FI911212A0 - PROTEIN MED URATOXIDASAKTIVITET, REKOMBINANTGEN SOM KODAR DETTA, EXPRESSIONSVEKTOR, MIKROORGANISMER OCH TRANSFORMERADE CELLER. - Google Patents

PROTEIN MED URATOXIDASAKTIVITET, REKOMBINANTGEN SOM KODAR DETTA, EXPRESSIONSVEKTOR, MIKROORGANISMER OCH TRANSFORMERADE CELLER.

Info

Publication number
FI911212A0
FI911212A0 FI911212A FI911212A FI911212A0 FI 911212 A0 FI911212 A0 FI 911212A0 FI 911212 A FI911212 A FI 911212A FI 911212 A FI911212 A FI 911212A FI 911212 A0 FI911212 A0 FI 911212A0
Authority
FI
Finland
Prior art keywords
protein
uratoxidasaktivitet
transformerade
rekombinantgen
mikroorganismer
Prior art date
Application number
FI911212A
Other languages
Finnish (fi)
Other versions
FI105047B (en
Inventor
Daniel Caput
Pascual Ferrara
Jean-Claude Guillemot
Mourad Kaghad
Richard Legoux
Gerard Loison
Elisabeth Larbre
Johannes Lupker
Pascal Leplatois
Marc Salome
Patrick Laurent
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8909550A external-priority patent/FR2649720A1/en
Priority claimed from FR8917466A external-priority patent/FR2656530B1/en
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of FI911212A0 publication Critical patent/FI911212A0/en
Application granted granted Critical
Publication of FI105047B publication Critical patent/FI105047B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0044—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7)
    • C12N9/0046—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7) with oxygen as acceptor (1.7.3)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
  • Glass Compositions (AREA)
  • Saccharide Compounds (AREA)

Abstract

The invention concerns a new urate oxidase activity protein which has the sequence (I), possibly preceeded by a methionine, or in that it may present a degree of substantial homology with this sequence. The invention is also aimed at medicines containing this protein, as well as the genetic engineering implements to obtain it.
FI911212A 1989-07-13 1991-03-12 A method for producing a recombinant protein having urate oxidase activity, a recombinant gene encoding this protein, and expression vectors, microorganisms and transformed cells containing it FI105047B (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
FR8909550 1989-07-13
FR8909550A FR2649720A1 (en) 1989-07-13 1989-07-13 Recombinant gene which encodes a protein such as urate oxidase
FR8917466 1989-12-29
FR8917466A FR2656530B1 (en) 1989-12-29 1989-12-29 RECOMBINANT GENE FOR EXPRESSION IN EUKARYOTIC CELLS OF A PROTEIN SUCH AS URATE OXIDASE.
FR9000532 1990-01-12
FR9001368A FR2657785A2 (en) 1989-12-29 1990-02-06 Recombinant gene for expression of a protein such as urate oxidase in animal cells
FR9001368 1990-02-06
PCT/FR1990/000532 WO1991000909A1 (en) 1989-07-13 1990-07-13 Urate oxidase activity protein, recombinant gene coding therefor, expression vector, micro-organisms and transformed cells

Publications (2)

Publication Number Publication Date
FI911212A0 true FI911212A0 (en) 1991-03-12
FI105047B FI105047B (en) 2000-05-31

Family

ID=27251947

Family Applications (1)

Application Number Title Priority Date Filing Date
FI911212A FI105047B (en) 1989-07-13 1991-03-12 A method for producing a recombinant protein having urate oxidase activity, a recombinant gene encoding this protein, and expression vectors, microorganisms and transformed cells containing it

Country Status (24)

