JPS54135724A - Preparation of amino-methylenedisulfonic acid derivative - Google Patents
Preparation of amino-methylenedisulfonic acid derivativeInfo
- Publication number
- JPS54135724A JPS54135724A JP4234978A JP4234978A JPS54135724A JP S54135724 A JPS54135724 A JP S54135724A JP 4234978 A JP4234978 A JP 4234978A JP 4234978 A JP4234978 A JP 4234978A JP S54135724 A JPS54135724 A JP S54135724A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- amino
- preparation
- dialkyl phosphite
- acid derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To obtain the title compound usable as main constituents of chelating agents, detergents, etc. according to a novel method in high yield with ease, by reacting a dialkyl phosphite with an alkyl orthoformate and a specific amine, and by hydrolyzing the reaction product.
CONSTITUTION: A dialkyl phosphite of formula I: (R' is lower alkyl group) is reacted with an alkyl orthoformate of formula II: (R is R1) and an organic primary or secondary amine having a boiling point higher than that of a lower alcohol of the formula R-OH under heating to form an amino methylene-diphosphonate of formula III, which is then hydrolyzed to give the objective compound of formula IV, e.g. N- (p-tolyl)-aminomethylene-diphosphonic acid. A high-boiling monoalkylamine, dialkenylamine, dialkylamine, or piperidine may be cited as the specific amine.
USE: Active ingredients of herbicides.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4234978A JPS54135724A (en) | 1978-04-11 | 1978-04-11 | Preparation of amino-methylenedisulfonic acid derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4234978A JPS54135724A (en) | 1978-04-11 | 1978-04-11 | Preparation of amino-methylenedisulfonic acid derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS54135724A true JPS54135724A (en) | 1979-10-22 |
Family
ID=12633543
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4234978A Pending JPS54135724A (en) | 1978-04-11 | 1978-04-11 | Preparation of amino-methylenedisulfonic acid derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54135724A (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0274346A1 (en) * | 1986-11-21 | 1988-07-13 | Ciba-Geigy Ag | Substituted aminomethane-diphosphonic acids |
US4929606A (en) * | 1987-11-13 | 1990-05-29 | Ciba-Geigy Corporation | Azacycloalkylalkanediphosphonic acids useful for treating diseases attributed to calcium metabolism disorders |
EP0563730A2 (en) * | 1992-03-28 | 1993-10-06 | Hoechst Aktiengesellschaft | Alkenylaminoalkylene phosphonic acid esters and process for the preparation of copolymers comprising alkenylaminoalkylene phosphonates and ethylenic unsaturated compounds |
EP0563729A2 (en) * | 1992-03-28 | 1993-10-06 | Hoechst Aktiengesellschaft | Alkenylaminoalkane-1,1-disphosphonic acid derivatives and its copolymers with unsaturated carboxylic acids |
JPH06172372A (en) * | 1991-11-06 | 1994-06-21 | Takeda Chem Ind Ltd | Squalene synthetase inhibitor and its use |
US5574024A (en) * | 1987-07-06 | 1996-11-12 | Ebetino; Frank H. | Methylene phosphonoalkylphosphinates, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism |
US5583122A (en) * | 1984-12-21 | 1996-12-10 | The Procter & Gamble Company | Pharmaceutical compositions containing geminal diphosphonates |
WO2021028496A1 (en) * | 2018-08-15 | 2021-02-18 | Chemische Fabrik Budenheim Kg | Polymer composition comprising phosphonate flame retardant |
-
1978
- 1978-04-11 JP JP4234978A patent/JPS54135724A/en active Pending
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5583122A (en) * | 1984-12-21 | 1996-12-10 | The Procter & Gamble Company | Pharmaceutical compositions containing geminal diphosphonates |
EP0274346A1 (en) * | 1986-11-21 | 1988-07-13 | Ciba-Geigy Ag | Substituted aminomethane-diphosphonic acids |
US5574024A (en) * | 1987-07-06 | 1996-11-12 | Ebetino; Frank H. | Methylene phosphonoalkylphosphinates, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism |
US4929606A (en) * | 1987-11-13 | 1990-05-29 | Ciba-Geigy Corporation | Azacycloalkylalkanediphosphonic acids useful for treating diseases attributed to calcium metabolism disorders |
JPH06172372A (en) * | 1991-11-06 | 1994-06-21 | Takeda Chem Ind Ltd | Squalene synthetase inhibitor and its use |
EP0563729A3 (en) * | 1992-03-28 | 1994-07-20 | Hoechst Ag | Alkenylaminoalkane-1,1-disphosphonic acid derivatives and its copolymers with unsaturated carboxylic acids |
US5302677A (en) * | 1992-03-28 | 1994-04-12 | Hoechst Aktiengesellschaft | Alkenylaminoalkane-1,1-diphosphonic acid derivatives and copolymers thereof with unsaturated carboxylic acids |
EP0563729A2 (en) * | 1992-03-28 | 1993-10-06 | Hoechst Aktiengesellschaft | Alkenylaminoalkane-1,1-disphosphonic acid derivatives and its copolymers with unsaturated carboxylic acids |
EP0563730A2 (en) * | 1992-03-28 | 1993-10-06 | Hoechst Aktiengesellschaft | Alkenylaminoalkylene phosphonic acid esters and process for the preparation of copolymers comprising alkenylaminoalkylene phosphonates and ethylenic unsaturated compounds |
WO2021028496A1 (en) * | 2018-08-15 | 2021-02-18 | Chemische Fabrik Budenheim Kg | Polymer composition comprising phosphonate flame retardant |
CN112805323A (en) * | 2018-08-15 | 2021-05-14 | 化学制造布敦海姆两合公司 | Polymer compositions with phosphonate flame retardants |
JP2021534279A (en) * | 2018-08-15 | 2021-12-09 | ケミッシュ ファブリーク ブーデンハイム カーゲーChemische Fabrik Budenheim Kg | Phosphonate flame retardant and polymer composition |
CN114258415A (en) * | 2018-08-15 | 2022-03-29 | 化学制造布敦海姆两合公司 | Polymer compounds containing phosphonate flame retardants |
US11692077B2 (en) | 2018-08-15 | 2023-07-04 | Chemische Fabrik Budenheim Kg | Polymer composition containing a phosphonate flame retardant |
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