AU2990492A - Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides - Google Patents

Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides

Info

Publication number
AU2990492A
AU2990492A AU29904/92A AU2990492A AU2990492A AU 2990492 A AU2990492 A AU 2990492A AU 29904/92 A AU29904/92 A AU 29904/92A AU 2990492 A AU2990492 A AU 2990492A AU 2990492 A AU2990492 A AU 2990492A
Authority
AU
Australia
Prior art keywords
polypeptides
nucleic acid
acid sequences
growth factor
sequences encoding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU29904/92A
Inventor
Joseph P. Brown
A. Gregory Bruce
Wen Chang
Thomas J. Franceschini
Shui-Lok Hu
Su Win Liu
Hans Marquardt
Gregory D. Plowman
Antonio F. Purchio
Timothy M. Rose
Mohammed Shoyab
George J. Todaro
Daniel R. Twardzik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AU2990492A publication Critical patent/AU2990492A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Virology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
AU29904/92A 1988-03-24 1992-12-04 Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides Abandoned AU2990492A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17265388A 1988-03-24 1988-03-24
US172653 1988-03-24

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
AU31695/89A Division AU3169589A (en) 1988-03-24 1989-03-23 Novel polypeptides capable of binding to epidermal growth factor receptors and inducing growth factor activity; nucleic acids coding for these peptides

Publications (1)

Publication Number Publication Date
AU2990492A true AU2990492A (en) 1993-03-04

Family

ID=22628611

Family Applications (2)

Application Number Title Priority Date Filing Date
AU31695/89A Abandoned AU3169589A (en) 1988-03-24 1989-03-23 Novel polypeptides capable of binding to epidermal growth factor receptors and inducing growth factor activity; nucleic acids coding for these peptides
AU29904/92A Abandoned AU2990492A (en) 1988-03-24 1992-12-04 Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AU31695/89A Abandoned AU3169589A (en) 1988-03-24 1989-03-23 Novel polypeptides capable of binding to epidermal growth factor receptors and inducing growth factor activity; nucleic acids coding for these peptides

Country Status (22)

Country Link
JP (1) JPH0279981A (en)
KR (1) KR890014743A (en)
AU (2) AU3169589A (en)
BE (1) BE1004202A5 (en)
CH (1) CH681081A5 (en)
DE (1) DE3910084A1 (en)
DK (1) DK146789A (en)
ES (1) ES2013408A6 (en)
FI (1) FI891308A (en)
FR (1) FR2632321A1 (en)
GB (1) GB2219799B (en)
GR (1) GR1000876B (en)
HU (1) HUT50501A (en)
IE (1) IE890950L (en)
IL (1) IL89673A0 (en)
IT (1) IT1234961B (en)
LU (1) LU87489A1 (en)
NL (1) NL8900724A (en)
NO (1) NO891273D0 (en)
NZ (1) NZ228427A (en)
PT (1) PT90118B (en)
SE (1) SE8901031L (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU626524B2 (en) * 1987-05-29 1992-08-06 Bristol-Myers Squibb Company Cloning and expression of simian transforming growth factor- beta 1
EP0444961A1 (en) * 1990-03-02 1991-09-04 Bristol-Myers Squibb Company Her3: A novel EGF receptor homolog
EP0739984A1 (en) * 1995-04-26 1996-10-30 San Tumorforschungs-Gmbh Bivalent polypeptides containing at least two domains
AU5549296A (en) * 1996-04-10 1997-10-29 Human Genome Sciences, Inc. Extracellular/epidermal growth factor-like protein
US6852506B1 (en) 1996-04-10 2005-02-08 Human Genome Sciences, Inc. Extracellular/epidermal growth factor-like protein

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0108132A1 (en) * 1982-05-06 1984-05-16 Applied Molecular Genetics Inc. The manufacture and expression of genes for urogastrone and polypeptide analogs thereof
JPS6028994A (en) * 1983-07-08 1985-02-14 Wakunaga Seiyaku Kk (21-leucine) human urogastrone, corresponding gene, corresponding recombinant plasmid, transformed cell and their preparation
WO1985002198A1 (en) * 1983-11-01 1985-05-23 Amgen Microbial expression of type i transforming growth factor, polypeptide analogs thereof and hybrid egf/tgf polypeptides
JP2554459B2 (en) * 1984-07-02 1996-11-13 アース製薬 株式会社 β-urogastron gene, corresponding plasmid recombinant and corresponding transformant
JPS62501071A (en) * 1984-10-30 1987-04-30 オンコゲン Novel polypeptides with growth factor activity and nucleic acid sequences encoding the polypeptides
GB8507666D0 (en) * 1985-03-25 1985-05-01 Wellcome Found Epidermal growth factor production
US4743679A (en) * 1986-02-24 1988-05-10 Creative Biomolecules, Inc. Process for producing human epidermal growth factor and analogs thereof
GB2210618B (en) * 1987-10-08 1991-10-16 British Bio Technology Synthetic egf gene
ES2081801T3 (en) * 1987-10-30 1996-03-16 Bristol Myers Squibb Co EXPRESSION PLASMIDS.
EP0372005A4 (en) * 1987-10-30 1990-06-26 Oncogen Expression systems for preparation of polypeptides in prokaryotic cells.

Also Published As

Publication number Publication date
PT90118B (en) 1994-07-29
LU87489A1 (en) 1989-10-26
AU3169589A (en) 1989-09-28
CH681081A5 (en) 1993-01-15
IE890950L (en) 1989-09-24
DK146789A (en) 1989-09-25
NO891273D0 (en) 1989-03-22
IT1234961B (en) 1992-06-09
JPH0279981A (en) 1990-03-20
FR2632321A1 (en) 1989-12-08
GB2219799B (en) 1992-10-14
GR1000876B (en) 1993-03-16
FI891308A (en) 1989-09-25
KR890014743A (en) 1989-10-25
GB2219799A (en) 1989-12-20
PT90118A (en) 1989-11-10
BE1004202A5 (en) 1992-10-13
SE8901031D0 (en) 1989-03-22
SE8901031L (en) 1989-09-25
DE3910084A1 (en) 1989-11-16
DK146789D0 (en) 1989-03-22
HUT50501A (en) 1990-02-28
NZ228427A (en) 1993-03-26
ES2013408A6 (en) 1990-05-01
GB8906758D0 (en) 1989-05-10
GR890100185A (en) 1990-01-19
NL8900724A (en) 1989-10-16
IL89673A0 (en) 1989-09-28
IT8919917A0 (en) 1989-03-24
FI891308A0 (en) 1989-03-20

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