DK1509537T3 - Cellulær akkumulering af phosphonatanaloger af HIV-protease-inhibitorforbindelser og forbindelserne som sådanne - Google Patents

Cellulær akkumulering af phosphonatanaloger af HIV-protease-inhibitorforbindelser og forbindelserne som sådanne

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Publication number
DK1509537T3
DK1509537T3 DK03747326T DK03747326T DK1509537T3 DK 1509537 T3 DK1509537 T3 DK 1509537T3 DK 03747326 T DK03747326 T DK 03747326T DK 03747326 T DK03747326 T DK 03747326T DK 1509537 T3 DK1509537 T3 DK 1509537T3
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DK
Denmark
Prior art keywords
compounds
hiv protease
protease inhibitor
cellular accumulation
phosphonate analogues
Prior art date
Application number
DK03747326T
Other languages
Danish (da)
English (en)
Inventor
Peter H Nelson
Hyung-Jung Pyun
Tanisha D Rowe
Sundaramoorthi Swaminathan
James D Tario
Lijun Zhang
Mark Sparacino
Jianying Wang
Matthew A Williams
Lianhong Xu
Zheng-Yu Yang
Richard H Yu
Jiancun Zhang
Murty N Arimilli
Mark W Becker
James M Chen
Xiaowu Chen
Maria Fardis
Gong-Xin He
Haolun Jin
Choung U Kim
William A Lee
Kuei-Ying Lin
Hongtao Liu
Richard L Mackman
Clifford Bryant
Azar Dastgah
Christopher P Lee
Michael L Mitchell
Original Assignee
Gilead Sciences Inc
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Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
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Publication of DK1509537T3 publication Critical patent/DK1509537T3/da

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    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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