IL95057A - Recombinant gene coding for a protein possessing urate oxidase activity - Google Patents

Recombinant gene coding for a protein possessing urate oxidase activity

Info

Publication number
IL95057A
IL95057A IL95057A IL9505790A IL95057A IL 95057 A IL95057 A IL 95057A IL 95057 A IL95057 A IL 95057A IL 9505790 A IL9505790 A IL 9505790A IL 95057 A IL95057 A IL 95057A
Authority
IL
Israel
Prior art keywords
oxidase activity
gene coding
urate oxidase
recombinant gene
protein possessing
Prior art date
Application number
IL95057A
Other versions
IL95057A0 (en
Inventor
Daniel Caput
Pascual Ferrara
Jean-Claude Guillemot
Mourad Kaghad
Richard Legoux
Gerard Loison
Elisabeth Larbre
Johannes Lupker
Pascal Leplatois
Marc Salome
Patrick Laurent
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8909550A external-priority patent/FR2649720A1/en
Priority claimed from FR8917466A external-priority patent/FR2656530B1/en
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of IL95057A0 publication Critical patent/IL95057A0/en
Publication of IL95057A publication Critical patent/IL95057A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0044—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7)
    • C12N9/0046—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7) with oxygen as acceptor (1.7.3)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
  • Glass Compositions (AREA)
  • Saccharide Compounds (AREA)

Abstract

A recombinant protein possessing a specific urate oxidase activity of at least 16 U/mg and having the following sequence: preceded, if appropriate, by a methionine.
IL95057A 1989-07-13 1990-07-12 Recombinant gene coding for a protein possessing urate oxidase activity IL95057A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR8909550A FR2649720A1 (en) 1989-07-13 1989-07-13 Recombinant gene which encodes a protein such as urate oxidase
FR8917466A FR2656530B1 (en) 1989-12-29 1989-12-29 RECOMBINANT GENE FOR EXPRESSION IN EUKARYOTIC CELLS OF A PROTEIN SUCH AS URATE OXIDASE.
FR9001368A FR2657785A2 (en) 1989-12-29 1990-02-06 Recombinant gene for expression of a protein such as urate oxidase in animal cells

Publications (2)

Publication Number Publication Date
IL95057A0 IL95057A0 (en) 1991-06-10
IL95057A true IL95057A (en) 1997-07-13

Family

ID=27251947

Family Applications (1)

Application Number Title Priority Date Filing Date
IL95057A IL95057A (en) 1989-07-13 1990-07-12 Recombinant gene coding for a protein possessing urate oxidase activity

Country Status (23)

Country Link
EP (1) EP0408461B1 (en)
JP (1) JP2664804B2 (en)
AT (1) ATE144282T1 (en)
AU (1) AU636637B2 (en)
BR (1) BR9006855A (en)
CA (1) CA2035900C (en)
DE (2) DE10199042I2 (en)
DK (1) DK0408461T3 (en)
ES (1) ES2095243T3 (en)
FI (1) FI105047B (en)
GR (1) GR3022085T3 (en)
HU (1) HU215948B (en)
IE (1) IE77158B1 (en)
IL (1) IL95057A (en)
LU (1) LU90781I2 (en)
LV (1) LV12000B (en)
MC (1) MC2145A1 (en)
NL (1) NL300046I2 (en)
NO (1) NO2001018I2 (en)
NZ (1) NZ234453A (en)
PT (1) PT94680B (en)
RU (1) RU2105812C1 (en)
WO (1) WO1991000909A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2971218B2 (en) * 1991-12-04 1999-11-02 協和醗酵工業株式会社 Uricase gene and method for producing uricase
US5691188A (en) 1994-02-14 1997-11-25 American Cyanamid Company Transformed yeast cells expressing heterologous G-protein coupled receptor
US6083725A (en) 1996-09-13 2000-07-04 Transkaryotic Therapies, Inc. Tranfected human cells expressing human α-galactosidase A protein
PL190041B1 (en) * 1996-09-13 2005-10-31 Transkaryotic Therapies Therapy against alpha-galactosidase a deficiency
PT2158923E (en) 1998-08-06 2013-06-04 Univ Duke Peg-urate oxidase conjugates and use thereof
RU2278680C2 (en) * 1998-08-06 2006-06-27 Маунтэн Вью Фармасьютикэлз, Инк. Method for isolation of tetra-dimensional form of uricase and uricase
US6783965B1 (en) * 2000-02-10 2004-08-31 Mountain View Pharmaceuticals, Inc. Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
EP1310560A4 (en) 2000-08-17 2005-07-13 Ajinomoto Kk Method of modifying microorganism-origin transglutaminase
DK1503788T3 (en) 2002-04-25 2011-10-17 Shire Human Genetic Therapies Treatment of alpha-galactosidase A deficiency
ES2538357T3 (en) 2005-04-11 2015-06-19 Crealta Pharmaceuticals Llc Variant forms of urate oxidase and use thereof
US8148123B2 (en) 2005-04-11 2012-04-03 Savient Pharmaceuticals, Inc. Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
CA2604545A1 (en) 2005-04-11 2006-10-19 Savient Pharmaceuticals, Inc. A variant form of urate oxidase and use thereof
TWI418564B (en) * 2005-04-11 2013-12-11 Savient Pharmaceuticals Inc Purification of proteins with cationic surfactant
EP2013225B1 (en) * 2006-04-12 2014-12-17 Crealta Pharmaceuticals LLC Purification of proteins with cationic surfactant
RU2443426C2 (en) * 2008-11-07 2012-02-27 Мунтэн Вью Фармасьютикэлз, Инк. Urate oxidase conjugates, pharmaceutical composition for reduction in uric acid levels and method for preparing conjugates stated above
US9377454B2 (en) 2009-06-25 2016-06-28 Crealta Pharmaceuticals Llc Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy
JP2019535819A (en) 2016-11-11 2019-12-12 ホライゾン ファーマ リューマトロジー リミテッド ライアビリティ カンパニーＨｏｒｉｚｏｎ Ｐｈａｒｍａ Ｒｈｅｕｍａｔｏｌｏｇｙ Ｌｌｃ Combination therapy and use of prednisone and uricase molecules
CN109223707B (en) * 2018-09-13 2020-12-08 中国药科大学 A kind of uricase gel preparation for external use, its preparation method and use
WO2020160325A1 (en) 2019-01-30 2020-08-06 Horizon Pharma Rheumatology Llc Reducing immunogenicity to pegloticase
US12269875B2 (en) 2023-08-03 2025-04-08 Jeff R. Peterson Gout flare prevention methods using IL-1BETA blockers

