DK168754B1 - Farmaceutiske kompositioner indeholdende geminale diphosphonsyreforbindelser samt specifikke sådanne forbindelser - Google Patents
Farmaceutiske kompositioner indeholdende geminale diphosphonsyreforbindelser samt specifikke sådanne forbindelser Download PDFInfo
- Publication number
- DK168754B1 DK168754B1 DK599685A DK599685A DK168754B1 DK 168754 B1 DK168754 B1 DK 168754B1 DK 599685 A DK599685 A DK 599685A DK 599685 A DK599685 A DK 599685A DK 168754 B1 DK168754 B1 DK 168754B1
- Authority
- DK
- Denmark
- Prior art keywords
- diphosphonic acid
- amino
- hydrocarbon chain
- pyridyl
- hydroxy
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 33
- 150000001875 compounds Chemical class 0.000 title claims description 34
- XQRLCLUYWUNEEH-UHFFFAOYSA-N diphosphonic acid Chemical group OP(=O)OP(O)=O XQRLCLUYWUNEEH-UHFFFAOYSA-N 0.000 title claims description 11
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 37
- 239000011575 calcium Substances 0.000 claims abstract description 37
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 37
- 229910019142 PO4 Inorganic materials 0.000 claims abstract description 18
- 230000002159 abnormal effect Effects 0.000 claims abstract description 18
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims abstract description 18
- 239000010452 phosphate Substances 0.000 claims abstract description 18
- 230000004060 metabolic process Effects 0.000 claims abstract description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 8
- 201000010099 disease Diseases 0.000 claims abstract description 4
- -1 diphosphonic acid compound Chemical group 0.000 claims description 84
- 229910052739 hydrogen Inorganic materials 0.000 claims description 43
- 239000001257 hydrogen Substances 0.000 claims description 42
- FRCICXIVPRNPLM-UHFFFAOYSA-N [amino(phosphono)methyl]phosphonic acid Chemical compound OP(=O)(O)C(N)P(O)(O)=O FRCICXIVPRNPLM-UHFFFAOYSA-N 0.000 claims description 34
- 125000001424 substituent group Chemical group 0.000 claims description 34
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims description 30
- 150000003839 salts Chemical class 0.000 claims description 30
- 150000002148 esters Chemical class 0.000 claims description 29
- 150000002431 hydrogen Chemical class 0.000 claims description 28
- 125000003118 aryl group Chemical group 0.000 claims description 23
- 125000004432 carbon atom Chemical group C* 0.000 claims description 23
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 23
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims description 22
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- 239000002253 acid Substances 0.000 claims description 22
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 22
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 20
- 229920006395 saturated elastomer Polymers 0.000 claims description 20
- MGRVRXRGTBOSHW-UHFFFAOYSA-N (aminomethyl)phosphonic acid Chemical compound NCP(O)(O)=O MGRVRXRGTBOSHW-UHFFFAOYSA-N 0.000 claims description 19
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- 230000000144 pharmacologic effect Effects 0.000 claims description 15
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- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical group C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 claims description 10
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical group C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims description 9
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- 238000000034 method Methods 0.000 abstract description 7
