DE10075030I2 - Pharmazeutische Zusammensetzungen, die geminale Diphosphonate enthalten. - Google Patents

Pharmazeutische Zusammensetzungen, die geminale Diphosphonate enthalten.

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Publication number
DE10075030I2
DE10075030I2 DE2000175030 DE10075030C DE10075030I2 DE 10075030 I2 DE10075030 I2 DE 10075030I2 DE 2000175030 DE2000175030 DE 2000175030 DE 10075030 C DE10075030 C DE 10075030C DE 10075030 I2 DE10075030 I2 DE 10075030I2
Authority
DE
Germany
Prior art keywords
pharmaceutical compositions
compositions containing
geminal diphosphonates
containing geminal
diphosphonates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE2000175030
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English (en)
Other versions
DE10075030I1 (de
Inventor
James John Benedict
Christopher Mark Perkins
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24748488&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE10075030(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Application granted granted Critical
Publication of DE10075030I1 publication Critical patent/DE10075030I1/de
Publication of DE10075030I2 publication Critical patent/DE10075030I2/de
Active legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/3804Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
    • C07F9/3839Polyphosphonic acids
    • C07F9/3873Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576Six-membered rings
    • C07F9/58Pyridine rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509Six-membered rings
    • C07F9/650905Six-membered rings having the nitrogen atoms in the positions 1 and 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509Six-membered rings
    • C07F9/650952Six-membered rings having the nitrogen atoms in the positions 1 and 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509Six-membered rings
    • C07F9/6512Six-membered rings having the nitrogen atoms in positions 1 and 3
DE2000175030 1984-12-21 1985-12-16 Pharmazeutische Zusammensetzungen, die geminale Diphosphonate enthalten. Active DE10075030I2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68454384A 1984-12-21 1984-12-21

Publications (2)

Publication Number Publication Date
DE10075030I1 DE10075030I1 (de) 2000-12-21
DE10075030I2 true DE10075030I2 (de) 2004-01-29

Family

ID=24748488

Family Applications (2)

Application Number Title Priority Date Filing Date
DE2000175030 Active DE10075030I2 (de) 1984-12-21 1985-12-16 Pharmazeutische Zusammensetzungen, die geminale Diphosphonate enthalten.
DE8585309140T Expired - Lifetime DE3582033D1 (de) 1984-12-21 1985-12-16 Pharmazeutische zusammensetzungen, die geminale diphosphonate enthalten.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE8585309140T Expired - Lifetime DE3582033D1 (de) 1984-12-21 1985-12-16 Pharmazeutische zusammensetzungen, die geminale diphosphonate enthalten.

Country Status (11)

Country Link
US (1) US5583122A (de)
EP (1) EP0186405B1 (de)
AT (1) ATE61370T1 (de)
DE (2) DE10075030I2 (de)
DK (1) DK168754B1 (de)
ES (4) ES8707543A1 (de)
IE (1) IE58749B1 (de)
IL (1) IL77243A (de)
LU (1) LU90669I2 (de)
NL (1) NL300031I2 (de)
ZA (1) ZA859694B (de)

