DK3093291T3 - Disubstituerede octahy-dropyrrolo [3,4-c]pyrroler som orexinreceptormodulatorer - Google Patents

Disubstituerede octahy-dropyrrolo [3,4-c]pyrroler som orexinreceptormodulatorer Download PDF

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Publication number
DK3093291T3
DK3093291T3 DK16163733.5T DK16163733T DK3093291T3 DK 3093291 T3 DK3093291 T3 DK 3093291T3 DK 16163733 T DK16163733 T DK 16163733T DK 3093291 T3 DK3093291 T3 DK 3093291T3
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Prior art keywords
dropyrrolo
octahy
pyrroles
disubstituted
receptor modulators
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DK16163733.5T
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Danish (da)
English (en)
Inventor
Wenying Chai
Michael A Letavic
Kiev S Ly
Daniel J Pippel
Dale A Rudolph
Kathleen C Strother
Brad M Savall
Chandravadan R Shah
Brock T Shireman
Akinola Soyode-Johnson
Emily M Stocking
Devin M Swanson
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Janssen Pharmaceutica Nv
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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DK16163733.5T 2009-10-23 2010-10-21 Disubstituerede octahy-dropyrrolo [3,4-c]pyrroler som orexinreceptormodulatorer DK3093291T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25450909P 2009-10-23 2009-10-23
EP10773477.4A EP2491038B1 (en) 2009-10-23 2010-10-21 Disubstituted octahy - dropyrrolo [3,4-c]pyrroles as orexin receptor modulators

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DK3093291T3 true DK3093291T3 (da) 2019-07-29

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DK16163733.5T DK3093291T3 (da) 2009-10-23 2010-10-21 Disubstituerede octahy-dropyrrolo [3,4-c]pyrroler som orexinreceptormodulatorer
DK10773477.4T DK2491038T3 (da) 2009-10-23 2010-10-21 Disubstituerede octahydropyrrolo [3,4-c]pyrroler som orexin receptormodulatorer

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DK (2) DK3093291T3 (enExample)
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US9586962B2 (en) 2011-04-20 2017-03-07 Janssen Pharmaceutica Nv Disubstituted octahydropyrrolo [3,4-C] pyrroles as orexin receptor modulators
US8501768B2 (en) * 2011-05-17 2013-08-06 Hoffmann-La Roche Inc. Hexahydrocyclopentapyrrolone, hexahydropyrrolopyrrolone, octahydropyrrolopyridinone and octahydropyridinone compounds
MX343837B (es) 2011-11-08 2016-11-24 Actelion Pharmaceuticals Ltd Derivados de 2 - (1,2,3 -triazol - 2 - il) benzamida y 3 - (1,2,3 - triazol - 2 - il) picolinamida.
US9440982B2 (en) 2012-02-07 2016-09-13 Eolas Therapeutics, Inc. Substituted prolines/piperidines as orexin receptor antagonists
WO2013119639A1 (en) 2012-02-07 2013-08-15 Eolas Therapeutics, Inc. Substituted prolines / piperidines as orexin receptor antagonists
ES2617863T3 (es) 2012-06-04 2017-06-20 Actelion Pharmaceuticals Ltd. Derivados de bencimidazol-prolina
US9682966B2 (en) * 2012-08-16 2017-06-20 The Scripps Research Institute Kappa opioid ligands
SG11201502493XA (en) 2012-10-10 2015-04-29 Actelion Pharmaceuticals Ltd Orexin receptor antagonists which are [ortho bi (hetero )aryl]-[2-(meta bi (hetero )aryl)-pyrrolidin-1-yl]-methanone derivatives
CN103012293A (zh) * 2012-12-13 2013-04-03 同济大学 一种抗失眠药物mk-4305中间体的合成方法
CA2902135A1 (en) 2013-03-12 2014-09-18 Actelion Pharmaceuticals Ltd Azetidine amide derivatives as orexin receptor antagonists
TW201444849A (zh) 2013-03-13 2014-12-01 Janssen Pharmaceutica Nv 經取代的7-氮雜雙環類及其作為食慾激素受體調節劑之用途
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