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/650905—Six-membered rings having the nitrogen atoms in the positions 1 and 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Output Control And Ontrol Of Special Type Engine (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68454384A | 1984-12-21 | 1984-12-21 | |
US68454384 | 1984-12-21 |
Publications (3)
Publication Number | Publication Date |
---|---|
DK599685D0 DK599685D0 (da) | 1985-12-20 |
DK599685A DK599685A (da) | 1986-06-22 |
DK168754B1 true DK168754B1 (da) | 1994-06-06 |
Family
ID=24748488
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK599685A DK168754B1 (da) | 1984-12-21 | 1985-12-20 | Farmaceutiske kompositioner indeholdende geminale diphosphonsyreforbindelser samt specifikke sådanne forbindelser |
Country Status (11)
Country | Link |
---|---|
US (1) | US5583122A (de) |
EP (1) | EP0186405B1 (de) |
AT (1) | ATE61370T1 (de) |
DE (2) | DE10075030I2 (de) |
DK (1) | DK168754B1 (de) |
ES (4) | ES8707543B9 (de) |
IE (1) | IE58749B1 (de) |
IL (1) | IL77243A (de) |
LU (1) | LU90669I2 (de) |
NL (1) | NL300031I2 (de) |
ZA (1) | ZA859694B (de) |
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US4134969A (en) * | 1974-02-04 | 1979-01-16 | Henkel Kommanditgesellschaft Auf Aktien (Henkel Kgaa) | Method of treatment of calcium disorders using aminoalkane-diphosphonic acids |
DE2456666A1 (de) * | 1974-11-30 | 1976-08-12 | Henkel & Cie Gmbh | Verfahren zum stabilisieren von calcium-hydrogenphosphat-dihydrat gegen hydrolyse |
DE2513966C2 (de) * | 1975-03-29 | 1983-06-23 | Henkel KGaA, 4000 Düsseldorf | Piperidon-6,6-diphosphonsäure und Verfahren zu deren Herstellung |
DE2541981A1 (de) * | 1975-09-20 | 1977-03-24 | Bayer Ag | Verfahren zur herstellung von azacycloalkandiphosphonsaeuren |
JPS5359674A (en) * | 1976-10-25 | 1978-05-29 | Nissan Chem Ind Ltd | 1-piperidinoalkane-1,1-diphosphonic acid derivatives and herbicidescontaining the same as active agent |
US4239695A (en) * | 1977-03-24 | 1980-12-16 | Magna Corporation | Method of preparing phosphonates from nitriles |
US4100167A (en) * | 1977-05-09 | 1978-07-11 | Nalco Chemical Company | Production of 1-aminoalkane-1, 1-diphosphonic acids using phosphorous acid and nitriles in a non-aqueous system |
US4447256A (en) * | 1977-07-20 | 1984-05-08 | Nissan Chemical Industries, Ltd. | N-(Unsubstituted or substituted pyridyl)aminomethylene-diphosphonic acids, herbicidal compositions containing same, their use for herbicides, and process for preparing same |
DE2831578A1 (de) * | 1977-07-20 | 1979-02-01 | Nissan Chemical Ind Ltd | N-pyridylaminomethylendiphosphonsaeureverbindungen |
DE2745083C2 (de) * | 1977-10-07 | 1985-05-02 | Henkel KGaA, 4000 Düsseldorf | Hydroxydiphosphonsäuren und Verfahren zu deren Herstellung |
DE2755940C2 (de) * | 1977-12-15 | 1986-01-02 | Basf Ag, 6700 Ludwigshafen | Mittel zur Regulierung des Pflanzenwachstums |
JPS54135724A (en) * | 1978-04-11 | 1979-10-22 | Nissan Chem Ind Ltd | Preparation of amino-methylenedisulfonic acid derivative |
JPS5598193A (en) * | 1979-01-22 | 1980-07-25 | Nissan Chem Ind Ltd | Methylenediphosphonic acid derivative and herbicide comprising it as active constituent |
DE3016289A1 (de) * | 1980-04-28 | 1981-10-29 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren |
US4304734A (en) * | 1980-10-16 | 1981-12-08 | Vysoka Skola Chemicko-Technologicka | 6-Amino-1-hydroxyhexylidene diphosphonic acid, salts and a process for production thereof |
