YU11503A - Postupak za pripremanje citaloprama - Google Patents

Postupak za pripremanje citaloprama

Info

Publication number
YU11503A
YU11503A YU11503A YUP11503A YU11503A YU 11503 A YU11503 A YU 11503A YU 11503 A YU11503 A YU 11503A YU P11503 A YUP11503 A YU P11503A YU 11503 A YU11503 A YU 11503A
Authority
YU
Yugoslavia
Prior art keywords
citalopram
preparation
compound
formula
fluorophenyl
Prior art date
Application number
YU11503A
Other languages
English (en)
Inventor
Hans Petersen
Haleh Ahmadian
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of YU11503A publication Critical patent/YU11503A/sh
Publication of RS50287B publication Critical patent/RS50287B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Furan Compounds (AREA)

Abstract

Otkriven je postupak za pripremanje citaloprama koji obuhvata pretvaranje jedinjenje Formule VIII 1 [(3-dimetilamino)prop-3-il]-1-(4-fluorofenil)-5-Z-1,3-dihidroizobenzofuran gde je Z halogen, u jedinjenje Formule IV 5-karboksi-1-(3-(N,N-dimetilamino)prop-1-il)-1-(4-fluorofenil)-1,3-dihidroizobenzofuran praćeno pretvaranjem jedinjenja Formule IV u citalopram. Takodje su otkriveni postupci pripremanja jedinjenja formule IV.[Disclosed is a method for the preparation of citalopram comprising conversion of a compound of Formula VIII 1-[(3-dimethylamino) prop-3-yl]-1-(4-fluorophenyl)-5-Z-1,3-dihydroisobenzofuranwherein Z is halogen, to a compound of Formula IV 5-carboxy-1-(3-(N,N-dimethylamino)prop-1-yl)-1-(4-fluorophenyl)-1,3-dihydroisobenz ofuranfollowed by conversion of the compound of Formula IV into citalopram. Methods for the preparation of the compound of Formula IV are also disclosed.
YUP-115/03A 2000-08-18 2001-08-14 Postupak za pripremanje citaloprama RS50287B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200001231 2000-08-18

Publications (2)

Publication Number Publication Date
YU11503A true YU11503A (sh) 2006-05-25
RS50287B RS50287B (sr) 2009-09-08

Family

ID=8159660

Country Status (41)

