AU6052390A - Urate oxidase activity protein, recombinant gene coding therefor, expression vector, micro-organisms and transformed cells - Google Patents

Urate oxidase activity protein, recombinant gene coding therefor, expression vector, micro-organisms and transformed cells

Info

Publication number
AU6052390A
AU6052390A AU60523/90A AU6052390A AU6052390A AU 6052390 A AU6052390 A AU 6052390A AU 60523/90 A AU60523/90 A AU 60523/90A AU 6052390 A AU6052390 A AU 6052390A AU 6052390 A AU6052390 A AU 6052390A
Authority
AU
Australia
Prior art keywords
organisms
micro
oxidase activity
expression vector
transformed cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU60523/90A
Other versions
AU636637B2 (en
Inventor
Daniel Caput
Pascual Ferrara
Jean-Claude Guillemot
Mourad Kaghad
Elisabeth Larbre
Patrick Laurent
Richard Legoux
Pascal Leplatois
Gerard Loison
Johannes Lupker
Marc Salome
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8909550A external-priority patent/FR2649720A1/en
Priority claimed from FR8917466A external-priority patent/FR2656530B1/en
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Publication of AU6052390A publication Critical patent/AU6052390A/en
Application granted granted Critical
Publication of AU636637B2 publication Critical patent/AU636637B2/en
Assigned to SANOFI-SYNTHELABO reassignment SANOFI-SYNTHELABO Request to Amend Deed and Register Assignors: SANOFI
Assigned to SANOFI-AVENTIS reassignment SANOFI-AVENTIS Request to Amend Deed and Register Assignors: SANOFI-SYNTHELABO
Adjusted expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0044—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7)
    • C12N9/0046—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7) with oxygen as acceptor (1.7.3)

Abstract

The invention concerns a new urate oxidase activity protein which has the sequence (I), possibly preceeded by a methionine, or in that it may present a degree of substantial homology with this sequence. The invention is also aimed at medicines containing this protein, as well as the genetic engineering implements to obtain it.
AU60523/90A 1989-07-13 1990-07-13 Urate oxidase activity protein, recombinant gene coding therefor, expression vector, micro-organisms and transformed cells Expired AU636637B2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
FR8909550 1989-07-13
FR8909550A FR2649720A1 (en) 1989-07-13 1989-07-13 Recombinant gene which encodes a protein such as urate oxidase
FR8917466A FR2656530B1 (en) 1989-12-29 1989-12-29 RECOMBINANT GENE FOR EXPRESSION IN EUKARYOTIC CELLS OF A PROTEIN SUCH AS URATE OXIDASE.
FR8917466 1989-12-29
FR9001368 1990-02-06
FR9001368A FR2657785A2 (en) 1989-12-29 1990-02-06 Recombinant gene for expression of a protein such as urate oxidase in animal cells

Publications (2)

Publication Number Publication Date
AU6052390A true AU6052390A (en) 1991-02-06
AU636637B2 AU636637B2 (en) 1993-05-06

Family

ID=27251947

Family Applications (1)

Application Number Title Priority Date Filing Date
AU60523/90A Expired AU636637B2 (en) 1989-07-13 1990-07-13 Urate oxidase activity protein, recombinant gene coding therefor, expression vector, micro-organisms and transformed cells

Country Status (24)

