DK3395820T3 - Antitumorforbindelser - Google Patents

Antitumorforbindelser Download PDF

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Publication number
DK3395820T3
DK3395820T3 DK18382287.3T DK18382287T DK3395820T3 DK 3395820 T3 DK3395820 T3 DK 3395820T3 DK 18382287 T DK18382287 T DK 18382287T DK 3395820 T3 DK3395820 T3 DK 3395820T3
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Prior art keywords
tumor compounds
tumor
compounds
Prior art date
Application number
DK18382287.3T
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Danish (da)
English (en)
Inventor
Marchante María Del Carmen Cuevas
Barrasa Valentín Martínez
Solloso Andrés Francesch
Original Assignee
Pharma Mar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa
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Publication of DK3395820T3 publication Critical patent/DK3395820T3/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D515/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995Pyrazines or piperazines forming part of bridged ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
DK18382287.3T 2017-04-27 2018-04-27 Antitumorforbindelser DK3395820T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17382228 2017-04-27
EP17382497 2017-07-26

Publications (1)

Publication Number Publication Date
DK3395820T3 true DK3395820T3 (da) 2019-08-12

Family

ID=62063080

Family Applications (5)

Application Number Title Priority Date Filing Date
DK18382287.3T DK3395820T3 (da) 2017-04-27 2018-04-27 Antitumorforbindelser
DK22187664.2T DK4101855T3 (da) 2017-04-27 2018-04-27 Antitumorforbindelser
DK18720255.1T DK3615544T3 (da) 2017-04-27 2018-04-27 Antitumorforbindelser
DK18382288.1T DK3395821T3 (da) 2017-04-27 2018-04-27 Antitumorforbindelser
DK22166571.4T DK4047002T3 (da) 2017-04-27 2018-04-27 Antitumorforbindelser

Family Applications After (4)

Application Number Title Priority Date Filing Date
DK22187664.2T DK4101855T3 (da) 2017-04-27 2018-04-27 Antitumorforbindelser
DK18720255.1T DK3615544T3 (da) 2017-04-27 2018-04-27 Antitumorforbindelser
DK18382288.1T DK3395821T3 (da) 2017-04-27 2018-04-27 Antitumorforbindelser
DK22166571.4T DK4047002T3 (da) 2017-04-27 2018-04-27 Antitumorforbindelser

Country Status (39)

Country Link
US (5) US10538535B2 (enExample)
EP (5) EP3615544B9 (enExample)
JP (5) JP6501946B2 (enExample)
KR (3) KR102510975B1 (enExample)
CN (4) CN114751920B (enExample)
AU (4) AU2018260314C1 (enExample)
BR (1) BR112019022282A2 (enExample)
CA (1) CA3061518A1 (enExample)
CL (1) CL2019003057A1 (enExample)
CO (1) CO2019011967A2 (enExample)
CY (3) CY1121885T1 (enExample)
DK (5) DK3395820T3 (enExample)
EC (1) ECSP19083967A (enExample)
ES (5) ES2741901T3 (enExample)
FI (3) FI3615544T3 (enExample)
HK (2) HK1255938B (enExample)
HR (5) HRP20230433T1 (enExample)
HU (5) HUE062032T2 (enExample)
IL (3) IL270153B2 (enExample)
JO (1) JOP20190254A1 (enExample)
LT (5) LT3395821T (enExample)
MA (2) MA44021B1 (enExample)
MD (5) MD3615544T2 (enExample)
ME (2) ME03466B (enExample)
MX (3) MX392601B (enExample)
MY (1) MY198004A (enExample)
PH (1) PH12019550224A1 (enExample)
PL (5) PL4101855T3 (enExample)
PT (2) PT3395821T (enExample)
RS (5) RS64200B1 (enExample)
SA (1) SA523440283B1 (enExample)
SG (2) SG11201909841RA (enExample)
SI (5) SI4047002T1 (enExample)
SM (5) SMT202300169T1 (enExample)
TN (2) TN2019000210A1 (enExample)
TW (3) TWI875118B (enExample)
UY (1) UY37706A (enExample)
WO (1) WO2018197663A1 (enExample)
ZA (1) ZA201907119B (enExample)

Families Citing this family (15)

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Publication number Priority date Publication date Assignee Title
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
TWI824043B (zh) * 2018-10-25 2023-12-01 西班牙商瑪製藥股份有限公司 藥物抗體共軛物
PH12022551216A1 (en) * 2019-11-21 2023-07-17 Pharma Mar Sa Methods of treating small cell lung cancer with lurbinectedin formulations
CA3175426A1 (en) * 2020-04-21 2021-10-28 Alfonso Latorre Lozano Drug antibody conjugates
TW202144369A (zh) * 2020-04-26 2021-12-01 大陸商江蘇恆瑞醫藥股份有限公司 海鞘素類衍生物及其製備方法與醫藥用途
CA3218171A1 (en) 2021-05-19 2022-11-24 Carmen KAHATT Dosage regimens for ecubectedin
WO2024186263A1 (en) * 2023-03-07 2024-09-12 Axcynsis Therapeutics Pte. Ltd. Antibody-drug conjugates comprising trabectedin and lurbinectedin derivatives
WO2025077996A1 (en) 2023-10-09 2025-04-17 Pharma Mar, S.A. Synthetic process for the manufacture of ecteinascidin compounds
EP4563149A1 (en) 2023-11-30 2025-06-04 Pharma Mar, S.A. Lurbinectedin, ecubectedin and a related compound for use in the treatment of skin cancers
TW202532075A (zh) * 2024-02-08 2025-08-16 大陸商映恩生物製藥(蘇州)有限公司 海鞘素類化合物及其應用
WO2025228595A1 (en) 2024-04-30 2025-11-06 Pharma Mar, S.A. Use of compound ia in the treatment of cancers including combination therapy with atezolizumab.
WO2025228597A1 (en) 2024-04-30 2025-11-06 Pharma Mar, S.A. Combination of compound ia and a topoisomerase i inhibitor in the treatment of cancer
WO2025228596A1 (en) 2024-04-30 2025-11-06 Pharma Mar, S.A. Combination of pm14 and a topoisomerase i inhibitor in the treatment of cancer
WO2025228594A1 (en) 2024-04-30 2025-11-06 Pharma Mar, S.A. Use of ecubectedin in the treatment of cancers including combination therapy with atezolizumab
WO2025233522A1 (en) 2024-05-10 2025-11-13 Pharma Mar, S.A. Synthetic process for an ecteinascidin

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