ECSP045220A - Derivados de n-fenil-2-pirimidin-amina - Google Patents

Derivados de n-fenil-2-pirimidin-amina

Info

Publication number
ECSP045220A
ECSP045220A EC2004005220A ECSP045220A ECSP045220A EC SP045220 A ECSP045220 A EC SP045220A EC 2004005220 A EC2004005220 A EC 2004005220A EC SP045220 A ECSP045220 A EC SP045220A EC SP045220 A ECSP045220 A EC SP045220A
Authority
EC
Ecuador
Prior art keywords
amina
pyrimidin
phenyl
derivatives
amides
Prior art date
Application number
EC2004005220A
Other languages
English (en)
Inventor
Olivier Loiseleur
Daniel Kaufmann
Stephan Abel
Hans Michael Buerger
Mark Meisenbach
Beat Schmitz
Gottfried Sedelmeier
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ECSP045220A publication Critical patent/ECSP045220A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Abstract

La presente invención se refiere a amidas novedosas y un procedimiento para la preparación de estas amidas.
EC2004005220A 2002-02-07 2004-08-04 Derivados de n-fenil-2-pirimidin-amina ECSP045220A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0202873.6A GB0202873D0 (en) 2002-02-07 2002-02-07 Organic compounds

Publications (1)

Publication Number Publication Date
ECSP045220A true ECSP045220A (es) 2004-09-28

Family

ID=9930607

Family Applications (2)

Application Number Title Priority Date Filing Date
EC2004005220A ECSP045220A (es) 2002-02-07 2004-08-04 Derivados de n-fenil-2-pirimidin-amina
EC2009005220A ECSP095220A (es) 2002-02-07 2009-07-28 Derivados de n-fenil-2-pirimidin-amina

Family Applications After (1)

Application Number Title Priority Date Filing Date
EC2009005220A ECSP095220A (es) 2002-02-07 2009-07-28 Derivados de n-fenil-2-pirimidin-amina

Country Status (26)

