DE60218703D1 - (-)-1-(3,4-dichlorphenyl)-3-azabicyclo ä3.1.0ühexan, zusammensetzungen davon und verwendung als dopamin-wiederaufnahme-hemmer - Google Patents

(-)-1-(3,4-dichlorphenyl)-3-azabicyclo ä3.1.0ühexan, zusammensetzungen davon und verwendung als dopamin-wiederaufnahme-hemmer

Info

Publication number
DE60218703D1
DE60218703D1 DE60218703T DE60218703T DE60218703D1 DE 60218703 D1 DE60218703 D1 DE 60218703D1 DE 60218703 T DE60218703 T DE 60218703T DE 60218703 T DE60218703 T DE 60218703T DE 60218703 D1 DE60218703 D1 DE 60218703D1
Authority
DE
Germany
Prior art keywords
dichlorphenyl
azabicyclo
compositions
dopamine
recovery inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60218703T
Other languages
English (en)
Other versions
DE60218703T2 (de
Inventor
Arnold Stan Lippa
Joseph Williams Epstein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DOV Pharmaceutical Inc
Original Assignee
DOV Pharmaceutical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DOV Pharmaceutical Inc filed Critical DOV Pharmaceutical Inc
Application granted granted Critical
Publication of DE60218703D1 publication Critical patent/DE60218703D1/de
Publication of DE60218703T2 publication Critical patent/DE60218703T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
DE60218703T 2001-08-24 2002-08-14 (-)-1-(3,4-dichlorphenyl)-3-azabicyclo ä3.1.0ühexan, zusammensetzungen davon und verwendung als dopamin-wiederaufnahme-hemmer Expired - Fee Related DE60218703T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US939071 2001-08-24
US09/939,071 US6569887B2 (en) 2001-08-24 2001-08-24 (−)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as a dopamine-reuptake
PCT/US2002/025870 WO2003017927A2 (en) 2001-08-24 2002-08-14 (-)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as a dopamine-reuptake inhibitor

Publications (2)

Publication Number Publication Date
DE60218703D1 true DE60218703D1 (de) 2007-04-19
DE60218703T2 DE60218703T2 (de) 2007-12-06

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
DE60218703T Expired - Fee Related DE60218703T2 (de) 2001-08-24 2002-08-14 (-)-1-(3,4-dichlorphenyl)-3-azabicyclo ä3.1.0ühexan, zusammensetzungen davon und verwendung als dopamin-wiederaufnahme-hemmer

Country Status (21)

Country Link
US (6) US6569887B2 (de)
EP (1) EP1427411B1 (de)
JP (1) JP2005504049A (de)
KR (1) KR20040065549A (de)
CN (2) CN101050199A (de)
AT (1) ATE355838T1 (de)
BR (1) BR0212147A (de)
CA (1) CA2458217A1 (de)
DE (1) DE60218703T2 (de)
DK (1) DK1427411T3 (de)
ES (1) ES2284968T3 (de)
HU (1) HUP0401515A2 (de)
IL (1) IL160545A0 (de)
MX (1) MXPA04001643A (de)
NO (1) NO327424B1 (de)
NZ (1) NZ531606A (de)
PL (1) PL368601A1 (de)
PT (1) PT1427411E (de)
RU (1) RU2300522C2 (de)
WO (1) WO2003017927A2 (de)
ZA (1) ZA200401545B (de)

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Also Published As

Publication number Publication date
CN1575170A (zh) 2005-02-02
CN101050199A (zh) 2007-10-10
US20040157870A1 (en) 2004-08-12
EP1427411B1 (de) 2007-03-07
US20040157908A1 (en) 2004-08-12
PT1427411E (pt) 2007-06-15
MXPA04001643A (es) 2004-05-31
PL368601A1 (en) 2005-04-04
ES2284968T3 (es) 2007-11-16
RU2004108694A (ru) 2005-03-10
US7098230B2 (en) 2006-08-29
US20040157869A1 (en) 2004-08-12
JP2005504049A (ja) 2005-02-10
US7041835B2 (en) 2006-05-09
HUP0401515A2 (hu) 2004-12-28
DE60218703T2 (de) 2007-12-06
KR20040065549A (ko) 2004-07-22
IL160545A0 (en) 2004-07-25
DK1427411T3 (da) 2007-07-02
NO327424B1 (no) 2009-06-29
WO2003017927A3 (en) 2003-04-17
NO20040794L (no) 2004-05-17
BR0212147A (pt) 2004-08-24
CA2458217A1 (en) 2003-03-06
NZ531606A (en) 2005-08-26
US20030045567A1 (en) 2003-03-06
ZA200401545B (en) 2005-03-10
WO2003017927A2 (en) 2003-03-06
EP1427411A4 (de) 2005-04-20
US6569887B2 (en) 2003-05-27
ATE355838T1 (de) 2007-03-15
US7081471B2 (en) 2006-07-25
US6716868B2 (en) 2004-04-06
US20030181508A1 (en) 2003-09-25
US20070082938A1 (en) 2007-04-12
RU2300522C2 (ru) 2007-06-10
EP1427411A2 (de) 2004-06-16

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