IL95057A0 - Recombinant gene coding for a protein such as urate oxidase - Google Patents

Recombinant gene coding for a protein such as urate oxidase

Info

Publication number
IL95057A0
IL95057A0 IL95057A IL9505790A IL95057A0 IL 95057 A0 IL95057 A0 IL 95057A0 IL 95057 A IL95057 A IL 95057A IL 9505790 A IL9505790 A IL 9505790A IL 95057 A0 IL95057 A0 IL 95057A0
Authority
IL
Israel
Prior art keywords
protein
urate oxidase
gene coding
recombinant gene
sequence
Prior art date
Application number
IL95057A
Other versions
IL95057A (en
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8909550A external-priority patent/FR2649720A1/en
Priority claimed from FR8917466A external-priority patent/FR2656530B1/en
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of IL95057A0 publication Critical patent/IL95057A0/en
Publication of IL95057A publication Critical patent/IL95057A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0044—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7)
    • C12N9/0046—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7) with oxygen as acceptor (1.7.3)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Saccharide Compounds (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
  • Glass Compositions (AREA)

Abstract

The invention concerns a new urate oxidase activity protein which has the sequence (I), possibly preceeded by a methionine, or in that it may present a degree of substantial homology with this sequence. The invention is also aimed at medicines containing this protein, as well as the genetic engineering implements to obtain it.
IL95057A 1989-07-13 1990-07-12 Recombinant gene coding for a protein possessing urate oxidase activity IL95057A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR8909550A FR2649720A1 (en) 1989-07-13 1989-07-13 Recombinant gene which encodes a protein such as urate oxidase
FR8917466A FR2656530B1 (en) 1989-12-29 1989-12-29 RECOMBINANT GENE FOR EXPRESSION IN EUKARYOTIC CELLS OF A PROTEIN SUCH AS URATE OXIDASE.
FR9001368A FR2657785A2 (en) 1989-12-29 1990-02-06 Recombinant gene for expression of a protein such as urate oxidase in animal cells

Publications (2)

Publication Number Publication Date
IL95057A0 true IL95057A0 (en) 1991-06-10
IL95057A IL95057A (en) 1997-07-13

Family

ID=27251947

Family Applications (1)

Application Number Title Priority Date Filing Date
IL95057A IL95057A (en) 1989-07-13 1990-07-12 Recombinant gene coding for a protein possessing urate oxidase activity

Country Status (24)

