DK200101216A - Fremgangsmåde til fremstilling af citalopram - Google Patents

Fremgangsmåde til fremstilling af citalopram Download PDF

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Publication number
DK200101216A
DK200101216A DK200101216A DKPA200101216A DK200101216A DK 200101216 A DK200101216 A DK 200101216A DK 200101216 A DK200101216 A DK 200101216A DK PA200101216 A DKPA200101216 A DK PA200101216A DK 200101216 A DK200101216 A DK 200101216A
Authority
DK
Denmark
Prior art keywords
preparation
formula
carboxylic acid
citalopram
acid intermediate
Prior art date
Application number
DK200101216A
Other languages
Danish (da)
English (en)
Inventor
Petersen Hans
Ahmadian Haleh
Dancer Robert
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Priority to DK200101216A priority Critical patent/DK200101216A/da
Publication of DK200101216A publication Critical patent/DK200101216A/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)
  • Furan Compounds (AREA)
DK200101216A 2000-08-18 2001-08-14 Fremgangsmåde til fremstilling af citalopram DK200101216A (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK200101216A DK200101216A (da) 2000-08-18 2001-08-14 Fremgangsmåde til fremstilling af citalopram

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200001231 2000-08-18
DK200101216A DK200101216A (da) 2000-08-18 2001-08-14 Fremgangsmåde til fremstilling af citalopram

Publications (1)

Publication Number Publication Date
DK200101216A true DK200101216A (da) 2002-02-19

Family

ID=8159660

Family Applications (4)

Application Number Title Priority Date Filing Date
DK200101216A DK200101216A (da) 2000-08-18 2001-08-14 Fremgangsmåde til fremstilling af citalopram
DK01957785T DK1309581T3 (da) 2000-08-18 2001-08-14 Fremgangsmåde til fremstilling af citalopram
DK01957786T DK1309582T3 (da) 2000-08-18 2001-08-14 Fremgangsmåde til fremstilling af citalopram
DK200101219A DK200101219A (da) 2000-08-18 2001-08-14 Fremgangsmåde til fremstilling af citalopram

Family Applications After (3)

Application Number Title Priority Date Filing Date
DK01957785T DK1309581T3 (da) 2000-08-18 2001-08-14 Fremgangsmåde til fremstilling af citalopram
DK01957786T DK1309582T3 (da) 2000-08-18 2001-08-14 Fremgangsmåde til fremstilling af citalopram
DK200101219A DK200101219A (da) 2000-08-18 2001-08-14 Fremgangsmåde til fremstilling af citalopram

Country Status (41)