Families Citing this family (127)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4902679A (en) * 1985-12-13 1990-02-20 Norwich Eaton Pharmaceuticals, Inc. Methods of treating diseases with certain geminal diphosphonates
DE10199052I1 (de) * 1986-11-21 2002-01-10 Novartis Ag Neue substituierte Alkandiphosphonsaeuren
IL84494A (en) * 1986-11-21 1992-08-18 Ciba Geigy Ag Heteroaryl substituted aminomethane-diphosphonic acids,their preparation and pharmaceutical compositions containing them
ATE64397T1 (de) * 1986-11-21 1991-06-15 Ciba Geigy Ag Aromatisch substituierte azacycloalkylalkandiphosphons|uren.
US5057505A (en) * 1986-11-21 1991-10-15 Ciba-Geigy Corporation Substituted aminomethanediphosphonic acids and use in medicaments
DE3640938A1 (de) * 1986-11-29 1988-06-01 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindung enthaltende arzneimittel
IL84731A0 (en) * 1986-12-19 1988-05-31 Norwich Eaton Pharma Heterocycle-substituted diphosphonic acids and salts and esters and pharmaceutical compositions containing them
FR2611203B1 (fr) * 1987-02-20 1989-06-09 Sturtz Georges Analogues gem-diphosphoniques d'amethopterine (methotrexate) et de derives deaza-n-10 amethopterine. leur preparation et les compositions pharmaceutiques qui les contiennent
DK126888A (da) * 1987-03-10 1988-09-11 Yamanouchi Pharma Co Ltd Bisphosphonsyrederivater og terapeutiske praeparater indeholdende disse forbindelser
EP0282309A3 (de) * 1987-03-11 1990-03-14 Yamanouchi Pharmaceutical Co. Ltd. Azolaminomethylenbiphosphonsäurederivate
IL86951A (en) * 1987-07-06 1996-07-23 Procter & Gamble Pharma Methylene phosphonoalkylphosphinates and pharmaceutical preparations containing them
EP0317505A1 (de) * 1987-11-13 1989-05-24 Ciba-Geigy Ag Neue Azacycloalkylalkandiphosphonsäuren
ATE90353T1 (de) * 1987-12-11 1993-06-15 Ciba Geigy Ag Araliphatylaminoalkandiphosphonsaeuren.
US5110807A (en) * 1988-12-01 1992-05-05 Ciba-Geigy Corporation Araliphatylaminoalkanediphosphonic acids
US5190930A (en) * 1987-12-11 1993-03-02 Ciba-Geigy Corporation Araliphatylaminoalkanediphosphonic acids
US4933472A (en) * 1988-04-08 1990-06-12 Yamanouchi Pharmaceutical Co., Ltd. Substituted aminomethylenebis(phosphonic acid) derivatives
DE3822650A1 (de) * 1988-07-05 1990-02-01 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
TW198039B (de) * 1988-11-28 1993-01-11 Ciba Geigy Ag
IL92586A (en) * 1988-12-14 1994-06-24 Pfizer History of 5-hydroxy and 5-methoxy-2-aminopyrimidines as inhibitors of interleukin-1 formation
PH26923A (en) * 1989-03-08 1992-12-03 Ciba Geigy N-substituted amino alkanediphosphonic acids
FI83421C (fi) * 1989-06-21 1991-07-10 Huhtamaeki Oy Foerfarande foer framstaellning av farmakologiskt anvaendbara metylenbisfosfonsyraderivat.
US5139786A (en) * 1989-07-07 1992-08-18 Ciba-Geigy Corporation Topical formulations
MX21452A (es) * 1989-07-07 1994-01-31 Ciba Geigy Ag Preparaciones farmaceuticas que se administran en forma topica.
FI89366C (fi) * 1990-12-20 1993-09-27 Leiras Oy Foerfarande foer framstaellning av nya farmakologiskt anvaendbara metylenbisfosfonsyraderivat
ATE164163T1 (de) * 1991-06-19 1998-04-15 Upjohn Co Dialkyl (dialkoxyphosphinyl)methyl phosphate als antientzündungsmittel
