AU2003242988A1 - Process for the preparation of the anti-cancer drug imatinib and its analogues - Google Patents

Process for the preparation of the anti-cancer drug imatinib and its analogues

Info

Publication number
AU2003242988A1
AU2003242988A1 AU2003242988A AU2003242988A AU2003242988A1 AU 2003242988 A1 AU2003242988 A1 AU 2003242988A1 AU 2003242988 A AU2003242988 A AU 2003242988A AU 2003242988 A AU2003242988 A AU 2003242988A AU 2003242988 A1 AU2003242988 A1 AU 2003242988A1
Authority
AU
Australia
Prior art keywords
analogues
preparation
cancer drug
drug imatinib
imatinib
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003242988A
Inventor
Adibhatla Kali Sathya Bhujanga Rao
Amala Kompella
Rachakonda Srinivas
Nannapaneni Venkaiah Chowdary
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Natco Pharma Ltd
Original Assignee
Natco Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Natco Pharma Ltd filed Critical Natco Pharma Ltd
Publication of AU2003242988A1 publication Critical patent/AU2003242988A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2003242988A 2003-06-06 2003-06-06 Process for the preparation of the anti-cancer drug imatinib and its analogues Abandoned AU2003242988A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IN2003/000211 WO2004108699A1 (en) 2003-06-06 2003-06-06 Process for the preparation of the anti-cancer drug imatinib and its analogues

Publications (1)

Publication Number Publication Date
AU2003242988A1 true AU2003242988A1 (en) 2005-01-04

Family

ID=33495846

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003242988A Abandoned AU2003242988A1 (en) 2003-06-06 2003-06-06 Process for the preparation of the anti-cancer drug imatinib and its analogues

Country Status (2)

Country Link
AU (1) AU2003242988A1 (en)
WO (1) WO2004108699A1 (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA013328B1 (en) 2004-09-09 2010-04-30 Натко Фарма Лимитед Novel phenylaminopyrimidine derivatives as inhibitors of bcr-abl kinase
SI1833815T1 (en) * 2004-12-30 2011-01-31 Inst Farmaceutyczny A process for preparation of imatinib base
US7977348B2 (en) 2006-04-27 2011-07-12 Sicor Inc. Polymorphic forms of imatinib mesylate and processes for preparation of novel crystalline forms as well as amorphous and form α
US8067421B2 (en) 2006-04-27 2011-11-29 Sicor Inc. Polymorphic forms of imatinib mesylate and processes for preparation of novel crystalline forms as well as amorphous and form α
EP1988089A1 (en) 2006-10-26 2008-11-05 Sicor, Inc. Imatinib base, and imatinib mesylate and processes for preparation thereof
WO2008070350A2 (en) 2006-10-27 2008-06-12 The Board Of Regents Of The University Of Texas System Methods and compositions related to wrapping of dehydrons
US8168787B2 (en) 2006-11-16 2012-05-01 F.I.S. Fabbrica Italiana Sintetici S.P.A. Process for the preparation of imatinib and intermediates thereof
CN100451015C (en) * 2007-02-14 2009-01-14 杭州盛美医药科技开发有限公司 Preparing method of imatinib
WO2008117298A1 (en) * 2007-03-26 2008-10-02 Natco Pharma Limited A novel method of preparation of imatinib
JP2010540465A (en) 2007-09-25 2010-12-24 テバ ファーマシューティカル インダストリーズ リミティド Stable imatinib composition
EP2231161A1 (en) * 2007-12-22 2010-09-29 Synthon B.V. A process of making imatinib
PL215042B1 (en) * 2008-08-01 2013-10-31 Temapharm Spolka Z Ograniczona Odpowiedzialnoscia Method of imatinib manufacturing
US20100330130A1 (en) 2009-05-22 2010-12-30 Actavis Group Ptc Ehf Substantially pure imatinib or a pharmaceutically acceptable salt thereof
CN102070604B (en) * 2009-11-20 2014-06-25 成都弘达药业有限公司 Method for preparing imatinib free alkali
WO2011095835A1 (en) 2010-02-02 2011-08-11 Actavis Group Ptc Ehf Highly pure imatinib or a pharmaceutically acceptable salt thereof
KR20130055576A (en) * 2010-03-15 2013-05-28 낫코 파마 리미티드 Process for the preparation of highly pure crystalline imatinib base
WO2011130918A1 (en) 2010-04-23 2011-10-27 上海百灵医药科技有限公司 Process for synthesizing imatinib
SI2582689T1 (en) 2010-06-18 2017-05-31 Krka, D.D., Novo Mesto New polymorphic form of imatinib base and preparation of salts thereof
CN102372690B (en) * 2010-08-20 2014-05-28 成都地奥制药集团有限公司 Intermediate for synthesizing imatinib and application of intermediate in imatinib synthesis
TR201007005A2 (en) 2010-08-23 2011-09-21 Mustafa Nevzat İlaç Sanayi̇i̇ A.Ş. Imatinib base production method
KR101367228B1 (en) * 2010-10-22 2014-03-14 상하이 팔링 파마테크 씨오., 엘티디. New method for Synthesiging Imatinib
CN102382100B (en) * 2011-03-09 2014-04-16 上海昕盛医药科技有限公司 Preparation method of imatinib
CN102731474B (en) * 2011-04-13 2014-12-03 石药集团中奇制药技术（石家庄）有限公司 Preparation method of imatinib
CN102796110B (en) * 2011-05-23 2016-03-30 复旦大学 Aniline pyrimidine compound and its production and use
CN102863383A (en) * 2011-07-08 2013-01-09 华东理工大学 Preparation method of oxygen bleaching activator tribasic copper chloride (TBCC)
WO2013035102A1 (en) 2011-09-05 2013-03-14 Natco Pharma Limited Processes for the preparation of imatinib base and intermediates thereof
US20140343282A1 (en) 2013-05-16 2014-11-20 Apicore, Llc Processes for making ponatinib and intermediates thereof
CN104230884B (en) * 2013-06-09 2016-06-08 北大方正集团有限公司 Imatinib intermediate and its preparation method
CN103420976B (en) * 2013-07-26 2014-12-10 天津禾盛医药技术开发有限公司 Method for preparing imatinib and mesylate
US9988389B2 (en) * 2015-06-11 2018-06-05 Apicore Us Llc Processes for making ponatinib and intermediates thereof
EP3333162A1 (en) 2016-12-12 2018-06-13 Silesian Catalysts sp. z o.o. Metod for preparing n-(2-methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine
DE102017004596B4 (en) 2017-05-13 2021-02-11 Alzchem Trostberg Gmbh Process for the production of phenylguanidines or their salts
CN108358776A (en) * 2018-01-29 2018-08-03 江苏佳麦化工有限公司 The preparation method of 4- chloromethyl benzoic acid chlorides
CN111909024B (en) * 2019-05-08 2022-08-02 金凯(辽宁)生命科技股份有限公司 Preparation method of 4-formylbenzoic acid

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521184A (en) * 1992-04-03 1996-05-28 Ciba-Geigy Corporation Pyrimidine derivatives and processes for the preparation thereof
GB0022438D0 (en) * 2000-09-13 2000-11-01 Novartis Ag Organic Compounds
EP1395261B1 (en) * 2001-05-16 2006-06-28 GPC Biotech AG Pyridylpyrimidine derivatives as effective compounds against prion diseases
GB0202873D0 (en) * 2002-02-07 2002-03-27 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
WO2004108699A1 (en) 2004-12-16

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase