CN102712641B - Mk2抑制剂 - Google Patents
Mk2抑制剂 Download PDFInfo
- Publication number
- CN102712641B CN102712641B CN201080056801.XA CN201080056801A CN102712641B CN 102712641 B CN102712641 B CN 102712641B CN 201080056801 A CN201080056801 A CN 201080056801A CN 102712641 B CN102712641 B CN 102712641B
- Authority
- CN
- China
- Prior art keywords
- pyridine
- pyrrolo
- piperidines
- spiral shell
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CC[C@@](C)C(C)(C)C([C@](C*1)C2C(C)C2)*11C(C)(CI(C)CC)C1CC Chemical compound CC[C@@](C)C(C)(C)C([C@](C*1)C2C(C)C2)*11C(C)(CI(C)CC)C1CC 0.000 description 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/20—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Neurosurgery (AREA)
- Otolaryngology (AREA)
- Toxicology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
Abstract
Description
Claims (16)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28609109P | 2009-12-14 | 2009-12-14 | |
EP09179043 | 2009-12-14 | ||
EP09179043.6 | 2009-12-14 | ||
US61/286091 | 2009-12-14 | ||
PCT/EP2010/069465 WO2011073119A1 (en) | 2009-12-14 | 2010-12-13 | Mk2 inhibitors |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510037679.6A Division CN104710423A (zh) | 2009-12-14 | 2010-12-13 | Mk2抑制剂 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102712641A CN102712641A (zh) | 2012-10-03 |
CN102712641B true CN102712641B (zh) | 2015-12-09 |
Family
ID=41565893
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201080056801.XA Expired - Fee Related CN102712641B (zh) | 2009-12-14 | 2010-12-13 | Mk2抑制剂 |
CN201510037679.6A Pending CN104710423A (zh) | 2009-12-14 | 2010-12-13 | Mk2抑制剂 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510037679.6A Pending CN104710423A (zh) | 2009-12-14 | 2010-12-13 | Mk2抑制剂 |
Country Status (13)
Country | Link |
---|---|
US (3) | US8772286B2 (zh) |
EP (1) | EP2513111B1 (zh) |
JP (2) | JP5859454B2 (zh) |
KR (1) | KR20120104241A (zh) |
CN (2) | CN102712641B (zh) |
AU (1) | AU2010333024B2 (zh) |
BR (1) | BR112012013199A8 (zh) |
CA (1) | CA2780290C (zh) |
HK (1) | HK1210159A1 (zh) |
IN (1) | IN2012DN04978A (zh) |
MX (1) | MX2012006778A (zh) |
RU (1) | RU2012129887A (zh) |
WO (1) | WO2011073119A1 (zh) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2012006778A (es) * | 2009-12-14 | 2012-07-23 | Msd Oss Bv | Inhibidores de proteina cinasa 2 activada por proteina cinasa activada por mitogeno. |
CN102936216B (zh) * | 2012-12-05 | 2015-03-04 | 南京药石药物研发有限公司 | 7,9-二氧代-2,6-氮杂-螺[3.5]壬-2-甲酸叔丁酯及其中间体的制备方法 |
WO2014149164A1 (en) * | 2013-03-15 | 2014-09-25 | Celgene Avilomics Research, Inc. | Mk2 inhibitors and uses thereof |
US9969726B2 (en) | 2014-06-10 | 2018-05-15 | Sanford-Burnham Medical Research Institute | Metabotropic glutamate receptor negative allosteric modulators (NAMS) and uses thereof |
CN108794496B (zh) * | 2018-04-28 | 2020-04-24 | 北京施安泰医药技术开发有限公司 | 一类cdk抑制剂、其药物组合物、制备方法及用途 |
JP7349491B2 (ja) * | 2018-07-12 | 2023-09-22 | ユーシービー バイオファルマ エスアールエル | Il-17モジュレーターとしてのスピロ環状インダン類似体 |
CN114105834B (zh) * | 2022-01-26 | 2023-04-25 | 寿光诺盟化工有限公司 | 一种n,n,n,n-四烯丙基氧代双苯磺酰胺的制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005014572A1 (en) * | 2003-08-08 | 2005-02-17 | Pharmacia Italia S.P.A. | Pyrimidylpyrrole derivatives active as kinase inhibitors |
