SI2248807T1 - N-fenil-2-pirimidin-aminski derivati - Google Patents

N-fenil-2-pirimidin-aminski derivati

Info

Publication number
SI2248807T1
SI2248807T1 SI200332291T SI200332291T SI2248807T1 SI 2248807 T1 SI2248807 T1 SI 2248807T1 SI 200332291 T SI200332291 T SI 200332291T SI 200332291 T SI200332291 T SI 200332291T SI 2248807 T1 SI2248807 T1 SI 2248807T1
Authority
SI
Slovenia
Prior art keywords
pyrimidine
phenyl
amine derivatives
amine
derivatives
Prior art date
Application number
SI200332291T
Other languages
English (en)
Inventor
Olivier Loiseleur
Daniel Kaufmann
Stephan Abel
Hans Michael Buerger
Mark Meisenbach
Beat Schmitz
Gottfried Sedelmeier
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of SI2248807T1 publication Critical patent/SI2248807T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
SI200332291T 2002-02-07 2003-02-06 N-fenil-2-pirimidin-aminski derivati SI2248807T1 (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0202873.6A GB0202873D0 (en) 2002-02-07 2002-02-07 Organic compounds
EP10171388.1A EP2248807B1 (en) 2002-02-07 2003-02-06 N-phenyl-2-pyrimidine-amine derivatives

Publications (1)

Publication Number Publication Date
SI2248807T1 true SI2248807T1 (sl) 2013-10-30

Family

ID=9930607

Family Applications (2)

Application Number Title Priority Date Filing Date
SI200332291T SI2248807T1 (sl) 2002-02-07 2003-02-06 N-fenil-2-pirimidin-aminski derivati
SI200332155T SI1474408T1 (sl) 2002-02-07 2003-02-06 N fenil pirimidin aminski derivati

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI200332155T SI1474408T1 (sl) 2002-02-07 2003-02-06 N fenil pirimidin aminski derivati

Country Status (26)

Country Link
US (8) US7456283B2 (sl)
EP (2) EP2248807B1 (sl)
JP (2) JP4653954B2 (sl)
KR (1) KR101027044B1 (sl)
CN (2) CN100347162C (sl)
AU (1) AU2003244444B2 (sl)
BR (2) BR0307529A (sl)
CA (2) CA2474738C (sl)
CO (1) CO5601018A2 (sl)
CY (2) CY1112938T1 (sl)
DK (2) DK2248807T3 (sl)
EC (2) ECSP045220A (sl)
ES (2) ES2425980T3 (sl)
GB (1) GB0202873D0 (sl)
HK (2) HK1145322A1 (sl)
IL (3) IL163158A (sl)
MX (1) MXPA04007642A (sl)
NO (2) NO327366B1 (sl)
NZ (3) NZ534315A (sl)
PL (1) PL209475B1 (sl)
PT (2) PT1474408E (sl)
RU (2) RU2370493C2 (sl)
SG (1) SG160195A1 (sl)
SI (2) SI2248807T1 (sl)
WO (1) WO2003066613A1 (sl)
ZA (1) ZA200405970B (sl)

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CN100451015C (zh) * 2007-02-14 2009-01-14 杭州盛美医药科技开发有限公司 一种伊马替尼的制备方法
US7550591B2 (en) * 2007-05-02 2009-06-23 Chemagis Ltd. Imatinib production process
EP2152079A4 (en) 2007-06-04 2011-03-09 Avila Therapeutics Inc HETEROCYCLIC COMPOUNDS AND USES THEREOF
WO2009042803A1 (en) * 2007-09-25 2009-04-02 Teva Pharmaceutical Industries Ltd. Imatinib compositions
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CN101497601B (zh) * 2008-01-29 2012-11-07 福建南方制药股份有限公司 伊马替尼的合成方法
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WO2011095835A1 (en) 2010-02-02 2011-08-11 Actavis Group Ptc Ehf Highly pure imatinib or a pharmaceutically acceptable salt thereof
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WO2013035102A1 (en) 2011-09-05 2013-03-14 Natco Pharma Limited Processes for the preparation of imatinib base and intermediates thereof
US20140288073A1 (en) 2011-10-28 2014-09-25 Novartis Ag Method of Treating Gastrointestinal Stromal Tumors
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BR112015000349A2 (pt) 2012-07-11 2017-06-27 Novartis Ag método de tratamento de tumores estromais gastrointestinais
CN102827144A (zh) * 2012-09-05 2012-12-19 湖南欧亚生物有限公司 一种伊马替尼的制备方法
RU2537398C1 (ru) * 2013-08-20 2015-01-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Сибирский государственный технологический университет" (СибГТУ) Гексазамещенные пара-аминофенолы с ариламидными группами в 2,6-положениях по отношению к гидроксилу
CN103588754B (zh) * 2013-11-04 2015-05-27 遵义医学院 伊马替尼的制备方法
TWI674094B (zh) 2016-10-17 2019-10-11 日商德爾塔菲製藥股份有限公司 治療或緩解慢性骨髓性白血病用之醫藥組合物
PL3539138T3 (pl) 2016-11-11 2021-12-13 Curium Us Llc Sposoby generowania germanu-68 ze zmniejszoną ilością części lotnych
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RU2764243C2 (ru) 2017-09-22 2022-01-14 ДЖУБИЛАНТ ЭПИПЭД ЭлЭлСи Гетероциклические соединения в качестве ингибиторов PAD
HUE061607T2 (hu) 2017-10-18 2023-07-28 Jubilant Epipad LLC Imidazopiridin vegyületek mint PAD inhibitorok
CA3080677A1 (en) 2017-11-06 2019-05-09 Jubilant Prodel LLC Pyrimidine derivatives as inhibitors of pd1/pd-l1 activation
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Also Published As

