YU6903A - Postupak za pripremanje citaloprama - Google Patents

Postupak za pripremanje citaloprama

Info

Publication number
YU6903A
YU6903A YU6903A YUP6903A YU6903A YU 6903 A YU6903 A YU 6903A YU 6903 A YU6903 A YU 6903A YU P6903 A YUP6903 A YU P6903A YU 6903 A YU6903 A YU 6903A
Authority
YU
Yugoslavia
Prior art keywords
formula
citalopram
compound
preparation
halo
Prior art date
Application number
YU6903A
Other languages
English (en)
Inventor
Hans Petersen
Haleh Ahmadian
Robert Dancer
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of YU6903A publication Critical patent/YU6903A/sh
Publication of RS50258B publication Critical patent/RS50258B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Opisan je postupak za pripremanje citaloprama i koji obuhvata reakciju 5-karboksiftalida i zatim sa Grignard-ovim reagensom 4-halo-fluorofenilom i Grignard-ovim 3-halo-N,N-dimetil-propilamin reagensom i posle izvršenog zatvaranja prstena dobijenog jedinjenja formule XI, u jedinjenje formule IV, sledeći pretvaranje jedinjenje formule IV u citalopram. Postupci za proizvodnju i pretvaranje jedinjenja formule IV su takodje opsiani.[A method for the preparation of citalopram comprising reacting 5-carboxyphthalide successively with a Grignard reagent of 4-halo- fluorophenyl and a Grignard reagent of 3-halo-N,N-dimethyl-propylamine and then effecting ring closure of the resulting compound of Formula XI, to a compound of Formula IV, followed by conversion of the compound of Formula IV into citalopram is disclosed. Methods for the manufacture and conversion of the compound of Formula IV are also disclosed.
YU6903A 2000-08-18 2001-08-14 Postupak za pripremanje citaloprama RS50258B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200001231 2000-08-18

Publications (2)

Publication Number Publication Date
YU6903A true YU6903A (sh) 2006-05-25
RS50258B RS50258B (sr) 2009-07-15

Family

ID=8159660

Country Status (41)

