CA2035900A1 - Protein having urate oxidase activity, recombinant gene coding for this protein, expression vector, microorganisms and transformed cells - Google Patents

Protein having urate oxidase activity, recombinant gene coding for this protein, expression vector, microorganisms and transformed cells

Info

Publication number
CA2035900A1
CA2035900A1 CA2035900A CA2035900A CA2035900A1 CA 2035900 A1 CA2035900 A1 CA 2035900A1 CA 2035900 A CA2035900 A CA 2035900A CA 2035900 A CA2035900 A CA 2035900A CA 2035900 A1 CA2035900 A1 CA 2035900A1
Authority
CA
Canada
Prior art keywords
protein
microorganisms
oxidase activity
expression vector
urate oxidase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2035900A
Other languages
French (fr)
Other versions
CA2035900C (en
Inventor
Daniel Caput
Pascual Ferrara
Jean-Claude Guillemot
Mourad Kaghad
Richard Legoux
Gerard Loison
Elisabeth Larbre
Johannes Lupker
Pascal Leplatois
Marc Salome
Patrick Laurent
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Daniel Caput
Pascual Ferrara
Jean-Claude Guillemot
Mourad Kaghad
Richard Legoux
Gerard Loison
Elisabeth Larbre
Johannes Lupker
Pascal Leplatois
Marc Salome
Patrick Laurent
Sanofi
Sanofi-Synthelabo
Sanofi-Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8909550A external-priority patent/FR2649720A1/en
Priority claimed from FR8917466A external-priority patent/FR2656530B1/en
Application filed by Daniel Caput, Pascual Ferrara, Jean-Claude Guillemot, Mourad Kaghad, Richard Legoux, Gerard Loison, Elisabeth Larbre, Johannes Lupker, Pascal Leplatois, Marc Salome, Patrick Laurent, Sanofi, Sanofi-Synthelabo, Sanofi-Aventis filed Critical Daniel Caput
Publication of CA2035900A1 publication Critical patent/CA2035900A1/en
Application granted granted Critical
Publication of CA2035900C publication Critical patent/CA2035900C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0044—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7)
    • C12N9/0046—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7) with oxygen as acceptor (1.7.3)

Abstract

The invention concerns a new urate oxidase activity protein which has the sequence (I), possibly preceeded by a methionine, or in that it may present a degree of substantial homology with this sequence. The invention is also aimed at medicines containing this protein, as well as the genetic engineering implements to obtain it.
CA002035900A 1989-07-13 1990-07-13 Protein having urate oxidase activity, recombinant gene coding for this protein, expression vector, microorganisms and transformed cells Expired - Lifetime CA2035900C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
FR8909550A FR2649720A1 (en) 1989-07-13 1989-07-13 Recombinant gene which encodes a protein such as urate oxidase
FR8909550 1989-07-13
FR8917466 1989-12-29
FR8917466A FR2656530B1 (en) 1989-12-29 1989-12-29 RECOMBINANT GENE FOR EXPRESSION IN EUKARYOTIC CELLS OF A PROTEIN SUCH AS URATE OXIDASE.
FR9001368 1990-02-06
FR9001368A FR2657785A2 (en) 1989-12-29 1990-02-06 Recombinant gene for expression of a protein such as urate oxidase in animal cells
PCT/FR1990/000532 WO1991000909A1 (en) 1989-07-13 1990-07-13 Urate oxidase activity protein, recombinant gene coding therefor, expression vector, micro-organisms and transformed cells

Publications (2)

Publication Number Publication Date
CA2035900A1 true CA2035900A1 (en) 1991-01-14
CA2035900C CA2035900C (en) 2000-01-11

Family

ID=27251947

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002035900A Expired - Lifetime CA2035900C (en) 1989-07-13 1990-07-13 Protein having urate oxidase activity, recombinant gene coding for this protein, expression vector, microorganisms and transformed cells

Country Status (24)