Country Link
EP (1) EP0408461B1 (en)
JP (1) JP2664804B2 (en)
AT (1) ATE144282T1 (en)
AU (1) AU636637B2 (en)
BR (1) BR9006855A (en)
CA (1) CA2035900C (en)
DE (2) DE69028884T2 (en)
DK (1) DK0408461T3 (en)
ES (1) ES2095243T3 (en)
FI (1) FI105047B (en)
GR (1) GR3022085T3 (en)
HK (1) HK1000099A1 (en)
HU (1) HU215948B (en)
IE (1) IE77158B1 (en)
IL (1) IL95057A (en)
LU (1) LU90781I2 (en)
LV (1) LV12000B (en)
MC (1) MC2145A1 (en)
NL (1) NL300046I2 (en)
NO (1) NO2001018I2 (en)
NZ (1) NZ234453A (en)
PT (1) PT94680B (en)
RU (1) RU2105812C1 (en)
WO (1) WO1991000909A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2971218B2 (en) * 1991-12-04 1999-11-02 協和醗酵工業株式会社 Uricase gene and method for producing uricase
US5691188A (en) 1994-02-14 1997-11-25 American Cyanamid Company Transformed yeast cells expressing heterologous G-protein coupled receptor
US6083725A (en) 1996-09-13 2000-07-04 Transkaryotic Therapies, Inc. Tranfected human cells expressing human α-galactosidase A protein
ES2234032T3 (en) * 1996-09-13 2005-06-16 Transkaryotic Therapies, Inc. THERAPY FOR THE DEFICIENCY OF ALFA-GALACTOSIDASE A.
US6783965B1 (en) * 2000-02-10 2004-08-31 Mountain View Pharmaceuticals, Inc. Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
ATE498409T1 (en) 1998-08-06 2011-03-15 Mountain View Pharmaceuticals PEG-URICASE CONJUGATES AND USE THEREOF
RU2260051C2 (en) 2000-08-17 2005-09-10 Адзиномото Ко., Инк. Modification of microorganism transglutaminase
EP2361631A1 (en) 2002-04-25 2011-08-31 Shire Human Genetic Therapies, Inc. Treatment of alpha-galactosidase a deficiency
US8148123B2 (en) 2005-04-11 2012-04-03 Savient Pharmaceuticals, Inc. Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
SG161247A1 (en) 2005-04-11 2010-05-27 Savient Pharmaceuticals Inc Variant forms of urate oxidase and use thereof
WO2008051178A2 (en) 2006-04-12 2008-05-02 Savient Pharmaceuticals, Inc. Purification of proteins with cationic surfactant
NZ562291A (en) 2005-04-11 2010-02-26 Savient Pharmaceuticals Inc A variant form of urate oxidase and use thereof
TWI418564B (en) * 2005-04-11 2013-12-11 Savient Pharmaceuticals Inc Purification of proteins with cationic surfactant
RU2443426C2 (en) * 2008-11-07 2012-02-27 Мунтэн Вью Фармасьютикэлз, Инк. Urate oxidase conjugates, pharmaceutical composition for reduction in uric acid levels and method for preparing conjugates stated above
EP2446260B1 (en) 2009-06-25 2018-12-26 Horizon Pharma Rheumatology LLC Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy
CN109223707B (en) * 2018-09-13 2020-12-08 中国药科大学 Uricase external gel preparation, preparation method and application thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1529675A (en) * 1967-03-29 1968-06-21 Applic Biochimiques Soc Et High activity urate oxidase and its preparation
SU457723A1 (en) * 1973-04-09 1977-08-05 Всесоюзный Научно-Исследовательский Витаминный Институт Strain 313-152 actinomyces sp.as producer of uratoxydase
DE3583194D1 (en) * 1984-07-27 1991-07-18 Unilever Nv METHOD FOR THE PRODUCTION OF A POLYPEPTIDE BY MEANS OF A TRANSFORMED MICROORGANISM, A TRANSFORMED MICROORGANISM SUITABLE FOR THIS, AND DNA SEQUENCES SUITABLE FOR THE PRODUCTION OF THESE MICROORGANISMS.
WO1988008450A1 (en) * 1987-05-01 1988-11-03 Birdwell Finlayson Gene therapy for metabolite disorders
JPH0671428B2 (en) * 1988-08-17 1994-09-14 サッポロビール株式会社 Uricase DNA sequence and process

Also Published As

Publication number Publication date
WO1991000909A1 (en) 1991-01-24
CA2035900C (en) 2000-01-11
EP0408461B1 (en) 1996-10-16
RU2105812C1 (en) 1998-02-27
IE902559A1 (en) 1991-02-27
NL300046I2 (en) 2001-12-01
BR9006855A (en) 1991-08-06
EP0408461A1 (en) 1991-01-16
ES2095243T3 (en) 1997-02-16
PT94680A (en) 1991-04-18
PT94680B (en) 1997-04-30
FI911212A0 (en) 1991-03-12
DE69028884D1 (en) 1996-11-21
LU90781I2 (en) 2001-07-23
DE69028884T2 (en) 1997-05-07
IE77158B1 (en) 1997-12-03
JP2664804B2 (en) 1997-10-22
HU906046D0 (en) 1991-07-29
JPH04501807A (en) 1992-04-02
DK0408461T3 (en) 1997-03-24
HUT56884A (en) 1991-10-28
HU215948B (en) 1999-03-29
HK1000099A1 (en) 1997-11-21
LV12000B (en) 1998-06-20
LV12000A (en) 1998-03-20
ATE144282T1 (en) 1996-11-15
MC2145A1 (en) 1992-02-18
NO2001018I2 (en) 2006-05-01
AU6052390A (en) 1991-02-06
NZ234453A (en) 1993-01-27
FI105047B (en) 2000-05-31
NL300046I1 (en) 2001-09-03
GR3022085T3 (en) 1997-03-31
AU636637B2 (en) 1993-05-06
IL95057A (en) 1997-07-13
CA2035900A1 (en) 1991-01-14
DE10199042I2 (en) 2003-10-23
DE10199042I1 (en) 2002-01-10

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Legal Events

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