DK3099688T3 - MACROCYLIC FACTOR XIA INHIBITORS CONDENSED WITH HETEROCYCLES - Google Patents

MACROCYLIC FACTOR XIA INHIBITORS CONDENSED WITH HETEROCYCLES Download PDF

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Publication number
DK3099688T3
DK3099688T3 DK15705427.1T DK15705427T DK3099688T3 DK 3099688 T3 DK3099688 T3 DK 3099688T3 DK 15705427 T DK15705427 T DK 15705427T DK 3099688 T3 DK3099688 T3 DK 3099688T3
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independently selected
chloro
mmol
octadeca
oxo
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DK15705427.1T
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Danish (da)
English (en)
Inventor
Andrew K Dilger
James R Corte
Lucca Indawati De
Tianan Fang
Wu Yang
Yufeng Wang
Kumar Balashanmuga Pabbisetty
William R Ewing
Yeheng Zhu
Ruth R Wexler
Donald J P Pinto
Michael J Orwat
Ii Leon M Smith
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Bristol Myers Squibb Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK15705427.1T 2014-01-31 2015-01-30 MACROCYLIC FACTOR XIA INHIBITORS CONDENSED WITH HETEROCYCLES DK3099688T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461933948P 2014-01-31 2014-01-31
PCT/US2015/013647 WO2015116882A1 (en) 2014-01-31 2015-01-30 Macrocyclic factor xia inhibitors condensed with heterocycles

Publications (1)

Publication Number Publication Date
DK3099688T3 true DK3099688T3 (en) 2018-01-15

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DK15705427.1T DK3099688T3 (en) 2014-01-31 2015-01-30 MACROCYLIC FACTOR XIA INHIBITORS CONDENSED WITH HETEROCYCLES

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US (3) US20170057961A1 (US07585860-20090908-C00112.png)
EP (1) EP3099688B1 (US07585860-20090908-C00112.png)
JP (1) JP6419836B2 (US07585860-20090908-C00112.png)
CN (1) CN106459051B (US07585860-20090908-C00112.png)
AR (1) AR099228A1 (US07585860-20090908-C00112.png)
BR (1) BR112016016741B1 (US07585860-20090908-C00112.png)
CA (1) CA2937738C (US07585860-20090908-C00112.png)
CY (1) CY1120534T1 (US07585860-20090908-C00112.png)
DK (1) DK3099688T3 (US07585860-20090908-C00112.png)
EA (1) EA032650B1 (US07585860-20090908-C00112.png)
ES (1) ES2655540T3 (US07585860-20090908-C00112.png)
HR (1) HRP20172002T1 (US07585860-20090908-C00112.png)
HU (1) HUE038060T2 (US07585860-20090908-C00112.png)
LT (1) LT3099688T (US07585860-20090908-C00112.png)
MX (1) MX2016009385A (US07585860-20090908-C00112.png)
NO (1) NO2760821T3 (US07585860-20090908-C00112.png)
PL (1) PL3099688T3 (US07585860-20090908-C00112.png)
PT (1) PT3099688T (US07585860-20090908-C00112.png)
RS (1) RS56785B1 (US07585860-20090908-C00112.png)
SI (1) SI3099688T1 (US07585860-20090908-C00112.png)
TW (1) TWI703144B (US07585860-20090908-C00112.png)
UY (1) UY35972A (US07585860-20090908-C00112.png)
WO (1) WO2015116882A1 (US07585860-20090908-C00112.png)

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CN114341714A (zh) * 2019-07-08 2022-04-12 加里夏普创新有限责任公司 具有高对比度的紧凑型基于偏振的准直器
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