Country Link
US (8) US7456283B2 (es)
EP (2) EP2248807B1 (es)
JP (2) JP4653954B2 (es)
KR (1) KR101027044B1 (es)
CN (2) CN101016262A (es)
AU (1) AU2003244444B2 (es)
BR (2) BR0307529A (es)
CA (2) CA2737565C (es)
CO (1) CO5601018A2 (es)
CY (2) CY1112938T1 (es)
DK (2) DK2248807T3 (es)
EC (2) ECSP045220A (es)
ES (2) ES2425980T3 (es)
GB (1) GB0202873D0 (es)
HK (2) HK1145322A1 (es)
IL (3) IL163158A (es)
MX (1) MXPA04007642A (es)
NO (2) NO327366B1 (es)
NZ (3) NZ569731A (es)
PL (1) PL209475B1 (es)
PT (2) PT2248807E (es)
RU (2) RU2370493C2 (es)
SG (1) SG160195A1 (es)
SI (2) SI1474408T1 (es)
WO (1) WO2003066613A1 (es)
ZA (1) ZA200405970B (es)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0202873D0 (en) 2002-02-07 2002-03-27 Novartis Ag Organic compounds
WO2004108699A1 (en) * 2003-06-06 2004-12-16 Natco Pharma Limited Process for the preparation of the anti-cancer drug imatinib and its analogues
PL1635835T3 (pl) * 2003-06-13 2010-06-30 Novartis Ag Pochodne 2-aminopirymidyny jako inhibitory kinazy RAF
MY144177A (en) * 2004-02-04 2011-08-15 Novartis Ag Salt forms of 4-(4-methylpiperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide.
US7507821B2 (en) 2004-12-30 2009-03-24 Chemagis Ltd. Process for preparing Imatinib
US7977348B2 (en) 2006-04-27 2011-07-12 Sicor Inc. Polymorphic forms of imatinib mesylate and processes for preparation of novel crystalline forms as well as amorphous and form α
US8067421B2 (en) 2006-04-27 2011-11-29 Sicor Inc. Polymorphic forms of imatinib mesylate and processes for preparation of novel crystalline forms as well as amorphous and form α
US20060223816A1 (en) * 2006-05-08 2006-10-05 Chemagis Ltd. Imatinib mesylate alpha form and production process therefor
CA2662265A1 (en) * 2006-09-01 2008-03-06 Teva Pharmaceutical Industries Ltd. Imatinib compositions
JP5735742B2 (ja) 2006-09-22 2015-06-17 ノバルティス アーゲー Ａｂｌチロシンキナーゼ阻害剤でのフィラデルフィア陽性白血病の処置を最適化する方法
EP2009008A1 (en) 2006-10-26 2008-12-31 Sicor, Inc. Imatinib base, and imatinib mesylate and processes for preparation thereof
WO2008051597A1 (en) * 2006-10-26 2008-05-02 Sicor Inc. Process for the preparation of imatinib
JP5265562B2 (ja) * 2006-11-16 2013-08-14 エッフェ．イー．エッセ． ファブリカ イタリアーナ シンテーティチ エッセ．ペー．アー． イマチニブおよびその中間体の調製方法
CN100451015C (zh) * 2007-02-14 2009-01-14 杭州盛美医药科技开发有限公司 一种伊马替尼的制备方法
US7550591B2 (en) 2007-05-02 2009-06-23 Chemagis Ltd. Imatinib production process
EP2152079A4 (en) 2007-06-04 2011-03-09 Avila Therapeutics Inc HETEROCYCLIC COMPOUNDS AND USES THEREOF
BRPI0817946A2 (pt) * 2007-09-25 2015-05-05 Teva Pharma Composições de imatinibe estável
WO2009080366A1 (en) * 2007-12-22 2009-07-02 Synthon B.V. A process of making imatinib
CN101497601B (zh) * 2008-01-29 2012-11-07 福建南方制药股份有限公司 伊马替尼的合成方法
PL215042B1 (pl) * 2008-08-01 2013-10-31 Temapharm Spolka Z Ograniczona Odpowiedzialnoscia Sposób wytwarzania imatinibu
KR20100021321A (ko) * 2008-08-14 2010-02-24 일양약품주식회사 Ν-페닐-2-피리미딘-아민 유도체의 제조방법
EP2370078A1 (en) 2008-12-01 2011-10-05 Novartis AG Method of optimizing the treatment of philadelphia-positive leukemia with imatinib mesylate
US20100330130A1 (en) 2009-05-22 2010-12-30 Actavis Group Ptc Ehf Substantially pure imatinib or a pharmaceutically acceptable salt thereof
CN101654416B (zh) * 2009-09-16 2013-06-05 成都神黄医药科技开发有限公司 N-[3-硝基-4-甲基-苯基]-4-醛基-苯甲酰胺及其制备方法以及其衍生物的制备方法
US20110306763A1 (en) 2009-12-10 2011-12-15 Shanghai Parling Pharmatech Co., Ltd. Process for the preparation of imatinib and salts thereof
WO2011095835A1 (en) 2010-02-02 2011-08-11 Actavis Group Ptc Ehf Highly pure imatinib or a pharmaceutically acceptable salt thereof
US8609842B2 (en) 2010-04-23 2013-12-17 Fujian South Pharmaceutical Co., Ltd. Method for synthesizing Imatinib
EP2582689B1 (en) 2010-06-18 2017-03-01 KRKA, D.D., Novo Mesto New polymorphic form of imatinib base and preparation of salts thereof
TR201007005A2 (tr) 2010-08-23 2011-09-21 Mustafa Nevzat İlaç Sanayi̇i̇ A.Ş. İmatinib baz üretim yöntemi
WO2013035102A1 (en) 2011-09-05 2013-03-14 Natco Pharma Limited Processes for the preparation of imatinib base and intermediates thereof
WO2013063003A1 (en) 2011-10-28 2013-05-02 Novartis Ag Method of treating gastrointestinal stromal tumors
CA2853095A1 (en) 2011-10-28 2013-05-02 Novartis Ag Method of treating gastrointestinal stromal tumors
WO2013120852A1 (en) 2012-02-13 2013-08-22 Grindeks, A Joint Stock Company Intermediates for a novel process of preparing imatinib and related tyrosine kinase inhibitors
BR112015000349A2 (pt) 2012-07-11 2017-06-27 Novartis Ag método de tratamento de tumores estromais gastrointestinais
CN102827144A (zh) * 2012-09-05 2012-12-19 湖南欧亚生物有限公司 一种伊马替尼的制备方法
RU2537398C1 (ru) * 2013-08-20 2015-01-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Сибирский государственный технологический университет" (СибГТУ) Гексазамещенные пара-аминофенолы с ариламидными группами в 2,6-положениях по отношению к гидроксилу