EP0522576A3 (en) * 1991-07-12 1993-07-14 Hoechst Aktiengesellschaft Aminoethane-1,1-bisphosphonic acids and aminoethane-1,1-alkylphospinic/phosphonic acids, process of their preparation and their use
DE69231313T2 (de) * 1991-11-22 2001-03-15 Procter & Gamble Pharma Risedronat enthaltende Arzneimittel mit verzögerter Wirkstoffabgabe
US6096342A (en) * 1997-03-12 2000-08-01 The Procter & Gamble Company Dosage forms of risedronate
TW222637B (de) * 1991-12-12 1994-04-21 Hoechst Ag
DE4141928A1 (de) * 1991-12-19 1993-06-24 Boehringer Mannheim Gmbh Neue phosphonobernsteinsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US5283057A (en) * 1992-04-24 1994-02-01 The Procter & Gamble Company Risedronate in oral compositions
SK145594A3 (en) * 1992-05-29 1995-07-11 Procter & Gamble Pharma Phosphonosulfonate compounds for treating abnormal calcium and phosphate metabolism
SK144894A3 (en) * 1992-05-29 1995-07-11 Procter & Gamble Pharma Quaternary nitrogen-containing phosphonate compounds for treating abnormal calcium and phosphate metabolism as well as dental calculus and plaque
US5391743A (en) * 1992-05-29 1995-02-21 Procter & Gamble Pharmaceuticals, Inc. Quaternary nitrogen-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism and methods of treating and preventing dental calculus and plaque
IL105838A (en) * 1992-05-29 1998-03-10 Procter & Gamble Pharma Pharmaceutical compositions containing phosphonocarboxylates and some novel compounds of this type
US5763611A (en) * 1992-05-29 1998-06-09 The Procter & Gamble Company Thio-substituted cyclic phosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism
US5753634A (en) * 1992-05-29 1998-05-19 The Procter & Gamble Company Quaternary nitrogen containing phosphonate compounds, pharmaceutical compostions, and methods for treating abnormal calcium and phosphate metabolism
RU2136691C1 (ru) * 1992-05-29 1999-09-10 Дзе Проктер энд Гэмбл Фармасьютикалз, Инк. Серусодержащие фосфоновые кислоты или их фармацевтически приемлемые соли или эфиры и фармацевтическая композиция на их основе
WO1993024500A1 (en) * 1992-05-29 1993-12-09 The Procter & Gamble Pharmaceuticals, Inc. Thio-substituted nitrogen-containing heterocyclic phosphonate compounds for treating abnormal calcium and phosphate metabolism
US5731299A (en) * 1992-05-29 1998-03-24 The Procter & Gamble Company Phosphonosulfonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism
US5760021A (en) * 1992-05-29 1998-06-02 The Procter & Gamble Company Phosphonocarboxylate compounds pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism
HUT72437A (en) * 1992-06-30 1996-04-29 Procter & Gamble Pharma Compositions for the treatment of arthritis containing phosphonates and nsaids
WO1994000129A1 (en) * 1992-06-30 1994-01-06 Procter & Gamble Pharmaceuticals, Inc. Use of phosphonates for the treatment of osteoporosis
US5635495A (en) * 1992-10-09 1997-06-03 The Upjohn Company Pyrimidine bisphosphonate esters and (alkoxymethylphosphinyl)alkyl phosphonic acids as anti-inflammatories
DE59309360D1 (de) * 1992-12-02 1999-03-18 Hoechst Ag Guanidinalkyl-1, 1-bisphosphonsäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung
CN1043423C (zh) * 1993-01-02 1999-05-19 曼海姆泊灵格股份公司 新膦酰基琥珀酸衍生物及其制备方法和含这些化合物的药物组合物
