DK0408461T3 - Protein with urate oxidase activity, recombinant gene encoding the protein, as well as expression vector, microorganisms and transformed cells - Google Patents

Protein with urate oxidase activity, recombinant gene encoding the protein, as well as expression vector, microorganisms and transformed cells

Info

Publication number
DK0408461T3
DK0408461T3 DK90402023.7T DK90402023T DK0408461T3 DK 0408461 T3 DK0408461 T3 DK 0408461T3 DK 90402023 T DK90402023 T DK 90402023T DK 0408461 T3 DK0408461 T3 DK 0408461T3
Authority
DK
Denmark
Prior art keywords
protein
well
microorganisms
oxidase activity
expression vector
Prior art date
Application number
DK90402023.7T
Other languages
Danish (da)
Inventor
Gerard Loison
Daniel Caput
Pascual Ferrara
Jean Claude Guillemot
Mourad Kaghad
Richard Legoux
Elizabeth Larbre
Johannes Lupker
Pascal Leplatois
Marc Salome
Patrick Laurent
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8909550A external-priority patent/FR2649720A1/en
Priority claimed from FR8917466A external-priority patent/FR2656530B1/en
Application filed by Sanofi Sa filed Critical Sanofi Sa
Application granted granted Critical
Publication of DK0408461T3 publication Critical patent/DK0408461T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0044—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7)
    • C12N9/0046—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7) with oxygen as acceptor (1.7.3)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
  • Glass Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)

Abstract

The invention concerns a new urate oxidase activity protein which has the sequence (I), possibly preceeded by a methionine, or in that it may present a degree of substantial homology with this sequence. The invention is also aimed at medicines containing this protein, as well as the genetic engineering implements to obtain it.
DK90402023.7T 1989-07-13 1990-07-13 Protein with urate oxidase activity, recombinant gene encoding the protein, as well as expression vector, microorganisms and transformed cells DK0408461T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR8909550A FR2649720A1 (en) 1989-07-13 1989-07-13 Recombinant gene which encodes a protein such as urate oxidase
FR8917466A FR2656530B1 (en) 1989-12-29 1989-12-29 RECOMBINANT GENE FOR EXPRESSION IN EUKARYOTIC CELLS OF A PROTEIN SUCH AS URATE OXIDASE.
FR9001368A FR2657785A2 (en) 1989-12-29 1990-02-06 Recombinant gene for expression of a protein such as urate oxidase in animal cells

Publications (1)

Publication Number Publication Date
DK0408461T3 true DK0408461T3 (en) 1997-03-24

Family

ID=27251947

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90402023.7T DK0408461T3 (en) 1989-07-13 1990-07-13 Protein with urate oxidase activity, recombinant gene encoding the protein, as well as expression vector, microorganisms and transformed cells

Country Status (24)