Country Link
US (2) US6509483B2 (sh)
EP (2) EP1309582B1 (sh)
JP (2) JP2004506729A (sh)
KR (2) KR100887207B1 (sh)
CN (3) CN1239490C (sh)
AR (3) AR029597A1 (sh)
AT (4) ATE281447T1 (sh)
AU (6) AU2001279609B2 (sh)
BE (2) BE1013443A6 (sh)
BG (2) BG65965B1 (sh)
CA (2) CA2354877C (sh)
CH (2) CH691968A5 (sh)
CL (2) CL2008002412A1 (sh)
CZ (2) CZ295863B6 (sh)
DE (4) DE60106932T2 (sh)
DK (4) DK200101219A (sh)
EA (2) EA005946B1 (sh)
ES (4) ES2230347T3 (sh)
FI (2) FI20011621A (sh)
FR (2) FR2813078B1 (sh)
GB (2) GB2362647B (sh)
GR (1) GR1004074B (sh)
HK (3) HK1044538B (sh)
HR (2) HRP20030064A2 (sh)
HU (2) HUP0103291A3 (sh)
IE (2) IES20010760A2 (sh)
IL (2) IL144816A (sh)
IS (2) IS2121B (sh)
ME (2) MEP2308A (sh)
MX (2) MXPA03001329A (sh)
NL (2) NL1018776C1 (sh)
NO (2) NO326772B1 (sh)
NZ (2) NZ523853A (sh)
PL (2) PL359825A1 (sh)
PT (2) PT1309582E (sh)
RS (2) RS50258B (sh)
SI (2) SI1309582T1 (sh)
SK (2) SK287008B6 (sh)
UA (2) UA71676C2 (sh)
WO (2) WO2002016341A1 (sh)
ZA (1) ZA200106683B (sh)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
ES2195554T5 (es) * 1999-04-14 2010-02-02 H. Lundbeck A/S Metodo para la preparacion de citalopram.
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
TR200401456T1 (tr) 1999-10-25 2005-04-21 H. Lundbeck A/S Sitalopram hazırlanması için yöntem.
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
NZ519739A (en) 1999-12-28 2004-03-26 H Method for the preparation of citalopram
IL150367A0 (en) 1999-12-30 2002-12-01 Lundbeck & Co As H Method for the preparation of citalopram
EA005134B1 (ru) * 2000-01-14 2004-12-30 Х.Лундбекк А/С Способ получения 5-цианофталида
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
CA2402553A1 (en) * 2000-03-13 2001-09-20 H. Lundbeck A/S Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
HUP0300274A2 (hu) 2000-03-13 2003-06-28 H. Lundbeck A/S Eljárás citalopram előállítására
CN1418205A (zh) 2000-03-14 2003-05-14 H·隆德贝克有限公司 制备西酞普兰的方法
HUP0300134A2 (en) * 2000-03-16 2003-05-28 Lundbeck & Co As H Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
FI20011621A (fi) 2000-08-18 2002-02-19 Lundbeck & Co As H Menetelmä sitalopraamin valmistamiseksi
PT1181713E (pt) 2000-12-22 2005-02-28 Lundbeck & Co As H Metodo para preparacao de citalopram puro
US7148364B2 (en) * 2002-01-07 2006-12-12 Sun Pharmaceutical Industries Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile
PE20040991A1 (es) 2002-08-12 2004-12-27 Lundbeck & Co As H Separacion de intermediarios para la preparacion de escitalopram
TR200504022T1 (tr) * 2003-03-24 2006-08-21 Hetero Drugs Limited (S)-sitalopram oksalatın yeni sıvı kristal formları.
US20050143350A1 (en) * 2003-11-19 2005-06-30 Seed John C. Combination drug therapy to treat obesity
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
US9339500B2 (en) * 2008-03-04 2016-05-17 Intra-Cellular Therapies, Inc. Methods of treating vasomotor symptoms
US20100087664A1 (en) * 2008-10-07 2010-04-08 Ravindra Vedantham Preparation of citalopram and salts thereof
JP6222973B2 (ja) * 2013-04-19 2017-11-01 日本テルペン化学株式会社 ジベンジルトリチオカーボネート誘導体
CN103936702A (zh) * 2014-05-07 2014-07-23 成都诺维尔生物医药有限公司 艾司西酞普兰杂质j的合成方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143702A (sh) 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
DE3926765A1 (de) 1989-08-12 1991-02-14 Hoechst Ag Verfahren zur verminderung von primaerem und sekundaerem amin in einem tertiaeren amin
DK213290D0 (da) 1990-09-06 1990-09-06 Lundbeck & Co As H Treatment of cerebrovascular disorders
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
ZA9711376B (en) 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives
PT1015416E (pt) * 1997-07-08 2002-03-28 Lundbeck & Co As H Metodo para a producao de citalopram
UA62985C2 (en) * 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
JP3813820B2 (ja) 1997-11-11 2006-08-23 ハー・ルンドベック・アクチエゼルスカベット シタロプラムの製造方法
EP1123284B1 (en) 1998-10-20 2003-01-08 H. Lundbeck A/S Method for the preparation of citalopram
ES2195644T3 (es) * 1998-12-23 2003-12-01 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida.
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
ES2195554T5 (es) 1999-04-14 2010-02-02 H. Lundbeck A/S Metodo para la preparacion de citalopram.
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
CH692421A5 (de) 1999-10-25 2002-06-14 Lundbeck & Co As H Verfahren zur Herstellung von Citalopram.
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
FR2805812A1 (fr) 2000-02-24 2001-09-07 Lundbeck & Co As H Procede de preparation du citalopram
GB0005477D0 (en) * 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
FI20011621A (fi) 2000-08-18 2002-02-19 Lundbeck & Co As H Menetelmä sitalopraamin valmistamiseksi
PT1181713E (pt) 2000-12-22 2005-02-28 Lundbeck & Co As H Metodo para preparacao de citalopram puro
PT1181272E (pt) 2000-12-28 2003-01-31 Lundbeck & Co As H Processo para a preparacao de citalopram puro

