CN102712641A - Mk2 抑制剂 - Google Patents
Mk2 抑制剂 Download PDFInfo
- Publication number
- CN102712641A CN102712641A CN201080056801XA CN201080056801A CN102712641A CN 102712641 A CN102712641 A CN 102712641A CN 201080056801X A CN201080056801X A CN 201080056801XA CN 201080056801 A CN201080056801 A CN 201080056801A CN 102712641 A CN102712641 A CN 102712641A
- Authority
- CN
- China
- Prior art keywords
- pyridine
- compound
- alkyl
- pyrrolo
- piperidines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
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-
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P7/06—Antianaemics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/20—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Transplantation (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Communicable Diseases (AREA)
- Reproductive Health (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Otolaryngology (AREA)
Abstract
Description
Claims (16)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28609109P | 2009-12-14 | 2009-12-14 | |
US61/286091 | 2009-12-14 | ||
EP09179043.6 | 2009-12-14 | ||
EP09179043 | 2009-12-14 | ||
PCT/EP2010/069465 WO2011073119A1 (en) | 2009-12-14 | 2010-12-13 | Mk2 inhibitors |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510037679.6A Division CN104710423A (zh) | 2009-12-14 | 2010-12-13 | Mk2抑制剂 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102712641A true CN102712641A (zh) | 2012-10-03 |
CN102712641B CN102712641B (zh) | 2015-12-09 |
Family
ID=41565893
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201080056801.XA Expired - Fee Related CN102712641B (zh) | 2009-12-14 | 2010-12-13 | Mk2抑制剂 |
CN201510037679.6A Pending CN104710423A (zh) | 2009-12-14 | 2010-12-13 | Mk2抑制剂 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510037679.6A Pending CN104710423A (zh) | 2009-12-14 | 2010-12-13 | Mk2抑制剂 |
Country Status (13)
Country | Link |
---|---|
US (3) | US8772286B2 (zh) |
EP (1) | EP2513111B1 (zh) |
JP (2) | JP5859454B2 (zh) |
KR (1) | KR20120104241A (zh) |
CN (2) | CN102712641B (zh) |
AU (1) | AU2010333024B2 (zh) |
BR (1) | BR112012013199A8 (zh) |
CA (1) | CA2780290C (zh) |
HK (1) | HK1210159A1 (zh) |
IN (1) | IN2012DN04978A (zh) |
MX (1) | MX2012006778A (zh) |
RU (1) | RU2012129887A (zh) |
WO (1) | WO2011073119A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102936216A (zh) * | 2012-12-05 | 2013-02-20 | 南京药石药物研发有限公司 | 7,9-二氧代-2,6-氮杂-螺[3.5]壬-2-甲酸叔丁酯及其中间体的制备方法 |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2780290C (en) * | 2009-12-14 | 2018-01-02 | Msd Oss B.V. | Mk2 inhibitors |
KR20150133172A (ko) * | 2013-03-15 | 2015-11-27 | 셀진 아빌로믹스 리서치, 인코포레이티드 | Mk2 억제제 및 이의 용도 |
US9969726B2 (en) | 2014-06-10 | 2018-05-15 | Sanford-Burnham Medical Research Institute | Metabotropic glutamate receptor negative allosteric modulators (NAMS) and uses thereof |
CN108794496B (zh) * | 2018-04-28 | 2020-04-24 | 北京施安泰医药技术开发有限公司 | 一类cdk抑制剂、其药物组合物、制备方法及用途 |
CN112334192A (zh) * | 2018-07-12 | 2021-02-05 | Ucb生物制药有限责任公司 | 作为il-17调节剂的螺环茚满类似物 |
CN114105834B (zh) * | 2022-01-26 | 2023-04-25 | 寿光诺盟化工有限公司 | 一种n,n,n,n-四烯丙基氧代双苯磺酰胺的制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005014572A1 (en) * | 2003-08-08 | 2005-02-17 | Pharmacia Italia S.P.A. | Pyrimidylpyrrole derivatives active as kinase inhibitors |
WO2005013986A1 (en) * | 2003-08-08 | 2005-02-17 | Pharmacia Italia S.P.A. | Pyridylpyrrole derivatives active as kinase inhibitors |
