ATE281448T1 - Verfahren zur herstellung von citalopram - Google Patents

Verfahren zur herstellung von citalopram

Info

Publication number
ATE281448T1
ATE281448T1 AT01957786T AT01957786T ATE281448T1 AT E281448 T1 ATE281448 T1 AT E281448T1 AT 01957786 T AT01957786 T AT 01957786T AT 01957786 T AT01957786 T AT 01957786T AT E281448 T1 ATE281448 T1 AT E281448T1
Authority
AT
Austria
Prior art keywords
producing citalopram
citalopram
producing
Prior art date
Application number
AT01957786T
Other languages
English (en)
Inventor
Hans Petersen
Haleh Ahmadian
Robert Dancer
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Application granted granted Critical
Publication of ATE281448T1 publication Critical patent/ATE281448T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
AT01957786T 2000-08-18 2001-08-14 Verfahren zur herstellung von citalopram ATE281448T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200001231 2000-08-18
PCT/DK2001/000542 WO2002016342A1 (en) 2000-08-18 2001-08-14 Method for the preparation of citalopram

Publications (1)

Publication Number Publication Date
ATE281448T1 true ATE281448T1 (de) 2004-11-15

Family

ID=8159660

Family Applications (4)

Application Number Title Priority Date Filing Date
AT01957785T ATE281447T1 (de) 2000-08-18 2001-08-14 Verfahren zur herstellung von citalopram
AT01957786T ATE281448T1 (de) 2000-08-18 2001-08-14 Verfahren zur herstellung von citalopram
AT0065001U AT4946U1 (de) 2000-08-18 2001-08-17 Verfahren zur herstellung von citalopram
AT0065101U AT5026U1 (de) 2000-08-18 2001-08-17 Verfahren zur herstellung von citalopram

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT01957785T ATE281447T1 (de) 2000-08-18 2001-08-14 Verfahren zur herstellung von citalopram

Family Applications After (2)

Application Number Title Priority Date Filing Date
AT0065001U AT4946U1 (de) 2000-08-18 2001-08-17 Verfahren zur herstellung von citalopram
AT0065101U AT5026U1 (de) 2000-08-18 2001-08-17 Verfahren zur herstellung von citalopram

Country Status (41)

