557A1 (en) * 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Pregabalin free of lactam and a process for preparation thereof
KR100893312B1 (ko) * 2005-05-10 2009-04-15 테바 파마슈티컬 인더스트리즈 리미티드 프레가발린 및 이의 염의 제조 방법
CN100410242C (zh) * 2005-06-23 2008-08-13 江苏恩华药业股份有限公司 普瑞巴林中间体及其制备方法
KR20070087596A (ko) * 2005-09-19 2007-08-28 테바 파마슈티컬 인더스트리즈 리미티드 (ｓ)-(+)-3-(아미노메틸)-5-메틸헥산산의 비대칭 합성
NL2000281C2 (nl) * 2005-11-02 2007-08-07 Pfizer Prod Inc Vaste farmaceutische samenstellingen die pregabaline bevatten.
BRPI0702865A2 (pt) * 2006-04-24 2012-08-07 Teva Pharma processos para preparaÇço do Ácido 3-isobutilglutÁrico e de (s)- pregabalin, a partir de combinaÇÕes de composiÇÕes com fàrmulas especÍficas para uso na dita preparaÇço
KR20080027880A (ko) * 2006-05-24 2008-03-28 테바 파마슈티컬 인더스트리즈 리미티드 Ｒ-(+)-3-(카바모일메틸)-5-메틸헥산산 및 이의 염의 제조방법
KR20080036060A (ko) 2006-05-31 2008-04-24 테바 파마슈티컬 인더스트리즈 리미티드 프레가발린의 중간체의 제조에 효소 분할을 이용하는 방법
EP1912931A2 (de) * 2006-05-31 2008-04-23 Teva Pharmaceutical Industries Ltd. (s)-prägabalin-nitril-präparat
ITMI20061297A1 (it) * 2006-07-04 2008-01-05 Laboratorio Chimico Int Spa Procedimento per la preparazione della'acido (r)-(-)-3-(carbamoilmetil)-5-metilesanoico e del pregabalin e intermedi di sintesi
GB0614133D0 (en) * 2006-07-15 2006-08-23 Pliva Istrazivanje I Razvoj D Process for preparing a pharmaceutical compound
BRPI0803092A2 (pt) * 2007-03-22 2011-08-30 Teva Pharma sìntese de (s)-(+)-3-(aminometil)-5-metil ácido hexanóico, (s)-pregabalina
WO2008137512A2 (en) * 2007-05-03 2008-11-13 Dr. Reddy's Laboratories Ltd. Process for preparing pregabalin via hofmann reaction and crystalline form thereof
WO2009004643A2 (en) * 2007-05-08 2009-01-08 Cadila Healthcare Limited An improved process for preparation of (s)-pregabalin and intermediates thereof
EP1992609A1 (de) * 2007-05-14 2008-11-19 Dipharma Francis S.r.l. Verfahren für die Herstellung einer (S)(+)-3-(Aminomethyl)-5-Methylhexan-Säure
US20090137842A1 (en) * 2007-10-03 2009-05-28 Vollerner Yuri Pregabalin -4-eliminate, pregabalin 5-eliminate, their use as reference marker and standard, and method to produce pregabalin containing low levels thereof
JP5234901B2 (ja) * 2007-10-04 2013-07-10 学校法人東京理科大学 不斉触媒マイケル反応生成物の製造方法
CA2706381C (en) 2007-11-30 2016-11-01 Medichem, S.A. Processes for preparing a substituted gamma-amino acid
ITMI20072262A1 (it) * 2007-12-03 2009-06-04 Dipharma Francis Srl Procedimento per la preparazione di acido (s)(+)-3-(amminometil)-5-metilesanoico
EP2225199A2 (de) * 2007-12-18 2010-09-08 Watson Pharma Private Limited Verbessertes herstellungsverfahren für (s)-pregabalin
US20110144383A1 (en) * 2008-02-18 2011-06-16 Matrix Laboratories Limited Process for preparing (s)-3-(aminomethyl)-5-methylhexanoic acid
WO2009141362A2 (en) 2008-05-21 2009-11-26 Sandoz Ag Process for the stereoselective enzymatic hydrolysis of 5-methyl-3-nitromethyl-hexanoic acid ester
US20100087525A1 (en) * 2008-06-23 2010-04-08 Lilach Hedvati Stereoselective enzymatic synthesis of (s) or (r)-iso-butyl-glutaric ester
WO2010070593A2 (en) 2008-12-19 2010-06-24 Pfizer Ireland Pharmaceuticals Malonate esters
EP2213659A1 (de) 2009-01-29 2010-08-04 The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth near Dublin Zwischenprodukte bei der enantioselektiven Synthese von 3-(Aminomethyl)-5-Methyl-Hexansäure
CN101987826A (zh) * 2009-08-04 2011-03-23 铜陵凯顺生物科技有限公司 一种(3s)-3-氨甲基-5-甲基己酸的合成方法
CN102126979A (zh) * 2009-12-15 2011-07-20 中国科学院成都有机化学有限公司 一种光学纯的3-(氨甲酰甲基)-5-甲基己酸的制备方法
WO2011077463A1 (en) * 2009-12-24 2011-06-30 Msn Laboratories Limited Process for preparing pregabalin and its intermediate
ES2362913B1 (es) 2009-12-24 2012-05-24 Moehs Iberica S.L. Nuevo método para la preparación de (s)-pregabalina.
