IL95057A - Recombinant gene coding for a protein possessing urate oxidase activity - Google Patents

Recombinant gene coding for a protein possessing urate oxidase activity

Info

Publication number
IL95057A
IL95057A IL95057A IL9505790A IL95057A IL 95057 A IL95057 A IL 95057A IL 95057 A IL95057 A IL 95057A IL 9505790 A IL9505790 A IL 9505790A IL 95057 A IL95057 A IL 95057A
Authority
IL
Israel
Prior art keywords
oxidase activity
gene coding
urate oxidase
recombinant gene
protein possessing
Prior art date
Application number
IL95057A
Other versions
IL95057A0 (en
Inventor
Daniel Caput
Pascual Ferrara
Jean-Claude Guillemot
Mourad Kaghad
Richard Legoux
Gerard Loison
Elisabeth Larbre
Johannes Lupker
Pascal Leplatois
Marc Salome
Patrick Laurent
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8909550A external-priority patent/FR2649720A1/en
Priority claimed from FR8917466A external-priority patent/FR2656530B1/en
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of IL95057A0 publication Critical patent/IL95057A0/en
Publication of IL95057A publication Critical patent/IL95057A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0044—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7)
    • C12N9/0046—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7) with oxygen as acceptor (1.7.3)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
  • Glass Compositions (AREA)
  • Saccharide Compounds (AREA)

Abstract

A recombinant protein possessing a specific urate oxidase activity of at least 16 U/mg and having the following sequence: preceded, if appropriate, by a methionine.
IL95057A 1989-07-13 1990-07-12 Recombinant gene coding for a protein possessing urate oxidase activity IL95057A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR8909550A FR2649720A1 (en) 1989-07-13 1989-07-13 Recombinant gene which encodes a protein such as urate oxidase
FR8917466A FR2656530B1 (en) 1989-12-29 1989-12-29 RECOMBINANT GENE FOR EXPRESSION IN EUKARYOTIC CELLS OF A PROTEIN SUCH AS URATE OXIDASE.
FR9001368A FR2657785A2 (en) 1989-12-29 1990-02-06 Recombinant gene for expression of a protein such as urate oxidase in animal cells

Publications (2)

Publication Number Publication Date
IL95057A0 IL95057A0 (en) 1991-06-10
IL95057A true IL95057A (en) 1997-07-13

Family

ID=27251947

Family Applications (1)

Application Number Title Priority Date Filing Date
IL95057A IL95057A (en) 1989-07-13 1990-07-12 Recombinant gene coding for a protein possessing urate oxidase activity

Country Status (24)