WO2005013986A1 (en) * | 2003-08-08 | 2005-02-17 | Pharmacia Italia S.P.A. | Pyridylpyrrole derivatives active as kinase inhibitors |
WO2009010488A1 (en) * | 2007-07-16 | 2009-01-22 | Novartis Ag | Heterocyclic compounds useful as mk2 inhibitors |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2510298A1 (en) * | 2002-12-20 | 2004-07-15 | Pharmacia Corporation | Acyclic pyrazole compounds |
PT1951684T (pt) * | 2005-11-01 | 2016-10-13 | Targegen Inc | Inibidores de cinases de tipo biaril-meta-pirimidina |
MX2012006778A (es) * | 2009-12-14 | 2012-07-23 | Msd Oss Bv | Inhibidores de proteina cinasa 2 activada por proteina cinasa activada por mitogeno. |
-
2010
- 2010-12-13 MX MX2012006778A patent/MX2012006778A/es not_active Application Discontinuation
- 2010-12-13 CN CN201080056801.XA patent/CN102712641B/zh not_active Expired - Fee Related
- 2010-12-13 CA CA2780290A patent/CA2780290C/en not_active Expired - Fee Related
- 2010-12-13 RU RU2012129887/04A patent/RU2012129887A/ru not_active Application Discontinuation
- 2010-12-13 WO PCT/EP2010/069465 patent/WO2011073119A1/en active Application Filing
- 2010-12-13 US US13/514,865 patent/US8772286B2/en active Active
- 2010-12-13 AU AU2010333024A patent/AU2010333024B2/en not_active Ceased
- 2010-12-13 EP EP10795655.9A patent/EP2513111B1/en not_active Withdrawn - After Issue
- 2010-12-13 KR KR1020127015233A patent/KR20120104241A/ko not_active Application Discontinuation
- 2010-12-13 BR BR112012013199A patent/BR112012013199A8/pt active Search and Examination
- 2010-12-13 IN IN4978DEN2012 patent/IN2012DN04978A/en unknown
- 2010-12-13 CN CN201510037679.6A patent/CN104710423A/zh active Pending
- 2010-12-13 JP JP2012542575A patent/JP5859454B2/ja not_active Expired - Fee Related
-
2014
- 2014-06-05 US US14/297,167 patent/US9102676B2/en active Active
-
2015
- 2015-07-09 US US14/795,085 patent/US20160159800A1/en not_active Abandoned
- 2015-11-06 HK HK15110942.1A patent/HK1210159A1/zh unknown
- 2015-12-16 JP JP2015245246A patent/JP2016128412A/ja active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005014572A1 (en) * | 2003-08-08 | 2005-02-17 | Pharmacia Italia S.P.A. | Pyrimidylpyrrole derivatives active as kinase inhibitors |
WO2005013986A1 (en) * | 2003-08-08 | 2005-02-17 | Pharmacia Italia S.P.A. | Pyridylpyrrole derivatives active as kinase inhibitors |
WO2009010488A1 (en) * | 2007-07-16 | 2009-01-22 | Novartis Ag | Heterocyclic compounds useful as mk2 inhibitors |
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JP2016128412A (ja) | 2016-07-14 |
KR20120104241A (ko) | 2012-09-20 |
JP5859454B2 (ja) | 2016-02-10 |
US8772286B2 (en) | 2014-07-08 |
BR112012013199A2 (pt) | 2016-03-01 |
WO2011073119A1 (en) | 2011-06-23 |
US20140288109A1 (en) | 2014-09-25 |
HK1210159A1 (zh) | 2016-04-15 |
EP2513111B1 (en) | 2013-10-02 |
MX2012006778A (es) | 2012-07-23 |
IN2012DN04978A (zh) | 2015-09-25 |
CA2780290C (en) | 2018-01-02 |
JP2013513585A (ja) | 2013-04-22 |
US20160159800A1 (en) | 2016-06-09 |
CN102712641A (zh) | 2012-10-03 |
AU2010333024A1 (en) | 2012-06-14 |
CN104710423A (zh) | 2015-06-17 |
CA2780290A1 (en) | 2011-06-23 |
EP2513111A1 (en) | 2012-10-24 |
AU2010333024B2 (en) | 2014-09-18 |
US20120245175A1 (en) | 2012-09-27 |
BR112012013199A8 (pt) | 2018-01-02 |
RU2012129887A (ru) | 2014-01-27 |
US9102676B2 (en) | 2015-08-11 |
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