Also Published As

Publication number Publication date
ATE281448T1 (de) 2004-11-15
BG65964B1 (bg) 2010-07-30
UA71676C2 (en) 2004-12-15
CN1222517C (zh) 2005-10-12
AU2001100271B4 (en) 2001-11-29
GB0119733D0 (en) 2001-10-03
FR2813077A1 (fr) 2002-02-22
NO20013943L (no) 2002-02-19
EP1309581B1 (en) 2004-11-03
HRP20030065A2 (en) 2005-02-28
GB2362647A (en) 2001-11-28
AU2001100278A4 (en) 2001-09-13
JP2004506729A (ja) 2004-03-04
AU7960901A (en) 2002-03-04
JP2004506730A (ja) 2004-03-04
CZ294746B6 (cs) 2005-03-16
HK1044538A1 (en) 2002-10-25
HUP0103295A2 (hu) 2002-05-29
ES2170735A1 (es) 2002-08-01
NL1018775C1 (nl) 2001-10-24
GB2365865A (en) 2002-02-27
ZA200106683B (en) 2002-08-05
EP1309582B1 (en) 2004-11-03
HUP0103295A3 (en) 2005-01-28
DE60106932D1 (de) 2004-12-09
SK3202003A3 (en) 2003-08-05
BG107583A (bg) 2004-01-30
DE60106933D1 (de) 2004-12-09
CZ295863B6 (cs) 2005-11-16
FR2813078A1 (fr) 2002-02-22
BG107584A (bg) 2004-01-30
PL359969A1 (en) 2004-09-06
CA2354877C (en) 2006-05-02
NO326772B1 (no) 2009-02-16
IL144816A0 (en) 2002-06-30
DK200101219A (da) 2002-02-19
CL2008002673A1 (es) 2009-01-02
KR100887206B1 (ko) 2009-03-06
US20020026062A1 (en) 2002-02-28
DK1309582T3 (da) 2005-03-14
SK287236B6 (sk) 2010-04-07
CL2008002412A1 (es) 2009-01-02
NO20013942D0 (no) 2001-08-14
HK1044538B (zh) 2006-07-07
CZ20012958A3 (cs) 2002-04-17
FR2813078B1 (fr) 2004-04-02
UA72340C2 (uk) 2005-02-15
AU2001100271A4 (en) 2001-09-13
CN1239490C (zh) 2006-02-01
AR029598A1 (es) 2003-07-10
DE10140029A1 (de) 2002-05-02
IS6047A (is) 2001-10-20
FI20011622A0 (fi) 2001-08-09
BG65965B1 (bg) 2010-07-30
EA200300277A1 (ru) 2003-08-28
FR2813077B1 (fr) 2004-08-20
EA005811B1 (ru) 2005-06-30
RS50258B (sr) 2009-07-15
MXPA03001329A (es) 2003-06-06
GB0119734D0 (en) 2001-10-03
FI20011621A (fi) 2002-02-19
DE10140028A1 (de) 2002-04-18
GR1004074B (el) 2002-11-26
EA200300279A1 (ru) 2003-08-28
GB2362647B (en) 2002-09-18
ATE281447T1 (de) 2004-11-15
KR20030022378A (ko) 2003-03-15
IL144817A0 (en) 2002-06-30
GB2365865B (en) 2002-07-17
IS6048A (is) 2001-10-19
ES2170735B2 (es) 2003-09-16
FI20011621A0 (fi) 2001-08-09
AT4946U1 (de) 2002-01-25
NO20013943D0 (no) 2001-08-14
PT1309581E (pt) 2005-03-31
HUP0103291A3 (en) 2003-02-28
NO20013942L (no) 2002-02-19
HU0103291D0 (en) 2001-10-28
AU2001279608B2 (en) 2006-10-05
BE1013444A6 (fr) 2002-01-15
SK3222003A3 (en) 2003-08-05
US20020025982A1 (en) 2002-02-28
PT1309582E (pt) 2005-03-31
NO326570B1 (no) 2009-01-12
CH691968A5 (de) 2001-12-14
US6426422B1 (en) 2002-07-30
IS2121B (is) 2006-06-15
AU7960801A (en) 2002-03-04
HUP0103291A2 (hu) 2002-05-29
HK1047086B (zh) 2005-04-22
AR066694A2 (es) 2009-09-09
FI20011622A (fi) 2002-02-19
HK1047086A1 (en) 2003-02-07
CA2354880C (en) 2003-06-03
MEP2308A (xx) 2010-02-10
SK287008B6 (sk) 2009-09-07
DK1309581T3 (da) 2005-03-14
CN1339436A (zh) 2002-03-13
CA2354880A1 (en) 2002-01-22
CZ20012959A3 (cs) 2002-04-17
IES20010760A2 (en) 2002-02-20
IL144816A (en) 2005-09-25
AT5026U1 (de) 2002-02-25
CN1515564A (zh) 2004-07-28
US6509483B2 (en) 2003-01-21
CA2354877A1 (en) 2002-02-18
HRP20030064A2 (en) 2005-02-28
AU2001279609B2 (en) 2007-09-06
DE60106932T2 (de) 2005-11-03
ES2228920T3 (es) 2005-04-16
RS50287B (sr) 2009-09-08
YU6903A (sh) 2006-05-25
NZ523877A (en) 2004-08-27
EP1309581A1 (en) 2003-05-14
HK1068069A1 (en) 2005-04-22
BE1013443A6 (fr) 2002-01-15
MEP2208A (xx) 2010-02-10
AR029597A1 (es) 2003-07-10
EP1309582A1 (en) 2003-05-14
SI1309581T1 (en) 2005-04-30
WO2002016341A1 (en) 2002-02-28
CH691969A5 (de) 2001-12-14
GR20010100398A (el) 2002-05-24
DE60106933T2 (de) 2005-12-01
CN1339435A (zh) 2002-03-13
KR100887207B1 (ko) 2009-03-06
SI1309582T1 (en) 2005-06-30
ES2170734B2 (es) 2003-09-16
DK200101216A (da) 2002-02-19
CN1159307C (zh) 2004-07-28
AU2001100278B4 (en) 2001-11-29
IS2120B (is) 2006-06-15
NZ523853A (en) 2004-07-30
WO2002016342A1 (en) 2002-02-28
ES2170734A1 (es) 2002-08-01
KR20030022385A (ko) 2003-03-15
EA005946B1 (ru) 2005-08-25
ES2230347T3 (es) 2005-05-01
NL1018776C1 (nl) 2001-10-24
IES20010761A2 (en) 2002-02-20
MXPA03000913A (es) 2003-06-24
PL359825A1 (en) 2004-09-06