CN103588754B (zh) * 2013-11-04 2015-05-27 遵义医学院 伊马替尼的制备方法
EP3527211B1 (en) 2016-10-17 2023-08-23 Delta-Fly Pharma, Inc. Pharmaceutical composition for treatment or remission of chronic myelogenous leukemia
EP3539138B1 (en) 2016-11-11 2021-05-19 Curium US LLC Processes for generating germanium-68 with reduced volatiles
EP3333162A1 (en) 2016-12-12 2018-06-13 Silesian Catalysts sp. z o.o. Metod for preparing n-(2-methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine
EP3684767B1 (en) 2017-09-22 2024-04-24 Jubilant Epipad LLC Heterocyclic compounds as pad inhibitors
CA3076476A1 (en) 2017-10-18 2019-04-25 Jubilant Epipad LLC Imidazo-pyridine compounds as pad inhibitors
AU2018362046B2 (en) 2017-11-06 2023-04-13 Jubilant Prodel LLC Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation
AU2018372211B2 (en) 2017-11-24 2023-02-02 Jubilant Episcribe LLC, Heterocyclic compounds as PRMT5 inhibitors
CN108164505B (zh) * 2018-01-16 2020-11-03 扬州大学 一种伊马替尼的合成方法
EP3749697A4 (en) 2018-02-05 2021-11-03 Bio-Rad Laboratories, Inc. CHROMATOGRAPHIC RESIN WITH A LIGAND WITH ANION EXCHANGE-HYDROPHOBIC MIXED MODE
SG11202008950PA (en) 2018-03-13 2020-10-29 Jubilant Prodel LLC Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE531480C (de) * 1929-07-03 1931-08-10 I G Farbenindustrie Akt Ges Verfahren zur Darstellung von Aryliden einer unsymmetrischen o-Xylenolcarbonsaeure
US2808433A (en) * 1953-08-21 1957-10-01 Du Pont Benzene dicarboxylic acid derivatives
GB862127A (en) 1958-07-04 1961-03-01 Ici Ltd Derivatives of 2-hydroxy-3-naphthanilide
US3505433A (en) * 1965-03-08 1970-04-07 Hooker Chemical Corp 2-haloperfluoro-1-cycloalken-1-ylphosphoryl compounds
US3505389A (en) * 1966-08-18 1970-04-07 Hooker Chemical Corp 4-amino-2,3,5,6-tetrachlorobenzoic acid and derivatives thereof
US3505398A (en) 1966-09-22 1970-04-07 Standard Oil Co Terephthalic acid crystallization
US3763234A (en) * 1970-12-03 1973-10-02 Halcon International Inc Preparation of amides
JPS4987761U (es) 1972-11-17 1974-07-30
JPS563375B2 (es) * 1972-12-25 1981-01-24
JPS5720923B2 (es) * 1974-04-02 1982-05-04
US4281000A (en) 1979-07-09 1981-07-28 American Cyanamid Company Substituted pyrazolo (1,5-a)pyrimidines and their use as anxiolytic agents
JPS5665804A (en) * 1979-11-01 1981-06-03 Ishihara Sangyo Kaisha Ltd Control agent against injurious organism
DE3305755A1 (de) * 1983-02-19 1984-08-23 Gödecke AG, 1000 Berlin N-phenyl-benzamid-derivate, verfahren zu deren herstellung und deren verwendung bei der bekaempfung von erkranungen des immunsystems
US4623486A (en) 1985-05-29 1986-11-18 Pfizer Inc. [4-substituted benzoyloxy]-N-substituted-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides having anti-arthritic activity
NZ219974A (en) * 1986-04-22 1989-08-29 Goedecke Ag N-(2'-aminophenyl)-benzamide derivatives, process for their preparation and their use in the control of neoplastic diseases
JP2894804B2 (ja) * 1989-07-19 1999-05-24 武田薬品工業株式会社 ２―アミノ―５―メチルベンゾフェノン類及びその製造法
JPH03130252U (es) 1990-04-11 1991-12-27
FR2664895B1 (fr) * 1990-07-20 1992-10-30 Theramex Laboratoire Nouveaux derives de la 6-methyl 19-nor progesterone, substitues en 3 et leur procede d'obtention.
DE4110483A1 (de) 1991-03-30 1992-10-01 Bayer Ag Substituierte salicylamide, mittel gegen pflanzenkrankheiten
US5521184A (en) 1992-04-03 1996-05-28 Ciba-Geigy Corporation Pyrimidine derivatives and processes for the preparation thereof
TW225528B (es) 1992-04-03 1994-06-21 Ciba Geigy Ag
FR2689925B1 (fr) 1992-04-08 1994-05-27 Valeo Securite Habitacle Dispositif de verrouillage d'une serrure dans son support.
US5543520A (en) 1993-10-01 1996-08-06 Ciba-Geigy Corporation Pyrimidine derivatives
DE4428380A1 (de) * 1994-08-11 1996-02-15 Bayer Ag 4-Trifluormethylbenzamide
JPH0987761A (ja) 1995-09-22 1997-03-31 Nikko Kinzoku Kk 銅転炉スラグからの銅の回収方法
JP3130252B2 (ja) 1996-07-12 2001-01-31 小糸工業株式会社 座席のヘッドレスト装置
DE69822300T2 (de) * 1997-06-30 2005-03-10 Targacept, Inc. 3-pyridyl-1-azabicycloalkan-derivate zur behandlung von zns-erkrankungen
CO4940418A1 (es) 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
ID26236A (id) * 1998-05-15 2000-12-07 Astrazeneca Ab Turunan benzamida untuk pengobatan penyakit yang diperantarai oleh sitokina
DE69912823T2 (de) 1998-09-25 2004-09-23 Astrazeneca Ab Benzamid-derivate und ihre verwendung als cytokine inhibitoren
GB9824579D0 (en) * 1998-11-10 1999-01-06 Novartis Ag Organic compounds
GB9924092D0 (en) 1999-10-13 1999-12-15 Zeneca Ltd Pyrimidine derivatives
GB0202873D0 (en) 2002-02-07 2002-03-27 Novartis Ag Organic compounds
GB2398565A (en) * 2003-02-18 2004-08-25 Cipla Ltd Imatinib preparation and salts
US7338957B2 (en) * 2003-08-28 2008-03-04 Irm Llc Compounds and compositions as protein kinase inhibitors

