BR112013015223A2 - derivados de 1,2-bis-sulfonamida como moduladores de receptores de quimiocinas - Google Patents

derivados de 1,2-bis-sulfonamida como moduladores de receptores de quimiocinas

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Publication number
BR112013015223A2
BR112013015223A2 BR112013015223A BR112013015223A BR112013015223A2 BR 112013015223 A2 BR112013015223 A2 BR 112013015223A2 BR 112013015223 A BR112013015223 A BR 112013015223A BR 112013015223 A BR112013015223 A BR 112013015223A BR 112013015223 A2 BR112013015223 A2 BR 112013015223A2
Authority
BR
Brazil
Prior art keywords
bis
chemokine receptor
receptor modulators
sulfonamide derivatives
sulfonamide
Prior art date
Application number
BR112013015223A
Other languages
English (en)
Other versions
BR112013015223B1 (pt
Inventor
Haiqing Yuan
John E Donello
Michael E Garst
Richard L Beard
Veena Viswanath
Xiaoxia Liu
Original Assignee
Allergan Inc
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Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of BR112013015223A2 publication Critical patent/BR112013015223A2/pt
Publication of BR112013015223B1 publication Critical patent/BR112013015223B1/pt

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    • A—HUMAN NECESSITIES
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    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
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    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A61K31/37—Coumarins, e.g. psoralen
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
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    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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US7622583B2 (en) * 2005-01-14 2009-11-24 Chemocentryx, Inc. Heteroaryl sulfonamides and CCR2
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US20160228407A1 (en) 2016-08-11
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US9603834B2 (en) 2017-03-28
HK1218910A1 (zh) 2017-03-17
RU2654213C9 (ru) 2018-06-25
CA2822044C (en) 2021-12-21
EP2955173B1 (en) 2017-10-04
RU2654213C2 (ru) 2018-05-17
EP2955173A1 (en) 2015-12-16
JP6030568B2 (ja) 2016-11-24
HK1259248A1 (zh) 2019-11-29
EP2651901B1 (en) 2015-05-27
CN108383828A (zh) 2018-08-10
BR112013015223B1 (pt) 2021-12-14
KR20130132541A (ko) 2013-12-04
US20140221351A1 (en) 2014-08-07
CA2822044A1 (en) 2012-06-21
US8729066B2 (en) 2014-05-20
AU2011344125B2 (en) 2017-04-20
US8580779B2 (en) 2013-11-12
ES2655090T3 (es) 2018-02-16
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EP2651901A1 (en) 2013-10-23
RU2013132649A (ru) 2015-01-27

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