ECSP18083443A - Formulaciones líquidas de (s)-n-(5-((r)-2-(2,5-difluorofenil) -pirrolidin-1-il)-pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidina-1-carboxamida - Google Patents

Formulaciones líquidas de (s)-n-(5-((r)-2-(2,5-difluorofenil) -pirrolidin-1-il)-pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidina-1-carboxamida

Info

Publication number
ECSP18083443A
ECSP18083443A ECSENADI201883443A ECDI201883443A ECSP18083443A EC SP18083443 A ECSP18083443 A EC SP18083443A EC SENADI201883443 A ECSENADI201883443 A EC SENADI201883443A EC DI201883443 A ECDI201883443 A EC DI201883443A EC SP18083443 A ECSP18083443 A EC SP18083443A
Authority
EC
Ecuador
Prior art keywords
hydroxypyrrolidine
pyrrolidin
pyrimidin
carboxamide
difluorophenil
Prior art date
Application number
ECSENADI201883443A
Other languages
English (en)
Spanish (es)
Inventor
Reynolds Mark
A Smith Steven
Original Assignee
Loxo Onology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=58549282&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP18083443(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Loxo Onology Inc filed Critical Loxo Onology Inc
Publication of ECSP18083443A publication Critical patent/ECSP18083443A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
ECSENADI201883443A 2016-04-04 2018-11-23 Formulaciones líquidas de (s)-n-(5-((r)-2-(2,5-difluorofenil) -pirrolidin-1-il)-pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidina-1-carboxamida ECSP18083443A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662318041P 2016-04-04 2016-04-04
US201662323452P 2016-04-15 2016-04-15
US201662329561P 2016-04-29 2016-04-29

Publications (1)

Publication Number Publication Date
ECSP18083443A true ECSP18083443A (es) 2019-07-31

Family

ID=58549282

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI201883443A ECSP18083443A (es) 2016-04-04 2018-11-23 Formulaciones líquidas de (s)-n-(5-((r)-2-(2,5-difluorofenil) -pirrolidin-1-il)-pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidina-1-carboxamida

Country Status (36)

Country Link
US (3) US10137127B2 (https=)
EP (1) EP3439662B1 (https=)
JP (1) JP7061602B2 (https=)
KR (1) KR102400423B1 (https=)
CN (1) CN109414442B (https=)
AU (1) AU2017246554B2 (https=)
CA (1) CA3019671C (https=)
CL (2) CL2018002806A1 (https=)
CO (1) CO2018010761A2 (https=)
CR (1) CR20180501A (https=)
CU (1) CU20180125A7 (https=)
DK (1) DK3439662T3 (https=)
DO (1) DOP2018000214A (https=)
EC (1) ECSP18083443A (https=)
ES (1) ES2987474T3 (https=)
FI (1) FI3439662T3 (https=)
GE (2) GEP20227339B (https=)
HR (1) HRP20241282T1 (https=)
HU (1) HUE068971T2 (https=)
IL (2) IL304018A (https=)
LT (1) LT3439662T (https=)
MA (1) MA44610A (https=)
MX (1) MX386416B (https=)
NI (1) NI201800102A (https=)
PE (1) PE20181888A1 (https=)
PH (1) PH12018502124B1 (https=)
PL (1) PL3439662T3 (https=)
PT (1) PT3439662T (https=)
RS (1) RS65987B1 (https=)
SA (1) SA518400168B1 (https=)
SG (1) SG11201808559PA (https=)
SI (1) SI3439662T1 (https=)
TN (1) TN2018000335A1 (https=)
TW (1) TWI746537B (https=)
UA (1) UA125026C2 (https=)
WO (1) WO2017176751A1 (https=)

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ME03376B (me) 2010-05-20 2020-01-20 Array Biopharma Inc Makrociklička jedinjenja kао inhibiтori trk kinaze
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FI3439662T3 (fi) 2016-04-04 2024-09-04 Loxo Oncology Inc (s)-n-(5-((r)-2-(2,5-difluorifenyyli)pyrrolidin-1-yyli)pyratsolo[1,5-a]pyrimidin-3-yyli)-3-hydroksipyrrolidiini-1-karboksamidin nesteformulaatioita
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JOP20190092A1 (ar) 2016-10-26 2019-04-25 Array Biopharma Inc عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها
JOP20190213A1 (ar) 2017-03-16 2019-09-16 Array Biopharma Inc مركبات حلقية ضخمة كمثبطات لكيناز ros1
JP7237013B2 (ja) * 2017-05-05 2023-03-10 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト 薬物調製キットおよび薬物を調製するプロセス
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