FR2703590B1 (fr) * 1993-04-05 1995-06-30 Sanofi Elf Utilisation de derives d'acide bisphosphonique pour la preparation de medicaments destines a favoriser la reparation osseuse .
JPH06298779A (ja) * 1993-04-15 1994-10-25 Hoechst Japan Ltd ヘテロ環イミノビスメチレンビスホスホン酸誘導体
US5451401A (en) * 1993-09-29 1995-09-19 The Procter & Gamble Company Diphosphonic acid esters as tartar control agents
US5728650A (en) * 1993-10-07 1998-03-17 Zeneca Limited Herbicidal aza bisphosphonic acids and compositions containing the same
US20010007863A1 (en) * 1998-06-18 2001-07-12 Merck & Co., Inc. Wet granulation formulation for bisphosphonic acids
SE9402001D0 (sv) * 1994-06-09 1994-06-09 Leiras Oy Pyridylbisphosphonates for use as a therapeutical agent
US5880111A (en) * 1995-06-07 1999-03-09 Farcasiu; Dan Therapeutic derivations of diphosphonates
US20010031244A1 (en) * 1997-06-13 2001-10-18 Chiesi Farmaceutici S.P.A. Pharmaceutical aerosol composition
US6432932B1 (en) 1997-07-22 2002-08-13 Merck & Co., Inc. Method for inhibiting bone resorption
US5994329A (en) 1997-07-22 1999-11-30 Merck & Co., Inc. Method for inhibiting bone resorption
IT1303672B1 (it) * 1998-07-28 2001-02-23 Nicox Sa Sali nitrati di farmaci attivi nei disordini ossei
EP1112275B9 (de) 1998-09-09 2004-03-10 Metabasis Therapeutics, Inc. Neue heteroaromatische fructose 1,6-bisphosphatase inhibitoren
US7205404B1 (en) * 1999-03-05 2007-04-17 Metabasis Therapeutics, Inc. Phosphorus-containing prodrugs
US20020103161A1 (en) * 1999-12-17 2002-08-01 Manfred Weigele Novel heterocycles
IL150062A0 (en) 1999-12-17 2002-12-01 Ariad Pharma Inc Proton pump inhibitors
IL150059A0 (en) * 1999-12-17 2002-12-01 Ariad Pharma Inc Novel heterocycles
US6562974B2 (en) 2000-02-01 2003-05-13 The Procter & Gamble Company Process for making geminal bisphosphonates
US6410520B2 (en) * 2000-02-01 2002-06-25 The Procter & Gamble Company Selective crystallization of 3-pyridyl-1-hydroxyethylidene-1, 1-bisphosphonic acid sodium as the hemipentahydrate or monohydrate
US7563774B2 (en) 2000-06-29 2009-07-21 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes
PL194770B1 (pl) * 2001-03-19 2007-07-31 Adamed Sp Z Oo Sposób wytwarzania kwasu rizedronowego
US20060269602A1 (en) * 2001-04-13 2006-11-30 Dasch James R Method of modifying the release profile of sustained release compositions
US6558702B2 (en) * 2001-04-13 2003-05-06 Alkermes Controlled Therapeutics, Inc. Method of modifying the release profile of sustained release compositions
TWI315982B (en) * 2001-07-19 2009-10-21 Novartis Ag Combinations comprising epothilones and pharmaceutical uses thereof
US20050070504A1 (en) * 2001-12-21 2005-03-31 The Procter & Gamble Co. Risedronate compositions and their methods of use
CN100479823C (zh) * 2001-12-21 2009-04-22 宝洁公司 双膦酸盐在制造药物套盒中的用途以及用于增加骨质的套盒
EP1494683A1 (de) * 2002-04-05 2005-01-12 Merck & Co., Inc. Verfahren zur hemmung der knochenresorption mit einer formulierung aus alendronat und vitamin d
IL164382A0 (en) * 2002-04-11 2005-12-18 Polymorphs and pseudopolymorphs of risedronate sodium
TW200413381A (en) 2002-11-04 2004-08-01 Hoffmann La Roche Novel amino-substituted dihydropyrimido [4,5-d]pyrimidinone derivatives, their manufacture and use as pharmaceutical agents