DE3203308A1 (de) * | 1982-01-27 | 1983-07-28 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Diphosphonsaeure-derivate und diese enthaltende pharmazeutische praeparate |
DE3365492D1 (en) * | 1982-01-27 | 1986-10-02 | Schering Ag | Diphosphonic acid derivatives and pharmaceutical preparations containing them |
DE3208600A1 (de) * | 1982-03-10 | 1983-09-22 | Henkel KGaA, 4000 Düsseldorf | Amidinodiphosphonsaeuren |
IT1201087B (it) * | 1982-04-15 | 1989-01-27 | Gentili Ist Spa | Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche |
FR2531088B1 (fr) * | 1982-07-29 | 1987-08-28 | Sanofi Sa | Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation |
DE3425812A1 (de) * | 1984-07-13 | 1986-01-16 | Deutsches Krebsforschungszentrum, 6900 Heidelberg | Neue 1-hydroxy-1,1-diphosphonsaeureverbindungen, verfahren zu ihrer herstellung und pharmakologische zubereitungen, insbesondere zur behandlung von knochentumoren |
CH664158A5 (fr) * | 1984-07-18 | 1988-02-15 | Symphar Sa | Derives propylidenediphosphonates-1,3 substitues en position 2, leur procede de preparation et compositions pharmaceutiques les contenant. |
DE3428524A1 (de) * | 1984-08-02 | 1986-02-13 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
US4687768A (en) * | 1984-12-21 | 1987-08-18 | The Procter & Gamble Company | Certain hexahydroindan-2,2-diphosphonic acids useful in treating diseases associated with abnormal calcium and phosphate metabolism |
DE3540150A1 (de) * | 1985-11-13 | 1987-05-14 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
DE3626058A1 (de) * | 1986-08-01 | 1988-02-11 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
-
1985
- 1985-12-05 IL IL7724385A patent/IL77243A/en not_active IP Right Cessation
- 1985-12-06 US US06/806,155 patent/US5583122A/en not_active Expired - Lifetime
- 1985-12-16 AT AT85309140T patent/ATE61370T1/de active
- 1985-12-16 EP EP85309140A patent/EP0186405B1/de not_active Expired - Lifetime
- 1985-12-16 DE DE2000175030 patent/DE10075030I2/de active Active
- 1985-12-16 DE DE8585309140T patent/DE3582033D1/de not_active Expired - Lifetime
- 1985-12-19 ZA ZA859694A patent/ZA859694B/xx unknown
- 1985-12-20 ES ES000550302D patent/ES8707543B9/es not_active Expired - Lifetime
- 1985-12-20 DK DK599685A patent/DK168754B1/da not_active IP Right Cessation
- 1985-12-20 ES ES550302A patent/ES8707543A1/es not_active Expired
- 1985-12-21 IE IE328685A patent/IE58749B1/en not_active IP Right Cessation
-
1987
- 1987-01-16 ES ES557322D patent/ES8802428B9/es not_active Expired - Lifetime
- 1987-01-16 ES ES557322A patent/ES8802428A1/es not_active Expired
-
2000
- 2000-11-10 LU LU90669C patent/LU90669I2/fr unknown
- 2000-12-01 NL NL300031C patent/NL300031I2/nl unknown
Also Published As
Publication number | Publication date |
---|---|
US5583122A (en) | 1996-12-10 |
IL77243A (en) | 1996-11-14 |
ES8707543B9 (es) | 2013-05-08 |
ATE61370T1 (de) | 1991-03-15 |
ZA859694B (en) | 1986-08-27 |
NL300031I2 (nl) | 2001-03-01 |
NL300031I1 (nl) | 2001-02-01 |
IE58749B1 (en) | 1993-11-03 |
DE3582033D1 (de) | 1991-04-11 |
LU90669I2 (fr) | 2001-01-10 |
IE853286L (en) | 1986-06-21 |
ES550302A0 (es) | 1987-08-01 |
ES557322A0 (es) | 1988-06-01 |
ES8802428A1 (es) | 1988-06-01 |
EP0186405A2 (de) | 1986-07-02 |
EP0186405A3 (en) | 1987-10-28 |
DE10075030I2 (de) | 2004-01-29 |
DK599685A (da) | 1986-06-22 |
DK599685D0 (da) | 1985-12-20 |
ES8802428B9 (en) | 2011-08-25 |
DE10075030I1 (de) | 2000-12-21 |
EP0186405B1 (de) | 1991-03-06 |
ES8707543A1 (es) | 1987-08-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B1 | Patent granted (law 1993) | ||
PUP | Patent expired |