WO2009010488A1 (en) * | 2007-07-16 | 2009-01-22 | Novartis Ag | Heterocyclic compounds useful as mk2 inhibitors |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003297431A1 (en) * | 2002-12-20 | 2004-07-22 | Pharmacia Corporation | Mitogen activated protein kinase-activated protein kinase-2 inhibiting compounds |
NZ567851A (en) * | 2005-11-01 | 2011-09-30 | Targegen Inc | Bi-aryl meta-pyrimidine inhibitors of kinases |
CA2780290C (en) * | 2009-12-14 | 2018-01-02 | Msd Oss B.V. | Mk2 inhibitors |
-
2010
- 2010-12-13 CA CA2780290A patent/CA2780290C/en not_active Expired - Fee Related
- 2010-12-13 RU RU2012129887/04A patent/RU2012129887A/ru not_active Application Discontinuation
- 2010-12-13 CN CN201080056801.XA patent/CN102712641B/zh not_active Expired - Fee Related
- 2010-12-13 EP EP10795655.9A patent/EP2513111B1/en not_active Withdrawn - After Issue
- 2010-12-13 CN CN201510037679.6A patent/CN104710423A/zh active Pending
- 2010-12-13 IN IN4978DEN2012 patent/IN2012DN04978A/en unknown
- 2010-12-13 US US13/514,865 patent/US8772286B2/en active Active
- 2010-12-13 KR KR1020127015233A patent/KR20120104241A/ko not_active Application Discontinuation
- 2010-12-13 JP JP2012542575A patent/JP5859454B2/ja not_active Expired - Fee Related
- 2010-12-13 WO PCT/EP2010/069465 patent/WO2011073119A1/en active Application Filing
- 2010-12-13 MX MX2012006778A patent/MX2012006778A/es not_active Application Discontinuation
- 2010-12-13 AU AU2010333024A patent/AU2010333024B2/en not_active Ceased
- 2010-12-13 BR BR112012013199A patent/BR112012013199A8/pt active Search and Examination
-
2014
- 2014-06-05 US US14/297,167 patent/US9102676B2/en active Active
-
2015
- 2015-07-09 US US14/795,085 patent/US20160159800A1/en not_active Abandoned
- 2015-11-06 HK HK15110942.1A patent/HK1210159A1/zh unknown
- 2015-12-16 JP JP2015245246A patent/JP2016128412A/ja active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005014572A1 (en) * | 2003-08-08 | 2005-02-17 | Pharmacia Italia S.P.A. | Pyrimidylpyrrole derivatives active as kinase inhibitors |
WO2005013986A1 (en) * | 2003-08-08 | 2005-02-17 | Pharmacia Italia S.P.A. | Pyridylpyrrole derivatives active as kinase inhibitors |
WO2009010488A1 (en) * | 2007-07-16 | 2009-01-22 | Novartis Ag | Heterocyclic compounds useful as mk2 inhibitors |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102936216A (zh) * | 2012-12-05 | 2013-02-20 | 南京药石药物研发有限公司 | 7,9-二氧代-2,6-氮杂-螺[3.5]壬-2-甲酸叔丁酯及其中间体的制备方法 |
CN102936216B (zh) * | 2012-12-05 | 2015-03-04 | 南京药石药物研发有限公司 | 7,9-二氧代-2,6-氮杂-螺[3.5]壬-2-甲酸叔丁酯及其中间体的制备方法 |
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KR20120104241A (ko) | 2012-09-20 |
EP2513111B1 (en) | 2013-10-02 |
AU2010333024A1 (en) | 2012-06-14 |
CA2780290A1 (en) | 2011-06-23 |
JP2013513585A (ja) | 2013-04-22 |
CN102712641B (zh) | 2015-12-09 |
EP2513111A1 (en) | 2012-10-24 |
HK1210159A1 (zh) | 2016-04-15 |
RU2012129887A (ru) | 2014-01-27 |
US20160159800A1 (en) | 2016-06-09 |
US20120245175A1 (en) | 2012-09-27 |
MX2012006778A (es) | 2012-07-23 |
US20140288109A1 (en) | 2014-09-25 |
CA2780290C (en) | 2018-01-02 |
BR112012013199A8 (pt) | 2018-01-02 |
BR112012013199A2 (pt) | 2016-03-01 |
WO2011073119A1 (en) | 2011-06-23 |
CN104710423A (zh) | 2015-06-17 |
JP5859454B2 (ja) | 2016-02-10 |
US9102676B2 (en) | 2015-08-11 |
US8772286B2 (en) | 2014-07-08 |
JP2016128412A (ja) | 2016-07-14 |
IN2012DN04978A (zh) | 2015-09-25 |
AU2010333024B2 (en) | 2014-09-18 |
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