Also Published As

Publication number Publication date
US20070293672A1 (en) 2007-12-20
EP1474408A1 (en) 2004-11-10
RU2007148217A (ru) 2009-07-10
SI2248807T1 (sl) 2013-10-30
SI1474408T1 (sl) 2012-07-31
ZA200405970B (en) 2006-05-31
IL189658A (en) 2011-05-31
CN1630648A (zh) 2005-06-22
NZ569731A (en) 2009-11-27
CA2737565C (en) 2013-04-09
HK1070893A1 (es) 2005-06-30
RU2004126941A (ru) 2005-10-10
MXPA04007642A (es) 2004-11-10
NO20043685L (no) 2004-11-05
AU2003244444B2 (en) 2007-08-09
ES2425980T3 (es) 2013-10-18
WO2003066613A1 (en) 2003-08-14
US7579467B2 (en) 2009-08-25
US7456283B2 (en) 2008-11-25
AU2003244444B9 (en) 2003-09-02
HK1145322A1 (es) 2011-04-15
PT1474408E (pt) 2012-07-25
GB0202873D0 (en) 2002-03-27
SG160195A1 (en) 2010-04-29
EP1474408B1 (en) 2012-05-23
CA2474738A1 (en) 2003-08-14
US20090137805A1 (en) 2009-05-28
US20060142580A1 (en) 2006-06-29
NO327366B1 (no) 2009-06-15
CY1112938T1 (el) 2016-04-13
US7816359B2 (en) 2010-10-19
AU2003244444A1 (en) 2003-09-02
JP4653954B2 (ja) 2011-03-16
PL209475B1 (pl) 2011-09-30
NZ554430A (en) 2008-08-29
CY1114351T1 (el) 2016-08-31
JP2005528340A (ja) 2005-09-22
RU2370493C2 (ru) 2009-10-20
NZ534315A (en) 2007-06-29
BR0307529A (pt) 2004-12-21
US20070293504A1 (en) 2007-12-20
CN100347162C (zh) 2007-11-07
CA2737565A1 (en) 2003-08-14
IL189658A0 (en) 2008-06-05
ES2384872T3 (es) 2012-07-13
IL189657A0 (en) 2008-06-05
KR101027044B1 (ko) 2011-04-11
ECSP095220A (es) 2009-08-28
DK1474408T3 (da) 2012-06-25
US7825247B2 (en) 2010-11-02
NO20091976L (no) 2004-11-05
US20070293673A1 (en) 2007-12-20
PT2248807E (pt) 2013-09-02
IL163158A (en) 2010-11-30
US20150018552A1 (en) 2015-01-15
PL371197A1 (en) 2005-06-13
JP2010138194A (ja) 2010-06-24
CN101016262A (zh) 2007-08-15
DK2248807T3 (da) 2013-08-26
IL189657A (en) 2010-12-30
CO5601018A2 (es) 2006-01-31
US9573928B2 (en) 2017-02-21
EP2248807B1 (en) 2013-07-03
EP2248807A1 (en) 2010-11-10
BRPI0307529B1 (pt) 2018-01-30
US20120226039A1 (en) 2012-09-06
KR20040081154A (ko) 2004-09-20
US20070293683A1 (en) 2007-12-20
CA2474738C (en) 2011-10-04

