HRP20230146T1 - Protutijelo protiv adrenomedulina (adm) ili fragment protutijela protiv adm ili ne-ig okosnica protutijela protiv adm, namijenjeno sprječavanju ili smanjivanju disfunkcije organa ili insuficijencije organa kod pacijenta s kroničnom ili akutnom bolešću ili akutnim stanjem - Google Patents
Protutijelo protiv adrenomedulina (adm) ili fragment protutijela protiv adm ili ne-ig okosnica protutijela protiv adm, namijenjeno sprječavanju ili smanjivanju disfunkcije organa ili insuficijencije organa kod pacijenta s kroničnom ili akutnom bolešću ili akutnim stanjem Download PDFInfo
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- HRP20230146T1 HRP20230146T1 HRP20230146TT HRP20230146T HRP20230146T1 HR P20230146 T1 HRP20230146 T1 HR P20230146T1 HR P20230146T T HRP20230146T T HR P20230146TT HR P20230146 T HRP20230146 T HR P20230146T HR P20230146 T1 HRP20230146 T1 HR P20230146T1
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- fragment
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- 208000030090 Acute Disease Diseases 0.000 title claims 4
- 208000017667 Chronic Disease Diseases 0.000 title claims 4
- 108010021625 Immunoglobulin Fragments Proteins 0.000 title claims 3
- 102000008394 Immunoglobulin Fragments Human genes 0.000 title claims 3
- 230000001154 acute effect Effects 0.000 title claims 3
- 230000001684 chronic effect Effects 0.000 title claims 3
- 230000004768 organ dysfunction Effects 0.000 title claims 2
- 206010053159 Organ failure Diseases 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
- 239000012634 fragment Substances 0.000 claims 30
- 102000004379 Adrenomedullin Human genes 0.000 claims 6
- 101800004616 Adrenomedullin Proteins 0.000 claims 6
- ULCUCJFASIJEOE-NPECTJMMSA-N adrenomedullin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)NCC(=O)N[C@@H]1C(N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CSSC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)[C@@H](C)O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 ULCUCJFASIJEOE-NPECTJMMSA-N 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 3
- 206010051379 Systemic Inflammatory Response Syndrome Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 108700020473 Cyclic AMP Receptor Proteins 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 101000935587 Homo sapiens Flavin reductase (NADPH) Proteins 0.000 claims 1
- 101000690940 Homo sapiens Pro-adrenomedullin Proteins 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- 201000009906 Meningitis Diseases 0.000 claims 1
- 241001529936 Murinae Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010062237 Renal impairment Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 206010040070 Septic Shock Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 238000004458 analytical method Methods 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 210000004204 blood vessel Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 238000002825 functional assay Methods 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 102000046663 human ADM Human genes 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 230000005977 kidney dysfunction Effects 0.000 claims 1
- 208000019423 liver disease Diseases 0.000 claims 1
- 230000005976 liver dysfunction Effects 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 231100000572 poisoning Toxicity 0.000 claims 1
- 230000000607 poisoning effect Effects 0.000 claims 1
- 230000036303 septic shock Effects 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 230000035939 shock Effects 0.000 claims 1
- 230000000087 stabilizing effect Effects 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 230000008733 trauma Effects 0.000 claims 1
Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C07K—PEPTIDES
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
Claims (17)
1. Monoklonsko protutijelo ili njegov fragment protutijela, naznačeno time što se protutijelo ili fragment veže na regiju adrenomedulina (ADM) koja se nalazi u N-terminalnom dijelu, aminokiseline 1-21 SEQ ID br. 23, pri čemu je monoklonsko protutijelo ili njegov fragment protutijela ljudsko ili humanizirano protutijelo i pri čemu teški lanac (H lanac) sadrži sekvence
SEQ ID NO: 1
GYTFSRYW
SEQ ID NO: 2
ILPGSGST
SEQ ID NO: 3
TEGYEYDGFDY
te gdje laki lanac sadrži sljedove
SEQ ID NO: 4
QSIVYSNGNTY
SEQ ID NO: 5
RVS
SEQ ID NO: 6
FQGSHIPYT.
2. Monoklonsko protutijelo ili fragment prema zahtjevu 1, naznačeno time što je protutijelo ili fragment proizveden rekombinantno.
3. Monoklonsko protutijelo ili fragment prema zahtjevu 2, naznačeno time što je protutijelo IgG.
4. Monoklonsko protutijelo ili fragment prema zahtjevu 1, naznačeno time što je fragment Fv fragment, scFv fragment, Fab fragment, scFab fragment, F(ab)2 fragment ili scFv-Fc fuzijski protein.
5. Monoklonsko protutijelo ili fragment prema bilo kojem od prethodnih zahtjeva, naznačeno time što je protutijelo ili fragment ljudsko protutijelo.