Similar Documents

Publication Publication Date Title
ES2170734A1 (es) Metodo para la preparacion de citalopram.
CA2360287A1 (en) Crystalline base of citalopram
HUP0300078A2 (en) Method for the preparation of citalopram
NZ514982A (en) Method for the preparation of citalopram
EA200200982A1 (ru) Способ получения 5-циано-1-(4-фторфенил)-1,3-дигидроизобензофуранов
PE20030253A1 (es) Metodo para la preparacion de escitalopram
TR200202166T2 (tr) Sitalopramın preparasyon metodu
UA85428C2 (ru) Способ получения с-2, с-3 замещенных n-алкилированных индолов, а также промежуточные соединения и способы их получения
EA200201211A1 (ru) Способ получения циталопрама
BG107046A (en) Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
FI953513A (fi) Parannettu menetelmä 3-(4-aminoetoksibentsoyyli)bentso(B)-tiofeenien valmistamiseksi
HUP0300180A2 (en) Method for the preparation of citalopram
ES2195923T3 (es) Procedimiento para epoxidar cicloyexanonas sustituidas.
NO20021118L (no) Fremgangsmåte for fremstilling av citalopram
NO20055495L (no) 4-(4-trans-hydroksysykloheksyl)amino-2-fenyl-7H-pyrrolo[2,3-d]-pyrimidinhydrogenmesylat og dets polymorfe former
DK1733042T3 (da) Kemo-enzymatisk fremgangsmåde til fremstilling af escitalopram
BG104073A (en) Method for preparing alkyloxy furanone derivatives, compounds obtained by said method and use of said compounds
HRP20020021B1 (en) Method for preparing 2-(2-arylmorpholin-2-yl)ethanol derivatives and intermediates
DK1232151T3 (da) Fremgangsmåde til fremstilling af benzofuranonoximer
HUP0003666A2 (en) Method for the preparation of citalopram and pharmaceutical compositions containing them
WO2001018231A3 (de) VERFAHREN ZUR HERSTELLUNG VON (R)- ODER (S)-HYDROXY-η-BUTYROLACTON