EA004771B1 - Производные мочевины и их применение в качестве ингибиторов инозин-5`-монофосфат- дегидрогеназы - Google Patents
Производные мочевины и их применение в качестве ингибиторов инозин-5`-монофосфат- дегидрогеназы Download PDFInfo
- Publication number
- EA004771B1 EA004771B1 EA199800943A EA199800943A EA004771B1 EA 004771 B1 EA004771 B1 EA 004771B1 EA 199800943 A EA199800943 A EA 199800943A EA 199800943 A EA199800943 A EA 199800943A EA 004771 B1 EA004771 B1 EA 004771B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- nhc
- νηο
- methoxy
- phenyl
- methyl
- Prior art date
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- 150000003672 ureas Chemical class 0.000 title 1
- -1 1,2-methylenedioxy Chemical group 0.000 claims abstract description 205
- 150000001875 compounds Chemical class 0.000 claims abstract description 193
- 125000001424 substituent group Chemical group 0.000 claims abstract description 58
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- 125000005842 heteroatom Chemical group 0.000 claims abstract description 20
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 19
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 19
- 125000000040 m-tolyl group Chemical group [H]C1=C([H])C(*)=C([H])C(=C1[H])C([H])([H])[H] 0.000 claims abstract description 17
- 125000002950 monocyclic group Chemical group 0.000 claims abstract description 14
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 9
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Classifications
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/636,361 US5807876A (en) | 1996-04-23 | 1996-04-23 | Inhibitors of IMPDH enzyme |
| US08/801,780 US6344465B1 (en) | 1996-04-23 | 1997-02-14 | Inhibitors of IMPDH enzyme |
| US08/832,165 US6054472A (en) | 1996-04-23 | 1997-04-02 | Inhibitors of IMPDH enzyme |
| PCT/US1997/006623 WO1997040028A1 (en) | 1996-04-23 | 1997-04-21 | Urea derivatives as inhibitors of impdh enzyme |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA199800943A1 EA199800943A1 (ru) | 1999-04-29 |
| EA004771B1 true EA004771B1 (ru) | 2004-08-26 |
Family
ID=27417590
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA199800943A EA004771B1 (ru) | 1996-04-23 | 1997-04-21 | Производные мочевины и их применение в качестве ингибиторов инозин-5`-монофосфат- дегидрогеназы |
Country Status (21)
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| GB1171904A (en) | 1965-10-21 | 1969-11-26 | Unilever Ltd | Anilinobenzimidazoles having Antibacterial Properties |
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| US5283257A (en) | 1992-07-10 | 1994-02-01 | The Board Of Trustees Of The Leland Stanford Junior University | Method of treating hyperproliferative vascular disease |
| WO1994012184A1 (en) | 1992-11-24 | 1994-06-09 | Syntex (U.S.A.) Inc. | Use of mycophenolic acid, mycophenolate mofetil or derivate thereof to inhibit stenosis |
| US5380879A (en) * | 1994-02-18 | 1995-01-10 | Syntex (U.S.A.) Inc. | Derivatives of mycophenolic acid |
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