Country Link
EP (1) EP0408461B1 (en)
JP (1) JP2664804B2 (en)
AT (1) ATE144282T1 (en)
AU (1) AU636637B2 (en)
BR (1) BR9006855A (en)
CA (1) CA2035900C (en)
DE (2) DE10199042I2 (en)
DK (1) DK0408461T3 (en)
ES (1) ES2095243T3 (en)
FI (1) FI105047B (en)
GR (1) GR3022085T3 (en)
HK (1) HK1000099A1 (en)
HU (1) HU215948B (en)
IE (1) IE77158B1 (en)
IL (1) IL95057A (en)
LU (1) LU90781I2 (en)
LV (1) LV12000B (en)
MC (1) MC2145A1 (en)
NL (1) NL300046I2 (en)
NO (1) NO2001018I2 (en)
NZ (1) NZ234453A (en)
PT (1) PT94680B (en)
RU (1) RU2105812C1 (en)
WO (1) WO1991000909A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2971218B2 (en) * 1991-12-04 1999-11-02 協和醗酵工業株式会社 Uricase gene and method for producing uricase
US5691188A (en) 1994-02-14 1997-11-25 American Cyanamid Company Transformed yeast cells expressing heterologous G-protein coupled receptor
US6083725A (en) 1996-09-13 2000-07-04 Transkaryotic Therapies, Inc. Tranfected human cells expressing human α-galactosidase A protein
DK2374876T3 (en) * 1996-09-13 2016-05-30 Shire Human Genetic Therapies A process for the purification of alpha-galactosidase A
US6783965B1 (en) * 2000-02-10 2004-08-31 Mountain View Pharmaceuticals, Inc. Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
EP1588716B1 (en) 1998-08-06 2011-02-16 Mountain View Pharmaceuticals, Inc. Peg-urate oxidase conjugates and use thereof
AU2001278739A1 (en) 2000-08-17 2002-02-25 Ajinomoto Co. Inc. Method of modifying microorganism-origin transglutaminase
CA2483270C (en) 2002-04-25 2015-03-31 Transkaryotic Therapies, Inc. Treatment of alpha-galactosidase a deficiency
US8148123B2 (en) 2005-04-11 2012-04-03 Savient Pharmaceuticals, Inc. Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
TWI418564B (en) * 2005-04-11 2013-12-11 Savient Pharmaceuticals Inc Purification of proteins with cationic surfactant
MX2007012547A (en) 2005-04-11 2008-03-11 Savient Pharmaceuticals Inc Variant forms of urate oxidase and use thereof.
PL215157B1 (en) 2005-04-11 2013-10-31 Savient Pharmaceuticals Variant of urate oxidase and its application
HU230758B1 (en) * 2006-04-12 2018-03-28 Crealta Pharmaceuticals LLC 100% Purification of proteins with cationic surfactant
RU2443426C2 (en) * 2008-11-07 2012-02-27 Мунтэн Вью Фармасьютикэлз, Инк. Urate oxidase conjugates, pharmaceutical composition for reduction in uric acid levels and method for preparing conjugates stated above
CA2766309A1 (en) 2009-06-25 2010-12-29 Savient Pharmaceuticals, Inc. Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy
CN109223707B (en) * 2018-09-13 2020-12-08 中国药科大学 Uricase external gel preparation, preparation method and application thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR6301M (en) * 1967-03-29 1968-09-09
SU457723A1 (en) * 1973-04-09 1977-08-05 Всесоюзный Научно-Исследовательский Витаминный Институт Strain 313-152 actinomyces sp.as producer of uratoxydase
EP0173378B1 (en) * 1984-07-27 1991-06-12 Unilever N.V. Process for preparing a polypeptide by culturing a transformed microorganism, a transformed microorganism suitable therefor and dna sequences suitable for preparing such microorganism
WO1988008450A1 (en) * 1987-05-01 1988-11-03 Birdwell Finlayson Gene therapy for metabolite disorders
JPH0671428B2 (en) * 1988-08-17 1994-09-14 サッポロビール株式会社 Uricase DNA sequence and process

Also Published As

Publication number Publication date
IE902559A1 (en) 1991-02-27
HU215948B (en) 1999-03-29
HU906046D0 (en) 1991-07-29
AU6052390A (en) 1991-02-06
HK1000099A1 (en) 1997-11-21
PT94680B (en) 1997-04-30
DE10199042I1 (en) 2002-01-10
HUT56884A (en) 1991-10-28
FI911212A0 (en) 1991-03-12
DE69028884T2 (en) 1997-05-07
CA2035900C (en) 2000-01-11
WO1991000909A1 (en) 1991-01-24
LU90781I2 (en) 2001-07-23
EP0408461A1 (en) 1991-01-16
LV12000B (en) 1998-06-20
MC2145A1 (en) 1992-02-18
JPH04501807A (en) 1992-04-02
AU636637B2 (en) 1993-05-06
ATE144282T1 (en) 1996-11-15
NL300046I1 (en) 2001-09-03
DE69028884D1 (en) 1996-11-21
NZ234453A (en) 1993-01-27
EP0408461B1 (en) 1996-10-16
NL300046I2 (en) 2001-12-01
IL95057A (en) 1997-07-13
DE10199042I2 (en) 2003-10-23
CA2035900A1 (en) 1991-01-14
IL95057A0 (en) 1991-06-10
GR3022085T3 (en) 1997-03-31
BR9006855A (en) 1991-08-06
IE77158B1 (en) 1997-12-03
JP2664804B2 (en) 1997-10-22
PT94680A (en) 1991-04-18
ES2095243T3 (en) 1997-02-16
FI105047B (en) 2000-05-31
RU2105812C1 (en) 1998-02-27
NO2001018I2 (en) 2006-05-01
LV12000A (en) 1998-03-20

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