WO2011078172A1 (ja) * 2009-12-25 2011-06-30 株式会社カネカ 光学活性３－置換グルタル酸モノアミドの製造法
US8212072B2 (en) 2010-08-13 2012-07-03 Divi's Laboratories, Ltd. Process for the preparation of pregabalin
WO2012025861A1 (en) 2010-08-23 2012-03-01 Pfizer Manufacturing Ireland Process for the preparation of ( s ) - 3 - cyano - 5 - methylhexanoic acid derivatives adn of pregabalin
KR101306585B1 (ko) * 2011-04-14 2013-09-10 한국외국어대학교 연구산학협력단 프레가발린의 제조방법
US8895769B2 (en) 2011-04-20 2014-11-25 Kemphys Ltd. Silicon-containing carboxylic acid derivative
BR112014012595A2 (pt) 2011-11-24 2017-06-06 Lupin Ltd processo de racemização de ácido (s)-3-carbamoilmetil-5-metil-hexanoico
CN102863326A (zh) * 2012-03-20 2013-01-09 常州制药厂有限公司 一种抗癫痫药物中间体的制备方法
JP5572783B1 (ja) 2012-10-18 2014-08-13 有限会社ケムフィズ ケイ素含有カルボン酸誘導体
CN102898320A (zh) * 2012-10-26 2013-01-30 浙江省天台县奥锐特药业有限公司 (3r)-(-)-3-(2-乙酰氨基)-5-甲基己酸的制备方法
CA2888877C (en) 2012-11-07 2021-07-27 Hikal Limited A process for the preparation of pregabalin
CN102964263B (zh) * 2012-11-29 2014-12-03 太仓市茜泾化工有限公司 一种(±)-3-(氨甲酰基)-5-甲基己酸的制备方法
CN103980144B (zh) * 2014-05-16 2018-08-17 浙江华海药业股份有限公司 一种普瑞巴林中间体母液的套用方法
CN104086439B (zh) * 2014-06-30 2018-11-16 浙江华海药业股份有限公司 一种pregabalin中间体拆分剂(R)-(+)-α-苯乙胺的回收方法
CN104356016B (zh) * 2014-10-24 2019-08-23 浙江华海药业股份有限公司 一种用回收制备3-异丁基戊二酸单酰胺的方法
WO2016075082A1 (en) 2014-11-10 2016-05-19 Sandoz Ag Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam
CN104496832A (zh) * 2014-11-21 2015-04-08 浙江美诺华药物化学有限公司 一种普瑞巴林的合成方法
CN104557577B (zh) * 2014-12-26 2016-08-17 上海臣邦医药科技有限公司 高纯度(+)-普瑞巴林和(-)-普瑞巴林的制备方法
AU2015376077A1 (en) * 2015-01-08 2017-07-27 Lee Pharma Limited Novel process for the preparation of dipeptidyl peptidase-4 (DDP-4) enzyme inhibitor
CN104803868B (zh) * 2015-03-27 2020-10-02 浙江华海药业股份有限公司 一种回收3-异丁基戊二酸单酰胺的方法
CN104803869A (zh) * 2015-03-27 2015-07-29 浙江华海药业股份有限公司 一种无溶剂反应制备3-异丁基戊二酸单酰胺的方法
CN104803871B (zh) * 2015-05-12 2021-03-05 浙江华海药业股份有限公司 一种制备普瑞巴林中间体的方法
CN104892441A (zh) * 2015-05-22 2015-09-09 浙江华海药业股份有限公司 一种制备普瑞巴林异构体r-普瑞巴林的方法
WO2016187718A1 (en) 2015-05-26 2016-12-01 Isa Odidi Controlled extended release pregabalin
WO2017019791A1 (en) 2015-07-27 2017-02-02 Teva Pharmaceuticals International Gmbh Synthesis of (s)-pregabalin
CN105481712A (zh) * 2015-11-30 2016-04-13 常州市阳光药业有限公司 普瑞巴林中间体拆分母液的消旋回收方法
WO2019193607A1 (en) * 2018-04-04 2019-10-10 Msn Laboratories Private Limited, R&D Center An improved process for the preparation of pregabalin
CN108912004B (zh) * 2018-08-01 2021-05-07 宏冠生物药业有限公司 一种普瑞巴林中间体的合成方法
CN109942446B (zh) * 2019-04-17 2021-09-07 黄冈鲁班药业股份有限公司 一种普瑞巴林的制备方法
CN112062689A (zh) * 2019-06-11 2020-12-11 太仓市茜泾化工有限公司 一种r-3-（氨甲酰基）-5-甲基己酸的制备方法
CN113045468A (zh) * 2019-12-26 2021-06-29 上虞京新药业有限公司 一种布瓦西坦中间体的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2944969A (en) * 1957-02-06 1960-07-12 Petrolite Corp Prevention of rust and corrosion
US3544467A (en) * 1966-02-07 1970-12-01 Chevron Res Acid-amide pour point depressants
US3857879A (en) * 1967-12-04 1974-12-31 W Abramitis Amine salts of substituted succinamic acids
US4024174A (en) * 1973-12-25 1977-05-17 Ono Pharmaceutical Company Tranes-delta 2-prostaglandins
US4123438A (en) * 1975-03-05 1978-10-31 Stamicarbon, B.V. Process for preparing 2-pyrrolidones
US4739114A (en) * 1982-09-30 1988-04-19 Rhone-Poulenc Agrochimie Process for the preparation of 3-alkyl-substituted glutaric acids and 2-alkyl-substituted succinic acids
US4711671A (en) * 1985-10-03 1987-12-08 National Starch And Chemical Corporation Storage stable paper size composition containing ethoxylated lanolin
DE4033259A1 (de) * 1990-10-19 1992-04-23 Basf Ag Verfahren zur herstellung von 2-pyrrolidinonen
EP0641330B1 (de) * 1992-05-20 2001-10-17 Northwestern University Gaba und l-glutaminsaüre analoga zur behandlung der epilepsie

