MC2145A1 - PROTEIN HAVING URATE OXIDASE ACTIVITY, RECOMBINANT GENE ENCODING THE SAME, EXPRESSION VECTOR, MICROORGANISMS AND TRANSFORMED CELLS - Google Patents
PROTEIN HAVING URATE OXIDASE ACTIVITY, RECOMBINANT GENE ENCODING THE SAME, EXPRESSION VECTOR, MICROORGANISMS AND TRANSFORMED CELLSInfo
- Publication number
- MC2145A1 MC2145A1 MC@@@@D MC2145D MC2145A1 MC 2145 A1 MC2145 A1 MC 2145A1 MC 2145 D MC2145 D MC 2145D MC 2145 A1 MC2145 A1 MC 2145A1
- Authority
- MC
- Monaco
- Prior art keywords
- protein
- microorganisms
- oxidase activity
- expression vector
- same
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0044—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7)
- C12N9/0046—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7) with oxygen as acceptor (1.7.3)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Superconductors And Manufacturing Methods Therefor (AREA)
- Peptides Or Proteins (AREA)
- Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
- Glass Compositions (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention concerns a new urate oxidase activity protein which has the sequence (I), possibly preceeded by a methionine, or in that it may present a degree of substantial homology with this sequence. The invention is also aimed at medicines containing this protein, as well as the genetic engineering implements to obtain it.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8909550A FR2649720A1 (en) | 1989-07-13 | 1989-07-13 | Recombinant gene which encodes a protein such as urate oxidase |
FR8917466A FR2656530B1 (en) | 1989-12-29 | 1989-12-29 | RECOMBINANT GENE FOR EXPRESSION IN EUKARYOTIC CELLS OF A PROTEIN SUCH AS URATE OXIDASE. |
FR9001368A FR2657785A2 (en) | 1989-12-29 | 1990-02-06 | Recombinant gene for expression of a protein such as urate oxidase in animal cells |
PCT/FR1990/000532 WO1991000909A1 (en) | 1989-07-13 | 1990-07-13 | Urate oxidase activity protein, recombinant gene coding therefor, expression vector, micro-organisms and transformed cells |
Publications (1)
Publication Number | Publication Date |
---|---|
MC2145A1 true MC2145A1 (en) | 1992-02-18 |
Family
ID=27251947
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MC@@@@D MC2145A1 (en) | 1989-07-13 | 1990-07-13 | PROTEIN HAVING URATE OXIDASE ACTIVITY, RECOMBINANT GENE ENCODING THE SAME, EXPRESSION VECTOR, MICROORGANISMS AND TRANSFORMED CELLS |
Country Status (24)
Country | Link |
---|---|
EP (1) | EP0408461B1 (en) |
JP (1) | JP2664804B2 (en) |
AT (1) | ATE144282T1 (en) |
AU (1) | AU636637B2 (en) |
BR (1) | BR9006855A (en) |
CA (1) | CA2035900C (en) |
DE (2) | DE69028884T2 (en) |
DK (1) | DK0408461T3 (en) |
ES (1) | ES2095243T3 (en) |
FI (1) | FI105047B (en) |
GR (1) | GR3022085T3 (en) |
HK (1) | HK1000099A1 (en) |
HU (1) | HU215948B (en) |
IE (1) | IE77158B1 (en) |
IL (1) | IL95057A (en) |
LU (1) | LU90781I2 (en) |
LV (1) | LV12000B (en) |
MC (1) | MC2145A1 (en) |
NL (1) | NL300046I2 (en) |
NO (1) | NO2001018I2 (en) |
NZ (1) | NZ234453A (en) |
PT (1) | PT94680B (en) |
RU (1) | RU2105812C1 (en) |
WO (1) | WO1991000909A1 (en) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2971218B2 (en) * | 1991-12-04 | 1999-11-02 | 協和醗酵工業株式会社 | Uricase gene and method for producing uricase |
US5691188A (en) | 1994-02-14 | 1997-11-25 | American Cyanamid Company | Transformed yeast cells expressing heterologous G-protein coupled receptor |
US6083725A (en) | 1996-09-13 | 2000-07-04 | Transkaryotic Therapies, Inc. | Tranfected human cells expressing human α-galactosidase A protein |
RU2179034C2 (en) * | 1996-09-13 | 2002-02-10 | Транскариотик Терапиз, Инк. | METHOD TO TREAT α-GALACTOSIDASE A DEFICIENCY |
US6783965B1 (en) * | 2000-02-10 | 2004-08-31 | Mountain View Pharmaceuticals, Inc. | Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates |
DE69925917T2 (en) | 1998-08-06 | 2006-05-11 | Mountain View Pharmaceuticals, Inc., Menlo Park | PEG-uricase conjugates and use thereof |
