DK2311432T3 - Modificerede Kunitz-domæne-polypeptider og deres anvendelse til reduktion af iskæmi eller indtræden af en systemisk inflammatorisk reaktion i forbindelse med en kirurgisk procedure - Google Patents

Modificerede Kunitz-domæne-polypeptider og deres anvendelse til reduktion af iskæmi eller indtræden af en systemisk inflammatorisk reaktion i forbindelse med en kirurgisk procedure Download PDF

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Publication number
DK2311432T3
DK2311432T3 DK10180484.7T DK10180484T DK2311432T3 DK 2311432 T3 DK2311432 T3 DK 2311432T3 DK 10180484 T DK10180484 T DK 10180484T DK 2311432 T3 DK2311432 T3 DK 2311432T3
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Denmark
Prior art keywords
phe
cys
glu
gly
polypeptide
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DK10180484.7T
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English (en)
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Robert Charles Ladner
Arthur C Ley
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Dyax Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6445—Kallikreins (3.4.21.34; 3.4.21.35)

Claims (11)

1. Et polypeptid bestående ag aminosyresekvensen: Xaal Xaa2 Xaa3 Xaa4 Cys Xaa6 Xaa7 Xaa8 Xaa9 XaalO Xaal 1 Gly Xaal 3 Cys Xaal 5 Xaal 6 Xaal 7 Xaal 8 Xaal 9 Xaa20 Xaa21 Xaa22 Xaa23 Xaa24 Xaa25 Xaa26 Xaa27 Xaa28 Xaa29 Cys Xaa31 Xaa32 Phe Xaa34 Xaa35 Gly Gly Cys Xaa39 Xaa40 Xaa41 Xaa42 Xaa43 Xaa44 Xaa45 Xaa46 Xaa47 Xaa48 Xaa49 Xaa50 Cys Xaa52 Xaa53 Xaa54 Cys Xaa56 Xaa57 Xaa58 (SEQ ID NO:l), hvori Xaal, Xaa2, Xaa3, Xaa4, Xaa56, Xaa57 eller Xaa58 er individuel, en aminosyre eller fraværende; Xaal 0 er Asp; Xaall er Asp; Xaal 3 er Pro; Xaal 5 er Arg; Xaal 6 er Ala; Xaal 7 er Ala; Xaal 8 er His; Xaal 9 er Pro; Xaa21 erTrp; Xaa22 er en aminosyre valgt fra gruppen bestående af Tyr og Phe; Xaa23 er en aminosyre valgt lfa gruppen bestående af Tyr og Phe; Xaa31 er Glu; Xaa32 er Glu; Xaa34 er Ile; Xaa35 er Tyr; Xaa39 er Glu; Xaa40 er en aminosyre valgt fra gruppen bestående af Gly og Ala; Xaa43 er en aminosyre valgt fra gruppen bestående af Asn og Gly; Xaa45 er en aminosyre valgt fra gruppen bestående af Phe og Tyr; og hvori polypeptidet inhiberer kallikrein.
2. Polypeptidet i henhold til patentkrav 1, hvor polypeptidet består af aminosyresekvensen: Ser Phe Cys Ala Phe Lys Ala Asp Asp Gly Pro Cys Arg Ala Ala His Pro Arg Trp Phe Phe Asn Ile Phe Thr Arg Gin Cys Glu Glu Phe Ile Tyr Gly Gly Cys Glu Gly Asn Gin Asn Arg Phe Glu Ser Leu Glu Glu Cys Lys Lys Met Cys Thr Arg Asp (aminosyre 5-60 af SEQ ID NO:2).
3. Polypeptidet i henhold til patentkrav 1, hvor aminosyresekvensen er mindst 95% identitisk med SEQ ID NO: 2.
4. Et polypeptid bestående af en del af aminosyresekvensen, der er angivet i et hvilket som helst af kravene 1 til 3, hvor nævnte del binder kallikrein.
5. Polypeptidet i henhold til hvilket som helst af kravene 1 til 4 til brug ved forebyggelse eller reduktion af iskæmi i en patient, eller til brug ved forebyggelse eller begrænsning af indtræden af en systemisk inflammatorisk reaktion i forbindelse med en kirurgisk procedure i en patient.
6. Et nukleinsyremolekyle bestående af en nukleinsyresekvens, der koder for polypeptidet i henhold et hvilket som helst af kravene 1 til 4.
7. En ekspressionsvektor bestående af nukleinsyren i henhold til krav 6.
8. Polypeptid i henhold til krav 5, hvor den kirurgiske procedure er hjerte-thoraxkirurgi.
9. Polypeptid i henhold til krav 5, hvor den kirurgiske procedure er koronararterie bypassoperation.
10. Polypeptid i henhold til krav 5, hvor den kirurgiske procedure er kardiopulmonal bypassoperation.
11. Polypeptid i henhold til krav 5, hvor den kirurgiske procedure er en hofteudskiftning eller en stemalsplitting.
DK10180484.7T 2002-06-07 2003-06-06 Modificerede Kunitz-domæne-polypeptider og deres anvendelse til reduktion af iskæmi eller indtræden af en systemisk inflammatorisk reaktion i forbindelse med en kirurgisk procedure DK2311432T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38723902P 2002-06-07 2002-06-07
US40700302P 2002-08-28 2002-08-28
EP07023364A EP1941867B1 (en) 2002-06-07 2003-06-06 Modified kunitz domain polypeptide

Publications (1)

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DK2311432T3 true DK2311432T3 (da) 2015-02-02

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ID=29739936

Family Applications (4)

Application Number Title Priority Date Filing Date
DK10180486.2T DK2298278T3 (da) 2002-06-07 2003-06-06 Forebyggelse og reduktion af blodtab og inflammatorisk respons
DK03757339.1T DK1531791T3 (da) 2002-06-07 2003-06-06 Forebyggelse og begrænsning af iskæmi
DK10180484.7T DK2311432T3 (da) 2002-06-07 2003-06-06 Modificerede Kunitz-domæne-polypeptider og deres anvendelse til reduktion af iskæmi eller indtræden af en systemisk inflammatorisk reaktion i forbindelse med en kirurgisk procedure
DK07023364.8T DK1941867T3 (da) 2002-06-07 2003-06-06 Polypeptid med modificeret Kunitz domæne

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DK10180486.2T DK2298278T3 (da) 2002-06-07 2003-06-06 Forebyggelse og reduktion af blodtab og inflammatorisk respons
DK03757339.1T DK1531791T3 (da) 2002-06-07 2003-06-06 Forebyggelse og begrænsning af iskæmi

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DK07023364.8T DK1941867T3 (da) 2002-06-07 2003-06-06 Polypeptid med modificeret Kunitz domæne

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US (13) US7064107B2 (da)
EP (4) EP1531791B1 (da)
JP (3) JP2005534647A (da)
AT (2) ATE528014T1 (da)
AU (3) AU2003243394B2 (da)
CA (1) CA2488558C (da)
CY (1) CY1112228T1 (da)
DE (1) DE60333758D1 (da)
DK (4) DK2298278T3 (da)
ES (4) ES2372978T3 (da)
HK (3) HK1154211A1 (da)
PT (4) PT1531791E (da)
WO (1) WO2003103475A2 (da)

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