Country Link
US (2) US6426422B1 (de)
EP (2) EP1309581B1 (de)
JP (2) JP2004506729A (de)
KR (2) KR100887207B1 (de)
CN (3) CN1159307C (de)
AR (3) AR029597A1 (de)
AT (4) ATE281447T1 (de)
AU (6) AU2001279609B2 (de)
BE (2) BE1013443A6 (de)
BG (2) BG65965B1 (de)
CA (2) CA2354880C (de)
CH (2) CH691969A5 (de)
CL (2) CL2008002412A1 (de)
CZ (2) CZ295863B6 (de)
DE (4) DE60106932T2 (de)
DK (4) DK1309582T3 (de)
EA (2) EA005811B1 (de)
ES (4) ES2230347T3 (de)
FI (2) FI20011622A (de)
FR (2) FR2813078B1 (de)
GB (2) GB2365865B (de)
GR (1) GR1004074B (de)
HK (3) HK1044538B (de)
HR (2) HRP20030065A2 (de)
HU (2) HUP0103291A3 (de)
IE (2) IES20010760A2 (de)
IL (2) IL144816A (de)
IS (2) IS2121B (de)
ME (2) MEP2208A (de)
MX (2) MXPA03001329A (de)
NL (2) NL1018776C1 (de)
NO (2) NO326570B1 (de)
NZ (2) NZ523877A (de)
PL (2) PL359969A1 (de)
PT (2) PT1309582E (de)
RS (2) RS50258B (de)
SI (2) SI1309581T1 (de)
SK (2) SK287236B6 (de)
UA (2) UA72340C2 (de)
WO (2) WO2002016342A1 (de)
ZA (1) ZA200106683B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
ES2195554T5 (es) * 1999-04-14 2010-02-02 H. Lundbeck A/S Metodo para la preparacion de citalopram.
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
DE69935355T2 (de) 1999-10-25 2007-11-08 H. Lundbeck A/S, Valby Verfahren zur Herstellung von Citalopram
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
MXPA02006503A (es) 1999-12-28 2002-12-09 Lundbeck & Co As H Metodo para la preparacion de citalopram.
EA004055B1 (ru) 1999-12-30 2003-12-25 Х.Лундбекк А/С Способ получения циталопрама
ATE252570T1 (de) * 2000-01-14 2003-11-15 Lundbeck & Co As H Verfahren zur herstellung von 5-cyanophthalid
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
WO2001068629A1 (en) * 2000-03-13 2001-09-20 H. Lundbeck A/S Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
AU2001242298A1 (en) 2000-03-13 2001-09-24 H Lunbeck A/S Method for the preparation of citalopram
MXPA02008653A (es) 2000-03-14 2003-02-24 Lundbeck & Co As H Metodo para la preparacion de citalopram.
CN1418206A (zh) * 2000-03-16 2003-05-14 H·隆德贝克有限公司 5－氰基－1－(4－氟苯基)－1,3－二氢异苯并呋喃的制备方法
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
FI20011622A (fi) 2000-08-18 2002-02-19 Lundbeck & Co As H Menetelmä sitalopraamin valmistamiseksi
SI1181713T1 (en) 2000-12-22 2005-02-28 H. Lundbeck A/S Method for the preparation of pure citalopram
US7148364B2 (en) * 2002-01-07 2006-12-12 Sun Pharmaceutical Industries Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile
TWI306846B (en) * 2002-08-12 2009-03-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
WO2004085416A1 (en) * 2003-03-24 2004-10-07 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
US20050143350A1 (en) * 2003-11-19 2005-06-30 Seed John C. Combination drug therapy to treat obesity
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
US9339500B2 (en) * 2008-03-04 2016-05-17 Intra-Cellular Therapies, Inc. Methods of treating vasomotor symptoms
US20100087664A1 (en) * 2008-10-07 2010-04-08 Ravindra Vedantham Preparation of citalopram and salts thereof
JP6222973B2 (ja) * 2013-04-19 2017-11-01 日本テルペン化学株式会社 ジベンジルトリチオカーボネート誘導体
CN103936702A (zh) * 2014-05-07 2014-07-23 成都诺维尔生物医药有限公司 艾司西酞普兰杂质j的合成方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143702A (de) 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
DE3926765A1 (de) 1989-08-12 1991-02-14 Hoechst Ag Verfahren zur verminderung von primaerem und sekundaerem amin in einem tertiaeren amin
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DK213290D0 (da) 1990-09-06 1990-09-06 Lundbeck & Co As H Treatment of cerebrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
ZA9711376B (en) 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives
ATE205824T1 (de) 1997-07-08 2001-10-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
TR200001341T2 (tr) 1997-11-11 2000-11-21 H. Lundbeck A/S Sitalopramın hazırlandığı metot
WO2000023431A1 (en) 1998-10-20 2000-04-27 H. Lundbeck A/S Method for the preparation of citalopram
ES2195644T3 (es) 1998-12-23 2003-12-01 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida.
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
ES2195554T5 (es) 1999-04-14 2010-02-02 H. Lundbeck A/S Metodo para la preparacion de citalopram.
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
AU742554B2 (en) 1999-10-25 2002-01-03 H. Lundbeck A/S Method for the preparation of citalopram
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
NL1017415C1 (nl) 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
GB0005477D0 (en) * 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
FI20011622A (fi) 2000-08-18 2002-02-19 Lundbeck & Co As H Menetelmä sitalopraamin valmistamiseksi
SI1181713T1 (en) 2000-12-22 2005-02-28 H. Lundbeck A/S Method for the preparation of pure citalopram
TR200200018T1 (tr) 2000-12-28 2002-06-21 H. Lundbeck A/S Saf sitalopram hazırlanması için yöntem.