Country Link
US (2) US6509483B2 (cs)
EP (2) EP1309581B1 (cs)
JP (2) JP2004506730A (cs)
KR (2) KR100887207B1 (cs)
CN (3) CN1159307C (cs)
AR (3) AR029597A1 (cs)
AT (4) ATE281448T1 (cs)
AU (6) AU7960901A (cs)
BE (2) BE1013443A6 (cs)
BG (2) BG65965B1 (cs)
CA (2) CA2354877C (cs)
CH (2) CH691969A5 (cs)
CL (2) CL2008002412A1 (cs)
CZ (2) CZ294746B6 (cs)
DE (4) DE60106933T2 (cs)
DK (4) DK200101216A (cs)
EA (2) EA005946B1 (cs)
ES (4) ES2228920T3 (cs)
FI (2) FI20011621A7 (cs)
FR (2) FR2813078B1 (cs)
GB (2) GB2362647B (cs)
GR (1) GR1004074B (cs)
HK (2) HK1044538B (cs)
HR (2) HRP20030065A2 (cs)
HU (2) HUP0103291A3 (cs)
IE (2) IES20010761A2 (cs)
IL (2) IL144816A (cs)
IS (2) IS2121B (cs)
ME (2) MEP2208A (cs)
MX (2) MXPA03001329A (cs)
NL (2) NL1018776C1 (cs)
NO (2) NO326570B1 (cs)
NZ (2) NZ523853A (cs)
PL (2) PL359969A1 (cs)
PT (2) PT1309582E (cs)
RS (2) RS50287B (cs)
SI (2) SI1309581T1 (cs)
SK (2) SK287236B6 (cs)
UA (2) UA71676C2 (cs)
WO (2) WO2002016341A1 (cs)
ZA (1) ZA200106683B (cs)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
WO1999030548A2 (en) 1999-04-14 1999-06-24 H. Lundbeck A/S Method for the preparation of citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
PT1298124E (pt) 1999-10-25 2007-05-31 Lundbeck & Co As H Método para a preparação de citalopram
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
KR20020073489A (ko) 1999-12-28 2002-09-26 하. 룬트벡 아크티에 셀스카브 시탈로프람의 제조 방법
KR100653141B1 (ko) 1999-12-30 2006-12-01 하. 룬트벡 아크티에 셀스카브 시탈로프람의 제조 방법
HUP0300343A2 (hu) * 2000-01-14 2003-06-28 H. Lundbeck A/S Eljárás 5-cianoftalid előállítására
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
TR200202166T2 (tr) * 2000-03-13 2002-12-23 H. Lndbeck A/S Sitalopramın preparasyon metodu
TR200202195T2 (tr) * 2000-03-13 2002-12-23 H. Lundbeck A/S 5-Yer değiştirmiş 1-(4-florofenil)-1,3- dihidroizobenzofuran'ın adım adım alkillenmesi
CA2402557A1 (en) 2000-03-14 2001-09-20 Hans Petersen Method for the preparation of citalopram
WO2001068632A1 (en) * 2000-03-16 2001-09-20 H. Lundbeck A/S Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
IL144816A (en) 2000-08-18 2005-09-25 Lundbeck & Co As H Method for the preparation of citalopram
JP3798982B2 (ja) 2000-12-22 2006-07-19 ハー・ルンドベック・アクチエゼルスカベット 純粋なシタロプラムの製造方法
US7148364B2 (en) * 2002-01-07 2006-12-12 Sun Pharmaceutical Industries Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile
AR040970A1 (es) * 2002-08-12 2005-04-27 Lundbeck & Co As H Metodo para la separacion de intermediarios que pueden ser utilizados para la preparacion de escitalopram
TR200504022T1 (tr) * 2003-03-24 2006-08-21 Hetero Drugs Limited (S)-sitalopram oksalatın yeni sıvı kristal formları.
US20050143350A1 (en) * 2003-11-19 2005-06-30 Seed John C. Combination drug therapy to treat obesity
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
WO2009111031A2 (en) * 2008-03-04 2009-09-11 Intra-Cellular Therapies, Inc. Methods of treating vasomotor symptoms
US20100087664A1 (en) * 2008-10-07 2010-04-08 Ravindra Vedantham Preparation of citalopram and salts thereof
JP6222973B2 (ja) * 2013-04-19 2017-11-01 日本テルペン化学株式会社 ジベンジルトリチオカーボネート誘導体
CN103936702A (zh) * 2014-05-07 2014-07-23 成都诺维尔生物医药有限公司 艾司西酞普兰杂质j的合成方法
US9809524B1 (en) * 2014-10-14 2017-11-07 Syngenta Participations Process for the preparation of 1-(3,5-dichloro-4-fluoro-phenyl)-2,2,2-trifluoro-ethanone