Country Link
US (2) US6426422B1 (sh)
EP (2) EP1309581B1 (sh)
JP (2) JP2004506729A (sh)
KR (2) KR100887207B1 (sh)
CN (3) CN1159307C (sh)
AR (3) AR029598A1 (sh)
AT (4) ATE281448T1 (sh)
AU (6) AU2001279609B2 (sh)
BE (2) BE1013443A6 (sh)
BG (2) BG65964B1 (sh)
CA (2) CA2354880C (sh)
CH (2) CH691968A5 (sh)
CL (2) CL2008002412A1 (sh)
CZ (2) CZ295863B6 (sh)
DE (4) DE60106933T2 (sh)
DK (4) DK200101216A (sh)
EA (2) EA005811B1 (sh)
ES (4) ES2228920T3 (sh)
FI (2) FI20011622A (sh)
FR (2) FR2813078B1 (sh)
GB (2) GB2362647B (sh)
GR (1) GR1004074B (sh)
HK (3) HK1044538B (sh)
HR (2) HRP20030065A2 (sh)
HU (2) HUP0103291A3 (sh)
IE (2) IES20010760A2 (sh)
IL (2) IL144816A (sh)
IS (2) IS2121B (sh)
ME (2) MEP2208A (sh)
MX (2) MXPA03001329A (sh)
NL (2) NL1018775C1 (sh)
NO (2) NO326570B1 (sh)
NZ (2) NZ523853A (sh)
PL (2) PL359825A1 (sh)
PT (2) PT1309581E (sh)
RS (2) RS50258B (sh)
SI (2) SI1309582T1 (sh)
SK (2) SK287008B6 (sh)
UA (2) UA72340C2 (sh)
WO (2) WO2002016341A1 (sh)
ZA (1) ZA200106683B (sh)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
PL198024B1 (pl) 1999-04-14 2008-05-30 Lundbeck & Co As H Sposób wytwarzania citalopramu, związki pośrednie i ich zastosowanie do wytwarzania citalopramu
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
SK287140B6 (sk) 1999-10-25 2010-01-07 H. Lundbeck A/S Spôsob prípravy citalopramu a medziprodukt na jeho výrobu
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
PL355532A1 (en) 1999-12-28 2004-05-04 H.Lundbeck A/S Method for the preparation of citalopram
CZ20022627A3 (cs) 1999-12-30 2002-10-16 H. Lundbeck A/S Způsob výroby citalopramu
SK286879B6 (sk) * 2000-01-14 2009-07-06 H. Lundbeck A/S Spôsob prípravy 5-kyanoftalidu
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
JP2003527387A (ja) 2000-03-13 2003-09-16 ハー・ルンドベック・アクチエゼルスカベット シタロプラムの製造方法
JP2003527385A (ja) * 2000-03-13 2003-09-16 ハー・ルンドベック・アクチエゼルスカベット ５−置換された１−（４−フルオロフェニル）−１，３−ジヒドロイソベンゾフランの段階的アルキル化法
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
PT1265882E (pt) 2000-03-14 2004-06-30 Lundbeck & Co As H Metodo para preparacao de citalopram; composto e citalopram
TR200202168T2 (tr) * 2000-03-16 2002-12-23 H. Lundbeck A/S 5-Siyano-1-(4-Florofenil)-1,3-Dihidroizobenzofuranların preparasyon metodu
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
FI20011622A (fi) 2000-08-18 2002-02-19 Lundbeck & Co As H Menetelmä sitalopraamin valmistamiseksi
DK1181713T3 (da) 2000-12-22 2005-01-31 Lundbeck & Co As H Fremgangsmåde til fremstilling af rent citalopram
WO2003057132A2 (en) * 2002-01-07 2003-07-17 Sun Pharmaceutical Industries Limited Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
PE20040991A1 (es) * 2002-08-12 2004-12-27 Lundbeck & Co As H Separacion de intermediarios para la preparacion de escitalopram
US20050154052A1 (en) * 2003-03-24 2005-07-14 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
US20050143350A1 (en) * 2003-11-19 2005-06-30 Seed John C. Combination drug therapy to treat obesity
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
US9339500B2 (en) * 2008-03-04 2016-05-17 Intra-Cellular Therapies, Inc. Methods of treating vasomotor symptoms
US20100087664A1 (en) * 2008-10-07 2010-04-08 Ravindra Vedantham Preparation of citalopram and salts thereof
JP6222973B2 (ja) * 2013-04-19 2017-11-01 日本テルペン化学株式会社 ジベンジルトリチオカーボネート誘導体
CN103936702A (zh) * 2014-05-07 2014-07-23 成都诺维尔生物医药有限公司 艾司西酞普兰杂质j的合成方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143703A (sh) 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
DE3926765A1 (de) 1989-08-12 1991-02-14 Hoechst Ag Verfahren zur verminderung von primaerem und sekundaerem amin in einem tertiaeren amin
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DK213290D0 (da) 1990-09-06 1990-09-06 Lundbeck & Co As H Treatment of cerebrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
ZA9711376B (en) 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives
EA001728B1 (ru) 1997-07-08 2001-08-27 Х.Лундбекк А/С Способ получения циталопрама
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
SK283907B6 (sk) 1997-11-11 2004-04-06 H. Lundbeck A/S Spôsob výroby citalopramu a medziprodukty
AU746665B2 (en) 1998-10-20 2002-05-02 H. Lundbeck A/S Method for the preparation of citalopram
BR9916955A (pt) 1998-12-23 2001-09-11 Lundbeck & Co As H Método para preparação de 5-cianoftalida
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
PL198024B1 (pl) 1999-04-14 2008-05-30 Lundbeck & Co As H Sposób wytwarzania citalopramu, związki pośrednie i ich zastosowanie do wytwarzania citalopramu
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
CH692421A5 (de) 1999-10-25 2002-06-14 Lundbeck & Co As H Verfahren zur Herstellung von Citalopram.
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
NL1017415C1 (nl) 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
GB0005477D0 (en) * 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
FI20011622A (fi) 2000-08-18 2002-02-19 Lundbeck & Co As H Menetelmä sitalopraamin valmistamiseksi
DK1181713T3 (da) 2000-12-22 2005-01-31 Lundbeck & Co As H Fremgangsmåde til fremstilling af rent citalopram
KR100430746B1 (ko) 2000-12-28 2004-05-10 하. 룬트벡 아크티에 셀스카브 순수한 시탈로프람의 제조방법