Country Link
EP (1) EP0408461B1 (en)
JP (1) JP2664804B2 (en)
AT (1) ATE144282T1 (en)
AU (1) AU636637B2 (en)
BR (1) BR9006855A (en)
CA (1) CA2035900C (en)
DE (2) DE10199042I2 (en)
DK (1) DK0408461T3 (en)
ES (1) ES2095243T3 (en)
FI (1) FI105047B (en)
GR (1) GR3022085T3 (en)
HK (1) HK1000099A1 (en)
HU (1) HU215948B (en)
IE (1) IE77158B1 (en)
IL (1) IL95057A (en)
LU (1) LU90781I2 (en)
LV (1) LV12000B (en)
MC (1) MC2145A1 (en)
NL (1) NL300046I2 (en)
NO (1) NO2001018I2 (en)
NZ (1) NZ234453A (en)
PT (1) PT94680B (en)
RU (1) RU2105812C1 (en)
WO (1) WO1991000909A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2971218B2 (en) * 1991-12-04 1999-11-02 協和醗酵工業株式会社 Uricase gene and method for producing uricase
US5691188A (en) 1994-02-14 1997-11-25 American Cyanamid Company Transformed yeast cells expressing heterologous G-protein coupled receptor
US6083725A (en) 1996-09-13 2000-07-04 Transkaryotic Therapies, Inc. Tranfected human cells expressing human α-galactosidase A protein
HU227189B1 (en) * 1996-09-13 2010-10-28 Transkaryotic Therapies Therapy for alpha-galactosidase a deficiency
HU226294B1 (en) * 1998-08-06 2008-08-28 Mountain View Pharmaceuticals Peg-urate oxidase conjugates and use thereof
US6783965B1 (en) * 2000-02-10 2004-08-31 Mountain View Pharmaceuticals, Inc. Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
CA2338665C (en) 1998-08-06 2011-01-18 Mountain View Pharmaceuticals, Inc. Peg-urate oxidase conjugates and use thereof
BR0113304A (en) 2000-08-17 2004-01-06 Ajinomoto Kk Method for designing and preparing a mutant transglutaminase, mutant mtg mutant transglutaminase, gene, recombinant DNA, microorganisms, method for producing a mutant mtg or mutant transglutaminase, and monocyclic mtg crystals
ES2367257T3 (en) 2002-04-25 2011-10-31 Shire Human Genetic Therapies, Inc. TREATMENT OF DEFICIT OF ALFA-GALACTOSIDASA A.
TWI418564B (en) * 2005-04-11 2013-12-11 Savient Pharmaceuticals Inc Purification of proteins with cationic surfactant
WO2008051178A2 (en) * 2006-04-12 2008-05-02 Savient Pharmaceuticals, Inc. Purification of proteins with cationic surfactant
US8148123B2 (en) 2005-04-11 2012-04-03 Savient Pharmaceuticals, Inc. Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
US8188224B2 (en) 2005-04-11 2012-05-29 Savient Pharmaceuticals, Inc. Variant forms of urate oxidase and use thereof
US7811800B2 (en) 2005-04-11 2010-10-12 Savient Pharmaceuticals, Inc. Variant form of urate oxidase and use thereof
RU2443426C2 (en) * 2008-11-07 2012-02-27 Мунтэн Вью Фармасьютикэлз, Инк. Urate oxidase conjugates, pharmaceutical composition for reduction in uric acid levels and method for preparing conjugates stated above
EP4635567A3 (en) 2009-06-25 2025-12-03 Horizon Therapeutics USA, Inc. Methods and kits for preventing infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy
US20200237881A1 (en) 2019-01-30 2020-07-30 Horizon Pharma Rheumatology Llc Reducing immunogenicity to pegloticase
CN110234340A (en) 2016-11-11 2019-09-13 好利恩风湿病制药有限责任公司 Combination therapy of prednisone and uricase molecules and uses thereof
CN109223707B (en) * 2018-09-13 2020-12-08 中国药科大学 A kind of uricase gel preparation for external use, its preparation method and use
US12269875B2 (en) 2023-08-03 2025-04-08 Jeff R. Peterson Gout flare prevention methods using IL-1BETA blockers

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR6301M (en) * 1967-03-29 1968-09-09
SU457723A1 (en) * 1973-04-09 1977-08-05 Всесоюзный Научно-Исследовательский Витаминный Институт Strain 313-152 actinomyces sp.as producer of uratoxydase
EP0423890A3 (en) * 1984-07-27 1991-07-03 Unilever Nv Use of oxidoreductases in bleaching and/or detergent compositions and their preparation by microorganisms engineered by recombinant dna technology
WO1988008450A1 (en) * 1987-05-01 1988-11-03 Birdwell Finlayson Gene therapy for metabolite disorders
JPH0671428B2 (en) * 1988-08-17 1994-09-14 サッポロビール株式会社 Uricase DNA sequence and process

Also Published As

Publication number Publication date
NO2001018I2 (en) 2006-05-01
LV12000A (en) 1998-03-20
IE77158B1 (en) 1997-12-03
IE902559A1 (en) 1991-02-27
FI911212A0 (en) 1991-03-12
NL300046I1 (en) 2001-09-03
WO1991000909A1 (en) 1991-01-24
JPH04501807A (en) 1992-04-02
HU215948B (en) 1999-03-29
CA2035900C (en) 2000-01-11
PT94680B (en) 1997-04-30
IL95057A0 (en) 1991-06-10
AU6052390A (en) 1991-02-06
HUT56884A (en) 1991-10-28
DE10199042I2 (en) 2003-10-23
NZ234453A (en) 1993-01-27
MC2145A1 (en) 1992-02-18
GR3022085T3 (en) 1997-03-31
DE10199042I1 (en) 2002-01-10
DK0408461T3 (en) 1997-03-24
AU636637B2 (en) 1993-05-06
BR9006855A (en) 1991-08-06
HU906046D0 (en) 1991-07-29
LV12000B (en) 1998-06-20
ATE144282T1 (en) 1996-11-15
EP0408461A1 (en) 1991-01-16
NL300046I2 (en) 2001-12-01
HK1000099A1 (en) 1997-11-21
RU2105812C1 (en) 1998-02-27
FI105047B (en) 2000-05-31
DE69028884D1 (en) 1996-11-21
DE69028884T2 (en) 1997-05-07
CA2035900A1 (en) 1991-01-14
JP2664804B2 (en) 1997-10-22
LU90781I2 (en) 2001-07-23
PT94680A (en) 1991-04-18
EP0408461B1 (en) 1996-10-16
ES2095243T3 (en) 1997-02-16

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Legal Events

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KB Patent renewed
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KB Patent renewed