US7358331B2 (en) * 2003-05-19 2008-04-15 Elan Pharmaceuticals, Inc. Truncated fragments of alpha-synuclein in Lewy body disease
WO2005009348A2 (en) * 2003-06-25 2005-02-03 Ariad Pharmaceuticals, Inc. Substituted purine derivatives
US20040265565A1 (en) * 2003-06-30 2004-12-30 Fischer Patrick J. Microporous article containing flame retardant
JP4423614B2 (ja) * 2003-07-30 2010-03-03 味の素株式会社 リセドロネートの結晶構造の制御方法
JP2007505886A (ja) * 2003-09-19 2007-03-15 ファイザー・プロダクツ・インク 2−メチレン−19−ノル−ビタミンd誘導体及びビスホスフォネートの組み合わせを含む医薬組成物及び方法
DE602004032577D1 (de) * 2003-12-23 2011-06-16 Alchymars S P A Amorphe Form das Natriumsalzes der Ibandronsäure
WO2005090370A1 (en) 2004-02-05 2005-09-29 The Regents Of The University Of California Pharmacologically active agents containing esterified phosphonates and methods for use thereof
EP1571152B1 (de) * 2004-03-03 2007-08-08 CHEMI S.p.A. Amorphe 3-Pyridyl-1-Hydroxyethyliden-1,1-Bisphosphonsäure Mononatriumsalz und Verfahren zu deren Herstellung
US20050260272A1 (en) * 2004-05-05 2005-11-24 Alkermes Controlled Therapeutics, Inc. Method of forming microparticles that include a bisphosphonate and a polymer
US20050261250A1 (en) * 2004-05-19 2005-11-24 Merck & Co., Inc., Compositions and methods for inhibiting bone resorption
WO2005115331A2 (en) 2004-05-24 2005-12-08 The Procter & Gamble Company Enteric solid oral dosage form of bisphosphonate containing a chelating agent
EP1793832B1 (de) * 2004-08-25 2014-07-23 University of Iowa Research Geranylgeranylpyrophosphat-synthase-hemmer
US7358361B2 (en) * 2004-10-08 2008-04-15 The Board Of Trustees Of The University Of Illinois Biophosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases
WO2007109585A2 (en) * 2006-03-17 2007-09-27 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods
WO2008128056A1 (en) * 2004-10-08 2008-10-23 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods with enhanced potency for multiple targets including fpps, ggpps, and dpps
WO2006051553A1 (en) * 2004-11-09 2006-05-18 Jubilant Organosys Limited Process for preparing a pure polymorphic form of 3-pyridyl-1-hydroxyethylidine-1,1-bisphosphonic acid sodium salt
PL199215B1 (pl) 2004-12-28 2008-08-29 Politechnika Gdanska Sposób wytwarzania kwasu [1-hydroksy-2-(3-pirydylo)etylidenobisfosfonowego] oraz jego soli monosodowej dwu i pół wodnej
EP1868628B1 (de) 2005-04-08 2014-06-11 Chimerix, Inc. Verbindungen, zusammensetzungen und verfahren zur behandlung von pockenvirus-infektionen
US20070003608A1 (en) 2005-04-08 2007-01-04 Almond Merrick R Compounds, compositions and methods for the treatment of viral infections and other medical disorders
US8247572B2 (en) * 2005-04-21 2012-08-21 Duke University Facilitated transport of bisphosphonates by vitamin C
AR057291A1 (es) * 2005-05-06 2007-11-28 Medichem Sa Proceso para la preparacion de acidos bisfosfonicos geminales y las sales y/o hidratos farmaceuticamente aceptables de los mismos, una composicion farmaceutica que los contiene y el uso de esta en el tratamiento de la osteoporosis
WO2007026379A2 (en) * 2005-08-30 2007-03-08 Natco Pharma Limited Novel crystalline forms of risedronate monosodium