Also Published As

Publication number Publication date
WO2002016341A1 (en) 2002-02-28
CA2354877A1 (en) 2002-02-18
CN1239490C (zh) 2006-02-01
CN1222517C (zh) 2005-10-12
CH691969A5 (de) 2001-12-14
AT4946U1 (de) 2002-01-25
IL144816A (en) 2005-09-25
FR2813078B1 (fr) 2004-04-02
EP1309581B1 (en) 2004-11-03
IS2120B (is) 2006-06-15
HUP0103291A3 (en) 2003-02-28
MXPA03001329A (es) 2003-06-06
KR20030022378A (ko) 2003-03-15
DK1309581T3 (da) 2005-03-14
PT1309581E (pt) 2005-03-31
EA005946B1 (ru) 2005-08-25
DE10140028A1 (de) 2002-04-18
AT5026U1 (de) 2002-02-25
BE1013443A6 (fr) 2002-01-15
HUP0103295A2 (hu) 2002-05-29
NL1018775C1 (nl) 2001-10-24
ES2170735B2 (es) 2003-09-16
FI20011621A0 (fi) 2001-08-09
BE1013444A6 (fr) 2002-01-15
CL2008002412A1 (es) 2009-01-02
HUP0103295A3 (en) 2005-01-28
HRP20030065A2 (en) 2005-02-28
IL144817A0 (en) 2002-06-30
SK287236B6 (sk) 2010-04-07
NO326570B1 (no) 2009-01-12
BG65964B1 (bg) 2010-07-30
GB0119734D0 (en) 2001-10-03
FI20011622A (fi) 2002-02-19
JP2004506730A (ja) 2004-03-04
DK200101216A (da) 2002-02-19
CN1339435A (zh) 2002-03-13
DE60106933T2 (de) 2005-12-01
GB2365865A (en) 2002-02-27
DE60106933D1 (de) 2004-12-09
SK3222003A3 (en) 2003-08-05
KR20030022385A (ko) 2003-03-15
KR100887206B1 (ko) 2009-03-06
GB2362647A (en) 2001-11-28
SK287008B6 (sk) 2009-09-07
CA2354880C (en) 2003-06-03
DE60106932T2 (de) 2005-11-03
US6426422B1 (en) 2002-07-30
AU2001100271A4 (en) 2001-09-13
ES2230347T3 (es) 2005-05-01
CN1159307C (zh) 2004-07-28
HK1047086B (zh) 2005-04-22
ATE281448T1 (de) 2004-11-15
JP2004506729A (ja) 2004-03-04
AR029597A1 (es) 2003-07-10
HRP20030064A2 (en) 2005-02-28
FI20011621A (fi) 2002-02-19
SK3202003A3 (en) 2003-08-05
AR066694A2 (es) 2009-09-09
RS50258B (sr) 2009-07-15
NZ523877A (en) 2004-08-27
WO2002016342A1 (en) 2002-02-28
HU0103291D0 (en) 2001-10-28
ES2170734A1 (es) 2002-08-01
NO20013942L (no) 2002-02-19
HUP0103291A2 (hu) 2002-05-29
ES2228920T3 (es) 2005-04-16
MXPA03000913A (es) 2003-06-24
MEP2308A (xx) 2010-02-10
PT1309582E (pt) 2005-03-31
RS50287B (sr) 2009-09-08
EA005811B1 (ru) 2005-06-30
BG65965B1 (bg) 2010-07-30
AU2001100271B4 (en) 2001-11-29
EA200300277A1 (ru) 2003-08-28
NO20013942D0 (no) 2001-08-14
FR2813077A1 (fr) 2002-02-22
CH691968A5 (de) 2001-12-14
IS6047A (is) 2001-10-20
GR1004074B (el) 2002-11-26
AU2001279609B2 (en) 2007-09-06
EA200300279A1 (ru) 2003-08-28
EP1309582A1 (en) 2003-05-14
AU2001100278B4 (en) 2001-11-29
HK1044538A1 (en) 2002-10-25
GB2362647B (en) 2002-09-18
CZ20012958A3 (cs) 2002-04-17
NO20013943D0 (no) 2001-08-14
NL1018776C1 (nl) 2001-10-24
IS2121B (is) 2006-06-15
US6509483B2 (en) 2003-01-21
EP1309582B1 (en) 2004-11-03
BG107583A (bg) 2004-01-30
CL2008002673A1 (es) 2009-01-02
US20020026062A1 (en) 2002-02-28
AU7960801A (en) 2002-03-04
PL359825A1 (en) 2004-09-06
EP1309581A1 (en) 2003-05-14
SI1309581T1 (en) 2005-04-30
FI20011622A0 (fi) 2001-08-09
GB2365865B (en) 2002-07-17
NO326772B1 (no) 2009-02-16
MEP2208A (xx) 2010-02-10
FR2813077B1 (fr) 2004-08-20
GR20010100398A (el) 2002-05-24
ES2170734B2 (es) 2003-09-16
IES20010760A2 (en) 2002-02-20
IES20010761A2 (en) 2002-02-20
CZ20012959A3 (cs) 2002-04-17
CZ295863B6 (cs) 2005-11-16
IS6048A (is) 2001-10-19
CZ294746B6 (cs) 2005-03-16
UA71676C2 (en) 2004-12-15
HK1068069A1 (en) 2005-04-22
AU7960901A (en) 2002-03-04
SI1309582T1 (en) 2005-06-30
AU2001279608B2 (en) 2006-10-05
KR100887207B1 (ko) 2009-03-06
ES2170735A1 (es) 2002-08-01
CN1339436A (zh) 2002-03-13
DK1309582T3 (da) 2005-03-14
AU2001100278A4 (en) 2001-09-13
CA2354877C (en) 2006-05-02
US20020025982A1 (en) 2002-02-28
HK1047086A1 (en) 2003-02-07
AR029598A1 (es) 2003-07-10
NO20013943L (no) 2002-02-19
UA72340C2 (uk) 2005-02-15
GB0119733D0 (en) 2001-10-03
IL144816A0 (en) 2002-06-30
HK1044538B (zh) 2006-07-07
CA2354880A1 (en) 2002-01-22
NZ523853A (en) 2004-07-30
DK200101219A (da) 2002-02-19
CN1515564A (zh) 2004-07-28
DE60106932D1 (de) 2004-12-09
ATE281447T1 (de) 2004-11-15
YU11503A (sh) 2006-05-25
DE10140029A1 (de) 2002-05-02
BG107584A (bg) 2004-01-30
PL359969A1 (en) 2004-09-06
ZA200106683B (en) 2002-08-05
FR2813078A1 (fr) 2002-02-22

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