CA2066263A1 - Tsh receptor - Google Patents

Tsh receptor

Info

Publication number
CA2066263A1
CA2066263A1 CA2066263A CA2066263A CA2066263A1 CA 2066263 A1 CA2066263 A1 CA 2066263A1 CA 2066263 A CA2066263 A CA 2066263A CA 2066263 A CA2066263 A CA 2066263A CA 2066263 A1 CA2066263 A1 CA 2066263A1
Authority
CA
Canada
Prior art keywords
tsh receptor
protein
nucleic acid
biological activity
acid encoding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2066263A
Other languages
French (fr)
Other versions
CA2066263C (en
Inventor
Roger Cone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
New England Medical Center Hospitals Inc
Original Assignee
New England Medical Center Hospitals, Inc.
Roger Cone
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New England Medical Center Hospitals, Inc., Roger Cone filed Critical New England Medical Center Hospitals, Inc.
Publication of CA2066263A1 publication Critical patent/CA2066263A1/en
Application granted granted Critical
Publication of CA2066263C publication Critical patent/CA2066263C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor

Abstract

A protein having the biological activity of a mammalian TSH receptor, and purified nucleic acid encoding such a protein.
CA002066263A 1989-09-08 1990-09-07 Tsh receptor Expired - Fee Related CA2066263C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US40489989A 1989-09-08 1989-09-08
US404,899 1989-09-08
US56566990A 1990-08-10 1990-08-10
US565,669 1990-08-10
PCT/US1990/005066 WO1991003483A1 (en) 1989-09-08 1990-09-07 Tsh receptor

Publications (2)

Publication Number Publication Date
CA2066263A1 true CA2066263A1 (en) 1991-03-09
CA2066263C CA2066263C (en) 1999-11-02

Family

ID=27018824

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002066263A Expired - Fee Related CA2066263C (en) 1989-09-08 1990-09-07 Tsh receptor

Country Status (4)

Country Link
EP (1) EP0493434A4 (en)
JP (1) JP3181582B2 (en)
CA (1) CA2066263C (en)
WO (1) WO1991003483A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5732190A (en) * 1989-05-05 1990-11-29 Genentech Inc. Glycoprotein hormone receptor molecules
US6261800B1 (en) 1989-05-05 2001-07-17 Genentech, Inc. Luteinizing hormone/choriogonadotropin (LH/CG) receptor
US5744348A (en) * 1989-09-08 1998-04-28 New England Medical Center Hospitals, Inc. TSH receptor
US5614363A (en) * 1990-01-25 1997-03-25 New England Medical Center Hospitals, Inc. TSH receptor
ES2092998T3 (en) * 1989-12-14 1996-12-16 Brahms Diagnostica Gmbh POLYPEPTIDES THAT HAVE ACTIVITY OF TYROTROPINE RECEPTORS, NUCLEIC ACID SEQUENCES THAT CODE FOR SUCH RECEPTORS AND POLYPEPTIDES, AND APPLICATIONS OF THESE POLYPEPTIDES.
EP0506890A4 (en) * 1989-12-20 1993-06-30 Nichols Institute Diagnostics Recombinant thyrotropin receptor
DE19645729C1 (en) * 1996-11-06 1998-06-04 Brahms Diagnostica Gmbh Receptor binding assay for detecting auto-antibodies to thyroid stimulating hormone receptor
DE19651093C2 (en) * 1996-12-09 1999-06-10 Brahms Diagnostica Gmbh Receptor binding assay for the detection of TSH receptor autoantibodies and set of reagents for performing such a receptor binding assay
WO1999015545A1 (en) * 1997-09-24 1999-04-01 Merck & Co., Inc. G-protein coupled glycoprotein hormone receptor aomf05
GB9823397D0 (en) * 1998-10-27 1998-12-23 Rsr Ltd Assays for thyroid autoantibodies
EP1565492B1 (en) 2002-11-26 2006-12-20 B.R.A.H.M.S Aktiengesellschaft Identification of tsh receptor autoantibodies using affinity-purified antibodies

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5732190A (en) * 1989-05-05 1990-11-29 Genentech Inc. Glycoprotein hormone receptor molecules
ES2092998T3 (en) * 1989-12-14 1996-12-16 Brahms Diagnostica Gmbh POLYPEPTIDES THAT HAVE ACTIVITY OF TYROTROPINE RECEPTORS, NUCLEIC ACID SEQUENCES THAT CODE FOR SUCH RECEPTORS AND POLYPEPTIDES, AND APPLICATIONS OF THESE POLYPEPTIDES.
EP0506890A4 (en) * 1989-12-20 1993-06-30 Nichols Institute Diagnostics Recombinant thyrotropin receptor
FR2657014A1 (en) * 1990-01-15 1991-07-19 Inst Nat Sante Rech Med HUMAN RECEPTOR OF TSH. SEQUENCE ENCODING THIS RECEPTOR.

Also Published As

Publication number Publication date
JPH05501952A (en) 1993-04-15
EP0493434A1 (en) 1992-07-08
WO1991003483A1 (en) 1991-03-21
EP0493434A4 (en) 1993-05-05
JP3181582B2 (en) 2001-07-03
CA2066263C (en) 1999-11-02

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