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1529675A (en) * 1967-03-29 1968-06-21 Applic Biochimiques Soc Et High activity urate oxidase and its preparation
SU457723A1 (en) * 1973-04-09 1977-08-05 Всесоюзный Научно-Исследовательский Витаминный Институт Strain 313-152 actinomyces sp.as producer of uratoxydase
CA1341130C (en) * 1984-07-27 2000-10-31 Adrianus Marinus Ledeboer Use of oxidoreductases in bleaching and/or detergent compositions and their preparation by microorganisms engineered by recombinant dna technology
WO1988008450A1 (en) * 1987-05-01 1988-11-03 Birdwell Finlayson Gene therapy for metabolite disorders
JPH0671428B2 (en) * 1988-08-17 1994-09-14 サッポロビール株式会社 Uricase DNA sequence and process

Also Published As

Publication number Publication date
GR3022085T3 (en) 1997-03-31
ATE144282T1 (en) 1996-11-15
BR9006855A (en) 1991-08-06
LV12000B (en) 1998-06-20
AU636637B2 (en) 1993-05-06
NL300046I2 (en) 2001-12-01
FI105047B (en) 2000-05-31
PT94680B (en) 1997-04-30
HU215948B (en) 1999-03-29
CA2035900A1 (en) 1991-01-14
DE69028884T2 (en) 1997-05-07
HU906046D0 (en) 1991-07-29
ES2095243T3 (en) 1997-02-16
WO1991000909A1 (en) 1991-01-24
DE10199042I1 (en) 2002-01-10
PT94680A (en) 1991-04-18
MC2145A1 (en) 1992-02-18
IE77158B1 (en) 1997-12-03
EP0408461A1 (en) 1991-01-16
RU2105812C1 (en) 1998-02-27
DE10199042I2 (en) 2003-10-23
HK1000099A1 (en) 1997-11-21
JPH04501807A (en) 1992-04-02
LV12000A (en) 1998-03-20
LU90781I2 (en) 2001-07-23
FI911212A0 (en) 1991-03-12
AU6052390A (en) 1991-02-06
EP0408461B1 (en) 1996-10-16
NZ234453A (en) 1993-01-27
DK0408461T3 (en) 1997-03-24
NL300046I1 (en) 2001-09-03
JP2664804B2 (en) 1997-10-22
NO2001018I2 (en) 2006-05-01
DE69028884D1 (en) 1996-11-21
CA2035900C (en) 2000-01-11
IE902559A1 (en) 1991-02-27
HUT56884A (en) 1991-10-28
IL95057A0 (en) 1991-06-10

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