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143702A (cs) 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
DE3926765A1 (de) 1989-08-12 1991-02-14 Hoechst Ag Verfahren zur verminderung von primaerem und sekundaerem amin in einem tertiaeren amin
DK213290D0 (da) 1990-09-06 1990-09-06 Lundbeck & Co As H Treatment of cerebrovascular disorders
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
ZA9711376B (en) 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives
ATE205824T1 (de) 1997-07-08 2001-10-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
UA62985C2 (en) * 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
SK283907B6 (sk) 1997-11-11 2004-04-06 H. Lundbeck A/S Spôsob výroby citalopramu a medziprodukty
WO2000023431A1 (en) 1998-10-20 2000-04-27 H. Lundbeck A/S Method for the preparation of citalopram
UA70979C2 (uk) 1998-12-23 2004-11-15 Х. Луннбек А/С Спосіб одержання 5-ціанофталіду
AR022329A1 (es) * 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
WO1999030548A2 (en) 1999-04-14 1999-06-24 H. Lundbeck A/S Method for the preparation of citalopram
ITMI991579A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
CH692421A5 (de) 1999-10-25 2002-06-14 Lundbeck & Co As H Verfahren zur Herstellung von Citalopram.
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
NL1017415C1 (nl) 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
GB0005477D0 (en) * 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
IL144816A (en) 2000-08-18 2005-09-25 Lundbeck & Co As H Method for the preparation of citalopram
JP3798982B2 (ja) 2000-12-22 2006-07-19 ハー・ルンドベック・アクチエゼルスカベット 純粋なシタロプラムの製造方法
AU3920201A (en) 2000-12-28 2001-07-09 H. Lundbeck A/S Process for the preparation of pure citalopram

