DK0408461T3 - Protein med uratoxidase-aktivitet, rekombinant gen, der koder for proteinet, samt ekspressionsvektor, mikroorganismer og transformerede celler - Google Patents

Protein med uratoxidase-aktivitet, rekombinant gen, der koder for proteinet, samt ekspressionsvektor, mikroorganismer og transformerede celler

Info

Publication number
DK0408461T3
DK0408461T3 DK90402023.7T DK90402023T DK0408461T3 DK 0408461 T3 DK0408461 T3 DK 0408461T3 DK 90402023 T DK90402023 T DK 90402023T DK 0408461 T3 DK0408461 T3 DK 0408461T3
Authority
DK
Denmark
Prior art keywords
protein
well
microorganisms
oxidase activity
expression vector
Prior art date
Application number
DK90402023.7T
Other languages
English (en)
Inventor
Gerard Loison
Daniel Caput
Pascual Ferrara
Jean Claude Guillemot
Mourad Kaghad
Richard Legoux
Elizabeth Larbre
Johannes Lupker
Pascal Leplatois
Marc Salome
Patrick Laurent
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8909550A external-priority patent/FR2649720A1/fr
Priority claimed from FR8917466A external-priority patent/FR2656530B1/fr
Application filed by Sanofi Sa filed Critical Sanofi Sa
Application granted granted Critical
Publication of DK0408461T3 publication Critical patent/DK0408461T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0044—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7)
    • C12N9/0046—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7) with oxygen as acceptor (1.7.3)
DK90402023.7T 1989-07-13 1990-07-13 Protein med uratoxidase-aktivitet, rekombinant gen, der koder for proteinet, samt ekspressionsvektor, mikroorganismer og transformerede celler DK0408461T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR8909550A FR2649720A1 (en) 1989-07-13 1989-07-13 Recombinant gene which encodes a protein such as urate oxidase
FR8917466A FR2656530B1 (fr) 1989-12-29 1989-12-29 Gene recombinant pour une expression dans les cellules eucaryotes d'une proteine telle que l'urate oxydase.
FR9001368A FR2657785A2 (fr) 1989-12-29 1990-02-06 Gene recombinant pour une expression dans les cellules animales d'une proteine telle que l'urate oxydage.

Publications (1)

Publication Number Publication Date
DK0408461T3 true DK0408461T3 (da) 1997-03-24

Family

ID=27251947

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90402023.7T DK0408461T3 (da) 1989-07-13 1990-07-13 Protein med uratoxidase-aktivitet, rekombinant gen, der koder for proteinet, samt ekspressionsvektor, mikroorganismer og transformerede celler

Country Status (24)