6. Monoklonsko protutijelo ili fragment prema bilo kojem od zahtjeva 1-4, naznačeno time što je protutijelo ili fragment humanizirano protutijelo.
7. Monoklonsko protutijelo ili fragment prema zahtjevu 6, naznačeno time što je protutijelo ili fragment proizveden humanizacijom mišjeg protutijela, npr. presađivanjem mišjih CDR-ova u ljudsko protutijelo ili fragment.
8. Monoklonsko protutijelo ili fragment prema zahtjevu 7, naznačeno time što proces humanizacije uključuje:
a. analizu sekvence protutijela mišjeg protutijela za strukturnu interakciju okvirnih regija (FR) s regijama koje određuju komplementarnost (CDR) i antigen;
b. odabir odgovarajućeg FR ljudskog podrijetla na temelju strukturnog modeliranja; i
c. transplantaciju mišjih CDR sekvenci u ljudski FR.
9. Monoklonsko protutijelo ili fragment prema bilo kojem od prethodnih zahtjeva, naznačeno time što je protutijelo ili fragment stabilizirajuće protutijelo ili fragment koji produljuje poluživot ADM-a u serumu, krvi, plazmi za najmanje 10%, poželjno najmanje 50%, poželjnije >50%, najpoželjnije >100%.
10. Monoklonsko protutijelo ili fragment prema bilo kojem od prethodnih zahtjeva, naznačeno time što je protutijelo ili fragment ne-neutralizirajuće protutijelo ili fragment.
11. Monoklonsko protutijelo ili fragment prema bilo kojem od prethodnih zahtjeva, naznačeno time što protutijelo ili fragment blokira bioaktivnost ADM-a na manje od 80%, poželjno manje od 50%, pri određivanju bioaktivnosti ADM-a u ljudskom rekombinantnom funkcionalnom testu cAMP receptora adrenomedulina prema primjeru 2.
12. Monoklonsko protutijelo ili fragment prema bilo kojem od prethodnih zahtjeva, naznačeno time što protutijelo ili fragment pokazuju afinitet prema ljudskom ADM tako da je konstanta afiniteta veća od 10-7 M pri čemu je navedeni afinitet vezanja određen prema Primjeru 1.
13. Monoklonsko protutijelo ili fragment prema bilo kojem od prethodnih zahtjeva, za uporabu u metodi liječenja koja uključuje smanjenje rizika od smrtnosti tijekom kronične ili akutne bolesti ili akutnog stanja.
14. Monoklonsko protutijelo ili fragment za uporabu prema zahtjevu 13, naznačeno time što se kronična ili akutna bolest ili akutno stanje bira između teške infekcije, npr. meningitisa; sindroma sistemskog upalnog odgovora (SIRS); sepse; dijabetesa; raka; akutne i kronične bolesti krvnih žila, npr. zatajenje srca, infarkt miokarda, moždani udar, ateroskleroza; šok, npr. septički šok; disfunkcija organa, npr. disfunkcija bubrega, disfunkcija jetre; opekline; kirurgija; trauma; trovanje; i oštećenja kemoterapijom.
15. Farmaceutska formulacija koja sadrži monoklonsko protutijelo ili fragment prema bilo kojem od zahtjeva 1-12.
16. Farmaceutska formulacija prema zahtjevu 15, naznačena time što je farmaceutska formulacija za primjenu putem infuzije.