EP1775302A1 (de) 2005-10-11 2007-04-18 Sandoz A/S Methode zur Herstellung von kristallinem Natriumrisedronat
JP5354858B2 (ja) * 2006-05-09 2013-11-27 株式会社Adeka スルホンアミド化合物の金属塩を含有するポリエステル樹脂組成物
KR20090005206A (ko) * 2006-05-11 2009-01-12 인드-스위프트 래버러토리즈 리미티드 순수한 리세드론산 또는 염의 제조 방법
PT103600B (pt) 2006-11-06 2009-01-30 Hovione Farmaciencia Sa Processo para a preparação de ácidos biosfónicos e seus sais farmaceuticamente aceitáveis
US7781418B2 (en) 2006-12-14 2010-08-24 Isis Innovation Ltd. Composition for treating bone disorders
US20110039804A1 (en) 2006-12-20 2011-02-17 Landsteiner Scientific, S.A. De C.V. Composition of Risedronate and Vitamin D3
WO2009050731A2 (en) * 2007-06-20 2009-04-23 Alkem Laboratories Ltd Novel process for preparing risedronic acid
DE102007030370A1 (de) 2007-06-29 2009-01-02 Ratiopharm Gmbh Essigsäure-Solvate von Risedronat, Polymorph hiervon, deren Herstellung und Verwendung sowie pharmazeutische Zusammensetzung, enthaltend diese
US20090075940A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched risedronate
ITPA20070034A1 (it) * 2007-10-30 2009-04-30 Tetrapharm S R L Bifosfonati geminali, loro preparazione e loro impiego in campo oncologico.
JP2011517313A (ja) 2007-12-11 2011-06-02 ビアメト ファーマシューティカルズ,インク. 金属結合部分を標的化部分と組み合わせて使用する金属酵素阻害剤
AU2009206673B2 (en) 2008-01-25 2015-04-23 Chimerix, Inc. Methods of treating viral infections
TR200900878A2 (tr) 2009-02-05 2010-08-23 Bi̇lgi̇ç Mahmut Tek bir dozaj formunda kombine edilen farmasötik formülasyonlar
WO2011011519A1 (en) 2009-07-21 2011-01-27 Chimerix, Inc. Compounds, compositions and methods for treating ocular conditions
WO2011017253A1 (en) 2009-08-03 2011-02-10 Chimerix, Inc. Composition and methods of treating viral infections and viral induced tumors
FR2954320B1 (fr) 2009-12-17 2012-06-15 Cll Pharma Composition pharmaceutique orale suprabiodisponible contenant un acide biphosphonique ou un de ses sels
PL2534150T3 (pl) 2010-02-12 2017-09-29 Chimerix, Inc. Sposoby leczenia infekcji wirusowej
WO2011139709A2 (en) 2010-04-26 2011-11-10 Chimerix, Inc. Methods of treating retroviral infections and related dosage regimes
EP2661262B1 (de) 2011-01-06 2017-11-15 Mahmut Bilgic Verbesserte bisphosphonat-formulierungen
TR201100149A2 (tr) 2011-01-06 2012-07-23 Bi̇lgi̇ç Mahmut Geliştirilmiş risedronat formülasyonu.
CN102286024B (zh) * 2011-08-30 2013-12-04 江苏正大清江制药有限公司 利塞膦酸钠的合成方法
GB201200868D0 (en) 2012-01-19 2012-02-29 Depuy Int Ltd Bone filler composition
ES2617448T3 (es) 2012-07-05 2017-06-19 University Of Iowa Research Foundation Bisfosfonatos terapéuticos
WO2015123352A1 (en) 2014-02-13 2015-08-20 Ligand Pharmaceuticals, Inc. Prodrug compounds and their uses
CN106687118A (zh) 2014-07-02 2017-05-17 配体药物公司 前药化合物及其用途
WO2017011686A1 (en) 2015-07-14 2017-01-19 University Of Iowa Research Foundation Fluorescent prodrugs
JP7076798B2 (ja) * 2015-09-09 2022-05-30 清華大学 効果的なワクチンアジュバントとするメバロン酸経路の阻害剤
CA3133723C (en) 2015-11-02 2023-06-27 Pura Scents, Inc. Scent dispensation
USD809116S1 (en) 2015-11-02 2018-01-30 Pura Scents Dispenser
USD816506S1 (en) 2015-11-02 2018-05-01 Pura Scents, Inc. Vial for a scent dispenser
EP3737676B1 (de) 2018-01-09 2024-03-06 Ligand Pharmaceuticals, Inc. Acetalverbindungen und therapeutische verwendungen davon

