HRP20160781T1 - DISUPSTITUIRANI OKTAHIDROPIROLO[3,4-c]PIROLI KAO MODULATORI OREKSIN RECEPTORA - Google Patents

DISUPSTITUIRANI OKTAHIDROPIROLO[3,4-c]PIROLI KAO MODULATORI OREKSIN RECEPTORA

Info

Publication number
HRP20160781T1
HRP20160781T1 HRP20160781TT HRP20160781T HRP20160781T1 HR P20160781 T1 HRP20160781 T1 HR P20160781T1 HR P20160781T T HRP20160781T T HR P20160781TT HR P20160781 T HRP20160781 T HR P20160781T HR P20160781 T1 HRP20160781 T1 HR P20160781T1
Authority
HR
Croatia
Prior art keywords
dropyrrolo
octahy
pyrroles
disubstituted
receptor modulators
Prior art date
Application number
HRP20160781TT
Other languages
English (en)
Croatian (hr)
Inventor
Wenying Chai
Michael A. Letavic
Kiev S. Ly
Daniel J. Pippel
Dale A. Rudolph
Kathleen C. Strother
Brad M. Savall
Chandravadan R. Shah
Brock T. Shireman
Akinola Soyode-Johnson
Emily M. Stocking
Devin M. Swanson
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of HRP20160781T1 publication Critical patent/HRP20160781T1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Reproductive Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HRP20160781TT 2009-10-23 2010-10-21 DISUPSTITUIRANI OKTAHIDROPIROLO[3,4-c]PIROLI KAO MODULATORI OREKSIN RECEPTORA HRP20160781T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25450909P 2009-10-23 2009-10-23
PCT/US2010/053606 WO2011050198A1 (en) 2009-10-23 2010-10-21 Disubstituted octahy - dropyrrolo [3,4-c] pyrroles as orexin receptor modulators
EP10773477.4A EP2491038B1 (en) 2009-10-23 2010-10-21 Disubstituted octahy - dropyrrolo [3,4-c]pyrroles as orexin receptor modulators

Publications (1)

Publication Number Publication Date
HRP20160781T1 true HRP20160781T1 (hr) 2016-09-23

Family

ID=43385633

Family Applications (2)

Application Number Title Priority Date Filing Date
HRP20160781TT HRP20160781T1 (hr) 2009-10-23 2010-10-21 DISUPSTITUIRANI OKTAHIDROPIROLO[3,4-c]PIROLI KAO MODULATORI OREKSIN RECEPTORA
HRP20191220TT HRP20191220T1 (hr) 2009-10-23 2019-07-05 Disupstituirani oktahi-dropirolo[3,4-c]piroli kao modulatori oreksin receptora

Family Applications After (1)

Application Number Title Priority Date Filing Date
HRP20191220TT HRP20191220T1 (hr) 2009-10-23 2019-07-05 Disupstituirani oktahi-dropirolo[3,4-c]piroli kao modulatori oreksin receptora

Country Status (38)

Country Link
US (8) USRE48841E1 (enExample)
EP (3) EP3581575A1 (enExample)
JP (1) JP5759470B2 (enExample)
KR (3) KR20120105449A (enExample)
CN (1) CN102781942B (enExample)
AR (2) AR078731A1 (enExample)
AU (2) AU2010310595B2 (enExample)
BR (1) BR112012010820B1 (enExample)
CA (1) CA2778484C (enExample)
CL (1) CL2010001162A1 (enExample)
CO (1) CO6541572A2 (enExample)
CR (1) CR20120273A (enExample)
CY (2) CY1117743T1 (enExample)
DK (2) DK2491038T3 (enExample)
EA (1) EA022766B1 (enExample)
EC (1) ECSP12011908A (enExample)
ES (2) ES2735411T3 (enExample)
HR (2) HRP20160781T1 (enExample)
HU (2) HUE043962T2 (enExample)
IL (1) IL219234A (enExample)
JO (2) JO3267B1 (enExample)
LT (1) LT3093291T (enExample)
ME (2) ME03452B (enExample)
MX (1) MX2012004753A (enExample)
NI (1) NI201200062A (enExample)
NZ (1) NZ599629A (enExample)
PE (1) PE20110404A1 (enExample)
PH (1) PH12012500796A1 (enExample)
PL (2) PL2491038T3 (enExample)
PT (2) PT3093291T (enExample)
RS (2) RS54945B1 (enExample)
SI (2) SI3093291T1 (enExample)
SM (2) SMT201900392T1 (enExample)
TR (1) TR201910327T4 (enExample)
TW (1) TWI481613B (enExample)
UA (1) UA107812C2 (enExample)
UY (1) UY32966A (enExample)
WO (1) WO2011050198A1 (enExample)

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MX2012004753A (es) 2009-10-23 2012-09-07 Janssen Pharmaceutica Nv Octahidropirrolo[3,4-c]pirrolos disustituidos como moduladores del receptor de orexina.
US9586962B2 (en) * 2011-04-20 2017-03-07 Janssen Pharmaceutica Nv Disubstituted octahydropyrrolo [3,4-C] pyrroles as orexin receptor modulators
US8501768B2 (en) * 2011-05-17 2013-08-06 Hoffmann-La Roche Inc. Hexahydrocyclopentapyrrolone, hexahydropyrrolopyrrolone, octahydropyrrolopyridinone and octahydropyridinone compounds
EA024106B1 (ru) 2011-11-08 2016-08-31 Актелион Фармасьютиклз Лтд. Производные 2-(1,2,3-триазол-2-ил)бензамида и 3-(1,2,3-триазол-2-ил)пиколинамида
RU2014136339A (ru) 2012-02-07 2016-03-27 Иолас Терапьютикс, Инк. Замещенные пролины/пиперидины как антагонисты орексиновых рецепторов
US9440982B2 (en) 2012-02-07 2016-09-13 Eolas Therapeutics, Inc. Substituted prolines/piperidines as orexin receptor antagonists
PT2855453T (pt) 2012-06-04 2017-03-09 Actelion Pharmaceuticals Ltd Derivados de benzimidazol-prolina
ES2750640T3 (es) * 2012-08-16 2020-03-26 Scripps Research Inst Ligandos opioides kappa novedosos
WO2014057435A1 (en) 2012-10-10 2014-04-17 Actelion Pharmaceuticals Ltd Orexin receptor antagonists which are [ortho bi (hetero )aryl]-[2-(meta bi (hetero )aryl)-pyrrolidin-1-yl]-methanone derivatives
CN103012293A (zh) * 2012-12-13 2013-04-03 同济大学 一种抗失眠药物mk-4305中间体的合成方法
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