DK1951684T3 - Biarylmetapyrimidin-kinaseinhibitorer - Google Patents

Biarylmetapyrimidin-kinaseinhibitorer Download PDF

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DK1951684T3
DK1951684T3 DK06836583.2T DK06836583T DK1951684T3 DK 1951684 T3 DK1951684 T3 DK 1951684T3 DK 06836583 T DK06836583 T DK 06836583T DK 1951684 T3 DK1951684 T3 DK 1951684T3
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mmol
compound
mixture
filtered
concentrated
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DK06836583.2T
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John Hood
Chi Ching Mak
Andrew Mcpherson
Glenn Noronha
Ved PATHAK
Joel Renick
Richard M Soll
Binqi Zeng
Jianguo Cao
Daniel Lohse
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Targegen Inc
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Claims (19)

1. Forbindelse som vist ved: en første del, der er kemisk forbundet til en anden del, eller et farmaceutisk acceptabelt salt, hydrat, solvat eller N-oxid eller en farmaceutisk acceptabel krystalform eller individuel diastereomer deraf, hvor den første del er udvalgt fra gruppen, der består af:
og hvor den anden del er udvalgt fra gruppen, der består af:
2. Forbindelse ifølge krav 1 som vist ved:
eller et farmaceutisk acceptabelt salt deraf.
3. Forbindelse ifølge krav 1 som vist ved:
eller et farmaceutisk acceptabelt solvat eller hydrat deraf.
4. Forbindelse ifølge krav 1 som vist ved:
eller et farmaceutisk acceptabelt salt deraf.
5. Forbindelse udvalgt fra gruppen, der består af:
CLIX CIJC
CLXI CLXII eller et farmaceutisk acceptabelt salt, hydrat, solvat eller N-oxid eller en farmaceutisk acceptabel krystalform og individuelle diastereomerer deraf.
6. Farmaceutisk sammensætning, der omfatter mindst én forbindelse ifølge et hvilket som helst af kravene 1-5 eller et N-oxid deraf eller et farmaceutisk acceptabelt salt, hydrat eller solvat eller en farmaceutisk acceptabel krystalform og individuelle diastereomerer deraf og et farmaceutisk acceptabelt bæremateriale derfor.
7. Mindst én forbindelse ifølge et hvilket som helst af kravene 1-5 eller et farmaceutisk acceptabelt salt, hydrat, solvat eller N-oxid(er) eller en farmaceutisk acceptabel krystalform og individuelle diastereomerer deraf eller en sammensætning ifølge krav 6 til anvendelse til behandling af en forstyrrelse, der er forbundet med en kinase fra JAK-familien.
8. Forbindelse eller sammensætning til anvendelse ifølge krav 7, hvor forstyrrelsen er forbundet med JAK2-kinase.
9. Forbindelse eller sammensætning til anvendelse ifølge krav 7, hvor forstyrrelsen er an angiogenforbundet forstyrrelse.
10. Forbindelse eller sammensætning til anvendelse ifølge krav 7, hvor forstyrrelsen er en myeloproliferativ forstyrrelse, en cancer, en øjensygdom, inflammation, psoriasis eller en virusinfektion.
11. Forbindelse eller sammensætning til anvendelse ifølge krav 10, hvor forstyrrelsen er en øjensygdom, og øjensygdommen er proliferativ diabetisk retinopati.
12. Forbindelse eller sammensætning til anvendelse ifølge krav 7, hvor forstyrrelsen er en hvilken som helst myeloid-koblet forstyrrelse.