17. Farmaceutska formulacija prema zahtjevu 15 ili 16, naznačena time što je farmaceutska formulacija u osušenom stanju da se rekonstituira prije uporabe.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11189447 | 2011-11-16 | ||
EP12160014 | 2012-03-16 | ||
EP19162009.5A EP3553084B1 (en) | 2011-11-16 | 2012-11-16 | Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for prevention or reduction of organ dysfunction or organ failure in a patient having a chronic or acute disease or acute condition |
Publications (1)
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HRP20230146T1 true HRP20230146T1 (hr) | 2023-04-28 |
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HRP20230146TT HRP20230146T1 (hr) | 2011-11-16 | 2012-11-16 | Protutijelo protiv adrenomedulina (adm) ili fragment protutijela protiv adm ili ne-ig okosnica protutijela protiv adm, namijenjeno sprječavanju ili smanjivanju disfunkcije organa ili insuficijencije organa kod pacijenta s kroničnom ili akutnom bolešću ili akutnim stanjem |
HRP20191010TT HRP20191010T1 (hr) | 2011-11-16 | 2019-06-04 | Protutijelo protiv adrenomedulina (adm) ili fragment protutijela protiv adm ili ne-ig okosnica protutijela protiv adm, namijenjeno sprječavanju ili smanjivanju disfunkcije organa ili insuficijencije organa kod pacijenta s kroničnom ili akutnom bolešću ili akutnim stanjem |
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HRP20191010TT HRP20191010T1 (hr) | 2011-11-16 | 2019-06-04 | Protutijelo protiv adrenomedulina (adm) ili fragment protutijela protiv adm ili ne-ig okosnica protutijela protiv adm, namijenjeno sprječavanju ili smanjivanju disfunkcije organa ili insuficijencije organa kod pacijenta s kroničnom ili akutnom bolešću ili akutnim stanjem |
Country Status (18)
Country | Link |
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US (4) | US20140328853A1 (hr) |
EP (3) | EP3553084B1 (hr) |
JP (2) | JP6193871B2 (hr) |
AU (1) | AU2012338731B2 (hr) |
DK (2) | DK2780369T3 (hr) |
ES (2) | ES2938653T3 (hr) |
FI (1) | FI3553084T3 (hr) |
HR (2) | HRP20230146T1 (hr) |
HU (2) | HUE044383T2 (hr) |
LT (2) | LT3553084T (hr) |
NZ (1) | NZ624873A (hr) |
PL (2) | PL2780369T3 (hr) |
PT (2) | PT3553084T (hr) |
RS (2) | RS58880B1 (hr) |
SG (3) | SG10201801919QA (hr) |
SI (1) | SI3553084T1 (hr) |
WO (1) | WO2013072511A1 (hr) |
ZA (1) | ZA201906427B (hr) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015092021A1 (en) * | 2013-12-20 | 2015-06-25 | Spingotec Therapeutics Gmbh | Adrenomedullin binder for use in therapy of cancer |
EP3339324A1 (en) | 2016-12-22 | 2018-06-27 | sphingotec GmbH | Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for use in intervention and therapy of congestion in a patient in need thereof |
WO2018109228A1 (en) * | 2016-12-16 | 2018-06-21 | Adrenomed Ag | Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for use in intervention and therapy of congestion in a patient in need thereof |
CN111480076A (zh) | 2017-10-18 | 2020-07-31 | 艾德里诺医药公司 | 抗肾上腺髓质素(adm)结合剂治疗下的疗法监测 |
EP3871689A1 (en) | 2020-02-26 | 2021-09-01 | sphingotec GmbH | Anti-adm-antibodies binding to the free n-terminus for accelerated transition of adm-gly to bio-adm in patients with adm-gly/ bio-adm ratio above a threshold and combination with vitamin c |
CA3172349A1 (en) | 2020-02-27 | 2021-09-02 | 4TEEN4 Pharmaceuticals GmbH | Dpp3 for therapy guidance, monitoring and stratification of nt-adm antibodies in patients with shock |
EP4110811A1 (en) | 2020-02-27 | 2023-01-04 | AdrenoMed AG | Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for use in therapy or prevention of shock |
CN115244081A (zh) | 2020-02-27 | 2022-10-25 | 艾德里诺医药公司 | 用于治疗休克患者的抗肾上腺髓质素(adm)结合剂 |
BR112022017890A2 (pt) | 2020-03-16 | 2022-11-01 | Sphingotec Gmbh | Proadrenomedulina ou fragmento da mesma em pacientes infectados com coronavírus e tratamentos com ligante contra adrenomedulina |
CN111627559B (zh) * | 2020-06-17 | 2023-08-29 | 北京大学第三医院(北京大学第三临床医学院) | 预测患者死亡风险的系统 |
WO2023175035A1 (en) | 2022-03-15 | 2023-09-21 | Adrenomed Ag | Stable aqueous formulation of an anti-adrenomedullin (adm) antibody or anti-adm antibody fragment |
WO2024023368A1 (en) | 2022-07-29 | 2024-02-01 | 4TEEN4 Pharmaceuticals GmbH | Prediction of an increase of dpp3 in a patient with septic shock |
WO2024023369A1 (en) | 2022-07-29 | 2024-02-01 | Adrenomed Ag | Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for use in therapy or prevention of shock |