Also Published As

Publication number Publication date
NZ307030A (en) 1999-02-25
US5616793A (en) 1997-04-01
AU699982B2 (en) 1998-12-17
US5629447A (en) 1997-05-13
EP0828704A1 (de) 1998-03-18
ES2173279T3 (es) 2002-10-16
JPH11506098A (ja) 1999-06-02
JP3965440B2 (ja) 2007-08-29
SK162197A3 (en) 1998-10-07
WO1996038405A1 (en) 1996-12-05
HUP9802090A3 (en) 1999-08-30
EE9700311A (et) 1998-06-15
PL185034B1 (pl) 2003-02-28
SK283663B6 (sk) 2003-11-04
DE69619809D1 (de) 2002-04-18
EP0828704B1 (de) 2002-03-13
PT828704E (pt) 2002-08-30
DE69619809T2 (de) 2002-09-26
CZ297631B6 (cs) 2007-02-14
DK0828704T3 (da) 2002-07-01
HUP9802090A2 (hu) 1998-12-28
ATE214361T1 (de) 2002-03-15
AU5577896A (en) 1996-12-18
PL323563A1 (en) 1998-04-14
CZ374297A3 (cs) 1998-10-14

Similar Documents

Publication Publication Date Title
EE03964B1 (et) (S)-3-(aminometüül)-5-metüülheksaanhappe valmistamise meetodid
PT830338E (pt) Metodo para a preparacao de acido (s)-3-(aminometil)-5-metilhexanoico
KR870001229A (ko) 7-옥사비시 클로헵탄 치환 디아미드 및 그의 동종 프로스타글란딘 유사체의 제조 방법
ATE230737T1 (de) Aminsäure-salzverbindungen und ein verfahren zu ihrer herstellung
DE69325138D1 (de) Verfahren zur herstellung von ergolin derivaten
CA2219278A1 (en) Methods of making (s)-3-(aminomethyl)-5-methylhexanoic acid
MX9708338A (es) Metodos para hacer acido(s)-3-(aminometil)-5-metilhexanoico.
AU635239B2 (en) N-acyl-2-amino acid amides containing phosphinic esters, process for their preparation, and n-acyl-2-amino acid nitriles as precursors
ATE119202T1 (de) Verfahren zur herstellung von l-aminosäuren und aminosäure-amiden.
ATE303356T1 (de) Verfahren zur herstellung von alkylendiamintriessigsäure
DE69802388T2 (de) Verfahren zur herstellung von nicotinsäuren
DE69515770D1 (de) Verfahren zur Produktion von Thiophospholipiden des Aether-Typs
EA200000413A1 (ru) Способ синтеза пирроламидов
US5831119A (en) Process for the preparation of aminoacetic acids with a tertiary hydrocarbon radical in the α-position, or their nitriles
JPH05112796A (ja) Ｎ−長鎖アシルアミノ酸型界面活性剤の製造方法
DE69809205D1 (de) Verfahren zur herstellung von azyklischen nukleosiden
DE69920756D1 (de) Alpha-substituierung von ungeschützten beta-aminoestern
TW370520B (en) A process for the preparation of NG-monomethyl-L-arginine hydrochloride
ATE248841T1 (de) Verfahren zur herstellung von penicilling- phenylester
JPH01228488A (ja) パントテン酸またはその塩の製造法
MX9102823A (es) Proceso para producir una sal de acido aminocarboxilico a partir de un aminoalcohol.
AR005042A1 (es) Procedimiento para la preparacion de un antagonista endotelin.

Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20031231

KB4A Valid patent at the end of a year

Effective date: 20041231

KB4A Valid patent at the end of a year

Effective date: 20051231

KB4A Valid patent at the end of a year

Effective date: 20061231

KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

MM4A Lapsed by not paying the annual fees

Effective date: 20090426