13. Forbindelse eller sammensætning til anvendelse ifølge krav 10, hvor forstyrrelsen er en myeloproliferativ forstyrrelse udvalgt fra gruppen, der består af polycytæmia vera, essentiel trombocytæmi og myeloid fibrose med myeloid metaplasi.
14. Forbindelse eller sammensætning til anvendelse ifølge krav 10, hvor forstyrrelsen er en cancer udvlagt fra en gruppe, der består af en cancer i fordøjelses-/mave-tarm-kanalen, coloncancer, levercancer, hudcancer, brystcancer, ovariecancer, prostatacancer, lymfom, leukæmi, nyrecancer, lungecancer, muskelcancer, knoglecancer, blærecancer og hj ernecancer.
15. Forbindelse eller sammensætning til anvendelse ifølge krav 14, hvor forstyrrelsen er leukæmi, og leukæmien er kronisk myelogen leukæmi (CML).
16. Forbindelse eller sammensætning til anvendelse ifølge krav 15, hvor den kroniske myelogene leukæmi er resistent over for aktuelle behandlinger.
17. Forbindelse eller sammensætning til anvendelse ifølge krav 10, hvor forstyrrelsen er en myeloproliferativ forstyrrelse, og den myeloproliferative forstyrrelse er opstået på grund af funktionsforøgelse af en reaktionsvej for en kinase fra JAK-familien, eller hvor forstyrrelsen er en myeloproliferativ forstyrrelse og den myeloproliferative forstyrrelse er opstået som følge af geneller proteinfusioner på grund af funktionsforøgelse af en reaktionsvej for en kinase fra JAK-familien.
18. Forbindelse ifølge krav 2 eller krav 3 eller et farmaceutisk acceptabelt salt, hydrat eller solvat eller en farmaceutisk acceptabel krystalform deraf til anvendelse til behandling af en myeloproliferativ forstyrrelse hos en person, der behov derfor.
19. Forbindelse ifølge krav 4 eller et farmaceutisk acceptabelt salt, hydrat eller solvat eller en farmaceutisk acceptabel krystalform deraf til anvendelse til behandling af en myeloproliferativ forstyrrelse hos en person, der behov derfor.
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NL301104I2 (nl) 2021-06-17
BRPI0618179A2 (pt) 2011-08-23
AU2006309013B2 (en) 2012-06-28
EP1951684A4 (en) 2011-01-12
TWI444368B (zh) 2014-07-11
BR122021011787B1 (pt) 2022-01-25
BR122021011788B1 (pt) 2022-01-25
NO342221B1 (no) 2018-04-16
EP1951684A1 (en) 2008-08-06
CY1118330T1 (el) 2017-06-28
ES2595636T3 (es) 2017-01-02
IL191167A (en) 2014-07-31
HUS2100020I1 (hu) 2021-06-28
LTPA2021509I1 (da) 2021-06-10
CY2021013I1 (el) 2021-10-15
KR101467723B1 (ko) 2014-12-03
US20070191405A1 (en) 2007-08-16
JP5191391B2 (ja) 2013-05-08
CN103626742B (zh) 2017-04-26
NZ567851A (en) 2011-09-30
US8138199B2 (en) 2012-03-20
MX362412B (es) 2019-01-15
CY2021013I2 (el) 2021-12-31
AU2006309013A1 (en) 2007-05-10
US7825246B2 (en) 2010-11-02
US7528143B2 (en) 2009-05-05
NL301104I1 (nl) 2021-05-19
NO20082447L (no) 2008-07-30
FIC20210010I1 (fi) 2021-05-12
JP2013056930A (ja) 2013-03-28
CN103626742A (zh) 2014-03-12
HUE028987T2 (en) 2017-01-30
EP1951684B1 (en) 2016-07-13
NZ592990A (en) 2013-01-25
KR20080066066A (ko) 2008-07-15
LT1951684T (lt) 2016-11-10
JP5814903B2 (ja) 2015-11-17
RU2012103851A (ru) 2013-08-10
MY167260A (en) 2018-08-14
PL1951684T3 (pl) 2017-03-31
WO2007053452A1 (en) 2007-05-10
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JP2009513703A (ja) 2009-04-02
IL191167A0 (en) 2008-12-29

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