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3553314A (en) * 1968-12-23 1971-01-05 Procter & Gamble Oral compositions for calculus retardation
US3979385A (en) * 1969-11-19 1976-09-07 Henkel & Cie G.M.B.H. 1-Aminoalkane-1,1-diphosphonic acids and their salts
DE1958123C3 (de) * 1969-11-19 1978-09-28 Henkel Kgaa, 4000 Duesseldorf Verfahren zur Herstellung von 1 -Aminoalkan-1,1 -diphosphonsäuren oder deren Salzen
US3683080A (en) * 1970-08-28 1972-08-08 Procter & Gamble Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue
DE2104476C2 (de) * 1971-02-01 1983-12-01 Henkel KGaA, 4000 Düsseldorf Verfahren zur Verhinderung von Ausfällungen in Wasser oder wäßrigen Lösungen
CA1011820A (en) * 1972-09-14 1977-06-07 Richard H. Rein Shielding gas for laser welding
DE2343147C2 (de) * 1973-08-27 1982-06-09 Henkel KGaA, 4000 Düsseldorf Pyrrolidon-5,5-diphosphonsäuren, deren wasserlösliche Salze, und Verfahren zu ihrer Herstellung
DE2343196C3 (de) * 1973-08-27 1980-01-10 Henkel Kgaa, 4000 Duesseldorf Aiacycloalkan-2^-diphosphonsäuren oder deren wasserlösliche Salze
US3988443A (en) * 1973-08-27 1976-10-26 Henkel & Cie G.M.B.H. Azacycloalkane-2,2-diphosphonic acids
US4034086A (en) * 1973-08-27 1977-07-05 Henkel & Cie G.M.B.H. Pyrrolidone-5,5-diphosphonic acids
US4134969A (en) * 1974-02-04 1979-01-16 Henkel Kommanditgesellschaft Auf Aktien (Henkel Kgaa) Method of treatment of calcium disorders using aminoalkane-diphosphonic acids
DE2456666A1 (de) * 1974-11-30 1976-08-12 Henkel & Cie Gmbh Verfahren zum stabilisieren von calcium-hydrogenphosphat-dihydrat gegen hydrolyse
DE2513966C2 (de) * 1975-03-29 1983-06-23 Henkel KGaA, 4000 Düsseldorf Piperidon-6,6-diphosphonsäure und Verfahren zu deren Herstellung
DE2541981A1 (de) * 1975-09-20 1977-03-24 Bayer Ag Verfahren zur herstellung von azacycloalkandiphosphonsaeuren
JPS5359674A (en) * 1976-10-25 1978-05-29 Nissan Chem Ind Ltd 1-piperidinoalkane-1,1-diphosphonic acid derivatives and herbicidescontaining the same as active agent
US4239695A (en) * 1977-03-24 1980-12-16 Magna Corporation Method of preparing phosphonates from nitriles
US4100167A (en) * 1977-05-09 1978-07-11 Nalco Chemical Company Production of 1-aminoalkane-1, 1-diphosphonic acids using phosphorous acid and nitriles in a non-aqueous system
US4447256A (en) * 1977-07-20 1984-05-08 Nissan Chemical Industries, Ltd. N-(Unsubstituted or substituted pyridyl)aminomethylene-diphosphonic acids, herbicidal compositions containing same, their use for herbicides, and process for preparing same
DE2831578A1 (de) * 1977-07-20 1979-02-01 Nissan Chemical Ind Ltd N-pyridylaminomethylendiphosphonsaeureverbindungen
DE2745083C2 (de) * 1977-10-07 1985-05-02 Henkel KGaA, 4000 Düsseldorf Hydroxydiphosphonsäuren und Verfahren zu deren Herstellung
DE2755940C2 (de) * 1977-12-15 1986-01-02 Basf Ag, 6700 Ludwigshafen Mittel zur Regulierung des Pflanzenwachstums
JPS54135724A (en) * 1978-04-11 1979-10-22 Nissan Chem Ind Ltd Preparation of amino-methylenedisulfonic acid derivative
JPS5598193A (en) * 1979-01-22 1980-07-25 Nissan Chem Ind Ltd Methylenediphosphonic acid derivative and herbicide comprising it as active constituent
DE3016289A1 (de) * 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
US4304734A (en) * 1980-10-16 1981-12-08 Vysoka Skola Chemicko-Technologicka 6-Amino-1-hydroxyhexylidene diphosphonic acid, salts and a process for production thereof
EP0085321B1 (de) * 1982-01-27 1986-08-27 Schering Aktiengesellschaft Diphosphonsäure-Derivate und diese enthaltende pharmazeutische Präparate
DE3203308A1 (de) * 1982-01-27 1983-07-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Diphosphonsaeure-derivate und diese enthaltende pharmazeutische praeparate
DE3208600A1 (de) * 1982-03-10 1983-09-22 Henkel KGaA, 4000 Düsseldorf Amidinodiphosphonsaeuren
IT1201087B (it) * 1982-04-15 1989-01-27 Gentili Ist Spa Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche
FR2531088B1 (fr) * 1982-07-29 1987-08-28 Sanofi Sa Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation
DE3425812A1 (de) * 1984-07-13 1986-01-16 Deutsches Krebsforschungszentrum, 6900 Heidelberg Neue 1-hydroxy-1,1-diphosphonsaeureverbindungen, verfahren zu ihrer herstellung und pharmakologische zubereitungen, insbesondere zur behandlung von knochentumoren
CH664158A5 (fr) * 1984-07-18 1988-02-15 Symphar Sa Derives propylidenediphosphonates-1,3 substitues en position 2, leur procede de preparation et compositions pharmaceutiques les contenant.
DE3428524A1 (de) * 1984-08-02 1986-02-13 Boehringer Mannheim Gmbh, 6800 Mannheim Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US4687768A (en) * 1984-12-21 1987-08-18 The Procter & Gamble Company Certain hexahydroindan-2,2-diphosphonic acids useful in treating diseases associated with abnormal calcium and phosphate metabolism
DE3540150A1 (de) * 1985-11-13 1987-05-14 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3626058A1 (de) * 1986-08-01 1988-02-11 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel

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DK599685D0 (da) 1985-12-20
IE58749B1 (en) 1993-11-03
ES557322A0 (es) 1988-06-01
IE853286L (en) 1986-06-21
ES8707543A1 (es) 1987-08-01
ZA859694B (en) 1986-08-27
NL300031I2 (nl) 2001-03-01
LU90669I2 (fr) 2001-01-10
ES8802428A1 (es) 1988-06-01
ES8802428B9 (en) 2011-08-25
DK599685A (da) 1986-06-22
IL77243A (en) 1996-11-14
ES550302A0 (es) 1987-08-01
EP0186405A3 (en) 1987-10-28
DE3582033D1 (de) 1991-04-11
EP0186405B1 (de) 1991-03-06
ES8707543B9 (es) 2013-05-08
DE10075030I1 (de) 2000-12-21
ATE61370T1 (de) 1991-03-15
NL300031I1 (nl) 2001-02-01
DK168754B1 (da) 1994-06-06
US5583122A (en) 1996-12-10
EP0186405A2 (de) 1986-07-02

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