EP1310560A4 (en) | 2000-08-17 | 2005-07-13 | Ajinomoto Kk | Method of modifying microorganism-origin transglutaminase |
ATE514430T1 (en) | 2002-04-25 | 2011-07-15 | Shire Human Genetic Therapies | TREATMENT OF ALPHA-GALACTOSIDASE A DEFICIENCY |
US8148123B2 (en) | 2005-04-11 | 2012-04-03 | Savient Pharmaceuticals, Inc. | Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase |
US7811800B2 (en) | 2005-04-11 | 2010-10-12 | Savient Pharmaceuticals, Inc. | Variant form of urate oxidase and use thereof |
TWI418564B (en) * | 2005-04-11 | 2013-12-11 | Savient Pharmaceuticals Inc | Purification of proteins with cationic surfactant |
WO2006110819A2 (en) | 2005-04-11 | 2006-10-19 | Savient Pharmaceuticals, Inc. | Variant forms of urate oxidase and use thereof |
EP2013225B1 (en) * | 2006-04-12 | 2014-12-17 | Crealta Pharmaceuticals LLC | Purification of proteins with cationic surfactant |
RU2443426C2 (en) * | 2008-11-07 | 2012-02-27 | Мунтэн Вью Фармасьютикэлз, Инк. | Urate oxidase conjugates, pharmaceutical composition for reduction in uric acid levels and method for preparing conjugates stated above |
CN102803954A (en) | 2009-06-25 | 2012-11-28 | 萨文特制药公司 | Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during PEGylated uricase therapy |
CN109223707B (en) * | 2018-09-13 | 2020-12-08 | 中国药科大学 | Uricase external gel preparation, preparation method and application thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR6301M (en) * | 1967-03-29 | 1968-09-09 | ||
SU457723A1 (en) * | 1973-04-09 | 1977-08-05 | Всесоюзный Научно-Исследовательский Витаминный Институт | Strain 313-152 actinomyces sp.as producer of uratoxydase |
EP0173378B1 (en) * | 1984-07-27 | 1991-06-12 | Unilever N.V. | Process for preparing a polypeptide by culturing a transformed microorganism, a transformed microorganism suitable therefor and dna sequences suitable for preparing such microorganism |
WO1988008450A1 (en) * | 1987-05-01 | 1988-11-03 | Birdwell Finlayson | Gene therapy for metabolite disorders |
JPH0671428B2 (en) * | 1988-08-17 | 1994-09-14 | サッポロビール株式会社 | Uricase DNA sequence and process |
-
1990
- 1990-07-11 NZ NZ234453A patent/NZ234453A/en unknown
- 1990-07-12 IL IL95057A patent/IL95057A/en active IP Right Grant
- 1990-07-12 PT PT94680A patent/PT94680B/en not_active IP Right Cessation
- 1990-07-13 CA CA002035900A patent/CA2035900C/en not_active Expired - Lifetime
- 1990-07-13 WO PCT/FR1990/000532 patent/WO1991000909A1/en active IP Right Grant
- 1990-07-13 JP JP2510514A patent/JP2664804B2/en not_active Expired - Lifetime
- 1990-07-13 AT AT90402023T patent/ATE144282T1/en active
- 1990-07-13 DK DK90402023.7T patent/DK0408461T3/en active
- 1990-07-13 DE DE69028884T patent/DE69028884T2/en not_active Expired - Lifetime
- 1990-07-13 ES ES90402023T patent/ES2095243T3/en not_active Expired - Lifetime
- 1990-07-13 EP EP90402023A patent/EP0408461B1/en not_active Expired - Lifetime
- 1990-07-13 AU AU60523/90A patent/AU636637B2/en not_active Expired
- 1990-07-13 IE IE255990A patent/IE77158B1/en not_active IP Right Cessation
- 1990-07-13 MC MC@@@@D patent/MC2145A1/en unknown
- 1990-07-13 DE DE2001199042 patent/DE10199042I2/en active Active
- 1990-07-13 RU SU4895030/13A patent/RU2105812C1/en active
- 1990-07-13 HU HU906046A patent/HU215948B/en active Protection Beyond IP Right Term
- 1990-07-13 BR BR909006855A patent/BR9006855A/en not_active Application Discontinuation
-
1991
- 1991-03-12 FI FI911212A patent/FI105047B/en active Protection Beyond IP Right Term
-
1996
- 1996-12-18 GR GR960403531T patent/GR3022085T3/en unknown
-
1997
- 1997-07-08 HK HK97101519A patent/HK1000099A1/en not_active IP Right Cessation
- 1997-10-15 LV LVP-97-200A patent/LV12000B/en unknown
-
2001
- 2001-05-23 LU LU90781C patent/LU90781I2/en unknown
- 2001-06-12 NL NL300046C patent/NL300046I2/en unknown
- 2001-10-30 NO NO2001018C patent/NO2001018I2/en not_active IP Right Cessation
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