Also Published As

Publication number Publication date
CZ295863B6 (cs) 2005-11-16
JP2004506729A (ja) 2004-03-04
FR2813078A1 (fr) 2002-02-22
WO2002016341A1 (en) 2002-02-28
CA2354880A1 (en) 2002-01-22
DE60106933T2 (de) 2005-12-01
SK287008B6 (sk) 2009-09-07
DE10140028A1 (de) 2002-04-18
CL2008002412A1 (es) 2009-01-02
MXPA03001329A (es) 2003-06-06
MXPA03000913A (es) 2003-06-24
NO20013943D0 (no) 2001-08-14
UA71676C2 (en) 2004-12-15
IS6047A (is) 2001-10-20
CN1515564A (zh) 2004-07-28
US6426422B1 (en) 2002-07-30
CL2008002673A1 (es) 2009-01-02
IES20010761A2 (en) 2002-02-20
AU2001279608B2 (en) 2006-10-05
BE1013444A6 (fr) 2002-01-15
FR2813077A1 (fr) 2002-02-22
GB0119733D0 (en) 2001-10-03
HK1044538A1 (en) 2002-10-25
AU7960901A (en) 2002-03-04
HUP0103291A2 (hu) 2002-05-29
GR1004074B (el) 2002-11-26
IL144816A0 (en) 2002-06-30
IS2121B (is) 2006-06-15
GB2362647B (en) 2002-09-18
NO326772B1 (no) 2009-02-16
SI1309581T1 (en) 2005-04-30
PT1309582E (pt) 2005-03-31
RS50258B (sr) 2009-07-15
HUP0103295A2 (hu) 2002-05-29
DE60106933D1 (de) 2004-12-09
CN1339436A (zh) 2002-03-13
BG107583A (bg) 2004-01-30
HRP20030064A2 (en) 2005-02-28
AU2001100278B4 (en) 2001-11-29
PL359969A1 (en) 2004-09-06
ES2170735B2 (es) 2003-09-16
FI20011621A0 (fi) 2001-08-09
KR20030022385A (ko) 2003-03-15
WO2002016342A1 (en) 2002-02-28
EA005811B1 (ru) 2005-06-30
EA200300277A1 (ru) 2003-08-28
AU2001100271B4 (en) 2001-11-29
AU2001100271A4 (en) 2001-09-13
HUP0103295A3 (en) 2005-01-28
DK1309581T3 (da) 2005-03-14
RS50287B (sr) 2009-09-08
NO326570B1 (no) 2009-01-12
AT5026U1 (de) 2002-02-25
EP1309582B1 (de) 2004-11-03
BE1013443A6 (fr) 2002-01-15
MEP2208A (xx) 2010-02-10
AT4946U1 (de) 2002-01-25
AR029598A1 (es) 2003-07-10
DK1309582T3 (da) 2005-03-14
EP1309581B1 (de) 2004-11-03
ZA200106683B (en) 2002-08-05
ES2170734A1 (es) 2002-08-01
PL359825A1 (en) 2004-09-06
SK287236B6 (sk) 2010-04-07
CH691968A5 (de) 2001-12-14
GB0119734D0 (en) 2001-10-03
NL1018775C1 (nl) 2001-10-24
NO20013943L (no) 2002-02-19
SK3202003A3 (en) 2003-08-05
HU0103291D0 (en) 2001-10-28
HK1047086A1 (en) 2003-02-07
CZ20012958A3 (cs) 2002-04-17
DE10140029A1 (de) 2002-05-02
BG65965B1 (bg) 2010-07-30
CA2354880C (en) 2003-06-03
HUP0103291A3 (en) 2003-02-28
FI20011622A0 (fi) 2001-08-09
JP2004506730A (ja) 2004-03-04
FI20011621A (fi) 2002-02-19
DE60106932T2 (de) 2005-11-03
BG65964B1 (bg) 2010-07-30
AR066694A2 (es) 2009-09-09
AU7960801A (en) 2002-03-04
FR2813078B1 (fr) 2004-04-02
CZ20012959A3 (cs) 2002-04-17
IL144816A (en) 2005-09-25
YU6903A (sh) 2006-05-25
DK200101216A (da) 2002-02-19
EP1309582A1 (de) 2003-05-14
SI1309582T1 (en) 2005-06-30
IS6048A (is) 2001-10-19
PT1309581E (pt) 2005-03-31
HK1068069A1 (en) 2005-04-22
NZ523877A (en) 2004-08-27
GR20010100398A (el) 2002-05-24
IL144817A0 (en) 2002-06-30
AU2001100278A4 (en) 2001-09-13
IS2120B (is) 2006-06-15
EA200300279A1 (ru) 2003-08-28
ES2230347T3 (es) 2005-05-01
CN1159307C (zh) 2004-07-28
ES2228920T3 (es) 2005-04-16
CN1339435A (zh) 2002-03-13
AU2001279609B2 (en) 2007-09-06
CZ294746B6 (cs) 2005-03-16
ES2170734B2 (es) 2003-09-16
CN1222517C (zh) 2005-10-12
KR20030022378A (ko) 2003-03-15
GB2365865B (en) 2002-07-17
SK3222003A3 (en) 2003-08-05
CA2354877C (en) 2006-05-02
BG107584A (bg) 2004-01-30
GB2365865A (en) 2002-02-27
US20020025982A1 (en) 2002-02-28
DK200101219A (da) 2002-02-19
HK1044538B (zh) 2006-07-07
US6509483B2 (en) 2003-01-21
EA005946B1 (ru) 2005-08-25
NO20013942L (no) 2002-02-19
GB2362647A (en) 2001-11-28
KR100887206B1 (ko) 2009-03-06
YU11503A (sh) 2006-05-25
CH691969A5 (de) 2001-12-14
UA72340C2 (uk) 2005-02-15
HK1047086B (zh) 2005-04-22
ATE281447T1 (de) 2004-11-15
NO20013942D0 (no) 2001-08-14
NL1018776C1 (nl) 2001-10-24
CA2354877A1 (en) 2002-02-18
HRP20030065A2 (en) 2005-02-28
KR100887207B1 (ko) 2009-03-06
FR2813077B1 (fr) 2004-08-20
EP1309581A1 (de) 2003-05-14
IES20010760A2 (en) 2002-02-20
NZ523853A (en) 2004-07-30
ES2170735A1 (es) 2002-08-01
MEP2308A (xx) 2010-02-10
US20020026062A1 (en) 2002-02-28
FI20011622A (fi) 2002-02-19
AR029597A1 (es) 2003-07-10
CN1239490C (zh) 2006-02-01
DE60106932D1 (de) 2004-12-09

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