Family Cites Families (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
AU634716B2 (en) | 1988-08-01 | 1993-03-04 | Ciba Corning Diagnostics Corp. | Method for detection of an analyte using acridinium esters and liposomes |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
SG48759A1 (en) | 1990-01-12 | 2002-07-23 | Abgenix Inc | Generation of xenogenic antibodies |
US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
ATE185601T1 (de) | 1990-07-10 | 1999-10-15 | Cambridge Antibody Tech | Verfahren zur herstellung von spezifischen bindungspaargliedern |
AU3328493A (en) | 1991-12-17 | 1993-07-19 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
JP2774769B2 (ja) | 1993-04-26 | 1998-07-09 | 賢治 寒川 | アドレノメデュリン |
JPH11512087A (ja) | 1995-08-18 | 1999-10-19 | アメリカ合衆国 | ヒトの病理学及び生理学における、アドレノメジュリン(am)及び遺伝子関連産物(pamp)の機能的役割 |
CA2242308A1 (en) | 1997-12-08 | 1999-06-08 | Smithkline Beecham Laboratoires Pharmaceutiques | Novel compounds |
DE19847690A1 (de) | 1998-10-15 | 2000-04-20 | Brahms Diagnostica Gmbh | Verfahren und Substanzen für die Diagnose und Therapie von Sepsis und sepsisähnlichen systemischen Infektionen |
US6818418B1 (en) | 1998-12-10 | 2004-11-16 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
PT1214600E (pt) * | 1999-09-10 | 2006-05-31 | Us Gov Health & Human Serv | Determinacao de proteinas de ligacao a adrenomedulina |
CA2414073A1 (en) | 2001-05-04 | 2002-11-14 | Gunars E. Valkirs | Diagnostic markers of acute coronary syndromes and methods of use thereof |
EP1427750B1 (en) | 2001-08-30 | 2010-12-08 | Biorexis Pharmaceutical Corporation | Modified transferrin fusion proteins |
US6864237B2 (en) | 2002-05-17 | 2005-03-08 | Ping Wang | Treatment of shock using adrenomedullin and adrenomedullin binding protein-1 |
WO2003103475A2 (en) | 2002-06-07 | 2003-12-18 | Dyax Corp. | Prevention and reduction of blood loss |
DE10316583A1 (de) | 2003-04-10 | 2004-10-28 | B.R.A.H.M.S Aktiengesellschaft | Bestimmung eines midregionalen Proadrenomedullin-Teilpeptids in biologischen Flüssigkeiten zu diagnostischen Zwecken, sowie Immunoassays für die Durchführung einer solchen Bestimmung |
EP1620734A1 (en) | 2003-04-25 | 2006-02-01 | Genova Ltd. | Secreted polypeptide species reduced cardiovascular disorders |
US6884781B2 (en) | 2003-05-16 | 2005-04-26 | Ping Wang | Treatment of shock using adrenomedullin binding protein-1 |
US20050164301A1 (en) | 2003-10-24 | 2005-07-28 | Avidia Research Institute | LDL receptor class A and EGF domain monomers and multimers |
US20100028995A1 (en) | 2004-02-23 | 2010-02-04 | Anaphore, Inc. | Tetranectin Trimerizing Polypeptides |
EP1800131A2 (en) | 2004-09-09 | 2007-06-27 | Bayer HealthCare AG | Diagnostics and therapeutics for diseases associated with adrenomedullin receptor (amdr) |
WO2006032436A2 (en) | 2004-09-21 | 2006-03-30 | Nascacell Technologies Ag. | Use of microproteins as tryptase inhibitors |
US9829494B2 (en) | 2005-12-01 | 2017-11-28 | Adrenomed Ag | Methods of treatment using ADM antibodies |
US7825217B2 (en) | 2006-09-15 | 2010-11-02 | University Of Kansas Medical Center | Polypeptides for bone mineralization |
KR101686247B1 (ko) * | 2007-10-31 | 2016-12-14 | 메디뮨 엘엘씨 | 단백질 스캐폴드 |
ES2373832T3 (es) | 2007-12-19 | 2012-02-09 | Affibody Ab | Polipéptido derivado de proteína a y capaz de unirse a pdgf. |
DK2358746T3 (da) | 2008-11-03 | 2020-12-21 | Molecular Partners Ag | Bindingsproteiner til inhibering af vegf-a-receptorinteraktionen |
AU2010288542B2 (en) | 2009-08-27 | 2014-05-22 | Covagen Ag | IL-17 binding compounds and medical uses thereof |
KR101353677B1 (ko) | 2009-12-14 | 2014-02-12 | 쉴 프로테인즈 게엠베하 | 피브로넥틴의 엑스트라도메인 b에 대한 특이적 결합 활성을 갖는 변형된 유비퀴틴 단백질 |
DE102010040035A1 (de) | 2010-03-04 | 2011-09-08 | Robert Bosch Gmbh | Verbesserungen der Rückwärts-Analyse zur Bestimmung von Fehlermaskierungsfaktoren |
WO2011154420A2 (en) | 2010-06-08 | 2011-12-15 | Pieris Ag | Tear lipocalin muteins binding il-4 r alpha |
FR2964103B1 (fr) | 2010-08-30 | 2018-11-23 | Universite D'aix-Marseille | Anticorps se liant a l'adrenomedulline et aux recepteurs de l'adrenomedulline et leurs utilisations comme medicament |
PL2780717T3 (pl) | 2011-11-16 | 2017-06-30 | Sphingotec Gmbh | Oznaczenia adrenomeduliny i sposoby do oznaczania dojrzałej adrenomeduliny |
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