NO20055495L - 4-(4-trans-hydroksysykloheksyl)amino-2-fenyl-7H-pyrrolo[2,3-d]-pyrimidinhydrogenmesylat og dets polymorfe former - Google Patents

4-(4-trans-hydroksysykloheksyl)amino-2-fenyl-7H-pyrrolo[2,3-d]-pyrimidinhydrogenmesylat og dets polymorfe former

Info

Publication number
NO20055495L
NO20055495L NO20055495A NO20055495A NO20055495L NO 20055495 L NO20055495 L NO 20055495L NO 20055495 A NO20055495 A NO 20055495A NO 20055495 A NO20055495 A NO 20055495A NO 20055495 L NO20055495 L NO 20055495L
Authority
NO
Norway
Prior art keywords
pyrrolo
trans
phenyl
amino
cyclohexyl
Prior art date
Application number
NO20055495A
Other languages
English (en)
Other versions
NO20055495D0 (no
Inventor
Emil Finner
Timo Heinrich
Axel Pahl
Bernd-Martin Luitjens
Pieter C Verveer
Jan Zorgdrager
Original Assignee
Solvay Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Gmbh filed Critical Solvay Pharm Gmbh
Publication of NO20055495D0 publication Critical patent/NO20055495D0/no
Publication of NO20055495L publication Critical patent/NO20055495L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Den foreliggende oppfirmelsen vedrører den nye forbindelsen 4-(4-trans-hydroksycykloheksyl)amino-2- fenyl-7H-pyrrolo[2,3d]pyrimidinhydrogermiesylat, de polymorfe a og P formene derav og en fremgangsmåte for fremstilling av de nevnte forbindelsene.
NO20055495A 2003-04-22 2005-11-21 4-(4-trans-hydroksysykloheksyl)amino-2-fenyl-7H-pyrrolo[2,3-d]-pyrimidinhydrogenmesylat og dets polymorfe former NO20055495L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46442203P 2003-04-22 2003-04-22
EP03101093 2003-04-22
PCT/EP2004/050573 WO2004094428A1 (en) 2003-04-22 2004-04-21 4-(4-trans-hydroxycyclohexyl)amino-2-phenyl-7h-pyrrolo`2, 3d! pyrimidine hydrogen mesylate and its polymorphic forms

Publications (2)

Publication Number Publication Date
NO20055495D0 NO20055495D0 (no) 2005-11-21
NO20055495L true NO20055495L (no) 2006-01-23

Family

ID=36143550

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20055495A NO20055495L (no) 2003-04-22 2005-11-21 4-(4-trans-hydroksysykloheksyl)amino-2-fenyl-7H-pyrrolo[2,3-d]-pyrimidinhydrogenmesylat og dets polymorfe former

Country Status (26)

Country Link
US (1) US7381729B2 (no)
EP (1) EP1641797B1 (no)
JP (1) JP2006524214A (no)
KR (1) KR20060021296A (no)
CN (1) CN100360533C (no)
AR (1) AR043880A1 (no)
AT (1) ATE373002T1 (no)
AU (1) AU2004232495B2 (no)
BR (1) BRPI0409511A (no)
CA (1) CA2522810A1 (no)
DE (1) DE602004008919T2 (no)
DK (1) DK1641797T3 (no)
ES (1) ES2290696T3 (no)
HK (1) HK1089767A1 (no)
IL (1) IL171120A (no)
MX (1) MXPA05011348A (no)
NO (1) NO20055495L (no)
PL (1) PL1641797T3 (no)
PT (1) PT1641797E (no)
RU (1) RU2345994C2 (no)
SA (1) SA04250093B1 (no)
SI (1) SI1641797T1 (no)
TW (1) TWI324517B (no)
UA (1) UA81806C2 (no)
WO (1) WO2004094428A1 (no)
ZA (1) ZA200508519B (no)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR043880A1 (es) 2003-04-22 2005-08-17 Solvay Pharm Gmbh Mesilato acido de 4-(4.trans-hidroxiciclohexil) amino-2-fenil-7h-pirrolo (2,3-d) pirimidina y sus formas polimorfas
WO2007073855A1 (en) * 2005-12-23 2007-07-05 Bayer Healthcare Ag Use of adenosine a1 receptor agonists for the protection of renal cells against toxic effects caused by aminoglycosides during treatment of infectious diseases
TW200808819A (en) * 2006-06-19 2008-02-16 Solvay Pharm Gmbh Use of adenosine A1 antagonists in radiocontrast media induced nephrophaty
CN104945394B (zh) 2012-09-27 2017-12-05 广东东阳光药业有限公司 二氢嘧啶衍生物的晶型