Country Link
EP (1) EP0408461B1 (da)
JP (1) JP2664804B2 (da)
AT (1) ATE144282T1 (da)
AU (1) AU636637B2 (da)
BR (1) BR9006855A (da)
CA (1) CA2035900C (da)
DE (2) DE69028884T2 (da)
DK (1) DK0408461T3 (da)
ES (1) ES2095243T3 (da)
FI (1) FI105047B (da)
GR (1) GR3022085T3 (da)
HK (1) HK1000099A1 (da)
HU (1) HU215948B (da)
IE (1) IE77158B1 (da)
IL (1) IL95057A (da)
LU (1) LU90781I2 (da)
LV (1) LV12000B (da)
MC (1) MC2145A1 (da)
NL (1) NL300046I2 (da)
NO (1) NO2001018I2 (da)
NZ (1) NZ234453A (da)
PT (1) PT94680B (da)
RU (1) RU2105812C1 (da)
WO (1) WO1991000909A1 (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2971218B2 (ja) * 1991-12-04 1999-11-02 協和醗酵工業株式会社 ウリカーゼ遺伝子およびウリカーゼの製造法
US5691188A (en) 1994-02-14 1997-11-25 American Cyanamid Company Transformed yeast cells expressing heterologous G-protein coupled receptor
US6083725A (en) 1996-09-13 2000-07-04 Transkaryotic Therapies, Inc. Tranfected human cells expressing human α-galactosidase A protein
KR20050084473A (ko) * 1996-09-13 2005-08-26 트랜스케리오틱 쎄러피스, 인코포레이티드 α-갈락토시다아제 Ａ 결핍을 치료하는 방법
US6783965B1 (en) * 2000-02-10 2004-08-31 Mountain View Pharmaceuticals, Inc. Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
ES2245114T3 (es) 1998-08-06 2005-12-16 Mountain View Pharmaceuticals, Inc. Conjugados de peg-oxidasa de urato y su uso.
KR100575394B1 (ko) 2000-08-17 2006-05-03 아지노모토 가부시키가이샤 미생물 유래 트랜스글루타미나제의 변이 방법
DK1503788T3 (da) 2002-04-25 2011-10-17 Shire Human Genetic Therapies Behandling af alpha-galactosidase A-deficiens
US9534013B2 (en) * 2006-04-12 2017-01-03 Horizon Pharma Rheumatology Llc Purification of proteins with cationic surfactant
TWI418564B (zh) * 2005-04-11 2013-12-11 Savient Pharmaceuticals Inc 利用陽離子界面活性劑之蛋白質純化
CN101194016B (zh) 2005-04-11 2012-09-05 萨文特医药公司 尿酸氧化酶的变体形式及其用途
US8148123B2 (en) 2005-04-11 2012-04-03 Savient Pharmaceuticals, Inc. Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
PT3321359T (pt) 2005-04-11 2021-03-11 Horizon Pharma Rheumatology Llc Formas variantes de urato-oxidase e a sua utilização
RU2443426C2 (ru) * 2008-11-07 2012-02-27 Мунтэн Вью Фармасьютикэлз, Инк. Конъюгаты уратоксидазы, фармацевтическая композиция для снижения уровней мочевой кислоты и способ получения вышеупомянутых конъюгатов
SG10201408480RA (en) 2009-06-25 2015-02-27 Crealta Pharmaceuticals Llc Methods for preventing or predicting infusion reactions or antibody-mediated loss of response, by monitoring serum uric acid levels during pegylated uricase therapy
CN109223707B (zh) * 2018-09-13 2020-12-08 中国药科大学 一种尿酸酶外用凝胶制剂、其制备方法及用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1529675A (fr) * 1967-03-29 1968-06-21 Applic Biochimiques Soc Et Urate oxydase à haute activité et sa préparation
SU457723A1 (ru) * 1973-04-09 1977-08-05 Всесоюзный Научно-Исследовательский Витаминный Институт Штамм 313-152 - продуцент уратоксидазы
CA1341130C (en) * 1984-07-27 2000-10-31 Adrianus Marinus Ledeboer Use of oxidoreductases in bleaching and/or detergent compositions and their preparation by microorganisms engineered by recombinant dna technology
WO1988008450A1 (en) * 1987-05-01 1988-11-03 Birdwell Finlayson Gene therapy for metabolite disorders
JPH0671428B2 (ja) * 1988-08-17 1994-09-14 サッポロビール株式会社 ウリカーゼのｄｎａ配列および製法

Also Published As

Publication number Publication date
IE77158B1 (en) 1997-12-03
HU906046D0 (en) 1991-07-29
FI911212A0 (fi) 1991-03-12
IL95057A (en) 1997-07-13
FI105047B (fi) 2000-05-31
AU636637B2 (en) 1993-05-06
NL300046I1 (nl) 2001-09-03
ES2095243T3 (es) 1997-02-16
NO2001018I2 (no) 2006-05-01
PT94680A (pt) 1991-04-18
DE69028884D1 (de) 1996-11-21
GR3022085T3 (en) 1997-03-31
IE902559A1 (en) 1991-02-27
NZ234453A (en) 1993-01-27
IL95057A0 (en) 1991-06-10
RU2105812C1 (ru) 1998-02-27
NL300046I2 (nl) 2001-12-01
AU6052390A (en) 1991-02-06
EP0408461B1 (fr) 1996-10-16
MC2145A1 (fr) 1992-02-18
JP2664804B2 (ja) 1997-10-22
DE69028884T2 (de) 1997-05-07
DE10199042I2 (de) 2003-10-23
LU90781I2 (fr) 2001-07-23
DE10199042I1 (de) 2002-01-10
HU215948B (hu) 1999-03-29
HK1000099A1 (en) 1997-11-21
BR9006855A (pt) 1991-08-06
WO1991000909A1 (fr) 1991-01-24
PT94680B (pt) 1997-04-30
CA2035900C (fr) 2000-01-11
ATE144282T1 (de) 1996-11-15
CA2035900A1 (fr) 1991-01-14
EP0408461A1 (fr) 1991-01-16
LV12000B (lv) 1998-06-20
JPH04501807A (ja) 1992-04-02
LV12000A (lv) 1998-03-20
HUT56884A (en) 1991-10-28

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