Country Link
EP (1) EP0408461B1 (en)
JP (1) JP2664804B2 (en)
AT (1) ATE144282T1 (en)
AU (1) AU636637B2 (en)
BR (1) BR9006855A (en)
CA (1) CA2035900C (en)
DE (2) DE10199042I2 (en)
DK (1) DK0408461T3 (en)
ES (1) ES2095243T3 (en)
FI (1) FI105047B (en)
GR (1) GR3022085T3 (en)
HK (1) HK1000099A1 (en)
HU (1) HU215948B (en)
IE (1) IE77158B1 (en)
IL (1) IL95057A (en)
LU (1) LU90781I2 (en)
LV (1) LV12000B (en)
MC (1) MC2145A1 (en)
NL (1) NL300046I2 (en)
NO (1) NO2001018I2 (en)
NZ (1) NZ234453A (en)
PT (1) PT94680B (en)
RU (1) RU2105812C1 (en)
WO (1) WO1991000909A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2971218B2 (en) * 1991-12-04 1999-11-02 協和醗酵工業株式会社 Uricase gene and method for producing uricase
US5691188A (en) 1994-02-14 1997-11-25 American Cyanamid Company Transformed yeast cells expressing heterologous G-protein coupled receptor
US6083725A (en) 1996-09-13 2000-07-04 Transkaryotic Therapies, Inc. Tranfected human cells expressing human α-galactosidase A protein
MX340738B (en) * 1996-09-13 2016-07-22 Shire Human Genetic Therapies THERAPY FOR α-GALACTOSIDASE A DEFICIENCY.
ES2404074T3 (en) 1998-08-06 2013-05-23 Mountain View Pharmaceuticals, Inc. Conjugates of urate peg oxidase and its use
US6783965B1 (en) * 2000-02-10 2004-08-31 Mountain View Pharmaceuticals, Inc. Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
BR0113304A (en) 2000-08-17 2004-01-06 Ajinomoto Kk Method for designing and preparing a mutant transglutaminase, mutant mtg mutant transglutaminase, gene, recombinant DNA, microorganisms, method for producing a mutant mtg or mutant transglutaminase, and monocyclic mtg crystals
ATE514430T1 (en) 2002-04-25 2011-07-15 Shire Human Genetic Therapies TREATMENT OF ALPHA-GALACTOSIDASE A DEFICIENCY
US8148123B2 (en) 2005-04-11 2012-04-03 Savient Pharmaceuticals, Inc. Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
TWI418564B (en) * 2005-04-11 2013-12-11 Savient Pharmaceuticals Inc Purification of proteins with cationic surfactant
PL215157B1 (en) 2005-04-11 2013-10-31 Savient Pharmaceuticals Variant of urate oxidase and its application
ES2538357T3 (en) 2005-04-11 2015-06-19 Crealta Pharmaceuticals Llc Variant forms of urate oxidase and use thereof
WO2008051178A2 (en) 2006-04-12 2008-05-02 Savient Pharmaceuticals, Inc. Purification of proteins with cationic surfactant
RU2443426C2 (en) * 2008-11-07 2012-02-27 Мунтэн Вью Фармасьютикэлз, Инк. Urate oxidase conjugates, pharmaceutical composition for reduction in uric acid levels and method for preparing conjugates stated above
CZ2011827A3 (en) 2009-06-25 2012-09-26 Savient Pharmaceuticals, Inc. Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during PEGylated uricase therapy
CN109223707B (en) * 2018-09-13 2020-12-08 中国药科大学 Uricase external gel preparation, preparation method and application thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1529675A (en) * 1967-03-29 1968-06-21 Applic Biochimiques Soc Et High activity urate oxidase and its preparation
SU457723A1 (en) * 1973-04-09 1977-08-05 Всесоюзный Научно-Исследовательский Витаминный Институт Strain 313-152 actinomyces sp.as producer of uratoxydase
DE3583194D1 (en) * 1984-07-27 1991-07-18 Unilever Nv METHOD FOR THE PRODUCTION OF A POLYPEPTIDE BY MEANS OF A TRANSFORMED MICROORGANISM, A TRANSFORMED MICROORGANISM SUITABLE FOR THIS, AND DNA SEQUENCES SUITABLE FOR THE PRODUCTION OF THESE MICROORGANISMS.
WO1988008450A1 (en) * 1987-05-01 1988-11-03 Birdwell Finlayson Gene therapy for metabolite disorders
JPH0671428B2 (en) * 1988-08-17 1994-09-14 サッポロビール株式会社 Uricase DNA sequence and process

Also Published As

Publication number Publication date
ATE144282T1 (en) 1996-11-15
NZ234453A (en) 1993-01-27
HU906046D0 (en) 1991-07-29
PT94680A (en) 1991-04-18
DE69028884D1 (en) 1996-11-21
JP2664804B2 (en) 1997-10-22
NL300046I1 (en) 2001-09-03
CA2035900C (en) 2000-01-11
IE77158B1 (en) 1997-12-03
HU215948B (en) 1999-03-29
IL95057A0 (en) 1991-06-10
FI105047B (en) 2000-05-31
GR3022085T3 (en) 1997-03-31
AU636637B2 (en) 1993-05-06
MC2145A1 (en) 1992-02-18
HK1000099A1 (en) 1997-11-21
NL300046I2 (en) 2001-12-01
LV12000B (en) 1998-06-20
EP0408461A1 (en) 1991-01-16
FI911212A0 (en) 1991-03-12
DE10199042I2 (en) 2003-10-23
BR9006855A (en) 1991-08-06
NO2001018I2 (en) 2006-05-01
DK0408461T3 (en) 1997-03-24
JPH04501807A (en) 1992-04-02
EP0408461B1 (en) 1996-10-16
LV12000A (en) 1998-03-20
DE10199042I1 (en) 2002-01-10
AU6052390A (en) 1991-02-06
DE69028884T2 (en) 1997-05-07
IL95057A (en) 1997-07-13
PT94680B (en) 1997-04-30
LU90781I2 (en) 2001-07-23
ES2095243T3 (en) 1997-02-16
WO1991000909A1 (en) 1991-01-24
IE902559A1 (en) 1991-02-27
HUT56884A (en) 1991-10-28
RU2105812C1 (en) 1998-02-27

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