EA201100177A1 - СПОСОБЫ ОЧИСТКИ АНТИТЕЛ К β-АМИЛОИДУ - Google Patents

СПОСОБЫ ОЧИСТКИ АНТИТЕЛ К β-АМИЛОИДУ

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Publication number
EA201100177A1
EA201100177A1 EA201100177A EA201100177A EA201100177A1 EA 201100177 A1 EA201100177 A1 EA 201100177A1 EA 201100177 A EA201100177 A EA 201100177A EA 201100177 A EA201100177 A EA 201100177A EA 201100177 A1 EA201100177 A1 EA 201100177A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methods
protein
antibodies
binding
amyloid
Prior art date
Application number
EA201100177A
Other languages
English (en)
Inventor
Ранганатан Годаварти
Тимоти Искра
Original Assignee
Элан Фарма Интернэшнл Лимитед
Вайет
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Элан Фарма Интернэшнл Лимитед, Вайет filed Critical Элан Фарма Интернэшнл Лимитед
Publication of EA201100177A1 publication Critical patent/EA201100177A1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Настоящая заявка предусматривает способы очистки Аβ-связывающих белков, имеющих область Fc, например антител к Аβ или слитых антител, адсорбцией Аβ-связывающего белка на Fc-связывающем агенте, например, таком как Белок А или Белок G, промыванием буфером соли двухвалентного катиона для удаления примесей с последующей регенерацией адсорбированного Аβ-связывающего белка. Настоящая заявка также предусматривает способы элюции очищенного Аβ-связывающего белка, а также включение способов в схему (цепь) очистки. Также предусматриваются наборы, содержащие компоненты для осуществления способов и инструкции по применению.
EA201100177A 2005-06-17 2006-06-16 СПОСОБЫ ОЧИСТКИ АНТИТЕЛ К β-АМИЛОИДУ EA201100177A1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US69182105P 2005-06-17 2005-06-17

Publications (1)

Publication Number Publication Date
EA201100177A1 true EA201100177A1 (ru) 2011-06-30

Family

ID=37433887

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201100177A EA201100177A1 (ru) 2005-06-17 2006-06-16 СПОСОБЫ ОЧИСТКИ АНТИТЕЛ К β-АМИЛОИДУ
EA200800083A EA015148B1 (ru) 2005-06-17 2006-06-16 СПОСОБЫ ОЧИСТКИ Aβ-СВЯЗЫВАЮЩЕГО БЕЛКА, СОДЕРЖАЩЕГО ОБЛАСТЬ FC

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA200800083A EA015148B1 (ru) 2005-06-17 2006-06-16 СПОСОБЫ ОЧИСТКИ Aβ-СВЯЗЫВАЮЩЕГО БЕЛКА, СОДЕРЖАЩЕГО ОБЛАСТЬ FC

Country Status (26)

Country Link
US (3) US7825223B2 (ru)
EP (3) EP1896504B1 (ru)
JP (2) JP5270337B2 (ru)
KR (2) KR101247836B1 (ru)
CN (3) CN101213211A (ru)
AR (2) AR053632A1 (ru)
AU (2) AU2006261185B2 (ru)
BR (2) BRPI0611600B8 (ru)
CA (2) CA2611815A1 (ru)
CR (2) CR9582A (ru)
EA (2) EA201100177A1 (ru)
EC (1) ECSP088086A (ru)
ES (2) ES2402650T3 (ru)
HK (1) HK1117174A1 (ru)
IL (2) IL187642A (ru)
MA (1) MA29609B1 (ru)
MX (2) MX2007015051A (ru)
MY (1) MY144484A (ru)
NI (1) NI200700329A (ru)
NO (2) NO20076082L (ru)
NZ (1) NZ565044A (ru)
RU (1) RU2415865C2 (ru)
SG (1) SG162806A1 (ru)
TW (2) TWI372763B (ru)
WO (2) WO2006138737A2 (ru)
ZA (2) ZA200710331B (ru)

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