Also Published As

Publication number Publication date
BG107584A (bg) 2004-01-30
DK200101219A (da) 2002-02-19
UA71676C2 (en) 2004-12-15
SK287236B6 (sk) 2010-04-07
CH691968A5 (de) 2001-12-14
ES2170735B2 (es) 2003-09-16
FI20011621A0 (fi) 2001-08-09
CA2354880C (en) 2003-06-03
AT4946U1 (de) 2002-01-25
PL359969A1 (en) 2004-09-06
CN1239490C (zh) 2006-02-01
SK3222003A3 (en) 2003-08-05
NL1018775C1 (nl) 2001-10-24
CA2354877A1 (en) 2002-02-18
CL2008002673A1 (es) 2009-01-02
US6509483B2 (en) 2003-01-21
KR100887206B1 (ko) 2009-03-06
WO2002016342A1 (en) 2002-02-28
SI1309581T1 (en) 2005-04-30
ES2228920T3 (es) 2005-04-16
PT1309581E (pt) 2005-03-31
EA200300277A1 (ru) 2003-08-28
GB2362647A (en) 2001-11-28
YU11503A (sh) 2006-05-25
IL144816A0 (en) 2002-06-30
GB0119734D0 (en) 2001-10-03
AU2001279609B2 (en) 2007-09-06
AU2001100278B4 (en) 2001-11-29
JP2004506729A (ja) 2004-03-04
HUP0103295A3 (en) 2005-01-28
US20020026062A1 (en) 2002-02-28
DE60106932T2 (de) 2005-11-03
CA2354880A1 (en) 2002-01-22
EP1309581B1 (en) 2004-11-03
US20020025982A1 (en) 2002-02-28
ES2170734B2 (es) 2003-09-16
KR20030022378A (ko) 2003-03-15
FR2813077B1 (fr) 2004-08-20
NO20013942D0 (no) 2001-08-14
BE1013443A6 (fr) 2002-01-15
DK1309581T3 (da) 2005-03-14
SK3202003A3 (en) 2003-08-05
GB2365865B (en) 2002-07-17
GB2365865A (en) 2002-02-27
HK1044538A1 (en) 2002-10-25
ES2170735A1 (es) 2002-08-01
ES2170734A1 (es) 2002-08-01
DE10140028A1 (de) 2002-04-18
CN1339436A (zh) 2002-03-13
CA2354877C (en) 2006-05-02
HUP0103291A3 (en) 2003-02-28
RS50258B (sr) 2009-07-15
AR066694A2 (es) 2009-09-09
FI20011621L (fi) 2002-02-19
NO326570B1 (no) 2009-01-12
NL1018776C1 (nl) 2001-10-24
UA72340C2 (uk) 2005-02-15
ATE281448T1 (de) 2004-11-15
ATE281447T1 (de) 2004-11-15
EA005946B1 (ru) 2005-08-25
GB2362647B (en) 2002-09-18
BG65965B1 (bg) 2010-07-30
FR2813078B1 (fr) 2004-04-02
JP2004506730A (ja) 2004-03-04
HRP20030064A2 (en) 2005-02-28
MXPA03001329A (es) 2003-06-06
AU7960801A (en) 2002-03-04
AU2001100271B4 (en) 2001-11-29
NO326772B1 (no) 2009-02-16
CL2008002412A1 (es) 2009-01-02
NO20013943L (no) 2002-02-19
CN1339435A (zh) 2002-03-13
ES2230347T3 (es) 2005-05-01
AU2001279608B2 (en) 2006-10-05
IS2121B (is) 2006-06-15
DE60106932D1 (de) 2004-12-09
NZ523853A (en) 2004-07-30
MEP2208A (xx) 2010-02-10
AU2001100278A4 (en) 2001-09-13
KR100887207B1 (ko) 2009-03-06
DE60106933T2 (de) 2005-12-01
AT5026U1 (de) 2002-02-25
EP1309582A1 (en) 2003-05-14
DE60106933D1 (de) 2004-12-09
IL144817A0 (en) 2002-06-30
AU7960901A (en) 2002-03-04
HUP0103295A2 (hu) 2002-05-29
MEP2308A (xx) 2010-02-10
NO20013942L (no) 2002-02-19
FI20011622L (fi) 2002-02-19
DK1309582T3 (da) 2005-03-14
IL144816A (en) 2005-09-25
PT1309582E (pt) 2005-03-31
NZ523877A (en) 2004-08-27
IS2120B (is) 2006-06-15
EP1309582B1 (en) 2004-11-03
FR2813078A1 (fr) 2002-02-22
AR029597A1 (es) 2003-07-10
IS6048A (is) 2001-10-19
AR029598A1 (es) 2003-07-10
CZ295863B6 (cs) 2005-11-16
FR2813077A1 (fr) 2002-02-22
BG65964B1 (bg) 2010-07-30
EP1309581A1 (en) 2003-05-14
WO2002016341A1 (en) 2002-02-28
HU0103291D0 (en) 2001-10-28
SK287008B6 (sk) 2009-09-07
AU2001100271A4 (en) 2001-09-13
MXPA03000913A (es) 2003-06-24
BE1013444A6 (fr) 2002-01-15
EA005811B1 (ru) 2005-06-30
CZ20012958A3 (cs) 2002-04-17
GR20010100398A (el) 2002-05-24
SI1309582T1 (en) 2005-06-30
FI20011621A7 (fi) 2002-02-19
KR20030022385A (ko) 2003-03-15
US6426422B1 (en) 2002-07-30
CN1159307C (zh) 2004-07-28
PL359825A1 (pl) 2004-09-06
IS6047A (is) 2001-10-20
IES20010760A2 (en) 2002-02-20
HK1047086A1 (en) 2003-02-07
ZA200106683B (en) 2002-08-05
FI20011622A0 (fi) 2001-08-09
HK1044538B (zh) 2006-07-07
HUP0103291A2 (hu) 2002-05-29
GR1004074B (el) 2002-11-26
FI20011622A7 (fi) 2002-02-19
BG107583A (bg) 2004-01-30
CZ20012959A3 (cs) 2002-04-17
GB0119733D0 (en) 2001-10-03
RS50287B (sr) 2009-09-08
YU6903A (sh) 2006-05-25
CZ294746B6 (cs) 2005-03-16
EA200300279A1 (ru) 2003-08-28
CN1515564A (zh) 2004-07-28
CH691969A5 (de) 2001-12-14
CN1222517C (zh) 2005-10-12
HK1068069A1 (en) 2005-04-22
DE10140029A1 (de) 2002-05-02
HRP20030065A2 (en) 2005-02-28
NO20013943D0 (no) 2001-08-14
IES20010761A2 (en) 2002-02-20
HK1047086B (zh) 2005-04-22

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