Country Link
EP (1) EP0408461B1 (en)
JP (1) JP2664804B2 (en)
AT (1) ATE144282T1 (en)
AU (1) AU636637B2 (en)
BR (1) BR9006855A (en)
CA (1) CA2035900C (en)
DE (2) DE10199042I2 (en)
DK (1) DK0408461T3 (en)
ES (1) ES2095243T3 (en)
FI (1) FI105047B (en)
GR (1) GR3022085T3 (en)
HK (1) HK1000099A1 (en)
HU (1) HU215948B (en)
IE (1) IE77158B1 (en)
IL (1) IL95057A (en)
LU (1) LU90781I2 (en)
LV (1) LV12000B (en)
MC (1) MC2145A1 (en)
NL (1) NL300046I2 (en)
NO (1) NO2001018I2 (en)
NZ (1) NZ234453A (en)
PT (1) PT94680B (en)
RU (1) RU2105812C1 (en)
WO (1) WO1991000909A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2971218B2 (en) * 1991-12-04 1999-11-02 協和醗酵工業株式会社 Uricase gene and method for producing uricase
US5691188A (en) 1994-02-14 1997-11-25 American Cyanamid Company Transformed yeast cells expressing heterologous G-protein coupled receptor
RU2179034C2 (en) * 1996-09-13 2002-02-10 Транскариотик Терапиз, Инк. METHOD TO TREAT α-GALACTOSIDASE A DEFICIENCY
US6083725A (en) 1996-09-13 2000-07-04 Transkaryotic Therapies, Inc. Tranfected human cells expressing human α-galactosidase A protein
EP2158923B1 (en) 1998-08-06 2013-02-27 Mountain View Pharmaceuticals, Inc. Peg-urate oxidase conjugates and use thereof
US6783965B1 (en) * 2000-02-10 2004-08-31 Mountain View Pharmaceuticals, Inc. Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
CA2419453C (en) 2000-08-17 2010-03-09 Ajinomoto Co., Inc. Mutant transglutaminase from streptoverticillium having modified substrate specificity
JP5570677B2 (en) 2002-04-25 2014-08-13 シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド Treatment of α-galactosidase A deficiency
US8148123B2 (en) 2005-04-11 2012-04-03 Savient Pharmaceuticals, Inc. Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
TWI418564B (en) * 2005-04-11 2013-12-11 Savient Pharmaceuticals Inc Purification of proteins with cationic surfactant
ES2538357T3 (en) 2005-04-11 2015-06-19 Crealta Pharmaceuticals Llc Variant forms of urate oxidase and use thereof
JP2008535499A (en) 2005-04-11 2008-09-04 サビエント ファーマセウティカルズ インク． Mutant urate oxidase and use thereof
KR101288027B1 (en) * 2006-04-12 2013-07-22 새비언트 파마수티컬즈 인크. Purification of proteins with cationic surfactant
RU2443426C2 (en) * 2008-11-07 2012-02-27 Мунтэн Вью Фармасьютикэлз, Инк. Urate oxidase conjugates, pharmaceutical composition for reduction in uric acid levels and method for preparing conjugates stated above
NZ597089A (en) 2009-06-25 2014-05-30 Savient Pharmaceuticals Inc Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy
CN109223707B (en) * 2018-09-13 2020-12-08 中国药科大学 Uricase external gel preparation, preparation method and application thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR6301M (en) * 1967-03-29 1968-09-09
SU457723A1 (en) * 1973-04-09 1977-08-05 Всесоюзный Научно-Исследовательский Витаминный Институт Strain 313-152 actinomyces sp.as producer of uratoxydase
EP0423890A3 (en) * 1984-07-27 1991-07-03 Unilever Nv Use of oxidoreductases in bleaching and/or detergent compositions and their preparation by microorganisms engineered by recombinant dna technology
WO1988008450A1 (en) * 1987-05-01 1988-11-03 Birdwell Finlayson Gene therapy for metabolite disorders
JPH0671428B2 (en) * 1988-08-17 1994-09-14 サッポロビール株式会社 Uricase DNA sequence and process

Also Published As

Publication number Publication date
LV12000A (en) 1998-03-20
DK0408461T3 (en) 1997-03-24
FI105047B (en) 2000-05-31
HU215948B (en) 1999-03-29
ES2095243T3 (en) 1997-02-16
RU2105812C1 (en) 1998-02-27
AU636637B2 (en) 1993-05-06
CA2035900C (en) 2000-01-11
NZ234453A (en) 1993-01-27
IL95057A (en) 1997-07-13
EP0408461B1 (en) 1996-10-16
DE69028884D1 (en) 1996-11-21
EP0408461A1 (en) 1991-01-16
BR9006855A (en) 1991-08-06
NL300046I1 (en) 2001-09-03
PT94680A (en) 1991-04-18
HK1000099A1 (en) 1997-11-21
NL300046I2 (en) 2001-12-01
LU90781I2 (en) 2001-07-23
IE902559A1 (en) 1991-02-27
NO2001018I2 (en) 2006-05-01
PT94680B (en) 1997-04-30
FI911212A0 (en) 1991-03-12
WO1991000909A1 (en) 1991-01-24
CA2035900A1 (en) 1991-01-14
JPH04501807A (en) 1992-04-02
LV12000B (en) 1998-06-20
HU906046D0 (en) 1991-07-29
DE69028884T2 (en) 1997-05-07
DE10199042I2 (en) 2003-10-23
IL95057A0 (en) 1991-06-10
MC2145A1 (en) 1992-02-18
IE77158B1 (en) 1997-12-03
DE10199042I1 (en) 2002-01-10
ATE144282T1 (en) 1996-11-15
JP2664804B2 (en) 1997-10-22
HUT56884A (en) 1991-10-28
GR3022085T3 (en) 1997-03-31

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Free format text: SANOFI-SYNTHELABO

NDB Extension of term for standard patent granted (sect.76)

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Extension date: 20150713