ATE325810T1 - Verfahren zur herstellung von acetylamidiniophenylalanyl-cyclohexylglycyl- pyridylalaninamiden - Google Patents

Verfahren zur herstellung von acetylamidiniophenylalanyl-cyclohexylglycyl- pyridylalaninamiden

Info

Publication number
ATE325810T1
ATE325810T1 AT01911497T AT01911497T ATE325810T1 AT E325810 T1 ATE325810 T1 AT E325810T1 AT 01911497 T AT01911497 T AT 01911497T AT 01911497 T AT01911497 T AT 01911497T AT E325810 T1 ATE325810 T1 AT E325810T1
Authority
AT
Austria
Prior art keywords
pyridylalaninamides
acetylamidiniophenylalanyl
cyclohexylglycyl
producing
producing acetylamidiniophenylalanyl
Prior art date
Application number
AT01911497T
Other languages
English (en)
Inventor
Dr Gerhard Breipohl
Wolfgang Holla
Heiner Jendralla
Gerhard Beck
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Application granted granted Critical
Publication of ATE325810T1 publication Critical patent/ATE325810T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0821Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06139Dipeptides with the first amino acid being heterocyclic
AT01911497T 2000-01-28 2001-01-18 Verfahren zur herstellung von acetylamidiniophenylalanyl-cyclohexylglycyl- pyridylalaninamiden ATE325810T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10003586 2000-01-28

Publications (1)

Publication Number Publication Date
ATE325810T1 true ATE325810T1 (de) 2006-06-15

Family

ID=7628946

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01911497T ATE325810T1 (de) 2000-01-28 2001-01-18 Verfahren zur herstellung von acetylamidiniophenylalanyl-cyclohexylglycyl- pyridylalaninamiden

Country Status (30)

Country Link
US (2) US20010031858A1 (de)
EP (1) EP1254159B9 (de)
JP (1) JP4778181B2 (de)
KR (1) KR100758141B1 (de)
CN (1) CN1176104C (de)
AR (1) AR027246A1 (de)
AT (1) ATE325810T1 (de)
AU (1) AU779722B2 (de)
BR (1) BR0107804A (de)
CA (1) CA2398497C (de)
CZ (1) CZ20022583A3 (de)
DE (1) DE60119491T2 (de)
DK (1) DK1254159T3 (de)
EE (1) EE200200410A (de)
ES (1) ES2262632T3 (de)
HK (1) HK1051866A1 (de)
HR (1) HRP20020631A2 (de)
HU (1) HUP0301986A2 (de)
IL (2) IL150897A0 (de)
MX (1) MXPA02006762A (de)
NO (1) NO20023577L (de)
NZ (1) NZ520427A (de)
PL (1) PL356801A1 (de)
PT (1) PT1254159E (de)
RU (1) RU2250212C2 (de)
SK (1) SK10842002A3 (de)
TW (1) TWI236481B (de)
WO (1) WO2001055175A2 (de)
YU (1) YU51202A (de)
ZA (1) ZA200205990B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH695999A5 (de) * 2002-02-28 2006-11-15 Wilex Ag Verfahren zur Herstellung von 3- Amidinophenylalanin-Derivaten.
EP1968999A2 (de) * 2005-12-07 2008-09-17 Technische Universität München Kleine peptidische und peptidomimetische affinitätsliganden für faktor viii und faktor-viii-ähnliche proteine
CN101774942B (zh) * 2010-01-27 2012-08-22 宁波武盛化学有限公司 制备n-乙酰基-dl-环己基甘氨酸的方法
WO2011133651A1 (en) * 2010-04-20 2011-10-27 Chiral Quest , Inc. An enantioselective process for cycloalkenyl b-substituted alanines
JP5913352B2 (ja) * 2010-11-29 2016-04-27 高砂香料工業株式会社 不斉水素化触媒、およびそれを用いた光学活性カルボニル化合物の製造方法
CN115068469B (zh) * 2022-07-08 2024-02-27 深圳市小分子新药创新中心有限公司 Tigit抑制剂及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2916711A1 (de) 1979-04-25 1980-11-06 Behringwerke Ag Blutgerinnungsfaktoren und verfahren zu ihrer herstellung
US4623717A (en) * 1980-03-05 1986-11-18 Miles Laboratories, Inc. Pasteurized therapeutically active protein compositions
US4440679A (en) * 1980-03-05 1984-04-03 Cutter Laboratories, Inc. Pasteurized therapeutically active protein compositions
SK286094B6 (sk) * 1994-04-26 2008-03-05 Aventis Pharmaceuticals Inc. Zlúčenina špecificky inhibujúca aktivitu faktora Xa, farmaceutická kompozícia s jej obsahom a jej použitie
US5849510A (en) 1994-04-26 1998-12-15 Selectide Corporation Factor Xa inhibitors
PL185541B1 (pl) * 1995-12-20 2003-05-30 Aventis Pharmaceuticals Sposób wytwarzania N-acetylo-(L)-4-cyjanofenyloalaniny i N-acetylo-(L)-p-amidynofenyloalaninocykloheksyloglicyno-beta-(3-N-metylopirydynio)-alaniny
DE19856443A1 (de) 1998-12-08 2000-06-21 Centeon Pharma Gmbh Stabilisiertes Antithrombin III-Präparat

Also Published As

Publication number Publication date
BR0107804A (pt) 2002-10-22
TWI236481B (en) 2005-07-21
HUP0301986A2 (hu) 2003-09-29
CA2398497A1 (en) 2001-08-02
NO20023577L (no) 2002-08-28
IL150897A0 (en) 2003-02-12
US20010031858A1 (en) 2001-10-18
YU51202A (sh) 2005-11-28
US20040225109A1 (en) 2004-11-11
JP4778181B2 (ja) 2011-09-21
JP2003523364A (ja) 2003-08-05
AU4051601A (en) 2001-08-07
IL150897A (en) 2008-08-07
AU779722B2 (en) 2005-02-10
RU2002123046A (ru) 2004-01-10
US7084250B2 (en) 2006-08-01
DK1254159T3 (da) 2006-09-11
HRP20020631A2 (en) 2004-12-31
SK10842002A3 (sk) 2003-04-01
RU2250212C2 (ru) 2005-04-20
EP1254159B1 (de) 2006-05-10
DE60119491D1 (de) 2006-06-14
NZ520427A (en) 2004-02-27
AR027246A1 (es) 2003-03-19
KR100758141B1 (ko) 2007-09-13
WO2001055175A3 (en) 2002-02-21
NO20023577D0 (no) 2002-07-26
EE200200410A (et) 2003-12-15
DE60119491T2 (de) 2006-11-16
MXPA02006762A (es) 2002-10-23
WO2001055175A2 (en) 2001-08-02
CN1176104C (zh) 2004-11-17
CZ20022583A3 (cs) 2002-10-16
PT1254159E (pt) 2006-07-31
CN1396928A (zh) 2003-02-12
EP1254159B9 (de) 2006-06-28
KR20030019306A (ko) 2003-03-06
EP1254159A2 (de) 2002-11-06
ES2262632T3 (es) 2006-12-01
PL356801A1 (en) 2004-07-12
ZA200205990B (en) 2003-04-30
HK1051866A1 (en) 2003-08-22
CA2398497C (en) 2011-04-26

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