Country Link
EP (1) EP0408461B1 (en)
JP (1) JP2664804B2 (en)
AT (1) ATE144282T1 (en)
AU (1) AU636637B2 (en)
BR (1) BR9006855A (en)
CA (1) CA2035900C (en)
DE (2) DE10199042I2 (en)
DK (1) DK0408461T3 (en)
ES (1) ES2095243T3 (en)
FI (1) FI105047B (en)
GR (1) GR3022085T3 (en)
HK (1) HK1000099A1 (en)
HU (1) HU215948B (en)
IE (1) IE77158B1 (en)
IL (1) IL95057A (en)
LU (1) LU90781I2 (en)
LV (1) LV12000B (en)
MC (1) MC2145A1 (en)
NL (1) NL300046I2 (en)
NO (1) NO2001018I2 (en)
NZ (1) NZ234453A (en)
PT (1) PT94680B (en)
RU (1) RU2105812C1 (en)
WO (1) WO1991000909A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2971218B2 (en) * 1991-12-04 1999-11-02 協和醗酵工業株式会社 Uricase gene and method for producing uricase
US5691188A (en) 1994-02-14 1997-11-25 American Cyanamid Company Transformed yeast cells expressing heterologous G-protein coupled receptor
US6083725A (en) 1996-09-13 2000-07-04 Transkaryotic Therapies, Inc. Tranfected human cells expressing human α-galactosidase A protein
PL190041B1 (en) * 1996-09-13 2005-10-31 Transkaryotic Therapies Therapy against alpha-galactosidase a deficiency
ATE498409T1 (en) 1998-08-06 2011-03-15 Mountain View Pharmaceuticals PEG-URICASE CONJUGATES AND USE THEREOF
US6783965B1 (en) * 2000-02-10 2004-08-31 Mountain View Pharmaceuticals, Inc. Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
AU2001278739A1 (en) 2000-08-17 2002-02-25 Ajinomoto Co. Inc. Method of modifying microorganism-origin transglutaminase
AU2003228722B2 (en) 2002-04-25 2009-06-25 Takeda Pharmaceutical Company Limited Treatment of alpha-galactosidase A deficiency
DK3321359T3 (en) 2005-04-11 2021-03-08 Horizon Pharma Rheumatology Llc VARIANT FORMS OF URATOXIDASIS AND ITS USE
CN102807973A (en) 2005-04-11 2012-12-05 萨文特医药公司 A variant form of urate oxidase and use thereof
TWI418564B (en) * 2005-04-11 2013-12-11 Savient Pharmaceuticals Inc Purification of proteins with cationic surfactant
US8148123B2 (en) 2005-04-11 2012-04-03 Savient Pharmaceuticals, Inc. Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
EP2013225B1 (en) * 2006-04-12 2014-12-17 Crealta Pharmaceuticals LLC Purification of proteins with cationic surfactant
RU2443426C2 (en) * 2008-11-07 2012-02-27 Мунтэн Вью Фармасьютикэлз, Инк. Urate oxidase conjugates, pharmaceutical composition for reduction in uric acid levels and method for preparing conjugates stated above
NZ597089A (en) 2009-06-25 2014-05-30 Savient Pharmaceuticals Inc Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy
CN109223707B (en) * 2018-09-13 2020-12-08 中国药科大学 Uricase external gel preparation, preparation method and application thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR6301M (en) * 1967-03-29 1968-09-09
SU457723A1 (en) * 1973-04-09 1977-08-05 Всесоюзный Научно-Исследовательский Витаминный Институт Strain 313-152 actinomyces sp.as producer of uratoxydase
CA1341130C (en) * 1984-07-27 2000-10-31 Adrianus Marinus Ledeboer Use of oxidoreductases in bleaching and/or detergent compositions and their preparation by microorganisms engineered by recombinant dna technology
WO1988008450A1 (en) * 1987-05-01 1988-11-03 Birdwell Finlayson Gene therapy for metabolite disorders
JPH0671428B2 (en) * 1988-08-17 1994-09-14 サッポロビール株式会社 Uricase DNA sequence and process

Also Published As

Publication number Publication date
HUT56884A (en) 1991-10-28
JP2664804B2 (en) 1997-10-22
IL95057A (en) 1997-07-13
BR9006855A (en) 1991-08-06
RU2105812C1 (en) 1998-02-27
ATE144282T1 (en) 1996-11-15
EP0408461B1 (en) 1996-10-16
DE10199042I1 (en) 2002-01-10
JPH04501807A (en) 1992-04-02
DE69028884D1 (en) 1996-11-21
HU215948B (en) 1999-03-29
PT94680B (en) 1997-04-30
ES2095243T3 (en) 1997-02-16
NO2001018I2 (en) 2006-05-01
DE69028884T2 (en) 1997-05-07
WO1991000909A1 (en) 1991-01-24
FI105047B (en) 2000-05-31
AU6052390A (en) 1991-02-06
EP0408461A1 (en) 1991-01-16
HU906046D0 (en) 1991-07-29
PT94680A (en) 1991-04-18
HK1000099A1 (en) 1997-11-21
LU90781I2 (en) 2001-07-23
LV12000A (en) 1998-03-20
GR3022085T3 (en) 1997-03-31
IE902559A1 (en) 1991-02-27
NZ234453A (en) 1993-01-27
IL95057A0 (en) 1991-06-10
LV12000B (en) 1998-06-20
CA2035900C (en) 2000-01-11
NL300046I2 (en) 2001-12-01
IE77158B1 (en) 1997-12-03
DE10199042I2 (en) 2003-10-23
DK0408461T3 (en) 1997-03-24
AU636637B2 (en) 1993-05-06
CA2035900A1 (en) 1991-01-14
NL300046I1 (en) 2001-09-03
MC2145A1 (en) 1992-02-18

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Legal Events

Date Code Title Description
SPCF Supplementary protection certificate application filed

Spc suppl protection certif: L20010008

PC Transfer of assignment of patent

Owner name: SANOFI-AVENTIS

SPCG Supplementary protection certificate granted

Spc suppl protection certif: L194

Extension date: 20150712