SMT201600216B - Ottaidropirrolo[3,4.c]pirroli disostituiti come modulatori del recettore di orexina - Google Patents

Ottaidropirrolo[3,4.c]pirroli disostituiti come modulatori del recettore di orexina

Info

Publication number
SMT201600216B
SMT201600216B SM201600216T SM201600216T SMT201600216B SM T201600216 B SMT201600216 B SM T201600216B SM 201600216 T SM201600216 T SM 201600216T SM 201600216 T SM201600216 T SM 201600216T SM T201600216 B SMT201600216 B SM T201600216B
Authority
SM
San Marino
Prior art keywords
pirrols
orexina
octaidropirrol
modulators
receptor
Prior art date
Application number
SM201600216T
Other languages
English (en)
Inventor
Wenying Chai
Michael A Letavic
Kiev S Ly
Daniel J Pippel
Dale A Rudolph
Kathleen C Strother
Brad M Savall
Chandravadan R Shah
Brock T Shireman
Akinola Soyode-Johnson
Emily M Stocking
Devin M Swanson
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of SMT201600216B publication Critical patent/SMT201600216B/it

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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SM201600216T 2009-10-23 2016-07-05 Ottaidropirrolo[3,4.c]pirroli disostituiti come modulatori del recettore di orexina SMT201600216B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25450909P 2009-10-23 2009-10-23
PCT/US2010/053606 WO2011050198A1 (en) 2009-10-23 2010-10-21 Disubstituted octahy - dropyrrolo [3,4-c] pyrroles as orexin receptor modulators

Publications (1)

Publication Number Publication Date
SMT201600216B true SMT201600216B (it) 2016-08-31

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
SM201600216T SMT201600216B (it) 2009-10-23 2016-07-05 Ottaidropirrolo[3,4.c]pirroli disostituiti come modulatori del recettore di orexina

Country Status (38)

Country Link
US (8) US8653263B2 (it)
EP (3) EP3581575A1 (it)
JP (1) JP5759470B2 (it)
KR (3) KR101859400B1 (it)
CN (1) CN102781942B (it)
AR (2) AR078731A1 (it)
AU (2) AU2010310595B2 (it)
BR (1) BR112012010820B1 (it)
CA (1) CA2778484C (it)
CL (1) CL2010001162A1 (it)
CO (1) CO6541572A2 (it)
CR (1) CR20120273A (it)
CY (2) CY1117743T1 (it)
DK (2) DK2491038T3 (it)
EA (1) EA022766B1 (it)
EC (1) ECSP12011908A (it)
ES (2) ES2585806T3 (it)
HK (2) HK1175463A1 (it)
HR (2) HRP20160781T1 (it)
HU (2) HUE028650T2 (it)
IL (1) IL219234A (it)
JO (2) JO3267B1 (it)
LT (1) LT3093291T (it)
ME (2) ME03452B (it)
MX (1) MX2012004753A (it)
NI (1) NI201200062A (it)
NZ (1) NZ599629A (it)
PE (1) PE20110404A1 (it)
PL (2) PL2491038T3 (it)
PT (2) PT3093291T (it)
RS (2) RS54945B1 (it)
SI (2) SI2491038T1 (it)
SM (1) SMT201600216B (it)
TR (1) TR201910327T4 (it)
TW (1) TWI481613B (it)
UA (1) UA107812C2 (it)
UY (1) UY32966A (it)
WO (1) WO2011050198A1 (it)

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CN103012293A (zh) * 2012-12-13 2013-04-03 同济大学 一种抗失眠药物mk-4305中间体的合成方法
KR20150130413A (ko) 2013-03-12 2015-11-23 액테리온 파마슈티칼 리미티드 오렉신 수용체 길항제로서의 아제티딘 아미드 유도체
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JP6647592B2 (ja) * 2013-07-03 2020-02-14 ルンドベック ラ ホーヤ リサーチ センター，インク． ピロロピロールカルバメート、および関連する有機化合物、医薬組成物、ならびにその医学的使用
KR102330133B1 (ko) 2013-12-04 2021-11-23 이도르시아 파마슈티컬스 리미티드 벤즈이미다졸-프롤린 유도체의 용도
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US9611262B2 (en) 2014-09-11 2017-04-04 Janssen Pharmaceutica Nv Substituted 2-azabicycles and their use as orexin receptor modulators
WO2017012502A1 (en) 2015-07-17 2017-01-26 Sunshine Lake Pharma Co., Ltd. Substituted quinazoline compounds and preparation and uses thereof
SG11201804223TA (en) * 2015-11-23 2018-06-28 Sunshine Lake Pharma Co Ltd OCTAHYDROPYRROLO [3, 4-c] PYRROLE DERIVATIVES AND USES THEREOF
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