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE55646B1 (en) * 1982-08-19 1990-12-05 Warner Lambert Co 3-deazaguanine sulfonic acid salts
CS249455B1 (en) * 1985-01-24 1987-03-12 Miroslav Protiva N-substituted 2-chloro-7-fluoro-10-piperazino-10,11-dihydrodibenzo(b,f)thiepines and their salts and method of their preparation
JP2815691B2 (ja) * 1990-09-20 1998-10-27 麒麟麦酒株式会社 Ｋｒｎ２３９１酸付加塩およびその用途
FR2708604B1 (fr) * 1993-07-30 1995-10-20 Sanofi Elf Utilisation de dérivés de benzènesulfonyl-indole pour la préparation de médicaments.
JPH08198876A (ja) * 1995-01-30 1996-08-06 Yoshitomi Pharmaceut Ind Ltd トランス−Ｎ−（１Ｈ−ピラゾロ〔３，４−ｂ〕ピリジン−４−イル）−４−グアニジノメチルシクロヘキサンカルボキサミド・１メタンスルホン酸塩・１水和物
JPH08337584A (ja) * 1995-04-10 1996-12-24 Dai Ichi Seiyaku Co Ltd 縮合六環式アミノ化合物、これを含有する医薬及びその製法
FR2749846B1 (fr) * 1996-06-17 1998-09-11 Pf Medicament Sel de methanesulfonate d'une arylpiperazine derivee de tryptamine et ses solvates pour usage pharmaceutique
MA24500A1 (fr) * 1997-03-21 1998-10-01 Lg Life Sciences Ltd Derive du sel d'acide carboxylique de naphthyridine .
US6878716B1 (en) * 1998-06-02 2005-04-12 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptor and uses thereof
BR9911612A (pt) * 1998-06-02 2001-02-06 Osi Pharm Inc Composições de pirrolo[2,3d]pirimidina e seus usos
TWI223598B (en) * 1998-06-22 2004-11-11 Pfizer Ireland Pharmaceuticals An intranasal pharmaceutical composition for the treatment of male erectile dysfunction or female sexual disorders, an intranasal delivery system or device and sildenafil mesylate
IL149935A0 (en) * 1999-12-02 2002-11-10 Osi Pharm Inc Compounds specific to adenosine a1, a2a and a3 receptors and uses thereof
AP2002002611A0 (en) * 2000-03-03 2002-09-30 Pfizer 4-Amino-6,7-dimethoxy-2-(5-methanesulfonamido-1,2,3,4-tetrahydroisoquinol-2-yl)-5-(2-pyridyl) quinazoline mesylat and polymorphs.
EP1328519B1 (en) * 2000-10-17 2005-09-07 Merck & Co., Inc. Orally active salts with tyrosine kinase activity
US6680324B2 (en) * 2000-12-01 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
US6673802B2 (en) * 2000-12-01 2004-01-06 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
AR043880A1 (es) 2003-04-22 2005-08-17 Solvay Pharm Gmbh Mesilato acido de 4-(4.trans-hidroxiciclohexil) amino-2-fenil-7h-pirrolo (2,3-d) pirimidina y sus formas polimorfas

Also Published As

Publication number Publication date
JP2006524214A (ja) 2006-10-26
WO2004094428A1 (en) 2004-11-04
US20040248912A1 (en) 2004-12-09
SI1641797T1 (sl) 2007-12-31
EP1641797A1 (en) 2006-04-05
ZA200508519B (en) 2007-04-25
NO20055495D0 (no) 2005-11-21
DE602004008919D1 (de) 2007-10-25
RU2005136215A (ru) 2006-03-20
DE602004008919T2 (de) 2008-06-19
EP1641797B1 (en) 2007-09-12
IL171120A (en) 2011-01-31
UA81806C2 (uk) 2008-02-11
DK1641797T3 (da) 2007-10-29
AR043880A1 (es) 2005-08-17
US7381729B2 (en) 2008-06-03
CN100360533C (zh) 2008-01-09
ES2290696T3 (es) 2008-02-16
CA2522810A1 (en) 2004-11-04
RU2345994C2 (ru) 2009-02-10
TW200505457A (en) 2005-02-16
TWI324517B (en) 2010-05-11
MXPA05011348A (es) 2005-11-28
KR20060021296A (ko) 2006-03-07
HK1089767A1 (en) 2006-12-08
ATE373002T1 (de) 2007-09-15
SA04250093B1 (ar) 2008-07-12
PT1641797E (pt) 2007-12-21
CN1777606A (zh) 2006-05-24
PL1641797T3 (pl) 2008-01-31
AU2004232495A1 (en) 2004-11-04
BRPI0409511A (pt) 2006-04-18
AU2004232495B2 (en) 2010-04-22

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