Publication number Publication date
US7579467B2 (en) 2009-08-25
CY1112938T1 (el) 2016-04-13
AU2003244444B9 (en) 2003-09-02
GB0202873D0 (en) 2002-03-27
NO20091976L (no) 2004-11-05
JP2005528340A (ja) 2005-09-22
NZ554430A (en) 2008-08-29
ECSP045220A (es) 2004-09-28
BRPI0307529B1 (pt) 2018-01-30
CA2737565A1 (en) 2003-08-14
KR101027044B1 (ko) 2011-04-11
EP2248807A1 (en) 2010-11-10
WO2003066613A1 (en) 2003-08-14
JP4653954B2 (ja) 2011-03-16
ES2384872T3 (es) 2012-07-13
DK1474408T3 (da) 2012-06-25
CY1114351T1 (el) 2016-08-31
RU2007148217A (ru) 2009-07-10
US20150018552A1 (en) 2015-01-15
US20070293673A1 (en) 2007-12-20
US7816359B2 (en) 2010-10-19
ECSP095220A (es) 2009-08-28
SG160195A1 (en) 2010-04-29
DK2248807T3 (da) 2013-08-26
US7825247B2 (en) 2010-11-02
PT2248807E (pt) 2013-09-02
NO20043685L (no) 2004-11-05
US20090137805A1 (en) 2009-05-28
BR0307529A (pt) 2004-12-21
HK1070893A1 (sl) 2005-06-30
US20060142580A1 (en) 2006-06-29
US9573928B2 (en) 2017-02-21
IL189657A (en) 2010-12-30
NZ534315A (en) 2007-06-29
US20070293504A1 (en) 2007-12-20
US20120226039A1 (en) 2012-09-06
AU2003244444A1 (en) 2003-09-02
ES2425980T3 (es) 2013-10-18
CN101016262A (zh) 2007-08-15
RU2004126941A (ru) 2005-10-10
RU2370493C2 (ru) 2009-10-20
CA2474738C (en) 2011-10-04
JP2010138194A (ja) 2010-06-24
ZA200405970B (en) 2006-05-31
US7456283B2 (en) 2008-11-25
IL163158A (en) 2010-11-30
CA2737565C (en) 2013-04-09
PL371197A1 (en) 2005-06-13
IL189658A0 (en) 2008-06-05
IL189657A0 (en) 2008-06-05
NZ569731A (en) 2009-11-27
CO5601018A2 (es) 2006-01-31
EP1474408A1 (en) 2004-11-10
NO327366B1 (no) 2009-06-15
CN1630648A (zh) 2005-06-22
IL189658A (en) 2011-05-31
US20070293683A1 (en) 2007-12-20
EP1474408B1 (en) 2012-05-23
CA2474738A1 (en) 2003-08-14
AU2003244444B2 (en) 2007-08-09
KR20040081154A (ko) 2004-09-20
MXPA04007642A (es) 2004-11-10
US20070293672A1 (en) 2007-12-20
PL209475B1 (pl) 2011-09-30
CN100347162C (zh) 2007-11-07
PT1474408E (pt) 2012-07-25
SI1474408T1 (sl) 2012-07-31
EP2248807B1 (en) 2013-07-03
HK1145322A1 (sl) 2011-04-15

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