Similar Documents

Publication Publication Date Title
ECSP095220A (es) Derivados de n-fenil-2-pirimidin-amina
RS70904A (en) Process for preparing indolinone derivatives
EA200500201A1 (ru) Новый способ синтеза (7-метокси-1-нафтил)ацетонитрила и его применение при синтезе агомелатина
BR0308452A (pt) composições farmacêuticas e métodos de preparação de composição farmacêutica
ECSP056111A (es) Derivados de 2-acilamino-4-feniltiazol, su preparación y aplicación en terapeutica
UY26908A1 (es) Proceso para la fabricación de ácidos n - aril - antranílicos y sus derivados
EA200600621A1 (ru) Производные тетрагидронафталина, способ их получения и их применение в качестве противовоспалительных средств
EA200500202A1 (ru) Новый способ синтеза (7-метокси-3,4-дигидро-1-нафталинил)ацетонитрила и его применение при синтезе агомелатина
NO20051393L (no) Prosess og intermediater for fremstilling av tienopyrrol-derivater
DE602004013405D1 (de) Polymorphe formen von valsartan
ZA200404752B (en) 6-aminomorphinane derivatives method for the production and use thereof
HN2003000038A (es) Esteres hidroxamato de acido n-(4-fenil-sustituido)-antranilico
NO20060535L (no) Aztreonam-L-lysin og fremgangsmater for fremstilling av dette
EA200700550A1 (ru) Производные алкилидентетрагидронафталина, способ их получения и их применение в качестве противовоспалительных средств
CY1105526T1 (el) Διαδικασια συνθεσης και ενδιαμεσα της πυριδιν-2-υλ-μεθυναμινης
EA200500204A1 (ru) Новый способ синтеза (7-метокси-1-нафтил)ацетонитрила и его применение при синтезе агомелатина
MXPA05009282A (es) Derivados de anilina sustituidos.
EP1499586A4 (en) NEW FORM OF N- (TRANS-4-ISOPROPYLCYCLOHEXYLCARBONYL) -D-PHENYLALANINE
MY138550A (en) Method for synthesis of perindopril and its pharmaceutically acceptable salts
NO20025124D0 (no) Metode
SG144921A1 (en) Method and intermediates for the preparation of derivatives of n-(1- benzhydrylazetidin-3-yl)-n-phenylmethylsulphonamide
MY136288A (en) New process for the synthesis of perindopril and its pharmaceutically acceptable salts
SG171472A1 (en) Substituted aniline derivatives
UY28145A1 (es) Nuevos compuestos farmaceuticos
MY139289A (en) Process for the synthesis of perindopril and pharmaceutically acceptable salts thereof