HK1218910A1 - 作爲趨化因子受體調節劑的新的 -雙-磺酰胺衍生物 - Google Patents
作爲趨化因子受體調節劑的新的 -雙-磺酰胺衍生物Info
- Publication number
- HK1218910A1 HK1218910A1 HK16106859.9A HK16106859A HK1218910A1 HK 1218910 A1 HK1218910 A1 HK 1218910A1 HK 16106859 A HK16106859 A HK 16106859A HK 1218910 A1 HK1218910 A1 HK 1218910A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- bis
- novel
- chemokine receptor
- receptor modulators
- sulfonamide derivatives
- Prior art date
Links
- 102000009410 Chemokine receptor Human genes 0.000 title 1
- 108050000299 Chemokine receptor Proteins 0.000 title 1
- 229940124530 sulfonamide Drugs 0.000 title 1
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- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
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- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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HK16106859.9A HK1218910A1 (zh) | 2010-12-16 | 2016-06-15 | 作爲趨化因子受體調節劑的新的 -雙-磺酰胺衍生物 |
HK19101604.5A HK1259248A1 (zh) | 2010-12-16 | 2019-01-30 | 作為趨化因子受體調節劑的新的1,2-雙-磺醯胺衍生物 |
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GB201223308D0 (en) | 2012-12-21 | 2013-02-06 | Univ Sunderland | Enzyme inhibitors |
CN109749059A (zh) * | 2017-11-03 | 2019-05-14 | 华南协同创新研究院 | 一种主链含氰基茚酮的稠环n型聚合物及其应用 |
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JPH06135934A (ja) * | 1991-12-27 | 1994-05-17 | Ishihara Sangyo Kaisha Ltd | ピリジン誘導体又はその塩を含有するホスホリパーゼ▲a2▼阻害剤、抗炎症剤又は抗膵炎剤 |
US6423343B1 (en) * | 1998-01-23 | 2002-07-23 | Usbiomaterials Corporation | Bioactive glass treatment of inflammation in skin conditions |
GB9924522D0 (en) | 1999-10-15 | 1999-12-15 | Arrow Therapeutics Ltd | Enzyme inhibitors |
TWI328007B (en) * | 2002-01-16 | 2010-08-01 | Astrazeneca Ab | Novel compounds |
EP2402310A1 (en) | 2002-05-24 | 2012-01-04 | Millennium Pharmaceuticals, Inc. | CCR9 inhibitors and methods of use thereof |
WO2005004810A2 (en) | 2003-07-02 | 2005-01-20 | Merck & Co., Inc. | Arylsulfonamide derivatives |
CN101068804A (zh) * | 2004-10-21 | 2007-11-07 | 特兰斯泰克制药公司 | 作为GalR1激动剂的双磺酰胺化合物,组合物,及用法 |
AU2005299771A1 (en) * | 2004-10-21 | 2006-05-04 | High Point Pharmaceuticals, Llc | Bissulfonamide compounds as agonists of GalR1, compositions, and methods of use |
US7622583B2 (en) * | 2005-01-14 | 2009-11-24 | Chemocentryx, Inc. | Heteroaryl sulfonamides and CCR2 |
PL2354126T3 (pl) * | 2005-01-14 | 2014-03-31 | Chemocentryx Inc | Sulfonamidy heteroarylowe i CCR2 |
US7931909B2 (en) | 2005-05-10 | 2011-04-26 | Allergan, Inc. | Ocular therapy using alpha-2 adrenergic receptor compounds having enhanced anterior clearance rates |
GB0524786D0 (en) | 2005-12-05 | 2006-01-11 | Glaxo Group Ltd | Compounds |
WO2008008374A2 (en) | 2006-07-14 | 2008-01-17 | Chemocentryx, Inc. | Ccr2 inhibitors and methods of use thereof |
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KR20130132541A (ko) | 2013-12-04 |
EP2955173B1 (en) | 2017-10-04 |
US20160228407A1 (en) | 2016-08-11 |
CA2822044C (en) | 2021-12-21 |
HK1259248A1 (zh) | 2019-11-29 |
RU2654213C9 (ru) | 2018-06-25 |
JP6030568B2 (ja) | 2016-11-24 |
BR112013015223B1 (pt) | 2021-12-14 |
US8729066B2 (en) | 2014-05-20 |
ES2655090T3 (es) | 2018-02-16 |
RU2013132649A (ru) | 2015-01-27 |
BR112013015223A2 (pt) | 2016-09-13 |
CN108383828A (zh) | 2018-08-10 |
AU2011344125A1 (en) | 2013-07-25 |
JP2013545807A (ja) | 2013-12-26 |
US9603834B2 (en) | 2017-03-28 |
US8580779B2 (en) | 2013-11-12 |
US20120157444A1 (en) | 2012-06-21 |
RU2654213C2 (ru) | 2018-05-17 |
CN103384662A (zh) | 2013-11-06 |
HK1189890A1 (zh) | 2014-06-20 |
US20140221351A1 (en) | 2014-08-07 |
AU2011344125B2 (en) | 2017-04-20 |
WO2012082633A1 (en) | 2012-06-21 |
ES2552100T3 (es) | 2015-11-25 |
EP2651901B1 (en) | 2015-05-27 |
EP2651901A1 (en) | 2013-10-23 |
US20140051682A1 (en) | 2014-02-20 |
EP2955173A1 (en) | 2015-12-16 |
KR101840503B1 (ko) | 2018-03-20 |
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